Annalisa Schiepatti

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This study looked at how well patients with Crohn's Disease (CD) and Ulcerative Colitis (UC) followed the Mediterranean Diet and how much highly processed food they ate. Researchers found that CD patients followed the Mediterranean Diet less than UC patients, with scores of 9.3 compared to 9.8, and that higher intake of processed foods was linked to worse metabolic health. This matters because adopting healthier eating habits could improve the health of individuals with inflammatory bowel diseases. Who this helps: Patients with Crohn's Disease and Ulcerative Colitis.

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Researchers updated the guidelines for diagnosing and managing coeliac disease (CeD) in adults. The new recommendations include safe ways to include oats in the diet, approaches for managing persistent symptoms, and new treatment options for patients who don’t respond to the typical gluten-free diet. These changes aim to improve patient care and health outcomes by using the latest scientific findings to create more personalized treatment plans. Who this helps: This helps adults with coeliac disease and their healthcare providers.

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This study looked at how celiac disease affects people’s ability to work and the reasons they miss work. Out of 167 patients, 14% missed work in the past month, averaging about 6.6 hours lost. Those who missed work experienced more ongoing symptoms, higher depression levels, and a lower quality of life compared to those who did not miss work, showing that persistent symptoms and being on a gluten-free diet for less than a year are key factors. Who this helps: This information benefits patients with celiac disease and their doctors.

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This study looked at how common Whipple's disease (WD) is among patients with inflammatory rheumatic diseases. Out of over 23,000 patients, only 0.03% were diagnosed with WD, but among those suspected of having it, the prevalence jumped to nearly 16%, especially higher in males at around 24%. These findings highlight the need for doctors to be more aware of WD in rheumatology settings, which could help reduce delays in diagnosis and prevent the unnecessary use of treatments. Who this helps: This helps doctors and patients who may experience unexplained symptoms.

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The study looked at whether an additional procedure called terminal ileal intubation (TII) is useful during colonoscopies for people who don’t have any symptoms, specifically for colorectal cancer screening or after polyp removal. Researchers reviewed data from 11 studies involving over 25,000 patients and found that TII only detected important issues in 0.28% of cases and Crohn's disease in just 0.1% of cases, meaning it doesn’t significantly improve the chances of finding serious health problems. This matters because it suggests that doing TII for these patients is unnecessary and may just add time to the procedure without providing real benefits. Who this helps: This helps doctors and patients by clarifying which procedures are necessary during colonoscopy.

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This study looked at how well patients with ulcerative colitis (UC) prepare their bowels for colonoscopies when their disease is under control, and compared two different bowel prep methods. Among 379 patients, 90.5% had adequate bowel preparation, but those using the 1L-PEG-ASC method scored better on cleanliness (8 out of 9) compared to those using 2L-PEG (6 out of 9) and had a higher exam completion rate (99.5% vs. 95.7%). This is important because it shows that even without active disease, good bowel prep is essential for effective cancer screenings, highlighting the benefits of using the 1L-PEG-ASC method for better results. Who this helps: Patients with ulcerative colitis needing colonoscopies.

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This study looked at a marker called fecal calprotectin (FC) to understand its role in measuring gut inflammation in patients with celiac disease (CD) and non-celiac enteropathies (NCEs). The researchers found that 55 out of 177 patients had high levels of FC, which made it likely they would have more complications or die earlier; specifically, those with high FC levels were four times more likely to face these outcomes. This matters because it indicates that measuring FC can help doctors identify patients at greater risk for severe disease and complications. Who this helps: This helps patients with celiac disease and non-celiac enteropathies, as well as their doctors, by providing a simple way to assess disease risk.

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This study looked at adults who were on a gluten-free diet but had not yet been confirmed to have coeliac disease. Out of 158 patients tested after eating gluten for about 3 months, only 47 (about 30%) were confirmed to have coeliac disease, while most (108) did not have the disease. The findings highlight that a previous positive blood test for gluten sensitivity greatly increases the chances of actually having the disease, but doctors should be careful about interpreting other test results, especially in older patients with severe symptoms. Who this helps: This helps patients with suspected coeliac disease and their doctors in making more accurate diagnoses.

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This study looked at the occurrence of gastroesophageal reflux disease (GORD) in adults diagnosed with coeliac disease over a 20-year period. Initially, 16.8% of participants reported reflux symptoms at the time of their coeliac diagnosis, but only 21.9% of those continued to have these symptoms after following a gluten-free diet for about 16 months. Overall, during long-term follow-up, 20.8% of patients experienced ongoing reflux symptoms, showing that while many improve with dietary changes, some develop reflux after starting the diet, highlighting ongoing monitoring is important. Who this helps: This helps patients with coeliac disease and their doctors by providing insights into managing reflux symptoms associated with the condition.

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This study evaluated a new way to diagnose coeliac disease in adults without the need for invasive biopsies. Researchers looked at nearly 1,200 patients and found that 35.4% had coeliac disease, with an impressive accuracy of 99.1% using a blood test for antibodies. This matters because it suggests that many younger patients with mild symptoms might be diagnosed safely without needing uncomfortable procedures, while older patients with severe symptoms still require further testing to rule out other conditions. Who this helps: This helps patients suspected of having coeliac disease, especially younger ones.

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This study looked at how effective two different dental treatments were for people with tooth erosion caused by gastroesophageal reflux disease (GERD). Thirty patients participated, with one group using a special toothpaste and an additional paste, and the other group using just the toothpaste. While the extra paste didn’t make a significant difference in overall tooth erosion and sensitivity scores, patients using the treatments saw improvements in sensitivity and plaque control. Who this helps: Patients with GERD who experience dental erosion and sensitivity.

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This study looked at how common celiac disease (CeD) is among people diagnosed with irritable bowel syndrome (IBS). It found that about 6% of IBS patients have CeD based on blood tests, while about 2% have confirmed cases through biopsies. This is important because many doctors might misdiagnose IBS without checking for CeD, which could lead to untreated symptoms for patients. Who this helps: Patients with IBS who need proper diagnosis and treatment.

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The 2025 updated guidelines from the European Society for the Study of Coeliac Disease focus on improving how doctors diagnose coeliac disease in adults. Key changes include allowing some patients with high levels of a specific antibody to avoid a biopsy and emphasizing the use of accurate blood tests instead of older methods for confirming the disease. These updates are important because they aim to make diagnoses more accurate and less invasive, ultimately leading to better care and quality of life for patients. Who this helps: This helps patients with suspected coeliac disease and their healthcare providers.

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This paper looked at non-coeliac wheat sensitivity (NCWS), a condition where people experience symptoms like stomach issues and fatigue after eating wheat, even though they don't have coeliac disease or a wheat allergy. The study found that while more than 10% of people report having this condition, only about 30% can be confirmed with careful testing. Understanding NCWS is important because it can impact how people manage their diet, and clearer diagnostic tools are needed to help both patients and healthcare providers. Who this helps: This helps patients who suspect they have non-coeliac wheat sensitivity and may benefit from better diagnosis and management options.

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This research paper looked at different endoscopic techniques, which are procedures using a camera, to diagnose villous atrophy in patients with celiac disease. The study found that standard white-light endoscopy is good but has lower accuracy, with a sensitivity of 81.4% and specificity of 95.3%. In contrast, advanced techniques like water-immersion, narrow-band imaging, and dye-based chromoendoscopy performed much better, with sensitivities above 92% and specificities above 93%. This matters because accurate diagnosis can lead to better treatment for patients suffering from celiac disease. Who this helps: Patients with celiac disease seeking accurate diagnosis.

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This study looked at the long-term health outcomes of patients with nonceliac enteropathies (NCEs), which are digestive disorders not related to celiac disease, over a period of 30 years. Researchers found that 10 years after diagnosis, about 74% of patients were still alive, but mortality rates were significantly higher for these patients compared to the general population, with a mortality rate about three times higher. They created a scoring system to identify patients at higher risk of serious health issues, allowing for better monitoring and personalized treatment plans. Who this helps: This research benefits patients with nonceliac enteropathies and their doctors by providing insights for better management and care.

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This study looked at how generative artificial intelligence, like ChatGPT, can help with managing inflammatory bowel diseases (IBD), which are chronic conditions that can significantly affect patients' lives. Researchers reviewed 8 studies and found that ChatGPT gave accurate information for patient education 84.2% of the time, and effectively assisted doctors in classifying illness severity 80% of the time. However, there were still concerns about accuracy and consistency, so expert supervision is necessary before it can be widely used in medical practice. Who this helps: This benefits patients with inflammatory bowel disease and their doctors.

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In this study, researchers compared two types of bowel preparation methods, 1L-PEG-ASC and 2L-PEG, for patients with inflammatory bowel disease (IBD) undergoing outpatient colonoscopy. They found that 1L-PEG-ASC was more effective, with 89.8% of patients achieving adequate preparation compared to 83.8% with 2L-PEG. Additionally, factors like being male, having a history of specific surgeries, and having stricturing Crohn’s disease were linked to poorer preparation results. Who this helps: This benefits patients with IBD who need effective bowel preparation before a colonoscopy.

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This study looked at how flow cytometry (a lab technique) can help monitor a type of immune cell called intraepithelial lymphocytes (IELs) in patients with difficult-to-treat celiac disease and other related conditions. Researchers found that 22 of the 52 patients had consistent IEL characteristics over time, and having an abnormal IEL profile was linked to a higher risk of death (over four times more likely). This is important because it shows that flow cytometry can provide valuable insights into the health of these patients and help inform their treatment. Who this helps: This research benefits patients with celiac disease and their doctors by improving monitoring and treatment strategies.

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This study examined the problems caused by a type of medication called angiotensin II receptor blockers (ARBs) that can lead to a serious intestinal condition. Researchers analyzed 94 articles, finding that 183 patients, mostly older adults, experienced severe diarrhea (97%) and significant weight loss (84%), which often required hospital stays. Importantly, stopping the medication led to recovery in all patients who needed it, highlighting the importance of recognizing this issue so patients can be treated effectively. Who this helps: This helps patients taking ARBs, especially those experiencing gastrointestinal issues, as well as their doctors in diagnosing and managing the condition.

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This study looked at death rates in people with coeliac disease and compared them to the general population to see how different types of coeliac disease and other factors affect mortality. The researchers found that people with coeliac disease have a 16% higher risk of dying from all causes, a 21% higher risk from cancers, and a notably higher 10 times the risk from non-Hodgkin lymphoma. However, death rates have decreased over the last few decades, especially since 2015. Who this helps: This information benefits doctors and patients with coeliac disease by providing clearer insights into risks and improving treatment approaches.

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This study focused on a newly identified form of coeliac disease called ultra-short coeliac disease (USCD), which affects the duodenal bulb only. Researchers compared 137 patients with USCD to those with conventional coeliac disease, finding that USCD patients were younger (27 vs. 38 years) and had lower levels of specific antibodies (IgA-tTG) but experienced similar symptoms. Notably, almost all (95.7%) USCD patients saw their symptoms improve after starting a gluten-free diet, highlighting the importance of targeted testing during diagnosis. Who this helps: This research benefits patients with ultra-short coeliac disease and their doctors by improving diagnosis and treatment options.

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This study looked at whether a low-FODMAP diet could help people with celiac disease who still had IBS-like symptoms even after following a gluten-free diet. Researchers reviewed six studies involving 115 celiac patients and found that those on a low-FODMAP gluten-free diet experienced a significant reduction in symptoms compared to those on a regular gluten-free diet. This matters because it offers a possible solution for patients with lingering digestive issues despite strict adherence to their current diet. Who this helps: This helps celiac patients who continue to experience uncomfortable gut symptoms.

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This study looked at different bowel preparation methods for colonoscopies to see which one worked best in real-life settings. Researchers found that using a 1-liter PEG solution led to better bowel cleanliness compared to 2-liter PEG and picosulphate, with a 2.3 times higher chance of having an adequate preparation. This matters because it can make colonoscopies more effective, reduce the need for follow-up procedures, and save healthcare costs. Who this helps: This benefits patients undergoing colonoscopies and healthcare providers aiming for better outcomes.

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This study examined how well the SeHCAT test predicts the effectiveness of cholestyramine treatment in patients with chronic diarrhea suspected to be caused by bile acid malabsorption. Among 50 patients, 37 participated, and those with a positive SeHCAT test showed a long-term response to cholestyramine at a rate of 100%, compared to 65.2% for those with a negative test. This matters because it shows that the SeHCAT test helps identify patients who are more likely to need ongoing treatment for their symptoms, although cholestyramine can still help others who test negative. Who this helps: Patients with chronic diarrhea and their doctors.

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This study reported on a 62-year-old man with celiac disease who was diagnosed with a rare type of small bowel cancer called adenocarcinoma after experiencing abdominal pain and bleeding. He underwent surgery to remove the cancer, which was at an advanced stage, and genetic testing revealed a specific mutation in the DDR2 gene. After surgery, he received six months of chemotherapy and remains cancer-free nearly three years later, demonstrating that genetic changes in tumors might help in finding targeted treatments for similar patients. Who this helps: Patients with rare small bowel cancers and their doctors.

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This study looked at patients with potential coeliac disease (PCD) to understand how often they might develop more serious issues like villous atrophy or show improvement after switching to a gluten-free diet. Out of 1,010 patients, about 33% developed serious intestinal damage while still eating gluten, but when patients followed a gluten-free diet, 88% reported feeling better. These results are important because they help guide doctors on how to monitor and manage patients with PCD effectively. Who this helps: This helps patients with potential coeliac disease and their doctors.

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This study looks at treatments for coeliac disease, a condition affecting about 1% of people, where eating gluten from foods like wheat can damage the intestines. While a strict gluten-free diet is the main treatment, many patients struggle to follow it due to its high cost and difficulty, and some even face serious health issues as a result. The research reviews new drug treatments that are being tested in clinical trials to help patients who can't adhere to the diet or need additional support. Who this helps: This helps coeliac disease patients seeking alternatives to a gluten-free diet.

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This study looked at how common celiac disease (CD) is among people with rheumatoid arthritis (RA) compared to those without it. Researchers found that 0.24% of people with RA had CD, compared to 0.14% of those without RA. The increase was particularly notable in women with RA, with a prevalence of 0.3% versus 0.08% in female controls. This is important because it shows that women with RA are more likely to have celiac disease, highlighting a need for more awareness and testing in this group. Who this helps: This helps patients with rheumatoid arthritis, especially women, by encouraging better screening for celiac disease.

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In this study, researchers looked at how well adults with coeliac disease (a condition that requires a strict gluten-free diet) can bounce back from challenges in life. They found that 98% of the 305 patients had a high level of resilience. However, those with higher anxiety and depression tended to have lower resilience, indicating that addressing these mental health issues could help improve their overall well-being. Who this helps: This research benefits patients with coeliac disease and healthcare providers managing their care.

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Researchers studied patients with autoimmune gastritis (AIG) to understand how previous infections with Helicobacter pylori (a type of bacteria) or specific antibodies affect their health. They found that only 0.9% of patients developed gastric cancer, while 9.6% developed a type of tumor called gastric neuroendocrine neoplasm (gNEN), with a higher risk for those showing vitamin B12 deficiency at the time of diagnosis. This information is important because it helps identify which patients might need closer monitoring, particularly those with vitamin B12 issues. Who this helps: Patients with autoimmune gastritis and their doctors.

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This study looked at celiac disease patients who still had symptoms despite following a gluten-free diet for many years. It found that nearly half of these patients (47%) experienced significant health issues that wasn't primarily due to poor diet adherence, but rather due to functional gut disorders (30%), reflux disease (18%), and vitamin deficiencies (10%). This is important because it highlights the need for new follow-up care strategies based on a patient’s age and type of celiac disease. Who this helps: This helps celiac disease patients and their doctors manage ongoing symptoms more effectively.

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This study looked at the genetic markers of patients with noncoeliac enteropathies, which are conditions that cause gut damage but aren't related to gluten, in comparison to patients with coeliac disease. Researchers found that a specific genetic marker, DQA1*0102 DQB1*0602, was much more common in those with noncoeliac enteropathies than in those with coeliac disease—signifying that this marker can help distinguish between these conditions. This matters because better identification of the type of gut disorder can lead to more accurate treatment and management for patients. Who this helps: Patients with gut disorders, including those affected by noncoeliac enteropathies.

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This research studied how well COVID-19 vaccines work in patients with celiac disease, Whipple's disease, and other digestive disorders compared to healthy individuals. The findings showed that people with celiac disease had similar antibody levels after vaccination as healthy controls, while those with Whipple's disease had a significantly lower response, with those on immunosuppressive treatments showing very low antibody levels (14 compared to 520 BAU/mL). This is important because it highlights that celiac disease patients are adequately protected by the vaccines, but others, particularly those with Whipple's disease and on immunosuppressants, may need extra attention and booster shots. Who this helps: This helps patients with celiac disease, doctors managing their care, and those with Whipple's disease.

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This study examined the long-term effects of persistent villous atrophy (pVA) in adults with coeliac disease who are supposed to be on a gluten-free diet. Among 694 patients, 23% had pVA, and these patients faced a significantly higher risk of complications (nearly 10 times more likely) and a 3 times higher chance of dying compared to those without pVA. Researchers created a 5-point risk score to help identify patients at higher risk of pVA, with those scoring high having a 73% chance of having pVA. Who this helps: This helps doctors identify high-risk patients with coeliac disease who may need closer monitoring.

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This study examined patients with Whipple's disease (WD) to understand who is at higher risk of developing a serious complication called immune reconstitution inflammatory syndrome (IRIS). Among 45 patients, those who later developed IRIS had significantly lower rates of inflammation and platelet counts, with values like an average erythrocyte sedimentation rate of 33.4 mm/h compared to 67.1 mm/h for those who didn't develop IRIS. The study also found that the rate of IRIS in these patients has remained constant over the past 20 years at 22.2%. Who this helps: This information helps doctors identify and manage patients with Whipple's disease who are at greater risk for developing IRIS.

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This study looked at patients with Whipple's disease, a rare infection, to see how often they also had Helicobacter pylori (H. pylori) infections. The researchers found that 38% of Whipple’s disease patients had H. pylori infections compared to only 12% of people without the disease, which is a significant difference. This matters because H. pylori can cause serious stomach problems, including cancer, and knowing this can help doctors better manage treatment for their patients with Whipple's disease. Who this helps: Patients with Whipple's disease and their doctors.

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This study looked at how smoothly young people with celiac disease transition from pediatric to adult healthcare and its effect on sticking to a gluten-free diet, quality of life, and ongoing medical follow-ups. Out of 183 patients studied, the researchers found that those who maintained a good gluten-free diet as they moved into adult care (an increase in adherence of about 2.92 times) tended to report a better quality of life, with adult follow-up improving adherence nearly nine-fold. This is important because it highlights the need for continuous support and strategies tailored to individual patients during this transition to help them manage their condition effectively. Who this helps: This helps patients with celiac disease transitioning to adult care and their healthcare providers.

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This study created and tested a new 10-point questionnaire called the GLU10 to measure how well people understand gluten and gluten-free diets, especially in celiac patients. The researchers found that celiac patients scored an average of 6 points, while non-celiac participants scored just 2 points, showing that celiac patients generally know more about the gluten-free diet. This tool is important because it helps identify celiac patients who may need better dietary education, ensuring they can manage their condition effectively. Who this helps: This helps celiac patients who need proper guidance on gluten-free living.

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This study examined a condition called non-coeliac gluten sensitivity (NCGS), where people experience symptoms after eating gluten, even though they do not have celiac disease. Researchers found that about 24% of people tested showed a true sensitivity to gluten, with most affected being middle-aged women who reported symptoms like stomach pain and bloating. Understanding who gets affected by gluten sensitivity and how it presents is important for providing the right dietary recommendations. Who this helps: This helps patients experiencing unexplained digestive issues and their doctors in identifying potential dietary changes.

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The research reviewed studies using ultrasound to find hidden joint and tendon issues in patients with inflammatory bowel disease (IBD), who are more likely to develop joint problems. Out of over 2,300 studies, eight were chosen, revealing that up to 81.5% of patients had chronic thickening in tendons, with 14%-67% showing active inflammation. This is important because early detection of these issues can lead to better management of IBD and prevent further complications. Who this helps: This helps patients with inflammatory bowel disease and their doctors in managing joint health.

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This research looked at how to diagnose situations where adults have damage in their intestines without the typical markers for coeliac disease. An international group of 13 experts reached an agreement on how to identify two main conditions: seronegative coeliac disease and chronic non-coeliac enteropathies. They found that while seronegative coeliac disease is the most common cause for this intestinal damage, correctly distinguishing it from other non-coeliac conditions is important to prevent patients from unnecessarily following a strict gluten-free diet and to ensure proper treatment. Who this helps: This helps patients who may be misdiagnosed and provides doctors with clearer guidelines for diagnosis.

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This study looked at cases of small intestine damage in patients receiving immune-checkpoint inhibitors, which are cancer treatments that help the immune system attack tumors. The researchers reported two cases: a 65-year-old man with lung cancer and an 18-year-old woman with skin cancer, both experiencing villous atrophy in their small intestines due to these treatments. They found that stopping the drugs can lead to improvement, highlighting the need for doctors to consider such complications in cancer patients on these therapies. Who this helps: This information helps doctors and oncologists who treat cancer patients with immune-checkpoint inhibitors.

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This research looked at a rare group of digestive disorders in adults where patients have damage to the intestine but test negative for celiac disease. The study found that seronegative celiac disease is the most common type among these disorders, and doctors should confirm the diagnosis by observing how patients respond to a gluten-free diet after ruling out other causes. Understanding and accurately treating these conditions is important because they can lead to different health outcomes for patients. Who this helps: This helps patients with unexplained gastrointestinal symptoms.