Dr. Mattingly studies patients who have undergone thyroid or parathyroid surgeries, especially those with a history of nonbariatric gastrojejunostomy, which is a surgical procedure often performed for digestive issues rather than weight loss. Her research highlights how these patients are at a much higher risk of developing dangerously low calcium levels after their surgeries, particularly when their intestines have been rerouted. She examines the effects of these low calcium levels on hospital stays and the need for further medical care after surgery, aiming to improve patient monitoring and outcomes.
Key findings
In a study of 241 patients, 81% of those with a history of nonbariatric bypass surgery experienced low calcium levels shortly after neck surgery.
71% of these patients had persistent low calcium issues months after their surgery.
Patients with prior intestinal bypass surgery had longer hospital stays and higher rates of readmission due to calcium-related complications.
Frequently asked questions
Does Dr. Mattingly study calcium levels in surgery patients?
Yes, she specifically studies how previous intestinal surgeries impact calcium levels in patients undergoing neck surgeries.
What conditions does Dr. Mattingly focus on in her research?
Her research focuses on hypocalcemia following thyroid and parathyroid surgeries, particularly in patients with prior gastrointestinal surgeries.
Is Dr. Mattingly's work relevant to patients with a history of stomach surgery?
Yes, her findings are particularly relevant to patients who have undergone nonbariatric gastrojejunostomy surgery, as they face higher risks of low calcium levels post-surgery.
Publications in plain English
Intraoperative Molecular Imaging Can Detect Large Nerve Perineural Invasion: A Case Report.
2026
Head & neck
Burns CR, Mattingly AS, Ely K, Radevic A, Meeks N +5 more
Plain English This study looked at the use of special imaging technology during surgery to detect hidden cancer spread along nerves in a patient with a specific type of throat cancer. The procedure showed a strong signal indicating cancer presence on the hypoglossal nerve, which was later confirmed by biopsy. This approach could help doctors find and remove cancerous cells that may not be visible during standard surgery, potentially improving patient outcomes.
Who this helps: This helps patients with head and neck cancer, particularly those at risk for nerve involvement.
Hypocalcemia After Cervical Procedures in Patients with a History of Nonbariatric Gastrojejunostomy.
2026
Annals of surgical oncology
Mattingly AS, Kravchenko T, Chokshi S, Hakim C, Passman JE +7 more
Plain English Researchers studied 241 patients who had thyroid or parathyroid surgery and compared outcomes based on whether they'd previously had different types of stomach surgery—particularly whether their intestines had been rerouted to bypass the duodenum (the first part of the small intestine). They found that patients with prior intestinal bypass surgery developed dangerously low calcium levels after their neck surgery at much higher rates than patients who had sleeve gastrectomy (a different weight-loss procedure that doesn't reroute the intestines).
The risk was especially severe in patients with nonbariatric bypass surgery—those who had the intestinal rerouting for reasons other than weight loss—where 81% experienced low calcium levels shortly after surgery and 71% had persistent problems months later. Low calcium caused longer hospital stays and more readmissions.
This matters because doctors now know they need to screen and monitor calcium levels more carefully before and after
Minimally Invasive Surgery in the United States, 2022: Understanding Its Value Using New Datasets.
2023
The Journal of surgical research
Mattingly AS, Chen MM, Divi V, Holsinger FC, Saraswathula A
Plain English This study looked at how minimally invasive surgery (MIS) is being used in the United States between 2016 and 2018, using new nationwide data sources. The researchers found that the percentage of inpatient surgeries that were minimally invasive remained similar, around 11%, but there was a notable increase in ambulatory MIS procedures, rising from 16.9% to 18% over the years. Understanding these trends is important because it helps assess the value of MIS and identify gaps in how these surgeries are documented nationally.
Who this helps: This benefits patients and doctors by providing clearer insights into surgical options and trends.
A Closer Look at "Taller-Than-Wide" Thyroid Nodules: Examining Dimension Ratio to Predict Malignancy.
2022
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Mattingly AS, Noel JE, Orloff LA
Plain English This study looked at whether the height-to-width ratio of thyroid nodules can help predict if they are cancerous. Researchers analyzed data from patients who had thyroid surgery between 2010 and 2020 and found that for every 0.1 increase in the height-to-width ratio, the chances of the nodule being malignant increased by 25%. Specifically, nodules with a ratio of 1.5 or higher had a 4.9 times higher likelihood of being cancerous compared to those with a ratio below 0.8.
Who this helps: This information benefits doctors and patients by improving the assessment of thyroid nodules for potential cancer.
Pulse oximeter provision and training of non-physician anesthetists in Zambia: a qualitative study exploring perioperative care after training.
2022
BMC health services research
Peterson ME, Mattingly AS, Merrell SB, Asnake BM, Ahmed I +1 more
Plain English This study looked at how providing pulse oximeters and training for non-physician anesthetists in Zambia impacted patient care during surgeries. Of the 35 anesthetists who were trained, 10 were interviewed, and they reported that better knowledge of pulse oximetry made them more confident in monitoring patients, which led to improved assessments and quicker medical responses. However, many still faced challenges due to a lack of available devices and support, which sometimes delayed surgeries.
Who this helps: This helps patients undergoing surgery and the healthcare teams that support them.
Trends in US Surgical Procedures and Health Care System Response to Policies Curtailing Elective Surgical Operations During the COVID-19 Pandemic.
2021
JAMA network open
Mattingly AS, Rose L, Eddington HS, Trickey AW, Cullen MR +2 more
Plain English This study looked at how the COVID-19 pandemic and government policies impacted the number of surgeries performed in the United States. During the initial shutdown from March to May 2020, the number of surgeries dropped by nearly 48%, from 905,444 procedures in 2019 to 458,469 in 2020. However, after the shutdown, surgeries returned to 2019 levels, even during peak COVID-19 times in fall and winter, indicating that health systems adapted and maintained surgical capacity despite the challenges.
Who this helps: This research benefits patients needing elective surgeries and healthcare providers managing surgical operations during health crises.
Qualitative outcomes of Clean Cut: implementation lessons from reducing surgical infections in Ethiopia.
2019
BMC health services research
Mattingly AS, Starr N, Bitew S, Forrester JA, Negussie T +2 more
Plain English This study looked at a program called Clean Cut aimed at reducing surgical infections in hospitals in Ethiopia by improving key practices during surgeries. Interviews with 20 healthcare workers revealed that major challenges included a lack of resources and communication issues, while strong leadership and training were helpful factors. These findings are important because they identify what hospitals need to focus on to effectively prevent infections during surgeries in the future.
Who this helps: This helps hospitals, healthcare workers, and patients undergoing surgery.
Association of Sex With Postoperative Mortality Among Patients With Heart Failure Who Underwent Elective Noncardiac Operations.
2019
JAMA network open
Mattingly AS, Lerman BJ, Popat R, Wren SM
Plain English This study looked at heart failure (HF) patients who had non-heart-related surgeries to see if their sex affected the risk of dying after the operation. Among nearly 48,000 HF patients, it found that while women generally have lower surgery mortality risk, those with HF actually faced a higher risk compared to men—women had about 2.44 times the odds of dying after surgery compared to men’s 1.64 times. This is important because it highlights that heart failure can diminish the protective benefits typically seen in women after surgery.
Who this helps: This information benefits doctors and patients with heart failure by informing them about the increased risks involved.
T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults.
2017
The Pediatric infectious disease journal
Mattingly AS, Unsal AB, Purdy JB, Gharib AM, Rupert A +5 more
Plain English This study looked at the immune system and heart health in 31 young adults who acquired HIV early in life. Researchers found that higher levels of certain immune activation markers were linked to more coronary artery plaque, which can lead to heart problems. Specifically, they noted a connection between plaque and factors like lipids and a protein called E-selectin. Understanding these links is crucial as it highlights how HIV affects heart health even at a young age.
Who this helps: This benefits young adults with HIV and their healthcare providers.
Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life.
2017
The Journal of clinical endocrinology and metabolism
Unsal AB, Mattingly AS, Jones SE, Purdy JB, Reynolds JC +3 more
Plain English This study looked at how HIV medication affects bone and kidney health in young adults who have been on treatment since birth. Researchers found that these individuals had lower bone density and signs of kidney strain compared to healthy peers, with some specific metrics showing increased risks—like higher markers of kidney dysfunction linked to certain medications. However, over time, bone health showed improvement, and there are now less harmful treatments available that could benefit these patients in the long run.
Who this helps: This helps young adults living with HIV, especially those who have been on treatment from an early age.