B Morrone studies chronic diarrhea and its underlying causes, particularly focusing on individuals who struggle with bile acid malabsorption. Bile acids are important for digesting fats, and when the body cannot absorb them properly, it can lead to diarrhea. In their research, Morrone analyzed samples from patients' intestines to determine whether physical damage was present, concluding that the intestines appeared normal under the microscope in such cases. This means the issues likely stem from how the intestines work, rather than any visible wear or tear, which can help guide more effective treatment options for people suffering from this condition.
Key findings
In a study of 23 individuals with chronic diarrhea, there were no meaningful differences in tissue damage between the 14 patients with bile acid malabsorption and the 9 without.
The analysis indicated that chronic diarrhea associated with bile acid malabsorption does not involve visible structural damage in the ileum and colon.
This research underscores the importance of functional assessments over structural examinations in diagnosing the cause of chronic diarrhea.
Frequently asked questions
Does Dr. Morrone study chronic diarrhea?
Yes, Dr. Morrone specifically researches chronic diarrhea and its relationship with bile acid malabsorption.
What conditions has Dr. Morrone researched?
Dr. Morrone has focused on chronic diarrhea, particularly the issue of bile acid malabsorption and its effects on intestinal function.
Is Dr. Morrone's work relevant to people with digestive issues?
Yes, their research provides valuable insights into how functional problems in the intestines can lead to digestive issues like chronic diarrhea.
Publications in plain English
Analysis of a Division I Sports Medicine Program's COVID-19 Protocol: Identifying Factors that Predict Testing Demands and Positive Rates During a Pandemic.
2024
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
Stickler K, Morrone B, Brown A, Franks AM, Johnson P +2 more
Plain English This study looked at how often student-athletes and staff at a Division I sports program were tested for COVID-19 and how many tested positive. Out of over 20,000 tests conducted, only 201 people tested positive, which is about 1%. The study found that contact sports like football and basketball had higher positive rates, especially among male teams, and suggested that testing should focus more on these higher-risk sports to keep everyone safe.
Who this helps: This information helps sports teams, coaches, and health officials by guiding safer testing practices during pandemics.
The peculiar role of C/N and initial pH in anaerobic digestion of lactating and non-lactating water buffalo manure.
2020
Waste management (New York, N.Y.)
Carotenuto C, Guarino G, D'Amelia LI, Morrone B, Minale M
Plain English This study looked at how manure from lactating and non-lactating water buffaloes can be used to produce biogas in a specific environment without needing to add extra nutrients. Researchers found that the typical carbon to nitrogen (C/N) ratio, which is usually critical for the digestion process, had a minimal impact when they tested a wide range of ratios from 9.7 to 50.1. They also discovered that even when the initial pH of the manure was acidic (between 5.0 and 6.0), it still produced biogas effectively because the manure adjusted its pH to more neutral levels during digestion, which could save costs in processing.
Who this helps: This research benefits farmers and companies looking to efficiently process water buffalo manure into renewable energy.
Stereotypic Behavior in Sows Is Related to Emotionality Changes in the Offspring.
2020
Frontiers in veterinary science
Tatemoto P, Bernardino T, Morrone B, Queiroz MR, Zanella AJ
Plain English This study looked at how certain repetitive behaviors in pregnant pigs (sows) can affect the emotions of their piglets. Researchers found that piglets from sows who displayed more stereotypical behaviors were more active and explored more areas, while those from sows with fewer stereotypies made more vocalizations when presented with new objects. This matters because it highlights the impact of a mother's behavior on her offspring’s emotional development, which could influence their wellbeing as they grow.
Who this helps: This benefits animal researchers and farmers by improving understanding of animal behavior and welfare.
Plain English Researchers studied how the diet of pregnant pigs (gilts) affects the behavior and health of their piglets. They found that piglets born from mothers eating a high-fiber diet had fewer skin injuries before weaning compared to those from mothers on a low-fiber diet, indicating less fighting among siblings. This is important because it shows that a better diet for pregnant sows can lead to healthier, less aggressive piglets, which improves their welfare.
Who this helps: This helps farmers and animal welfare advocates.
Simultaneous detection and quantification of six equine cytokines in plasma using a fluorescent microsphere immunoassay (FMIA).
2015
MethodsX
Hall SA, Stucke D, Morrone B, Lebelt D, Zanella AJ
Plain English This study looked at measuring six different signaling proteins, called cytokines, in blood samples from horses using a new technology. Researchers found that they could successfully detect and measure these cytokines, which can indicate inflammation and disease, using a smaller amount of blood and in less time than older methods. This is important because it allows for better diagnosis and monitoring of health conditions in horses.
Who this helps: Horse owners and veterinarians.
DGGE analysis of buffalo manure eubacteria for hydrogen production: effect of pH, temperature and pretreatments.
2012
Molecular biology reports
Carillo P, Carotenuto C, Di Cristofaro F, Kafantaris I, Lubritto C +4 more
Plain English This study looked at using buffalo manure as a source for producing hydrogen fuel. Researchers found that certain bacteria, especially from the Clostridium cellulosi group, thrive in the right conditions (specific pH and temperature) and can effectively produce hydrogen from buffalo dung. The findings highlight the potential of buffalo manure as a cheap and effective material for renewable energy production.
Who this helps: This benefits renewable energy producers and researchers looking for sustainable fuel sources.
Urinary sevoflurane and hexafluoro-isopropanol as biomarkers of low-level occupational exposure to sevoflurane.
2005
International archives of occupational and environmental health
Accorsi A, Morrone B, Domenichini I, Valenti S, Raffi GB +1 more
Plain English This study focused on how to measure exposure to sevoflurane, a commonly used anesthetic, in people working in pediatric operating rooms. Researchers collected urine samples from 36 workers over two weeks and found that the median amount of sevoflurane in urine was 0.6 micrograms per liter, with the highest reaching 18.5 micrograms per liter. These findings are important because they can help improve health monitoring for medical personnel exposed to this anesthetic, ensuring safer working environments.
Who this helps: This helps healthcare workers who use sevoflurane in their jobs.
High-speed capillary gas chromatography for determination of inhalation anesthetics.
2005
Journal of chromatography. A
Accorsi A, Morrone B, Raffi GB, Violante FS
Plain English Researchers studied a new method for analyzing inhalation anesthetics, focusing on improving the speed and efficiency of the testing process. They found that by using a shorter capillary column, they could reduce the analysis time from 18 minutes to about 7 minutes while still effectively separating different anesthetic gases. This faster method more than doubles the number of samples that can be processed, which is important for improving patient care in medical settings.
Who this helps: This benefits doctors and healthcare facilities that use inhalation anesthetics during procedures.
Simultaneous determination of unmodified sevoflurane and of its metabolite hexafluoroisopropanol in urine by headspace sorptive extraction-thermal desorption-capillary gas chromatography-mass spectrometry.
2005
Journal of chromatography. A
Accorsi A, Morrone B, Benzo M, Gandini C, Raffi GB +1 more
Plain English This study looked at how to measure levels of sevoflurane and its breakdown product, hexafluoroisopropanol (HFIP), in the urine of operating room staff who use the anesthetic. Researchers found they could reliably detect these substances at very low levels, with a detection limit of just 1 microgram per liter. This is important because it helps ensure the safety and well-being of medical personnel who are regularly exposed to sevoflurane in their work.
Who this helps: Operating room staff and hospitals.
Absence of histopathological changes of ileum and colon in functional chronic diarrhea associated with bile acid malabsorption, assessed by SeHCAT test: a prospective study.
1994
The American journal of gastroenterology
Sciarretta G, Furno A, Morrone B, Malaguti P
Plain English Researchers studied 23 people with chronic diarrhea of unknown cause—14 of whom had a specific problem absorbing bile acids (a digestive fluid) and 9 who didn't—by taking tissue samples from their small and large intestines to look for visible damage or abnormalities. They found no meaningful differences in tissue damage between the two groups, meaning the problem wasn't caused by obvious structural damage to the intestines. This tells doctors that when diarrhea is linked to bile acid malabsorption, the intestines themselves look normal under a microscope, so the problem must be caused by how the intestines are *functioning* rather than any visible disease.
Pineal germinoma with massive supratentorial extension. Case report.
1983
Journal of neurosurgical sciences
Tognetti F, Galassi E, Gaist G, Morrone B
Plain English This research discusses a rare case of a large tumor called a pineal germinoma that spread significantly in the brain without causing swelling of the connected fluid-filled areas (ventricles). The tumor, which looked similar to a brain tissue growth on scans, was mostly removed through surgery, and after treatment with radiation, the patient experienced relief from symptoms for over a year. Understanding this case helps in recognizing unusual tumor behavior and can improve diagnosis and treatment for similar cases in the future.
Who this helps: Patients with brain tumors, especially those with unusual growth patterns.
Microsurgical removal of paraventricular cavernous angiomas. Report of two cases.
1981
Journal of neurosurgery
Pozzati E, Gaist G, Poppi M, Morrone B, Padovani R
Plain English This study looked at two patients with cavernous angiomas, which are abnormal blood vessel formations in the brain. One angioma was located in the fourth ventricle, and the other was in the thalamus, affecting the third ventricle. Both patients showed symptoms similar to those of brain tumors, but after surgery to remove the angiomas, they had positive outcomes.
Who this helps: This benefits patients with cavernous angiomas and their doctors.
Pozzati E, Padovani R, Morrone B, Finizio F, Gaist G
Plain English This study looked at five children with cerebral cavernous angiomas, which are abnormal blood vessel formations in the brain. Three of these children had seizures, while two experienced bleeding in the brain. The research highlights that these conditions are more common in adults, but seizures are often the first sign of the problem in children, making it important to use CT scans for early detection.
Who this helps: This helps doctors and patients by improving diagnosis and understanding of brain malformations in children.
Rhabdomyoma (adult type) of the sublingual region.
1977
Tumori
Ferracini R, Cavina C, Morrone B
Plain English This study reports a specific case of a rhabdomyoma, a rare type of tumor, found in the area under the tongue of a 40-year-old man. The researchers also reviewed 28 similar cases documented worldwide. Understanding this rare tumor is important because it helps doctors recognize and treat similar cases in patients.
Who this helps: This benefits doctors and medical professionals who encounter similar tumors in their patients.