Dr. Klausner studies how healthcare can be improved through better information and treatment strategies. He investigates how hospital pharmacies provide drug information, finding that complex inquiries often lead to lower quality responses. His research also emphasizes the need for diversity in brain aging studies to ensure that treatments consider the experiences of varied populations. Additionally, he has explored heart disease prevention strategies and evaluated the effectiveness of certain medications for heart failure, seeking ways to enhance patient outcomes.
Key findings
Hospital pharmacies showed a 75% higher chance of providing poor quality drug information for complex inquiries in 2018.
Diverse participant groups in brain aging research can lead to better treatment applicability for all communities.
Daily low-dose aspirin does not reduce the risk of death from heart-related issues in adults without a history of cardiovascular disease.
Implementation of the PROP tool in preoperative assessments reduced unnecessary tests from 3.39 to 0.60 per patient and increased guideline adherence from 1.6% to 49.3%.
Hydralazine treatment for chronic heart failure increased heart performance by 70% in patients who had not responded to other therapies.
Frequently asked questions
Does Dr. Klausner study conditions related to heart health?
Yes, Dr. Klausner's research includes various aspects of heart health, particularly heart failure treatments and the effectiveness of medications.
What is the focus of Dr. Klausner's research on brain aging?
Dr. Klausner focuses on the importance of including diverse populations in brain aging research to ensure treatments are applicable to everyone.
Has Dr. Klausner researched the effectiveness of aspirin for heart disease prevention?
Yes, he found that daily low-dose aspirin does not lower the risk of death from heart issues in adults without prior cardiovascular problems.
How can Dr. Klausner's work help patients undergoing surgery?
His research on preoperative assessments has led to tools that reduce unnecessary tests, improving the overall care for surgical patients.
What information does Dr. Klausner provide regarding drug information quality?
He studies how hospital pharmacies deliver drug information and highlights the need for specialized centers to improve the quality of responses, especially for complex inquiries.
Publications in plain English
Participant diversity is necessary to advance brain aging research.
2024
Trends in cognitive sciences
Wig GS, Klausner S, Chan MY, Sullins C, Rayanki A +1 more
Plain English This study looked at the importance of including a mix of people from different backgrounds in research about healthy brain aging. The researchers found that diverse participant groups can provide valuable insights, which can lead to better understanding and treatment of brain aging. Increasing diversity in research is crucial for making findings applicable to everyone, not just a select few.
Who this helps: This helps patients and healthcare providers by ensuring that brain aging research reflects the needs of all communities.
Factors Determining Quality of Drug Information by Hospital Pharmacies-Results from Five-Year Annual Quality Assessment.
2024
Pharmacy (Basel, Switzerland)
Strobach D, Chiriac U, Klausner S, Krebs S, Langebrake C +5 more
Plain English This study looked at how well hospital pharmacies provide drug information to healthcare professionals over five years. It found that when inquiries about drug information were more complex, the quality of responses dropped significantly, especially in 2018 and 2021, with chances of poor quality being 75% and 96% higher, respectively. Specialized drug information centers performed better than individual pharmacists and those juggling multiple tasks, suggesting that using these centers and double-checking answers could lead to better drug advice, particularly for complex questions.
Who this helps: This benefits hospital pharmacies, healthcare professionals, and ultimately patients receiving care.
Disrupted Choline Clearance and Sustained Acetylcholine Releaseby a Common Choline Transporter Coding Variant Associated with Poor Attentional Control in Humans.
2022
The Journal of neuroscience : the official journal of the Society for Neuroscience
Donovan E, Avila C, Klausner S, Parikh V, Fenollar-Ferrer C +2 more
Plain English This study looked at a common genetic variant in the choline transporter (named Val89) and its effects on attention in both humans and specially engineered mice. The findings showed that mice with this variant had over 80% less ability to clear choline from the brain, which led to a reduced release of a key brain chemical called acetylcholine, ultimately affecting their focus and cognitive flexibility. This matters because it helps us understand how this genetic variant may contribute to attention problems in people, potentially guiding future treatment options for those affected.
Who this helps: This helps patients with attention-related issues linked to the Val89 variant.
Low-dose aspirin as primary prevention for adults without cardiovascular disease.
2022
Journal of the American Association of Nurse Practitioners
Klausner S
Plain English This research focused on whether daily low-dose aspirin can help prevent heart disease or death in adults who have no history of cardiovascular disease. The study reviewed four relevant studies and found that taking low-dose aspirin does not reduce the risk of death from heart-related issues. This is important because it challenges the practice of prescribing aspirin for prevention and suggests that more research is needed to understand its effects better.
Who this helps: Patients and healthcare providers can make better decisions about aspirin use for heart disease prevention.
Quality improvement in preoperative assessment by implementation of an electronic decision support tool.
2013
Journal of the American Medical Informatics Association : JAMIA
Flamm M, Fritsch G, Hysek M, Klausner S, Entacher K +2 more
Plain English This study looked at how an online tool called PROP improved the process of assessing patients before surgery in Salzburg, Austria. Researchers compared 1,363 patients who were evaluated before PROP was available to 1,148 patients who were assessed using the tool afterward. They found that the number of unnecessary tests dropped significantly from 3.39 to 0.60 per patient, and guideline adherence for necessary tests increased from just 1.6% to 49.3%.
Who this helps: This benefits patients by reducing unnecessary tests and associated costs while improving overall care.
Biodegradation and aneurysm formation in umbilical vein grafts. Observations and a realistic strategy.
1984
Annals of surgery
Dardik H, Ibrahim IM, Sussman B, Kahn M, Sanchez M +4 more
Plain English Researchers studied 756 umbilical vein grafts used for surgery over 7.5 years and found that 7 of them developed aneurysms, which happened between 31 to 79 months after the procedure. Most cases were resolved through corrective surgery, which was successful in 4 out of 5 attempts. This study highlights the importance of monitoring patients with umbilical vein grafts, especially after a few years, as aneurysms can form, even though it's a low occurrence.
Who this helps: This helps patients undergoing surgeries that require umbilical vein grafts and their doctors.
Giant lipoma of the mesentery: report of an unusual case and review of the literature.
1976
The American surgeon
Signer RD, Bregman D, Klausner S
Plain English This study looks at a rare case of a giant lipoma, which is a fatty tumor, in the mesentery (the tissue that attaches the intestines to the abdominal wall). Researchers found that there have been fewer than 30 similar cases reported in previous literature, making it difficult to recognize before surgery. The best way to treat these tumors is through surgery, as they can potentially turn cancerous.
Who this helps: This helps doctors and patients by increasing awareness of a rare condition and highlighting the need for surgical treatment.
Effects of sodium nitroprusside and nitroglycerin on tension prolongation of cat papillary muscle during recovery from hypoxia.
1976
Circulation research
Brodie BR, Cuck L, Klausner S, Grossman W, Parmley W
Plain English This study looked at how two medications, sodium nitroprusside and nitroglycerin, affect the performance of heart muscle from cats after it has been deprived of oxygen. The researchers found that sodium nitroprusside significantly reduced the time the heart muscles took to recover after oxygen levels returned to normal, with recovery times improving from about 300 milliseconds to 208 milliseconds. This is important because it suggests that sodium nitroprusside could help the heart relax more effectively after a period of low oxygen, which is crucial for heart health.
Who this helps: This helps patients with heart conditions who experience oxygen deprivation.
Oral hydralazine therapy for chronic refractory heart failure.
1976
Circulation
Chatterjee K, Parmley WW, Massie B, Greenberg B, Werner J +2 more
Plain English This study looked at the effects of the medication hydralazine on ten patients with severe heart failure who had not responded well to other treatments. After taking hydralazine, patients experienced an average 5% drop in blood pressure and a significant 42% reduction in resistance in blood vessels, leading to a 70% increase in heart performance. Over the next 3 to 7 months, seven out of nine patients improved to a less severe class of heart failure, indicating that hydralazine can be an effective treatment for these patients.
Who this helps: This helps patients with chronic refractory heart failure.