DR. TANSEL TURGUT, M.D.

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This study looked at how well computer models can predict the success of a type of heart valve replacement procedure called transcatheter aortic valve implantation (TAVI). Researchers tested these models by comparing their predictions for 20 patients with actual clinical results and found that their predictions were quite accurate; for example, the effective opening area of the valve was off by less than 10%. This matters because validating these models ensures better planning for TAVI procedures, leading to improved patient outcomes. Who this helps: This helps patients undergoing TAVI and their doctors.

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This study looked at how reliable computer models can be when planning transcatheter aortic valve implantation (TAVI), a procedure to replace a heart valve. Researchers created four different models using simulations and found that while the models accurately predicted the size of the device needed (with less than a 1% error), they struggled more with predicting blood flow dynamics, sometimes exceeding the accepted margin of error. Improving the reliability of these models is important because it helps doctors make better decisions during TAVI procedures, potentially leading to better patient outcomes. Who this helps: This helps doctors and their patients undergoing heart valve procedures.

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This study looked at how concerns about artificial intelligence (AI) and job security affect future sports managers. Researchers surveyed 210 young individuals, revealing that while gender affected worries about AI, income level was a big factor in employment anxiety. Addressing these concerns is important because as the sports industry evolves digitally, students need support like career counseling, internships, and AI training to build their confidence and career prospects. Who this helps: This helps prospective sports managers and students in the sports management field.

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This study focused on understanding the material properties of the aortic root in patients who had transcatheter aortic valve implantation (TAVI), a procedure used to treat narrowed heart valves. Researchers developed a non-invasive method to estimate these properties and found that their predictions closely matched actual measurements from heart imaging, achieving a similarity score of 83.7% to 91.5% across 20 patients. This is important because it can enhance the accuracy of computer simulations used in planning TAVI procedures, potentially improving patient outcomes. Who this helps: This helps patients undergoing TAVI and the doctors treating them.

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This study tested whether genetic testing followed by treatment with a drug called zoledronic acid can help prevent the worsening of Paget's disease of bone in people at higher risk. Researchers followed 222 participants for about 7 years, and found that none of the participants who received zoledronic acid developed new bone lesions, while two in the placebo group did. Additionally, only one person from the zoledronic acid group had poor outcomes compared to eight from the placebo group, indicating the drug significantly helped in preventing disease progression. Who this helps: This benefits patients at risk of Paget's disease, as well as their doctors in making informed treatment decisions.

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This study looked at how adding coriander to yogurt affects its quality in various ways, including taste, texture, and how long it lasts. Researchers made four types of yogurt: a control without coriander and three with 1%, 2%, and 3% coriander. They found that mixing in coriander improved the taste and color of the yogurt, and it was still safe to eat even after storage, with bacteria counts staying above a healthy level. Who this helps: This research is beneficial for yogurt producers and health-conscious consumers looking for functional foods.

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This study looked at the factors that influence survival rates of patients with severe burns in an intensive care unit. Out of 381 patients treated from 2008 to 2013, 53 (13.6%) died, while 329 (86.4%) survived. It found that older patients, those with larger burns on their bodies, and individuals with flame burns or inhalation injuries were more likely to die. Who this helps: This research helps doctors better understand which burn patients are at higher risk so they can provide tailored and effective care.

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This study looked at how adding loquat marmalade (LM) to probiotic yogurt affects its quality over 21 days. Researchers found that yogurt with 10% and 15% LM had better texture and less separation of liquid compared to the plain yogurt, and the added marmalade changed the yogurt's color and acidity without negatively affecting the live probiotic bacteria. These findings matter because they show that loquat marmalade can enhance the quality of yogurt while keeping its health benefits. Who this helps: This helps yogurt manufacturers and health-conscious consumers looking for tasty, nutritious options.

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This study looked at how muscle loss (sarcopenia) affects blood pressure and fall risk in older adults. Among 72 elderly patients studied, 26.4% had severe muscle loss, and it was found that those with muscle loss had higher arterial stiffness and lower blood pressure measurements. This is important because understanding the connection between muscle loss and blood pressure can help assess the risk of falls in older adults, possibly leading to better patient care. Who this helps: This helps older patients and their doctors in managing fall risks and overall health.

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This study looked at how certain antiviral drugs affected the health of COVID-19 patients in hospitals in Turkey. Researchers analyzed data from 1,472 adults and found that using drugs like favipiravir and lopinavir/ritonavir was linked to longer hospital stays and higher chances of moving to the ICU or needing ventilators. Specifically, patients taking favipiravir had a 3-fold increased risk of being admitted to the ICU and nearly a 3-fold higher risk of requiring mechanical ventilation. Who this helps: This research benefits patients and healthcare providers by highlighting the risks of some antiviral drugs for treating COVID-19.

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The study examined the link between depression and overall health in 235 older patients visiting outpatient clinics for physical health issues. It found that 34.9% of the patients had high depression scores, which were associated with poorer cognitive function and nutrition, as well as higher levels of frailty and shorter, lower-quality sleep. This is important because it shows that depression in older adults can affect not just mood, but also their physical health and daily functioning. Who this helps: This helps elderly patients and their healthcare providers by highlighting the need for mental health assessments in routine care.

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This study looked at a substance called endocan in patients with chronic obstructive pulmonary disease (COPD) to see if it could indicate the severity of the disease and the likelihood of exacerbations, which are sudden worsens in symptoms. Researchers found that endocan levels were much higher in patients experiencing acute exacerbations (with an average of 434.29 pg/ml) compared to stable COPD patients and healthy controls. Specifically, the study showed that higher endocan levels were independently linked to a nine times greater chance of experiencing an exacerbation, which is important for managing and predicting treatments for COPD. Who this helps: This helps patients with COPD and their doctors in monitoring disease progress and preventing flare-ups.

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This study looked at using blink rate as a simple way to screen for dynapenia, a condition that involves muscle weakness, in older adults. Researchers tested 355 patients aged 65 and older and found that a blink rate of 15 seconds can help predict dynapenia, with a sensitivity of 70.3% and specificity of 43.3%. This method is important because it offers an accessible alternative for assessing muscle strength, especially for patients who cannot easily perform traditional grip strength tests. Who this helps: This helps older patients and healthcare providers in geriatric care.

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This study looked at how the Glasgow Prognostic Score (GPS) and the fibrinogen to albumin ratio (FAR) can predict outcomes for hospitalized COVID-19 patients. Among 400 patients, 86.25% were discharged, 7.75% needed intensive care, and 6% died. Patients with a higher GPS (specifically GPS 2) and higher FAR levels were more likely to face worse outcomes, meaning these measures can help identify patients at greater risk. Who this helps: This helps doctors identify which COVID-19 patients may need more intensive treatment.

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This study looked at 1,500 hospitalized adults in Turkey who had COVID-19 to understand what factors contributed to their risk of dying from the illness. They found that 67 patients died, resulting in a death rate of 4.5%. Key risk factors for higher mortality included being male, having severe pneumonia, multiple organ failures, certain cancers, sepsis, and lung diseases; for instance, men had a significantly higher risk, and patients with severe pneumonia had over six times the risk of dying compared to those without it. Who this helps: This information benefits doctors in treating COVID-19 patients by identifying those who need closer monitoring and care.

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This study looked at a procedure called endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), which helps doctors figure out why some patients have swollen lymph nodes in the chest. It found that EBUS-TBNA correctly diagnosed conditions in 88 out of 120 patients, with a success rate of 91.6%. This matters because it helps differentiate between serious issues like cancer and less concerning ones like reactive lymph nodes, improving patient care. Who this helps: This benefits patients with swollen lymph nodes in the chest and their doctors.

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This study looked at how the spread of lung damage seen in CT scans affects the severity and outcomes of COVID-19 in 200 patients. Of these patients, 89% were discharged, 8.5% went to the ICU, and 2.5% died. It was found that those with widespread lung damage had higher rates of ICU transfer and death, and certain blood tests (like troponin and fibrinogen levels) can help predict this serious lung involvement. Who this helps: This information benefits doctors and healthcare providers in managing COVID-19 patients more effectively.

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This study looked at how zoledronic acid, a medication commonly used to strengthen bones, impacts daily activities, brain function, mood, and muscle performance in 115 patients. The researchers found that while bone density improved significantly after treatment, patients showed a notable decline in brain function and walking speed, with mental function scores dropping by about 2 points and gait speed scores decreasing significantly. This matters because it suggests that while zoledronic acid is effective for bone health, it might negatively affect mental and physical capabilities. Who this helps: This helps patients using zoledronic acid, particularly older adults who may be at risk for cognitive decline and mobility issues.

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This study looked at how low levels of vitamin D might affect the chances of older adults getting an infection from Helicobacter pylori (H. pylori), a bacteria that can cause stomach problems. Among 254 patients aged 65 and older, 86% of those with H. pylori had vitamin D deficiency, compared to 67.3% of those without the infection. The research found that low vitamin D levels were linked to a three times higher chance of having H. pylori infection. Who this helps: This information is useful for doctors treating older patients, as it highlights the importance of monitoring and potentially correcting vitamin D deficiency to reduce infection risk.

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This study looked at how two conditions—sarcopenia (loss of muscle mass) and sarcopenic obesity (excess fat along with muscle loss)—affect the risk of dying in older people who are hospitalized. Among 350 older patients, 21.1% had sarcopenic obesity and 11.4% had sarcopenia. Both conditions significantly increased the risk of death within two years after discharge, with sarcopenic obesity increasing the risk by over five times and sarcopenia nearly nine times, highlighting the importance of addressing these health issues in hospital settings. Who this helps: This helps older patients and their healthcare providers understand the risks of sarcopenia and sarcopenic obesity.

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This study looked at how well two types of probiotics, Lactobacillus acidophilus and Bifidobacterium bifidum, survive in strawberry yogurt over two weeks. Researchers found that Lactobacillus acidophilus started strong with a count of 7.20 log cfu/g on day one, but its numbers dropped over time, while Bifidobacterium bifidum stayed steady and had a peak of 6.13 log cfu/g on day seven. This matters because it shows that yogurt can be a good source of probiotics if stored properly for about a week. Who this helps: Patients looking to improve their gut health through yogurt consumption.

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This study looked at how treating iron deficiency and iron deficiency anemia in older patients affects their nutrition, physical performance, and mental function. Researchers followed 81 patients for about six months after they received iron treatment and found that many areas improved, including daily living activities, mental status, hand grip strength, and walking speed. Specifically, improvements were noted in tools measuring daily activities and nutrition, and key blood markers related to iron levels also increased. Who this helps: This research benefits older patients suffering from iron deficiency and anemia.

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This study looked at how personality traits connect with values among Turkish university students and whether these connections differ from those found in global research. It found that Turkish traits and values align well with broader patterns seen worldwide, and that people with lower disposable income showed weaker links between certain traits and values. This matters because understanding these connections can help tailor support for individuals based on their economic situation, making it easier to encourage positive development. Who this helps: This helps students and educators in Turkey understand how personality and values interact, especially for those from different economic backgrounds.

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This study focused on patients with ankylosing spondylitis (AS) and looked at how their sleep quality was affected by the severity of their disease. It found that 47.5% of the patients were treated with anti-TNF medication, which significantly improved their sleep compared to those only taking NSAIDs. Specifically, the anti-TNF group had 33% more total sleep time and fewer disruptions, leading to much better overall sleep quality. Who this helps: This benefits patients with ankylosing spondylitis by highlighting the advantages of anti-TNF treatment for better sleep quality.

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This study looked at how traditional Turkish values relate to a well-known set of universal values created by researcher Shalom Schwartz. In a survey of 593 university students in Istanbul, researchers found that while Turkish values generally fit into Schwartz's framework, some aspects, especially regarding personal autonomy, showed unique cultural differences. Understanding these values better can help improve our grasp of human motivations worldwide. Who this helps: This benefits researchers and psychologists working with diverse cultures.

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This study looked at drowning deaths in Turkey from 2007 to 2011, finding that 3,216 people died from drowning, with 84% of the victims being male. The highest death rate was among those aged 10 to 19, at 1.76 per 100,000 people, and most drownings occurred in natural water environments. Understanding these statistics is crucial for developing strategies to prevent drownings, which are a significant public health issue in Turkey. Who this helps: This helps patients, families, and public health officials in Turkey.

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This study looked at levels of glutathione and nitrite in the sputum (mucus) of people with chronic obstructive pulmonary disease (COPD) and healthy smokers. Researchers found that during acute flare-ups, the glutathione and nitrite levels in sputum were much higher in COPD patients compared to healthy smokers and non-smokers—specifically, the levels were significantly higher by over three times (P<0.001). This is important because it shows that oxidative stress is a key factor in COPD and that a simple test like sputum induction can help identify this stress in patients. Who this helps: This information benefits doctors and researchers working to treat and understand COPD.

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This study looked at a rare condition called plastic bronchitis, where airways get blocked, in an adult male patient with multiple health issues, including heart failure and a history of pneumonia. The patient had been coughing up white, plaque-like mucus for six months, which was found to have the same shape as the bronchial tubes. After starting steroid treatment, the mucus almost completely disappeared. Who this helps: This benefits patients suffering from plastic bronchitis and their doctors by providing insight into effective treatment options.

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This study looked at factors related to appendicitis in children, focusing on their age, sex, and family history. Researchers reviewed records from 588 kids who had surgery for appendicitis and found that it was most common in boys and children over 10 years old, with appendicitis being 2.41 times more frequent in those older than 10 and 4.63 times more common in boys than girls. Understanding these factors can help doctors make better diagnoses and decisions about surgery for children with abdominal pain. Who this helps: This helps doctors and families of children experiencing abdominal pain.

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This study looked at drowning incidents in Turkey, focusing on situations where people who tried to rescue drowning victims also drowned. Between 2005 and 2008, there were 88 cases of these rescuer drownings, resulting in the deaths of 114 rescuers and 60 primary drowning victims; 47 of the rescued individuals drowned after the rescuers tried to help. Most of these incidents involved young males and happened in fresh water, highlighting the need for better awareness and training in swimming and rescue skills to prevent such tragedies. Who this helps: This research benefits parents, young swimmers, and organizations focused on water safety.

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This study looked at how common Chronic Obstructive Pulmonary Disease (COPD) is in the Elazig region of Turkey by surveying 1,270 adults and measuring their lung function. They found that 4.5% of adults aged 18 and older have COPD, increasing to 11.5% among those over 45. The majority of these cases were seen in early stages of the disease, and significant risk factors included being male, older age, and smoking, especially among current smokers who had a 5.8% prevalence. Who this helps: This research helps patients, healthcare providers, and public health officials understand and address COPD in the region.

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This study looked at the levels of ghrelin, a hormone that helps regulate appetite, and two inflammatory substances (IL-6 and TNF-α) in patients with chronic obstructive pulmonary disease (COPD). Researchers found that COPD patients had lower ghrelin levels and higher levels of IL-6 and TNF-α compared to healthy individuals. Specifically, cachectic COPD patients had even lower ghrelin and higher IL-6 levels than normal-weight COPD patients, indicating that inflammation and lower ghrelin might be linked to weight loss in these patients. Who this helps: This research benefits patients with COPD, particularly those struggling with weight loss.

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This study looked at T cells, which play a role in the immune response, in patients with active tuberculosis (TB). Researchers found that patients with TB had significantly lower levels of certain T cells compared to healthy individuals, specifically CD3+ and CD3+/alphabeta T cells. This matters because it suggests that these T cells might help protect against tuberculosis infections. Who this helps: Patients with tuberculosis.

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This study looked at how a drug called infliximab can reduce inflammation in a mouse model of acute asthma. The researchers found that both low and high doses of infliximab significantly reduced the number of specific immune cells (neutrophils and eosinophils) in the lungs, with the high dose showing a stronger effect. For example, the high-dose group had a noticeable drop in several inflammatory markers compared to control mice. Who this helps: This helps asthma patients and their doctors by providing insights into potential treatments for better managing inflammation associated with asthma.

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This study looked at how a drug called erdosteine affects inflammation and scarring in the lungs of rats that were given a substance (bleomycin) to induce lung damage. The researchers found that rats treated with erdosteine had lower levels of harmful substances and fewer signs of lung damage after 29 days compared to those not treated with the drug. Specifically, the erdosteine group showed significant reductions in markers of inflammation and lung scarring, indicating it may help protect against lung injury. Who this helps: This benefits patients with pulmonary fibrosis and similar lung conditions.

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This study examined how a drug called bosentan affects inflammation in rats with emphysema, a serious lung condition. The researchers found that bosentan significantly reduced the number of inflammatory cells and key inflammatory substances in the lungs compared to untreated rats, meaning it helped calm the lung inflammation. Specifically, there were decreases in levels of inflammatory markers like TNF-alpha and IL-6, which were elevated in untreated rats. Who this helps: This research benefits patients with emphysema by exploring new treatment options to reduce lung inflammation.

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This study looked at how salt intake (osmotic stress) affects the production of an enzyme called invertase in certain types of yeast. Researchers found that low salt levels increased invertase production in the yeasts Pichia anomala and Kluyveromyces lactis by three to four times, while high salt levels reduced this enzyme production in most yeast species, except for P. anomala. This is important because understanding how different yeast respond to stress can help improve their use in food production and fermentation processes. Who this helps: This helps food scientists and manufacturers working with yeast in food production.

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This study looked at a 35-year-old woman who developed osmotic demyelination syndrome (ODS) after a quick correction of low sodium levels due to her kidney problems. Using diffusion magnetic resonance imaging (MRI), researchers found specific brain changes that indicated ODS, with her condition improving over time in line with the MRI results. The findings showed that MRI could help predict how well patients with ODS might recover, which is important for treatment planning. Who this helps: This helps patients with osmotic demyelination syndrome and their doctors.

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This study looked at how a low dose of montelukast, a medication that blocks certain chemicals involved in asthma, affected changes in the airways of mice with asthma. It was found that montelukast significantly reduced inflammation and mucus buildup in the airways, as well as lung scarring, but it did not change the thickening of airway muscles. This is important because it shows that even a low dose of this medication can help control serious asthma symptoms and lung damage. Who this helps: Patients with asthma.

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This study looked at how levels of two substances, interleukin-2 (IL-2) and neopterin, in the blood can help track the treatment progress of patients with active tuberculosis (TB). Researchers found that these levels were much higher in patients with active TB (IL-2 at 164.53 pg/ml and neopterin at 69.54 nmol/l) compared to those with inactive TB or healthy individuals. This is important because monitoring these markers can help doctors assess how well a patient's treatment is working. Who this helps: Doctors treating patients with active tuberculosis.

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This study looked at a patient with acute myelomonocytic leukemia who developed autoimmune hemolytic anemia after starting antibiotic treatment. The patient began to have symptoms of anemia 15 days after hospitalization, during which they were receiving antibiotics, including teicoplanin, imipenem, and amphotericin B. The anemia improved with treatment using steroids, even though stopping the antibiotics was not an option due to the patient's condition. Who this helps: This research benefits doctors and patients undergoing treatment for leukemia who may experience similar complications.

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This study looked at a 2-year and 9-month-old boy with Down syndrome who had Moyamoya disease, a condition where blood flow to the brain is blocked, causing symptoms like seizures and headaches. The boy experienced focal convulsions due to this condition. Understanding the link between Moyamoya disease and Down syndrome is important because it can help doctors better diagnose and treat similar cases. Who this helps: This helps doctors and caregivers of children with Down syndrome.

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This study looked at changes in certain immune proteins, called cytokines, in people with active tuberculosis (TB) as they underwent treatment. Researchers found that levels of specific cytokines (IFN-gamma, TNF-alpha, and IL-10) were much higher in patients with active TB compared to those who had TB that was inactive or healthy controls. After treatment, these levels significantly decreased, indicating that these proteins could be important markers for monitoring how well TB treatment is working. Who this helps: This research helps doctors monitor treatment progress in patients with active tuberculosis.

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In this study, researchers tested how well dexamethasone, a type of steroid, reduces inflammation in mice that have asthma. They found that inflammation-causing cells (eosinophils) were significantly lower in the mice treated with dexamethasone compared to those that weren't (p<0.001). This is important because it shows that dexamethasone can effectively reduce harmful inflammation in asthma, potentially improving treatment options for patients. Who this helps: This helps asthma patients.

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This study examined the nutritional status of patients with chronic obstructive pulmonary disease (COPD) during flare-ups and stable periods, comparing them to healthy individuals. It found that patients experiencing a flare-up had lower body mass index (BMI) and albumin levels compared to those who were stable and to healthy controls, significantly affecting their exercise performance, as those in the flare-up group walked an average of only 225.8 meters in six minutes compared to 405.2 meters for stable patients. This matters because proper nutrition can significantly impact the health and physical capability of COPD patients, especially during exacerbations. Who this helps: This helps patients with COPD and their healthcare providers.

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This study looked at the rates of occupational asthma (OA) among workers who handle auto and furniture dyes in Elazig, Turkey. They found that 3.52% of these workers had OA, with 21 out of 22 showing symptoms and abnormal lung function. Understanding how common this condition is matters because it helps raise awareness and prompts better health monitoring for workers potentially exposed to harmful substances. Who this helps: This helps workers in hazardous jobs, employers in the automotive and furniture industries, and health professionals.

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The study looked at levels of two substances, glutathione (GSH) and nitrite (NO2-), in the sputum of asthma patients and compared them to a control group. It found that patients with stable asthma had the highest levels of GSH, while both stable and acute asthma patients had higher nitrite levels compared to controls—acutely affected patients showed a trend towards even higher levels, though not conclusively. These results are important because they help understand oxidative stress in asthma, which may lead to better ways to assess and manage the condition. Who this helps: This helps asthma patients and their doctors by improving insights into asthma management.

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This study looked at the thickness of airway walls in three groups: patients with chronic obstructive pulmonary disease (COPD), healthy smokers, and healthy non-smokers. The researchers used high-resolution scans and found that COPD patients had thicker airway walls compared to both types of smokers, and that patients with COPD experienced worse airflow. Specifically, patients with moderate and severe COPD showed significant differences in airway dimensions compared to healthy smokers and non-smokers. Who this helps: This research benefits patients with COPD and their doctors by providing important information about lung function and the effects of smoking.