Protection of organs during experimental ischemia.
1978Surgery, gynecology & obstetrics
Santiago-Delpín EA, Vivoni V, Suárez A, Román-Franco AA
Plain English
This study looked at ways to protect organs, specifically the small intestine and severed limbs, from damage caused by a lack of blood flow, known as ischemia. Researchers found that after blocking blood flow for 1.5 hours, 97% of tested rats died, but using a combination of two drugs, methylprednisolone and ampicillin, helped protect some survivors and preserved their tissue. Similarly, in dogs, reattaching limbs after a period without blood flow also resulted in high death rates, but using a special solution and the same drug reduced complications like gangrene.
Who this helps: Patients who suffer from conditions requiring limb reattachment or surgeries that restrict blood flow.