DR. TODD L. MONROE, MD

TOLEDO, OH

Research Active
Internal Medicine - Interventional Cardiology NPI registered 21+ years 40 publications 1996 – 2025 NPI: 1366446635
Alzheimer DiseaseDementiaTomography, X-Ray ComputedSurveys and QuestionnairesAcute DiseasePainHospitalizationSuicidal IdeationSubstance-Related DisordersHealth PolicyDeliriumNurse AnesthetistsProfessional ImpairmentSuicide PreventionGeriatric Nursing

Practice Location

2940 N MCCORD RD
TOLEDO, OH 43615-1753

Phone: (419) 842-3000

What does TODD MONROE research?

Dr. Monroe investigates multiple areas, primarily focusing on anesthesia practices and the management of mental health issues, particularly suicide prevention. He explores how certified registered nurse anesthetists (CRNAs) function within anesthesia teams and advocates for greater autonomy for these professionals to improve patient outcomes. Additionally, he studies the impact of housing stability on adolescent mental health and the role various healthcare providers, including tattoo artists, can play in identifying and supporting at-risk individuals. His research emphasizes the integration of palliative care for patients with chronic conditions and the importance of tailored strategies for managing pain in vulnerable populations such as those with Alzheimer’s disease.

Key findings

  • CRNAs reported increased job satisfaction and improved patient care when working independently, highlighting the need for policy changes regarding oversight (2025).
  • Frequent housing changes significantly correlated with increased suicidal thoughts among teens, particularly affecting LGBTQ+ youth and those with disabilities (2025).
  • Integrating palliative care early for patients with multiple chronic conditions led to fewer hospital visits and improved quality of life (2024).
  • Out of 79 tattoo artists surveyed, many reported having clients discuss mental health issues, suggesting the potential of training them to recognize at-risk individuals (2024).
  • Using genetic risk scores increased PSA screening uptake in at-risk men from 2.1% to 4.5%, indicating more effective screening strategies (2016).

Frequently asked questions

Does Dr. Monroe study mental health issues?
Yes, he investigates the mental health impacts of housing instability on teenagers and how tattoo artists can assist in suicide prevention.
What treatments has Dr. Monroe researched?
He has researched treatments related to anesthesia management, chronic conditions, and integrating palliative care to improve patient outcomes.
Is Dr. Monroe's work relevant to patients with Alzheimer's disease?
Yes, he studies pain management in patients with Alzheimer's, focusing on strategies for better care during medical procedures.
Can Dr. Monroe's research help nursing home residents?
Absolutely, his work includes examining appropriate treatment for urinary tract infections and improving care practices for older adults with conditions such as delirium.
What are Dr. Monroe's findings on diabetes management?
He developed a glucose-sensitive microneedle patch for insulin delivery, showing promising results for better blood sugar control in diabetic patients.

Publications in plain English

Investigating the association between housing mobility and self-reported adolescent suicidality and mental health.

2025

The American journal of orthopsychiatry

Kohlbeck SA, deRoon-Cassini T, Bergner C, Monroe T, McCoy K

Plain English
This study looked at how moving homes frequently impacts mental health and suicidal thoughts among teenagers in Wisconsin. It found that adolescents who had lived in multiple homes were more likely to report having thoughts of suicide, with disparities observed among different racial groups, those with disabilities, and LGBTQ+ youth. Understanding this connection is crucial for creating support systems that can better help at-risk teens and influence policies that promote stable housing. Who this helps: This helps students, parents, educators, and policymakers.

PubMed

A Narrative, Qualitative Research Study of CRNA Perspectives of Practice Within the Anesthesia Care Team Model.

2025

AANA journal

Dabney C, Carter M, Herr M, Monroe T, Moore J +1 more

Plain English
This study explored what certified registered nurse anesthetists (CRNAs) think about working within the anesthesia care team model, where they collaborate with other healthcare professionals. The CRNAs reported that teamwork improved patient care and problem-solving but felt that the requirement for physician supervision was unnecessary and sometimes hindered their work. They found that those who moved away from the team model to work independently were much happier in their jobs. Who this helps: This helps CRNAs and the patients they serve by advocating for more independence and collaboration in anesthesia care.

PubMed

Implementation of a countywide adult suicide review commission: Development, lessons learned, and recommendations.

2024

Suicide & life-threatening behavior

Kohlbeck SA, Schramm AT, Monroe T, Kant J, McLeod E +2 more

Plain English
This study focused on creating a local team to review adult suicides in order to understand and prevent these tragedies. The team found that looking beyond individual struggles to the larger social and environmental factors that contribute to stress is essential. Their work has led to specific recommendations for better prevention practices, emphasizing the need for a more comprehensive approach to mental health support. Who this helps: This benefits patients at risk of suicide and their families, as well as healthcare providers and community organizations working on mental health initiatives.

PubMed

Art on the skin, lifesaving within: Exploring the role of tattoo artists in suicide prevention.

2024

Journal of community psychology

Kohlbeck SA, Kant JM, Glassford R, Monroe T

Plain English
This study looked at how tattoo artists can play a role in preventing suicide by providing support to clients discussing mental health issues. Out of 79 surveyed tattoo artists, most reported having clients who talked about their mental health, with many having heard suicidal thoughts from clients at least once. This highlights the importance of training tattoo artists to recognize and assist clients at risk of suicide, as they often have these challenging conversations in their shops. Who this helps: This benefits both tattoo artists and clients who may be struggling with mental health issues.

PubMed

Integration of palliative care in the management of multiple chronic conditions: An expert consensus paper with policy implications.

2024

Nursing outlook

Kuebler K, Monroe T, Ricciardi R, Westlake C, Sorenson M +8 more

Plain English
This paper discusses the importance of integrating palliative care into the treatment of patients with multiple chronic conditions. The authors highlight that starting palliative care earlier can lead to fewer hospital visits, better physical health, and improved quality of life for these patients. With the aging population and rising healthcare costs, adopting this approach is crucial for enhancing overall patient care. Who this helps: This helps patients with chronic illnesses and their families.

PubMed

Understanding Pain in Alzheimer's Disease in Anesthesia.

2023

AANA journal

Dabney C, Monroe T, Cowan R, Carter M

Plain English
This study looked at how Alzheimer's Disease (AD) affects patients' pain responses and how anesthetists can better manage this pain during surgery. The research emphasized the need for personalized pain management plans because patients with AD often struggle to communicate their pain, and there's little guidance on how to approach their care. It matters because effective pain control can improve surgical outcomes and the overall comfort for these patients. Who this helps: This helps patients with Alzheimer's Disease and the healthcare providers caring for them.

PubMed

Polymeric Microneedle Arrays with Glucose-Sensing Dynamic-Covalent Bonding for Insulin Delivery.

2022

Biomacromolecules

Ye Z, Xiang Y, Monroe T, Yu S, Dong P +2 more

Plain English
This study investigated a new type of microneedle patch designed to deliver insulin for people with diabetes. The researchers created a patch that not only helps in delivering insulin through the skin but also senses glucose levels in the blood, making it more effective—especially since insulin release speeds up when glucose is present. In tests on diabetic rats, the patch successfully controlled blood sugar levels, showing promising results without the risks linked to traditional methods of making these devices. Who this helps: This benefits diabetes patients who need better ways to manage their blood sugar.

PubMed

Policy Issues Affecting Nursing Pain Management: A New Decade of Hope.

2021

Pain management nursing : official journal of the American Society of Pain Management Nurses

Monroe T

PubMed

Hemopericardium with subsequent cardiac tamponade secondary to rivaroxaban treatment: a case report.

2021

European heart journal. Case reports

Shastri P, Bhuta S, Oostra C, Monroe T

Plain English
This study looked at a patient who developed bleeding around the heart, known as hemopericardium, while taking a blood thinner called rivaroxaban. The patient had symptoms like dizziness and was found to be in serious heart trouble. After reversing the blood thinner and draining the excess fluid, the patient showed improvement, even though no cancer was found in the fluid tested. Who this helps: This helps patients on rivaroxaban and their doctors by highlighting potential complications.

PubMed

Assessment and management of pain in persons with dementia.

2018

Geriatric nursing (New York, N.Y.)

Anderson AR, Parish AL, Monroe T

PubMed

We need to question over treatment.

2018

The Veterinary record

Taylor P, Monroe T, Murphy K, Chennells D

PubMed

Implementing Nurse-Facilitated Person-Centered Care Approaches for Patients With Delirium Superimposed on Dementia in the Acute Care Setting.

2017

Journal of gerontological nursing

Yevchak A, Fick DM, Kolanowski AM, McDowell J, Monroe T +2 more

Plain English
This study focused on how nurses can provide more personalized care to older patients who have both delirium and dementia while they are hospitalized. The researchers analyzed 750 care sessions and identified five key ways that nurses can improve care by understanding each patient’s background and preferences, enhancing communication methods, and tailoring cognitive activities. The findings show that using person-centered care can help reduce stress for both patients and healthcare providers in these challenging situations. Who this helps: This helps older patients with delirium and dementia, as well as the nurses and doctors caring for them.

PubMed

A Family-Focused Delirium Educational Initiative With Practice and Research Implications.

2016

Gerontology & geriatrics education

Paulson CM, Monroe T, McDougall GJ, Fick DM

Plain English
This study focused on creating a helpful brochure for families of older adults who may experience delirium during hospital stays. The brochure, developed through expert feedback, explains the differences between delirium and dementia, signs to look for, potential causes, and prevention strategies. Improving family understanding is important as it can lead to better care and support for patients facing delirium, ultimately improving outcomes during hospitalizations. Who this helps: This benefits family caregivers of older adults, especially those with dementia.

PubMed

Randomized trial finds that prostate cancer genetic risk score feedback targets prostate-specific antigen screening among at-risk men.

2016

Cancer

Turner AR, Lane BR, Rogers D, Lipkus I, Weaver K +16 more

Plain English
This study looked at whether providing men at risk for prostate cancer with genetic risk scores, along with family history information, would affect their likelihood of getting prostate-specific antigen (PSA) screenings. Out of 700 men aged 40 to 49, 2.1% who received family history information alone, and 4.5% who received genetic risk scores along with family history, opted for PSA screening after three months. The findings indicate that using genetic risk scores can help identify who might benefit from screening without increasing anxiety or overdiagnosis. Who this helps: This benefits men at risk for prostate cancer and their doctors by providing better screening strategies.

PubMed

Canadian Association of Emergency Physicians position statement on acute ischemic stroke.

2015

CJEM

Harris D, Hall C, Lobay K, McRae A, Monroe T +5 more

Plain English
This report from the Canadian Association of Emergency Physicians focused on how to treat strokes caused by blocked blood vessels in the brain, particularly using clot-busting drugs called thrombolytics. The committee found that these drugs should be used within 3 hours of symptoms starting, as this timing improves outcomes for patients. They recommended against using these treatments between 3 and 4.5 hours due to higher risks of serious side effects and complications, and emphasized the importance of getting patients to specialized stroke centers quickly. Who this helps: This guidance benefits patients experiencing acute strokes and their doctors by providing clear treatment recommendations.

PubMed

Barriers and facilitators to implementing delirium rounds in a clinical trial across three diverse hospital settings.

2014

Clinical nursing research

Yevchak AM, Fick DM, McDowell J, Monroe T, May K +4 more

Plain English
This study looked at how to improve care for older patients with dementia who often experience delirium while hospitalized. Researchers found that specific strategies and having a local leader to guide the process made a significant difference in implementing nursing rounds—these rounds averaged 25 minutes and were done with a local champion about 64% of the time. Understanding these factors is important because it can help hospitals make better care practices for vulnerable older adults, ultimately improving their recovery and overall health. Who this helps: This helps patients with dementia and their caregivers.

PubMed

Potential Inappropriate Treatment of Suspected Urinary Tract Infections Among Nursing Home Residents.

2014

Clinical scholars review

Norman A, Monroe T, Carter M

Plain English
This study looked at how well nurse practitioners and doctors follow guidelines when treating suspected urinary tract infections (UTIs) in nursing home residents. Out of 175 reported UTI cases in two nursing homes, only 4 actually met the criteria for a UTI, meaning that 169 residents received unnecessary antibiotics. This matters because giving antibiotics when they are not needed can lead to harmful side effects and antibiotic resistance. Who this helps: This helps nursing home residents and their healthcare providers.

PubMed

Pain assessment in hospitalized older adults with dementia and delirium.

2014

Journal of gerontological nursing

Paulson CM, Monroe T, Mion LC

Plain English
This study looked at how to effectively assess and manage pain in older adults who have dementia or delirium in hospitals. It found that using the Pain Assessment In Advanced Dementia (PAINAD) scale can help identify pain in these patients, which is crucial because untreated pain can lead to longer hospital stays. The findings emphasize the importance of proper pain management to improve outcomes for these vulnerable patients. Who this helps: This helps patients with dementia and delirium, as well as their caregivers and healthcare providers.

PubMed

Assessing advanced cancer pain in older adults with dementia at the end-of-life.

2012

Journal of advanced nursing

Monroe T, Carter M, Feldt K, Tolley B, Cowan RL

Plain English
This study looked at how advanced cancer pain affects older adults with varying stages of dementia, especially focusing on those who may be unable to communicate their pain due to severe Alzheimer's disease. The researchers found that as dementia worsened, the ability to show pain behaviors diminished, with individuals who had very severe Alzheimer's showing significantly fewer pain reactions compared to those with moderate dementia. Despite this, there was no clear link between the amount of pain medication given and these pain behaviors, indicating difficulties in assessing pain effectively in these patients. Who this helps: This research benefits patients with dementia and their caregivers by highlighting the need for better ways to assess pain.

PubMed

Using the Folstein Mini Mental State Exam (MMSE) to explore methodological issues in cognitive aging research.

2012

European journal of ageing

Monroe T, Carter M

Plain English
This study looked at the Folstein Mini Mental State Exam (MMSE), a common test used to check for cognitive issues in older adults. The researchers found that out of 50 studies, only 14 clearly reported whether they assessed important factors like education level, sensory abilities, and language skills before giving the test. This inconsistency can lead to unreliable results and may affect how well we understand cognitive aging, which is crucial for accurate diagnosis and treatment. Who this helps: This benefits patients and healthcare providers working with older adults.

PubMed

Developing a culture of safety in the epilepsy monitoring unit: a retrospective study of safety outcomes.

2012

Epilepsy & behavior : E&B

Spanaki MV, McCloskey C, Remedio V, Budzyn D, Guanio J +3 more

Plain English
This study looked at nearly 1,000 patients admitted to an epilepsy monitoring unit to see how new safety measures affected incidents of falls and missed seizures. After implementing stricter safety protocols, missed seizures dropped from 26 to just 6, while fall incidents showed no significant change. This is important because it demonstrates that improved safety processes can greatly enhance patient care and reduce the chances of critical issues like missed seizures. Who this helps: This helps patients with epilepsy and their families, as well as healthcare providers in epilepsy monitoring units.

PubMed

Using Functional Magnetic Resonance Imaging to Describe Pain Pathways in the 'Oldest Old': A Case Study of a Healthy 97-year-old Female.

2012

Journal of pain & relief

Monroe T, Dornan A, Carter MA, Cowan RL

PubMed

Don't ask don't tell: substance abuse and addiction among nurses.

2011

Journal of clinical nursing

Monroe T, Kenaga H

Plain English
This paper discusses the struggles faced by nurses dealing with substance abuse and addiction, which affects up to 20% of them. Many nurses hesitate to seek help due to fear of punishment, which can endanger both their health and patient safety. The study emphasizes the importance of supportive, non-punitive environments that encourage early intervention and treatment, which is crucial for recovery. Who this helps: This benefits nurses struggling with addiction and ultimately improves patient care and safety.

PubMed

Better protection from blasts without sacrificing situational awareness.

2011

International journal of audiology

Killion MC, Monroe T, Drambarean V

Plain English
This study looked at how to provide better hearing protection for soldiers exposed to loud blasts without them losing their ability to hear important sounds around them. Researchers evaluated two new types of electronic earplugs that allow users to hear clearly while still protecting them from damage. The findings showed that these earplugs maintain good sound quality and help soldiers determine where sounds are coming from, making it easier for them to stay aware of their surroundings. Who this helps: Soldiers in combat situations can benefit from these advanced earplugs.

PubMed

The misuse and abuse of propofol.

2011

Substance use & misuse

Monroe T, Hamza H, Stocks G, Scimeca PD, Cowan R

Plain English
This study looked at how healthcare workers misuse propofol, a powerful anesthetic, and found that such misuse can lead to serious consequences, including death. It highlighted a lack of policies guiding these workers on how to safely return to their jobs after misusing the drug, suggesting that the absence of clear guidelines increases the risk of them returning to work in an unsafe manner. Establishing specific re-entry policies is crucial to ensure the safety of both the workers and their patients. Who this helps: This helps healthcare providers and the patients who rely on their care.

PubMed

Nurses recovering from substance use disorders: a review of policies and position statements.

2011

The Journal of nursing administration

Monroe T, Vandoren M, Smith L, Cole J, Kenaga H

Plain English
The study looked at the policies and statements from nursing organizations about how to handle substance use disorders among nurses. The authors found that there are important guidelines that can help ensure patient safety and support nurses in getting the help they need, but there are still gaps in these policies that need addressing. This is important because early detection and intervention can prevent harm to patients and help healthcare workers recover. Who this helps: This helps nurses struggling with substance use and the patients they care for.

PubMed

A case study using the beers list criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.

2011

Geriatric nursing (New York, N.Y.)

Monroe T, Carter M, Parish A

Plain English
This study looked at how prescriptions given to elderly residents in a rural nursing home differed between family doctors and geriatric specialists. The findings showed that family doctors prescribed an average of two times more medications per patient, and residents were significantly more likely to receive at least one potentially inappropriate medication (PIM) if their doctor wasn’t specifically trained in geriatrics. Specifically, 36.9% of residents received a PIM, and 72.8% were taking multiple medications, with promethazine being the most common PIM prescribed. Who this helps: This research benefits elderly patients in nursing homes by highlighting the importance of having doctors specially trained in geriatrics.

PubMed

Posterior occipitocervical (C0-3) fusion using polyaxial occipital condyle to cervical spine screw and rod fixation: a radiographic and cadaveric analysis.

2010

Journal of neurosurgery. Spine

Frankel BM, Hanley M, Vandergrift A, Monroe T, Morgan S +1 more

Plain English
This study looked at a new technique for surgery at the base of the skull and upper neck, specifically focusing on how to attach screws to the occipital condyles (the points where the skull connects to the spine). Researchers analyzed CT scans from 40 patients and tested the screw placement in 4 cadavers. They found that screws about 3.5 mm in diameter and 20-30 mm long can be safely inserted at an angle of 20-33 degrees, which is crucial for successful surgery in this area. Who this helps: This helps patients with conditions affecting the skull and spine, particularly those needing complex surgeries.

PubMed

Addressing substance abuse among nursing students: development of a prototype alternative-to-dismissal policy.

2009

The Journal of nursing education

Monroe T

Plain English
This study focused on creating a new policy to help nursing students struggling with substance abuse at the University of Memphis. The policy includes steps for prevention, education, and treatment, emphasizing the idea that addiction is an illness that can be treated. By providing support and not just punishment, the school aims to create an environment that aids recovery, which could be a model for other nursing schools to follow. Who this helps: This helps nursing students dealing with substance abuse issues.

PubMed

Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration.

2009

Journal of feline medicine and surgery

Slingsby LS, Taylor PM, Monroe T

Plain English
The study tested how different methods of giving the drug dexmedetomidine affect pain relief and sedation in cats. Twelve cats received the drug either through an injection or by placing it in their mouth. The results showed similar effects from both methods: cats experienced a 6°C increase in pain thresholds and sedation scores of around 43 for the injection and 39 for the oral method, indicating that both methods are effective. Who this helps: This benefits veterinarians treating pain in cats.

PubMed

Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage.

2008

Neurocritical care

Goodson K, Lapointe M, Monroe T, Chalela JA

Plain English
This study looked at using a drug called intraventricular nicardipine to treat painful blood vessel narrowing (vasospasm) in the brain after a type of bleeding called subarachnoid hemorrhage. In a group of eight patients who didn’t respond to regular treatments, seven improved and were able to go home after receiving the drug, although one patient unfortunately died. This matters because it offers a potential new way to help patients who have severe vasospasm when current treatments aren’t working. Who this helps: Patients experiencing severe vasospasm after a subarachnoid hemorrhage.

PubMed

Microsatellite instability and MLH1 hypermethylation - incidence and significance in colorectal polyps in young patients.

2007

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Koh DC, Luchtefeld MA, Kim DG, Attal H, Monroe T +1 more

Plain English
This study looked at certain changes in colon polyps from young patients (under 40 years old) to understand their risk of developing colorectal cancer. Researchers found that none of the polyps showed microsatellite instability, which is often linked to cancer, and about 16% had a specific gene change called MLH1 hypermethylation. This is important because it suggests that while the risk of cancer may be lower in these young patients, certain genetic changes could still signal a potential for progression to cancer. Who this helps: This helps doctors and young patients monitor and manage their colorectal health.

PubMed

Percutaneous vertebral augmentation: an elevation in adjacent-level fracture risk in kyphoplasty as compared with vertebroplasty.

2007

The spine journal : official journal of the North American Spine Society

Frankel BM, Monroe T, Wang C

Plain English
This study examined two types of medical procedures, kyphoplasty and vertebroplasty, used to treat painful fractures in the spine caused by osteoporosis. Researchers analyzed data from 36 patients and found that while both procedures effectively relieved pain for over 90% of the patients, those who had kyphoplasty were significantly more likely to develop new fractures nearby—25% of kyphoplasty patients did, compared to none in the vertebroplasty group. This is important because it suggests that vertebroplasty may be a safer option with a lower risk of complications. Who this helps: This research benefits patients with osteoporosis and doctors treating spine fractures.

PubMed

Local excision of stratified T1 rectal cancer.

2006

American journal of surgery

Wirsing K, Lorenzo-Rivero S, Luchtefeld M, Kim D, Monroe T +2 more

Plain English
Researchers studied patients with early-stage T1 rectal cancer who underwent a specific surgery called transrectal excision. They found that out of 101 patients, 26% had their cancer come back locally after surgery, and 13% died from cancer that spread to other parts of the body. This highlights that the chances of cancer returning are significant after this surgery, suggesting that patients might benefit from additional treatments like chemotherapy or more extensive surgery to improve their outcomes. Who this helps: This helps patients with early-stage rectal cancer and their doctors.

PubMed

Cerebellar hemorrhage caused by remote neurological surgery.

2006

Neurocritical care

Chalela JA, Monroe T, Kelley M, Auler M, Bryant T +3 more

Plain English
This study looked at rare cases of bleeding in the cerebellum (the part of the brain that controls balance) that happened after certain types of brain or spinal surgery. The researchers found three patients who experienced this bleeding, which was linked to low levels of cerebrospinal fluid. Understanding this complication is important because it helps doctors be more aware of potential risks during surgeries and how to prevent them. Who this helps: This helps patients undergoing brain or spinal surgery.

PubMed

WEB-BASED GRADUATE EDUCATION IN RURAL NURSING CASE MANAGEMENT.

2005

Online journal of rural nursing and health care : the official journal of the Rural Nurse Organization

Stanton M, Crow C, Morrison R, Skiba DJ, Monroe T +2 more

Plain English
This study looked at a web-based graduate program for nursing case management in rural areas. Researchers found that while students appreciated the program for its accessibility and the support from teachers, they struggled with technology and felt isolated. Faculty noted that access to education was a major benefit, but also highlighted challenges like increased workload and the need for more training. Who this helps: This helps rural nurses who want to advance their education and improve healthcare in their communities.

PubMed

Department of Defense picture archiving and communication system acceptance testing: results and identification of problem components.

2005

Journal of digital imaging

Allison SA, Sweet CF, Beall DP, Lewis TE, Monroe T

Plain English
This study looked at how well the Department of Defense's image storage and communication system, called PACS, is working and identified common problems. Between 1998 and 2000, 14 DOD facilities were evaluated, finding 16 main types of system issues that included 154 specific limitations. Many of the problems were linked to costly parts of the system, especially issues with workstations and information interfaces. Who this helps: This benefits healthcare providers and patients by improving the reliability and safety of medical imaging systems.

PubMed

Genetic testing for hereditary nonpolyposis colorectal cancer.

2003

The American surgeon

Hoedema R, Monroe T, Bos C, Palmer S, Kim D +2 more

Plain English
This study looked at genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC), a genetic condition that increases the risk of developing colorectal cancer. Researchers tested tissue samples from patients at high risk for HNPCC and found that out of 14 patients meeting strict criteria, five had harmful mutations in the MSH2 gene and two had variants in the MLH1 gene. These findings show that genetic testing can identify mutations in some patients and highlights the need for screening young patients with colorectal cancer, even if they don’t have a family history. Who this helps: This helps patients at risk for hereditary colorectal cancer and their doctors in making informed decisions about screening and treatment.

PubMed

Manufacturing challenges in the commercial production of recombinant coagulation factor VIII.

2002

Haemophilia : the official journal of the World Federation of Hemophilia

Jiang R, Monroe T, McRogers R, Larson PJ

Plain English
The research focused on the production challenges of a treatment for haemophilia A called recombinant coagulation Factor VIII (rFVIII). The study revealed that it took Bayer Corporation over 17 years of research and development to successfully create and improve rFVIII products, leading to a new version called KOGENATE Bayer, which has a simpler manufacturing process and aims to be safer by removing human proteins. This is important because enhancing the safety and availability of rFVIII can significantly help people with haemophilia A manage their condition more effectively. Who this helps: Patients with haemophilia A.

PubMed

[Economic contribution of mofetil mycofenolate as preventive immunosuppressive treatment after renal transplantation from cadaver].

1996

Presse medicale (Paris, France : 1983)

Louis-Touizer C, Nuijten MJ, Bayle F, Cantarovich D, Lang P +6 more

Plain English
This study looked at the costs and benefits of using mycophenolate mofetil, a medication that helps prevent the body from rejecting a new kidney after a transplant. Researchers compared its use in over 1,000 patients to other treatments and found that it led to a 19% to 38% reduction in healthcare costs in the first six months after the transplant, mainly due to fewer cases of organ rejection and the need for additional treatments. This finding is important because it shows that mycophenolate mofetil is not only effective at preventing rejection but also helps save money in the healthcare system. Who this helps: This benefits kidney transplant patients and healthcare providers.

PubMed

Frequent Co-Authors

Michael Carter Sara A Kohlbeck Donna M Fick Cindi Dabney Ronald Cowan Ann M Kolanowski Jane McDowell Christina May Paulson Ronald L Cowan Heidi Kenaga

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.