Dr. Soldatov studies how effective certain medications are in treating ischemic stroke, a condition caused by a blockage in a blood vessel supplying blood to the brain. In his recent work, he specifically evaluates a medication called Revelise (alteplase) and examines how it helps patients regain their ability to function after having a stroke. By tracking the progress of thousands of patients, he provides valuable insights into how different age groups and those with additional health problems respond to treatment. His research aims to improve recovery outcomes for stroke patients and assist healthcare providers in their treatment approaches.
Key findings
In a study involving 2,202 patients, 49.9% experienced good outcomes at discharge after treatment with Revelise.
The rate of good outcomes improved to 66.4% after 90 days, indicating a significant recovery over time.
The study highlights that Revelise effectively reduces stroke-related disabilities, showing promise even for older patients and those with other health conditions.
Frequently asked questions
Does Dr. Soldatov study ischemic strokes?
Yes, Dr. Soldatov focuses on treatments for ischemic stroke, specifically the effects of the medication Revelise.
What outcomes have his studies found regarding stroke treatment?
His research found that nearly 50% of stroke patients had good outcomes shortly after treatment, rising to about 66% after three months.
Is Dr. Soldatov's research relevant for elderly patients?
Yes, his studies show that older patients can benefit significantly from thrombolytic therapy, improving their recovery from strokes.
Are there any additional health issues considered in his research?
Yes, Dr. Soldatov's work includes older patients and those with other health conditions to see how they respond to treatment.
What is thrombolytic therapy?
Thrombolytic therapy is a treatment that uses medication to dissolve blood clots in conditions like ischemic stroke.
Publications in plain English
Phosphazene-Based Porous Polymer as Electrode Material for Electrochemical Applications.
2026
Polymers
Karpova EA, Sysoev AA, Tsvetkov ID, Klyuev AL, Raitman OA +1 more
Plain English Researchers created a new type of porous polymer that can be used in batteries and fuel cells. This polymer has a very high surface area and, after a special heating process, becomes even more effective with specific capacitance reaching 155.6 farads per gram and a high activity in reducing oxygen. This discovery is important because it offers a new material that could improve how we store energy and generate power in clean energy technologies.
Who this helps: This benefits engineers and scientists developing better energy storage and fuel cell systems.
[The first experience of using tenecteplase for the thrombolytic therapy in ischemic stroke in the Russian Federation].
2026
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Glotova NA, Tairova RT, Marskaya NA, Soldatov MA, Gubskiy IL +2 more
Plain English This study looked at the use of a new drug called tenecteplase for treating ischemic stroke in three patients in Russia. All three patients showed major improvements in their neurological symptoms within an hour of receiving the drug, and there were no increases in stroke damage after 24 hours. This matters because it highlights that tenecteplase is a safe and effective option for stroke treatment, leading to better patient outcomes.
Who this helps: This helps stroke patients and doctors treating them.
The structure of the NiONcoordination center in the [Ni(Salen)] complex and its polymer: a comparative study by X-ray absorption spectroscopy and quantum-chemical calculations.
2025
Physical chemistry chemical physics : PCCP
Korusenko PM, Petrova OV, Vereshchagin AA, Levin OV, Khramov EV +5 more
Plain English This study looked at the structure of a nickel compound called [Ni(Salen)] and its larger version, a polymer, using advanced X-ray techniques and computer models. Researchers found that, while the basic shape of the nickel center stays the same when the compound changes its charge state, there are distortions during oxidation that affect its properties. Specifically, they identified that the main structural unit of the polymer is a group of four nickel centers connected together, and changes in electron behavior occur when moving from a reduced to an oxidized state.
Who this helps: This research benefits scientists and researchers working on nickel compounds in materials science and chemistry.
4f-modified Ru-O polarity as a descriptor for efficient electrocatalytic acidic oxygen evolution.
2025
Nature communications
Zhang X, Zhang Y, Protsenko BO, Soldatov MA, Zhang J +7 more
Plain English This study looked at a new type of catalyst made of modified ruthenium oxide (RuO) to improve the process of producing hydrogen from water. The researchers found that a specific version of this catalyst, called 4f-Nd-RuO, worked particularly well, achieving impressive performance with an overpotential of just 214 millivolts at a current of 10 milliamperes per centimeter, which means it's efficient and stable in acidic conditions. This research matters because finding better catalysts could lead to more effective hydrogen production, which is essential for clean energy.
Who this helps: This helps energy researchers and companies looking to develop cleaner hydrogen production technologies.
Plain English This study looked at two methods for creating special materials that can be used in healthcare and technology, like batteries and strong plastics. The researchers found that one method, called the Piers-Rubinsztajn reaction, doesn't work well because it gets ruined by nitrogen in the materials. However, using another method called hydrosilylation, they successfully made new materials that could be useful in various applications.
Who this helps: This research benefits engineers and scientists developing new materials for medical and technological uses.
[Thrombolytic Therapy for Ischemic Stroke with Revelise: Results of a Two-Year Follow-Up in the International PRIMA Study].
2025
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Shamalov NA, Khasanova DR, Marchenko SV, Soldatov MA, Azarova AG +46 more
Plain English This study looked at how well and safely Revelise (alteplase), a medication for treating ischemic stroke (IS), works in real-life situations. It involved 2,202 patients, mostly around 68 years old, and found that nearly half (49.9%) of them had good outcomes when discharged, rising to 66.4% after 90 days. The results showed that Revelise effectively reduces stroke-related disabilities, even in older patients and those with other health issues.
Who this helps: This benefits patients who suffer from ischemic strokes and the doctors treating them.
In situ Activation of Molecular Oxygen at Intermetallic Spacing-Optimized Iron Network-Like Sites for Boosting Electrocatalytic Oxygen Reduction.
2024
Small (Weinheim an der Bergstrasse, Germany)
Jiang J, Zhou W, Jiang Y, Zhang X, An Q +6 more
Plain English This study looked at a new type of iron-based catalyst designed to improve a reaction that is important for energy conversion, specifically the oxygen reduction reaction (ORR). Researchers found that their catalyst, with a special structure allowing for better spacing between iron atoms, significantly boosts the reaction speed, resulting in a performance that outperforms many existing catalysts without expensive metals. The catalyst showed a half-wave potential of 0.89 volts and a kinetic current density of 72 milliamps per square centimeter, which are impressive numbers for this type of technology.
Who this helps: This research benefits scientists and engineers working on cleaner energy technologies.
Modification of Epoxy Coatings with Fluorocontaining Organosilicon Copolymers.
2024
Polymers
Krutskikh DV, Shapagin AV, Plyusnina IO, Budylin NY, Shcherbina AA +1 more
Plain English Researchers studied how to improve water-repelling coatings using special additives called organosilicon copolymers. They found that adding these additives can make epoxy coatings more compatible and increase their water resistance; specifically, the contact angle, which measures how much water beads on the surface, increased from 63 degrees to 87 degrees without harming the overall strength and quality of the coating. This is important because better water-repellent coatings can lead to improved performances in paints and other materials used in various industries.
Who this helps: This benefits manufacturers of paints and coatings, as well as the end users who rely on durable, water-resistant surfaces.
In situ tuning of platinum 5d valence states for four-electron oxygen reduction.
2024
Nature communications
Zhou W, Li B, Liu X, Jiang J, Bo S +7 more
Plain English This study looked at improving a chemical reaction essential for energy devices, specifically how oxygen is reduced using platinum catalysts. Researchers found that by using a special type of support, they could fine-tune the properties of the platinum, leading to better performance. Their best catalyst achieved over 97% efficiency in a key reaction while also showing good durability.
Who this helps: This benefits researchers and companies developing more efficient and sustainable energy technologies.
The Influence of Conditions of Polycondensation in Acid Medium on the Structure of Oligosilsesquioxanes with a Novel Eugenol-Containing Substituent.
2024
Polymers
Ageenkov AD, Bredov NS, Shcherbina AA, Khasbiullin RR, Tupikov AS +1 more
Plain English Researchers studied how different conditions in a chemical reaction affect the structure of new materials made from silicates that include eugenol, a natural compound found in clove oil. They found that changing the ratio of chemicals in the reaction increased the amount of certain structures in the final product from 28.2% to 41.7%, while also significantly reducing the number of less stable structures. Notably, using a reaction temperature of 95 degrees Celsius resulted in over 77% of the most desirable structures compared to 42% at a higher temperature of 117 degrees Celsius.
Who this helps: This benefits manufacturers looking for advanced materials for paints and coatings.
Phosphazene Functionalized Silsesquioxane-Based Porous Polymer as Thermally Stable and Reusable Catalyst for Bulk Ring-Opening Polymerization of ε-Caprolactone.
2023
Polymers
Piskun YA, Ksendzov EA, Resko AV, Soldatov MA, Timashev P +3 more
Plain English This study looked at a special porous material called HPCP that helps make a type of plastic called poly(ε-caprolactone) more efficiently at high temperatures (130-150 °C). Researchers found that this material allowed for the production of poly(ε-caprolactone) with controlled molecular weight, reaching up to 14,000 g/mol, while also being reusable for at least three cycles without losing effectiveness. This advancement is important because it can lead to more sustainable and efficient ways to produce plastics that have various industrial uses.
Who this helps: This helps manufacturers and researchers looking for better methods to produce biodegradable plastics.
Plain English This study explored a new method of creating tiny calcium carbonate particles using a special device that controls the mixing of liquids. Researchers found that their method produced smaller and more porous particles, which could carry more of a model drug—16% compared to just 9% with traditional methods. This is significant because it can enhance how well drugs are delivered to patients.
Who this helps: This benefits patients who need effective drug delivery systems.
Soldatov MA, Medvedev PV, Roldugin V, Novomlinskiy IN, Pankin I +3 more
Plain English This research focused on improving methods for converting solar energy into chemical fuel, specifically through processes like breaking down water and reducing carbon dioxide. The scientists explored how to study these processes in real-time using advanced imaging techniques, highlighting the importance of understanding how catalysts work at the atomic level. By using tools like X-ray Absorption and X-ray Photoelectron Spectroscopies, they hope to find better materials that are both effective and affordable for energy conversion.
Who this helps: This benefits researchers and engineers working on renewable energy technologies.
Plain English This study looked at a new way to deliver the cancer drug doxorubicin (DOX) using specially designed nanoparticles called UiO-66@SiO/F127-FA. Researchers found that these nanoparticles could effectively target cancer cells, particularly those with folate receptors, like MCF-7 breast cancer cells, while also remaining stable in the body. The nanoparticles successfully carried 5.6% of the drug and reduced uncontrolled release, making them a promising option for improving cancer treatment.
Who this helps: This helps cancer patients by providing a more effective delivery method for chemotherapy.
Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area.
2022
Inorganic chemistry
Spector DV, Erofeev AS, Gorelkin PV, Vaneev AN, Akasov RA +13 more
Plain English This study looked at a new type of cancer drug that releases its active ingredient in low-oxygen areas, which are common in tumors. Researchers found that instead of quickly breaking down, the drug gradually releases its active component, allowing it to stay in the tumor longer. Specifically, this drug was able to penetrate deeply into cancer cell clusters, which could make it more effective against tumors.
Who this helps: This benefits cancer patients by potentially improving treatment outcomes.
[Intravenous thrombolytic therapy of ischemic stroke with the drug Revelisa in real clinical practice: results of the IVT-AIS-R study].
2022
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Soldatov MA, Klimov LV, Tolmachev AP, Kiseleva TV, Androfagina OV +17 more
Plain English This study looked at the use of a drug called Revelisa to treat people who had ischemic strokes, which happen when blood flow to the brain is blocked. Researchers treated 550 patients and found that about 45% showed significant improvement in their condition one day after treatment. Additionally, 68.5% of patients had good recovery by the time they were discharged from the hospital after 90 days.
Who this helps: This research benefits patients experiencing ischemic strokes and their healthcare providers by showing that Revelisa can effectively reduce symptoms and improve recovery.
Plain English This paper explored how artificial intelligence (AI) can be used to speed up the creation of new materials and improve existing chemical processes. Researchers found that automated labs, using AI algorithms, can significantly boost the efficiency of developing functional materials. This is important because faster discovery of new materials can lead to advancements in various fields, from electronics to medicine.
Who this helps: This benefits researchers and companies working on new materials.
Loading of the Model Amino Acid Leucine in UiO-66 and UiO-66-NH: Optimization of Metal-Organic Framework Carriers and Evaluation of Host-Guest Interactions.
2021
Inorganic chemistry
Butova VV, Burachevskaya OA, Muratidi MA, Surzhikova II, Zolotukhin PV +4 more
Plain English This study looked at two types of materials, called UiO-66 and UiO-66-NH, to see how well they can store a nutritional amino acid called leucine. The researchers found that these materials can effectively hold leucine without harming human cells, even at tested concentrations of up to 50 micrograms per milliliter. This is important because it shows potential for using these materials in delivering drugs or other important substances in medicine.
Who this helps: Patients needing improved drug delivery systems.
Effects of Zinc Oxide Nanoparticles on Physiological and Anatomical Indices in Spring Barley Tissues.
2021
Nanomaterials (Basel, Switzerland)
Rajput VD, Minkina T, Fedorenko A, Chernikova N, Hassan T +5 more
Plain English This study looked at how tiny particles of zinc oxide (ZnO NPs) affected spring barley plants. The researchers found that these particles harmed the plants by reducing their growth, damaging their chloroplasts (the parts that help with photosynthesis), and increasing zinc levels in the leaves by up to 10 times. This matters because the damage to the plants' ability to produce food can affect crop yields and food supply.
Who this helps: This helps farmers and agricultural scientists.
Dynamic CoRu Bond Shrinkage at Atomically Dispersed Ru Sites for Alkaline Hydrogen Evolution Reaction.
2021
Small (Weinheim an der Bergstrasse, Germany)
Zhang H, Su H, Soldatov MA, Li Y, Zhao X +8 more
Plain English This study investigated a new material made of ruthenium (Ru) and cobalt nanoparticles designed to improve the process of producing hydrogen from water using electricity. The researchers found that this material achieves impressive efficiency, with a very low energy requirement of 34 millivolts to produce a significant amount of hydrogen, outperforming traditional platinum-based catalysts by 40 times. This discovery could lead to more effective and cost-efficient methods for hydrogen production, which is important for sustainable energy sources.
Who this helps: This helps energy researchers and industries focused on developing clean hydrogen fuel technologies.
[Intravenous thrombolytic therapy with Revelisa of ischemic stroke in real-world clinical practice: interim results of an open-label, prospective, multicenter, non-interventional study IVT-AIS-R].
2021
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Soldatov MA, Marskaya NA, Barsegova KA, Androfagina OV, Borisov DN +9 more
Plain English This study looked at the use of a drug called Revelisa for treating ischemic stroke patients in real-life hospital settings. Out of 223 patients treated, 7.1% experienced complications from bleeding in the brain, and 13.9% died during their hospital stay. After treatment, nearly half of the patients (48.2%) showed good recovery at discharge, which is comparable to results from other treatments like alteplase.
Who this helps: Patients who suffer from ischemic strokes.
Synthesis of ZnO Nanoparticles Doped with Cobalt Using Bimetallic ZIFs as Sacrificial Agents.
2020
Nanomaterials (Basel, Switzerland)
Butova VV, Polyakov VA, Erofeeva EA, Efimova SA, Soldatov MA +3 more
Plain English This study focused on creating tiny particles made of zinc and cobalt oxide, which are important for various applications. The researchers successfully made these particles in two steps, finding that they can incorporate up to 5% cobalt and control their size down to 5-10 nanometers when a protective layer is added. This process is significant because it improves the ability to design materials with specific properties for better performance in electronics or medicine.
Who this helps: This benefits researchers and developers working on advanced materials for technology and healthcare.
Novel Copper-Containing Cytotoxic Agents Based on 2-Thioxoimidazolones.
2020
Journal of medicinal chemistry
Krasnovskaya OO, Guk DA, Naumov AE, Nikitina VN, Semkina AS +24 more
Plain English This study looked at 73 new copper-based compounds to see how their structure affects their ability to kill cancer cells, focusing on their chemical properties and how they interact with tumor cells. They found that the way these compounds generate reactive oxygen species (harmful molecules) inside cells is crucial for their effectiveness, particularly at certain depths in tumor formations, like 40-60 micrometers. This research is important because it helps in the development of more effective cancer treatments that target tumors more efficiently.
Who this helps: Patients with cancer, particularly those whose tumors are hard to treat.
ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles.
2020
International journal of molecular sciences
Gorban IE, Soldatov MA, Butova VV, Medvedev PV, Burachevskaya OA +3 more
Plain English The study examined how well tiny particles made from a metal-organic framework (called MIL-100) could load and release a specific amino acid, called L-leucine. Researchers found that these particles were very porous and could effectively release L-leucine in water, with the amino acid reducing the particles' toxicity to cells. Specifically, while the original particles were somewhat toxic, the loaded L-leucine helped make them safer for use.
Who this helps: This benefits patients who might need safer drug delivery systems.
Synthesis of Iron Oxide Nanoclusters by Thermal Decomposition.
2018
Langmuir : the ACS journal of surfaces and colloids
Nikitin AA, Shchetinin IV, Tabachkova NY, Soldatov MA, Soldatov AV +6 more
Plain English Researchers developed a new way to create tiny iron oxide clusters, known as magnetite nanoclusters (MNCs), which can improve MRI scans. They found that these clusters can achieve high magnetic properties, with saturation magnetization values ranging from 65.1 to 81.5 emu/g, meaning they work well as contrast agents in imaging. This is important because it enhances the clarity and detail of MRI images, helping doctors to better diagnose and monitor patients.
Who this helps: Patients undergoing MRI scans.
Operando study of palladium nanoparticles inside UiO-67 MOF for catalytic hydrogenation of hydrocarbons.
2018
Faraday discussions
Bugaev AL, Guda AA, Lomachenko KA, Kamyshova EG, Soldatov MA +10 more
Plain English This research studied how tiny particles of palladium, a type of metal, can be used inside a special framework called UiO-67 to improve chemical reactions that convert hydrocarbons, like turning ethylene into ethane. The researchers created palladium particles that were about 2.1 nanometers in size and found that they worked effectively when heated in specific conditions. This is important because enhancing these reactions could lead to more efficient processes in producing fuels and other chemicals.
Who this helps: This helps chemists and industries looking to make cleaner and more efficient chemical processes.
Structure of the CoIntermediate of a Cobalt Pentapyridyl Catalyst for Hydrogen Evolution Revealed by Time-Resolved X-ray Spectroscopy.
2018
ChemSusChem
Smolentsev G, Soldatov MA, Probst B, Bachmann C, Azzaroli N +3 more
Plain English This study looked at a specific type of cobalt catalyst used for making hydrogen from water. Researchers found that one part of the catalyst temporarily detaches during the process, which may allow another part to help transfer protons, making the reaction more efficient. Understanding this mechanism helps improve the design of these catalysts for better performance in producing hydrogen, a clean energy source.
Who this helps: This benefits researchers and engineers working on renewable energy technologies.
[Post-stroke rehabilitation training with a brain-computer interface: a clinical and neuropsychological study].
2018
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Shukin IA, Lebedeva AV, Soldatov MA, Fidler MC
Plain English This study looked at how well a medication called cytoflavin works for patients aged 60-74 with chronic brain issues and mild memory problems due to blood vessel problems. Researchers found that patients taking cytoflavin experienced a significant increase in brain activity, with their P300 response improving by 1.3 times in the left side of the brain and 1.7 times in the right side, compared to those on a different treatment. This is important because it shows that cytoflavin is effective and safe, making it a good option for helping people with cognitive issues.
Who this helps: This helps patients with cognitive impairment, particularly those with issues related to chronic cerebral ischemia.
Low toxic maghemite nanoparticles for theranostic applications.
2017
International journal of nanomedicine
Kuchma EA, Zolotukhin PV, Belanova AA, Soldatov MA, Lastovina TA +4 more
Plain English This study focused on creating low-toxicity iron oxide nanoparticles, specifically a type called maghemite, for use in cancer diagnosis and treatment. The researchers successfully produced nearly spherical nanoparticles averaging 16 nanometers in size using a fast microwave method. These nanoparticles are important because they can target cancer cells while being less harmful to healthy cells, which may improve treatment outcomes for patients.
Who this helps: This helps cancer patients by providing potentially safer and more effective treatment options.
Optimized Finite Difference Method for the Full-Potential XANES Simulations: Application to Molecular Adsorption Geometries in MOFs and Metal-Ligand Intersystem Crossing Transients.
2015
Journal of chemical theory and computation
Guda SA, Guda AA, Soldatov MA, Lomachenko KA, Bugaev AL +6 more
Plain English This study looked at how to better model the X-ray absorption spectra of metals in complex materials, especially when these metals are influenced by molecules or light. The researchers improved the modeling technique, making it much faster—over ten times quicker—while also using half the computer memory. Their findings revealed that in one case, a nickel complex interacted with carbon monoxide in a straight line, while with nitric oxide, the orientation was nearly 90 degrees, indicating important differences in how these molecules interact with metals.
Who this helps: This benefits researchers and scientists studying metal-organic materials and their applications in various technologies.
Plain English This study looked at how chronic fatigue, emotional issues, and overall quality of life affected 35 patients with multiple sclerosis (MS). Researchers found that patients had high levels of fatigue and emotional distress, and those with older age or longer disease duration reported worse symptoms. After taking idebenon (noben) for six months, patients experienced a significant reduction in fatigue and depression, suggesting this treatment can improve their daily lives.
Who this helps: This benefits patients with multiple sclerosis who struggle with fatigue and emotional challenges.
[Possibilities of medical correction of moderate cognitive impairment].
2013
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Boĭko AN, Lebedeva AV, Shchukin IA, Soldatov MA, Ismailov AM +3 more
Plain English In this study, 34 outpatients with moderate cognitive impairment received a high dose of Ginkgo Biloba extract (240 mg daily) for three months. The results showed significant improvements in attention, memory, and orientation, along with reduced anxiety and depression, as measured by various cognitive and quality of life assessments. This is important because it indicates that Ginkgo Biloba can be an effective treatment option for those experiencing cognitive decline.
Who this helps: Patients with moderate cognitive impairment.
Local electronic structure of aqueous zinc acetate: oxygen K-edge X-ray absorption and emission spectroscopy on micro-jets.
2013
Physical chemistry chemical physics : PCCP
Golnak R, Atak K, Suljoti E, Hodeck KF, Lange KM +3 more
Plain English This study looked at the electronic structure of zinc acetate dissolved in water to understand how it interacts at a molecular level. Researchers used advanced X-ray techniques and found that the presence of zinc and water changes how the acetate ion behaves. Understanding these interactions is important for improving the use of zinc acetate in various applications, such as medicine and agriculture.
Who this helps: Patients and researchers looking for better treatments or processes involving zinc acetate.
[Emotional disorders and quality of life in patients with post stroke asthenia].
2013
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Boĭko AN, Lebedeva AV, Shchukin IA, Soldatov MA, Petrov SV +3 more
Plain English This study looked at how fatigue and emotional problems affect the quality of life in stroke survivors. Researchers followed 35 patients and found that taking idebenone (90 mg daily) for six months reduced feelings of fatigue and improved emotional well-being, leading to a better quality of life for the participants. Your overall daily activities and mood can improve significantly after such treatment.
Who this helps: This helps stroke survivors looking to improve their energy and emotional health.
Origin of dark-channel X-ray fluorescence from transition-metal ions in water.
2012
Journal of the American Chemical Society
Seidel R, Ghadimi S, Lange KM, Bonhommeau S, Soldatov MA +7 more
Plain English This study looked at how certain metals in water, specifically cobalt ions (Co²⁺), affect the way light is absorbed and emitted. Researchers found that energy transfer from the metal to water reduces fluorescence, which creates noticeable dips in the spectrum where light is usually expected. This finding helps improve understanding of how these charge-transfer processes work in biological and chemical systems, which can impact various scientific fields.
Who this helps: This benefits researchers studying chemical reactions in biological systems.