Zachary S Gala studies the dangerous health effects of synthetic cannabinoids, a type of drug that mimics marijuana but can cause severe injuries to the lungs and other organs. One particular focus of his research is the complications that can arise from using these drugs, especially in people who may not have easy access to medical care, like those in prison. His work highlights the importance of recognizing and treating serious conditions like collapsed lungs in these users, as they may not receive timely medical attention.
Key findings
A case study of a 21-year-old man showed that synthetic cannabinoid use led to life-threatening air pockets in his lungs and abdomen, requiring urgent medical treatment.
The research indicates a high risk of serious lung damage from synthetic cannabinoids, emphasizing that users may not realize the dangers involved.
The findings suggest that incarcerated individuals are especially at risk for complications due to delayed medical care, highlighting a gap in health services.
Frequently asked questions
Does Dr. Gala study synthetic cannabinoid effects?
Yes, he specifically investigates the severe health consequences of synthetic cannabinoid use.
What health issues has Dr. Gala researched related to synthetic cannabinoids?
He has researched serious complications such as collapsed lungs and lung damage resulting from synthetic cannabinoid use.
Is Dr. Gala's work relevant for incarcerated individuals?
Absolutely, as his research highlights the heightened risk of severe health issues among incarcerated users of synthetic cannabinoids.
Publications in plain English
Efficacy of Microsurgical Venous Couplers in Lymphovenous Anastomosis of the Thoracic Duct: An Examination of Outcomes and Patency at Follow-Up.
2026
Journal of reconstructive microsurgery
Crystal DT, Gala Z, Brkic S, Broach R, Azoury SC +2 more
Plain English This study looked at a surgical method called lymphovenous anastomosis (LVA) using a special tool to help patients with problems in their thoracic duct, which can cause serious health issues like swelling and fluid build-up. Among 23 patients treated, 56.5% showed improvement with their symptoms and their duct connections remained open over time. This is important because it indicates that using this coupling method for surgery is not only safe but also effective for helping many patients feel better.
Who this helps: This benefits patients suffering from lymphedema and related conditions.
The Impact of Psychiatric Comorbidities on Outcomes and Quality of Life in Plastic Surgery: A Literature Review and Matched Analysis.
2026
Plastic and reconstructive surgery
Amro C, Chang AE, Ewing JN, Lemdani MS, Gala Z +3 more
Plain English This study looked at how mental health issues affect patients undergoing plastic surgery, specifically those having breast reduction or body contouring surgeries. Out of 554 patients, those with psychiatric conditions faced more complications and longer hospital stays; for example, they were three times more likely to have surgical site problems and nearly five times more likely to return to the hospital. Despite these challenges, all patients reported improvements in their quality of life after surgery, highlighting the importance of these procedures for everyone involved.
Who this helps: This research benefits patients with mental health issues considering plastic surgery, as well as their doctors.
A Closer Look at Prepectoral Implant-Based Breast Reconstruction: A Matched-Pair Comparison of Direct-to-Implant versus 2-Stage Outcomes.
2026
Plastic and reconstructive surgery
Amro C, Ryan IA, Ewing JN, Gala Z, Lemdani MS +5 more
Plain English This study looked at two types of breast reconstruction after mastectomy: direct-to-implant (DTI) and a two-stage approach. Researchers found that the two-stage method resulted in more complications, such as seromas (fluid buildup), occurring in 18.2% of cases compared to only 5.2% with DTI. Overall, the two-stage reconstruction had a higher rate of surgical complications, showing that the DTI method may be preferable for certain patients.
Who this helps: This information benefits patients undergoing breast reconstruction and their doctors in making informed choices.
Word of the Wise: A Propensity-Matched Comparative Analysis of Breast Reduction Incision Patterns on Clinical Outcomes and Quality of Life.
2025
Aesthetic plastic surgery
Amro C, Ryan IA, Lemdani MS, Ewing JN, Gala Z +2 more
Plain English This study looked at two different surgical methods for breast reduction—the Wise pattern and the vertical pattern—to see how they affect patients' health outcomes and quality of life. Researchers examined data from 379 patients and found that both methods significantly improved quality of life in areas like breast satisfaction and overall well-being, but those who had the Wise pattern also reported better sexual well-being. Since both techniques are safe and effective, the findings can help doctors explain expected outcomes to their patients.
Who this helps: This benefits patients considering breast reduction surgery.
A Prospective Comparison of Patient-Reported Outcomes after Facial Laser Resurfacing.
2025
Plastic and reconstructive surgery
Arias F, Gala Z, Stetz L, Elfanagely O, Greco G
Plain English This study looked at how effective facial laser resurfacing is for improving skin appearance, based on feedback from patients who underwent the procedure. Out of 71 patients surveyed, most reported significant improvements in their facial and skin appearance after treatment, with scores indicating high satisfaction (P < 0.001). Although many experienced some tightness and swelling initially, these side effects lessened over time, and overall, patients felt good about their decision to have the procedure.
Who this helps: This helps patients seeking skin rejuvenation and doctors who perform laser resurfacing treatments.
Looped Penrose Drainages of Acute Hand Infections in Vulnerable Populations.
2025
The Journal of hand surgery
Ewing JN, Toyoda Y, Lemdani MS, Vaile JR, Malphrus E +4 more
Plain English This study examined a new method for treating acute hand infections in a group of patients who face social challenges, like low income or homelessness. It involved 53 patients who underwent a simpler, less invasive drainage technique, and the results showed it was effective: only 1.9% had a recurrent infection and there were no amputations or readmissions. This matters because it offers a viable treatment option for vulnerable populations who often struggle with healthcare access and follow-up.
Who this helps: Vulnerable patients with acute hand infections.
A cross-sectional survey investigating surgeon perceptions of pre-operative risk prediction models incorporating radiomic features.
2025
Hernia : the journal of hernias and abdominal wall surgery
Ewing JN, Gala Z, Voytik M, Broach RB, Udupa JK +3 more
Plain English This study looked at how surgeons view the use of imaging data, called radiomic features, to predict the risk of patients developing incisional hernias after abdominal surgery. Out of 166 surveyed surgeons, most felt that a prediction tool would be beneficial and believed it would need to show at least a 74.5% accuracy to change their surgical decisions. This matters because improving predictions could lead to better patient outcomes and reduce complications from hernias.
Who this helps: This helps patients preparing for abdominal surgery.
Abdominal wall reconstruction in ventral hernia repair: do current models predict surgical site risk?
2025
Hernia : the journal of hernias and abdominal wall surgery
Gala Z, Lemdani MS, Crystal D, Ewing JN, Broach RB +2 more
Plain English This study looked at two risk assessment models used to predict complications like infections and other issues after surgery for ventral hernias. Out of 1,414 patients reviewed, 12.4% had infections and 26.0% experienced other complications. The researchers found that while both models could offer some insight, they didn't perform well in predicting these risks, suggesting they need improvement for better patient care.
Who this helps: This research helps doctors and surgeons who treat patients with ventral hernias.
National trends and outcomes of same-day discharge after direct-to-implant breast reconstruction: A 15-year NSQIP analysis.
2025
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Kauke-Navarro M, Knoedler S, Klimitz FJ, Lizardi J, Allam O +9 more
Plain English This study looked at the safety and outcomes of women who had same-day discharge after direct-to-implant breast reconstruction, comparing them with those who stayed overnight. Out of 11,505 women studied, 2,457 (21.4%) went home the same day, and these patients experienced fewer complications, needing reoperations, or being readmitted to the hospital compared to those who stayed overnight. Specifically, same-day discharge patients had about 21% lower odds of any complications, 28% lower odds of needing reoperations, and 30% lower odds of being readmitted, showing that it can be a safe option for selected patients.
Who this helps: This benefits patients undergoing breast reconstruction by offering a safer, more efficient discharge process.
Surgeon-Informed Clinical Decision Support Software for Surgical Risk Prediction and Outcomes Tracking.
2025
The Journal of surgical research
Hornick MM, Talwar A, Voytik M, Gala Z, Amro C +7 more
Plain English This study focused on creating a new software tool to help surgeons predict surgical risks and track patient outcomes, specifically for hernia surgeries. The research involved feedback from 30 surgeons who provided input on what features the software should include, such as a clear representation of risk factors and ease of use. The findings showed that surgeons want the software to be user-friendly, with a focus on minimizing complexity and improving communication with patients, making it more likely to be accepted and used in practice.
Who this helps: This tool benefits surgeons and their patients by improving risk assessment and communication in surgical care.
Onlay Resorbable Biosynthetic Versus Underlay Biologic Mesh Ventral Hernia Repair in Contaminated Fields.
2025
The Journal of surgical research
Amro C, Ewing JN, Romeo DJ, Rhodes IJ, Gala Z +5 more
Plain English This study looked at two types of mesh used for repairing ventral hernias in patients with infected or contaminated wounds: a resorbable biosynthetic mesh placed on top (onlay) and a biologic mesh placed underneath (underlay). Out of 94 patients, those with the biosynthetic mesh had significantly fewer surgical site problems (47% compared to 72%) and required fewer additional surgeries for these issues (19% versus 38%). These findings are important because they suggest that using resorbable biosynthetic mesh may lead to better recovery outcomes and lower costs for patients facing complicated hernia repairs.
Who this helps: Patients with ventral hernias in contaminated surgical situations.
Longitudinal Outcomes of Abdominoperineal Resection Reconstruction: A Single-center Retrospective Review.
2025
Plastic and reconstructive surgery. Global open
Gala Z, Lemdani MS, Ewing JN, McGraw JR, Crystal DT +5 more
Plain English This study looked at different methods of rebuilding the area after a surgical procedure called abdominoperineal resection (APR), which is often done for cancers of the rectum. Researchers followed 80 patients who had reconstructive surgery using three types of skin flaps: VRAM, gracilis, and omental. They found that while 72.5% of patients experienced complications, those who received gracilis flaps had a significantly lower chance of developing a specific complication called enterocutaneous fistula compared to those who received VRAM flaps.
Who this helps: This information helps patients undergoing APR by informing their doctors about safer reconstruction options.
Outcomes and Quality of Life After Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields.
2024
Annals of plastic surgery
Lemdani MS, Niu EF, Amro C, Gala Z, Ewing JN +3 more
Plain English This study looked at how well a special mesh called P4HB works for repairing hernias in situations where there is an infection. Researchers followed 55 patients over nearly four years and found that only 7.3% had their hernias come back and 14.5% had to have another surgery. Most importantly, patients reported that their quality of life improved significantly after surgery, and this improvement stayed consistent over five years.
Who this helps: This benefits patients recovering from hernia surgery in contaminated environments.
Balancing the Scales: Caution in Reduction Mammaplasty Recommendations for Obesity Class III Patients.
2024
Annals of plastic surgery
Ewing JN, Niu EF, Amro C, Gala Z, Lemdani MS +4 more
Plain English This study looked at the effects of weight on the results of breast reduction surgery in patients with varying levels of obesity. Researchers found that patients with obesity class III, who are severely overweight, experienced a significantly higher rate of complications after the surgery—15.8% had surgical site infections compared to just 0% in healthy patients. While all other weight groups showed improved quality of life after surgery, those in class III did not see the same benefits.
Who this helps: This research helps doctors better understand the risks for severely obese patients considering breast reduction surgery.
Unveiling the Need to Improve Personalized Applicant Tools: A Critical Evaluation of the Reliability of the Texas STAR database in Predicting Match Success for Plastic Surgery Applicants.
2024
Journal of surgical education
Ewing JN, Gala Z, Lemdani MS, Crystal D, Broach RB +1 more
Plain English This study looked at factors that influence success in getting a residency position in plastic surgery by analyzing data from applicants between 2021 and 2023. Out of 209 applicants, 147 were successful, which is about 70%. Important predictors for success included taking a year for research, having 8 or more published papers, being geographically connected to the program, and attending 13 or more interviews. Understanding these factors helps future applicants better prepare for residency.
Who this helps: This benefits medical students applying for plastic surgery residency programs.
Reevaluation of Recipient Vessel Selection in Breast Free Flap Reconstruction.
2024
Microsurgery
Lemdani MS, Crystal DT, Ewing JN, Gala Z, Amro C +4 more
Plain English This study looked at two types of blood vessels used in breast reconstruction surgery: the internal mammary vessels (IMV) and thoracodorsal vessels (TDV). Researchers analyzed data from 4,754 breast reconstructions and found that while 89.8% of surgeries used IMV, the TDV also showed good outcomes, with low rates of flap loss (1.0% for IMV and 1.2% for TDV). Importantly, patients whose surgeries used TDV had a significantly lower chance of experiencing skin necrosis compared to those using IMV (45% less likely).
Who this helps: This benefits patients undergoing breast reconstruction by providing options for their surgery.
Marijuana and Its Implications in Breast Reduction Surgery Outcomes and Quality of Life: A Matched Analysis.
2024
Plastic and reconstructive surgery. Global open
Ewing JN, Amro C, Chang A, Gala Z, Lemdani MS +4 more
Plain English The study looked at how marijuana use affects the results of breast reduction surgery. Among 415 patients, 140 reported using marijuana, but when comparing 54 marijuana users to 54 nonusers, the researchers found no significant differences in surgery outcomes or quality of life improvements after the procedure. This is important because it shows that marijuana use does not negatively impact the success of breast reduction surgeries, allowing doctors to better inform their patients.
Who this helps: This helps patients considering breast reduction surgery.
A Longitudinal Evaluation of Collaboration in Plastic Surgery Clinical Research.
2024
Plastic and reconstructive surgery. Global open
Ewing JN, Lemdani MS, Gala Z, Amro C, Broach RB +2 more
Plain English This study looked at how collaboration in plastic surgery research affects the quality and quantity of published work. It found that from 2008 to 2020, research fellows who worked together with others more frequently produced better results, indicated by higher publication counts and greater diversity in journals, with strong correlations between external collaboration and research impact scores. The findings highlight the importance of fostering collaboration, as this leads to more significant advancements in plastic surgery research.
Who this helps: This helps researchers and institutions working in the field of plastic surgery.
Multimodal Pilot Evaluation of a Hyaluronic Acid Infraorbital Filler Using Precise, Multipositional, 3-Dimensional Imaging Quantification, Patient-Reported Outcomes, and Anatomic Cadaveric Assessments.
2024
Aesthetic surgery journal. Open forum
Honig SE, Toyoda Y, Ewing JN, Lemdani MS, Gala Z +4 more
Plain English Researchers studied the effects of a specific type of filler (Volbella XC) injected under the eyes to reduce hollowness. They found that the filler maintained most of its volume (70% to 81%) after 30 days and 50% to 70% after 90 days, and patients reported significant improvements in their appearance. Understanding how this filler works better informs doctors about safe and effective injection techniques, ultimately leading to better results for patients.
Who this helps: This helps patients seeking cosmetic treatments for under-eye hollowness.
Analysis of the microsurgery fellowship match: 2019-2022 update.
2024
Microsurgery
McGraw JR, Sulkar RS, Amro C, Gala Z, Mehrara BJ +4 more
Plain English This study looked at the trends in matching applicants to microsurgery fellowships from 2019 to 2022, comparing them to earlier data from 2016 to 2018. The analysis showed that while the number of fellowship programs and positions increased, the number of applicants per position decreased, leading to a higher match rate of 80.2% in the more recent period, compared to 67.8% earlier. However, by 2022, a record low was reached, with only 75.4% of available positions filled.
Who this helps: This helps future microsurgery fellows and residency programs by providing insights into the competitive landscape of fellowship matches.
Barriers in exclusive breastfeeding encountered by mothers in urban slum area of a metropolitan city.
2023
Journal of family medicine and primary care
Gala Z, Shetye S, Sadawarte DM, Autade M
Plain English This study examined the challenges faced by mothers in an urban slum in Mumbai when trying to exclusively breastfeed their babies. It found that many mothers encounter barriers such as lack of knowledge, health issues, cultural beliefs, and insufficient support, with 17 mothers interviewed about their experiences. The research highlights the importance of education and support from healthcare providers and families to encourage exclusive breastfeeding, which is essential for infant health.
Who this helps: This benefits mothers and their infants in urban slum areas.
Subcutaneous Emphysema, Pneumothorax, Pneumomediastinum, and Pneumoperitoneum Following Synthetic Cannabinoid Toxicity in an Incarcerated Man.
2023
The American surgeon
Gala Z, Kravchenko T, Volk L, Chatani P, Kar R +1 more
Plain English A 21-year-old man in prison smoked synthetic cannabinoids (fake marijuana) and developed life-threatening air pockets in his lungs, chest cavity, and abdomen days later, which could have killed him if not treated. Synthetic cannabinoids are dangerous drugs that can cause severe lung and organ damage beyond what people typically expect. This case shows that doctors need to watch for collapsed lungs in synthetic cannabinoid users, and that incarcerated people are especially vulnerable because they may not get medical care quickly or follow up with doctors afterward.
Head Computed Tomography Versus Maxillofacial Computed Tomography: An Evaluation of the Efficacy of Facial Imaging in the Detection of Facial Fractures.
2022
Eplasty
Gala Z, Bai D, Halsey J, Ayyala H, Riddle K +4 more
Plain English The study looked at how well two types of CT scans—one for the head (CTH) and one specifically for facial injuries (CTMF)—detect facial fractures after trauma. They found that CTH identified about 45% of the facial fractures, while CTMF found all of them, highlighting that CTH often misses significant injuries. This matters because missing fractures can delay treatment and increase healthcare costs.
Who this helps: This helps doctors and patients by ensuring better diagnosis and treatment of facial injuries after trauma.
Pediatric Palate Fractures: An Assessment of Patterns and Management at a Level 1 Trauma Center.
2021
Craniomaxillofacial trauma & reconstruction
Gala Z, Halsey JN, Kapadia K, Otaguro L, Hoppe IC +2 more
Plain English This study looked at palate fractures in children who were treated at a major trauma center between 2000 and 2016. They found that nine children had these fractures, mostly caused by being hit by cars or in motor vehicle accidents. Many of these children had serious additional injuries, including skull fractures and brain bleeding; among them, one child needed emergency treatment to stop bleeding in the face.
Who this helps: This research benefits doctors and healthcare providers working with injured children.
Relevance of Academic Productivity in the Assessment of Integrated Plastic Surgery Applicants.
2020
Journal of surgical education
Oleck NC, Gala Z, Weisberger JS, Therattil PJ, Dobitsch AA +2 more
Plain English This study looked at how the academic productivity of applicants to integrated plastic surgery programs relates to their chances of being accepted. Researchers measured the h-index, a number that represents both the quality and impact of an applicant's academic work, finding an average h-index of 1.26 among 131 candidates. Those matched to top programs had higher scores: 1.57 at funded institutions and 1.96 at top-ranked programs, indicating that a strong academic background is important for getting into prestigious residency programs.
Who this helps: This helps medical students applying for plastic surgery residencies.
An Analysis of Trends in National Residency Matching Program Match Data for Orthopedic Surgery.
2020
Orthopedics
Rynecki N, Para A, Gantz O, Coban D, Gala Z +5 more
Plain English This study looked at trends in medical school applicants trying to get into orthopedic surgery residency programs from 2009 to 2018. It found that while more students are applying (an increase of about 1.26% each year), the number of available residency spots is growing too (by 1.51% annually), meaning the competition hasn’t changed much, despite both groups achieving higher scores on a common exam (Step 1). This is important because it clarifies that rising exam scores should not be mistaken for a rise in overall competitiveness for orthopedic surgery.
Who this helps: This helps medical students looking to specialize in orthopedic surgery.
Saved by the SPY: Ulnar Artery Reconstruction With LCFA Graft for Hypothenar Hammer Syndrome.
2020
Eplasty
Gala ZS, Ayyala H, Viviano SL, Ignatiuk A
Plain English This study looked at a specific condition called Hypothenar Hammer syndrome, where a person's ulnar artery in the wrist gets blocked, causing pain and possibly serious damage in the fingers. The researchers performed surgery using a graft from another artery to fix the problem in a patient, and they also used a special dye during the operation to find additional issues that were not seen in earlier scans. They found that this approach led to a more complete treatment, highlighting the importance of using new imaging techniques during surgery.
Who this helps: This helps patients suffering from Hypothenar Hammer syndrome.
Rigid External Distractors in Midface Fractures: A Review of Relevant and Related Literature.
2020
Eplasty
Gala Z, Halsey J, Kogan S, Hoppe I, Ciminello FS +1 more
Plain English This study looked at the use of special devices called rigid external distractors for treating severe fractures in the face. The researchers found very limited evidence, with only two articles focused specifically on their use for facial injuries, while other studies looked at similar devices for different facial surgeries. These devices help stabilize broken bones and allow for better healing without needing to perform invasive surgery, which is important for recovery.
Who this helps: This benefits patients with complex facial fractures and their doctors by providing more treatment options.
Effects of Operating Room Size on Surgical Site Infection Following Lumbar Fusion Surgery.
2019
International journal of spine surgery
Salmons HI, Lendner M, Divi SN, Dworkin M, McKenzie J +15 more
Plain English This study looked at whether the size of the operating room affects the rate of infections after spine surgery, specifically lumbar fusion. Out of 2,523 patients, 63 developed infections, with 3.02% in larger operating rooms compared to 1.81% in smaller ones. Although the study found a higher infection rate in larger rooms, the size was not a strong predictor of infection. This matters because understanding infection risk factors can help improve surgical outcomes.
Who this helps: This helps patients undergoing spine surgery and their doctors.
Concomitant Proximal and Distal Tibiofibular Joint Dislocation Associated With a Tibial Shaft Fracture.
2018
The Journal of the American Academy of Orthopaedic Surgeons
Hwang JS, Sirkin MS, Gala Z, Adams M, Reilly MC
Plain English This study looked at a rare type of injury where both the upper and lower joints of the fibula (the smaller bone in the lower leg) are dislocated, happening at the same time as a fracture in the main leg bone (the tibia). The researchers reported the first known case of these two injuries occurring together, which has not been documented before. This finding is important because it helps doctors recognize this specific injury pattern, which can lead to better treatment options for patients.
Who this helps: This helps doctors by improving their understanding of complex leg injuries.
Pathology of callosal damage in ALS: An, 7 T diffusion tensor MRI study.
2017
NeuroImage. Clinical
Cardenas AM, Sarlls JE, Kwan JY, Bageac D, Gala ZS +8 more
Plain English This study looked at how the brain's white matter is affected in patients with ALS (amyotrophic lateral sclerosis) by using advanced MRI technology. Researchers found that the structure of a segment of the brain called the corpus callosum was significantly damaged in ALS patients compared to healthy individuals, specifically showing a decrease in a measurement known as fractional anisotropy (FA). Notably, they observed an increase in certain immune cells, which suggests inflammation may play a role in this damage.
Who this helps: This information benefits ALS patients and their doctors by providing insights into the disease's impact on the brain.
Analytic morphomics identifies predictors of new-onset diabetes after liver transplantation.
2015
Clinical transplantation
Vaughn VM, Cron DC, Terjimanian MN, Gala ZS, Wang SC +2 more
Plain English This study looked at whether a new method called analytic morphomics, which uses CT scans, can help predict the risk of developing new-onset diabetes after liver transplantation (NODAT). Among 216 liver transplant patients, 61 (or 28%) went on to develop NODAT. The findings showed that the thickness of subcutaneous fat was significantly linked to the risk of NODAT, particularly for patients who developed diabetes within ten months after their transplant.
Who this helps: This benefits liver transplant patients and their doctors by providing better risk assessment for diabetes after surgery.