Dr. Meis studies the treatment and recovery of bone fractures, notably stress fractures in athletes' feet. His research highlights how surgical interventions can significantly enhance recovery times and improve foot function, allowing athletes to return to their sports quickly. In addition to his orthopedic focus, he has also worked on genetic methods, especially techniques for inserting DNA into organisms, to advance the field of genetic research and improve experimental outcomes in microbiology and genetics.
Key findings
In a study of 11 athletes with fourth metatarsal stress fractures, surgery enabled them to return to sports in an average of 12 weeks, with foot function scores improving from 55 to 94 post-surgery.
Dr. Meis's electroporation technique for genetic insertion achieved successful DNA insertions in all tested bacteria and yeast, demonstrating a high efficiency rate.
The genetic analysis of liver tumors in transgenic mice revealed that chromosome 7 often loses genetic material, suggesting that imprinted genes may play a role in tumor development.
Frequently asked questions
Does Dr. Meis study stress fractures?
Yes, Dr. Meis focuses on stress fractures, particularly in athletes, and studies surgical options for effective recovery.
What techniques has Dr. Meis researched?
He has researched electroporation, a method that uses electric pulses to insert DNA into bacteria and yeast, enhancing genetic manipulation.
Is Dr. Meis's work relevant to athletes?
Absolutely, his research on surgical recovery from foot fractures directly benefits athletes seeking effective treatment options.
What genetic conditions does Dr. Meis investigate?
He investigates genetic factors in tumor development, specifically in liver cancer models.
Can Dr. Meis's research help in cancer treatment?
Yes, his findings related to imprinted genes in tumors could provide insights for new cancer treatment strategies.
Publications in plain English
Fourth metatarsal base stress fractures in athletes: a case series.
2013
Foot & ankle international
Rongstad KM, Tueting J, Rongstad M, Garrels K, Meis R
Plain English This study looked at how surgery helps athletes recover from fourth metatarsal stress fractures, which are breaks in a bone in the foot. Eleven athletes who had this type of fracture were treated with surgery and were able to return to their sports in an average of 12 weeks. Their foot function improved significantly, with scores increasing from an average of 55 to 94 after surgery, meaning the treatment was effective.
Who this helps: This benefits athletes who suffer from fourth metatarsal stress fractures and want to return to their sports quickly.
Plain English This study looked at a new technique for inserting DNA pieces called transposons into the genomes of bacteria and yeast, using a method called electroporation, which uses electric pulses to help introduce the DNA. The researchers found that this new method produced successful DNA insertions in all tested bacteria, including E. coli and Salmonella, and also in yeast, demonstrating a high efficiency rate. This is important because it simplifies genetic experiments by avoiding the complications of traditional methods, making genetic manipulations easier and more reliable.
Who this helps: This benefits researchers and scientists working in genetics and microbiology.
Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.
1994
Cancer research
Held WA, Pazik J, O'Brien JG, Kerns K, Gobey M +3 more
Plain English This study looked at liver tumors in genetically modified mice to understand which genes might be involved in tumor development. The researchers found that certain chromosomes frequently lost genetic information, especially chromosome 7, where a specific gene called H19 was often lost. This is important because it suggests that certain inherited genes might play a role in how tumors grow, revealing targets for further research on cancer treatment.
Who this helps: This helps researchers and doctors looking for new ways to understand and treat liver cancer.