Claire M McCarthy

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This study looked at the experiences and management of pregnant women with Friedreich's ataxia (FRDA), a condition that affects movement and has other health impacts. The researchers discussed the specific challenges these pregnancies face and provided recommendations based on their findings, focusing on the largest group of Irish patients studied. This is important because it helps improve care for both mothers with FRDA and their babies. Who this helps: This helps pregnant women with Friedreich's ataxia and their healthcare providers.

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This study looked at whether using acellular dermal matrix (ADM) is just as safe as not using it in a specific type of breast reconstruction surgery. Out of 368 patients, both groups experienced similar rates of major complications after surgery (13.2% with ADM compared to 13.1% without), which showed that ADM is a safe option. The results also indicated that patients' comfort levels and minor complications were comparable, suggesting that using ADM isn't riskier. Who this helps: This benefits patients undergoing breast reconstruction surgery.

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This study looked at a 22-year-old woman with Glycogen Storage Disease Type IIIA, a rare condition that affects how her body stores and uses sugar. Through a team of specialists working together in areas like nutrition and pregnancy care, she had a successful pregnancy and delivery. This is important because it shows that with the right support, women with this rare disease can have positive pregnancy experiences. Who this helps: This helps patients with Glycogen Storage Disease Type IIIA and their medical teams.

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This research looked at how nursing studies that use online surveys protect themselves against fake responses, like those from bots. Out of 132 articles reviewed, only 21 mentioned any methods to check for fraud, such as reviewing answers for inconsistencies or using software tools. This is important because ensuring the quality and accuracy of survey responses helps build trust in the research findings. Who this helps: This helps researchers and healthcare professionals who rely on accurate data for better patient care.

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This study looked at a rare condition where the splenic vein can rupture during pregnancy. They reported a case involving a 30-year-old woman who experienced severe abdominal pain at 37 weeks of pregnancy, leading to an emergency surgery. Both the mother and baby survived with no lasting issues, which is significant since only two other similar cases had been documented before. Who this helps: This helps pregnant women and healthcare providers by highlighting the risks and management of splenic vein issues during pregnancy.

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This study looked at how well surgeons are trained to perform vaginal hysterectomies, especially in treating pelvic organ prolapse (POP). Out of 471 surgeons surveyed, 94% felt skilled in vaginal hysterectomy, but 45% had done fewer surgeries over the past ten years. It's important to ensure surgeons keep their skills sharp as the type of procedures they choose can be influenced by factors like patient preferences and their training experience. Who this helps: This helps patients with pelvic organ prolapse by ensuring that their surgeons are well-trained and proficient.

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This study focused on a pregnant woman who developed a serious lung condition called bullous lung disease, which caused a collapsed lung (pneumothorax) late in her pregnancy. The medical team, including obstetricians and surgeons, worked together to manage her care, leading to a Caesarean delivery at 36 weeks due to her increasing pain. After delivery, the lung condition was confirmed through a surgical procedure, highlighting the need for teamwork in handling complicated health issues during pregnancy. Who this helps: This helps pregnant patients and their healthcare teams, especially in managing rare and complex conditions.

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This study looked at 37 births that took place in a general hospital not specialized in maternity care over a decade. The researchers found that many mothers had serious health issues, and 15 needed intensive support after giving birth. It’s important to recognize that these deliveries involved multiple healthcare specialists and highlight that proper care for mothers and newborns is crucial even in non-maternity hospitals. Who this helps: This helps mothers giving birth in non-obstetric hospitals and the healthcare providers caring for them.

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The study looked at what patients expect before getting breast reconstruction after mastectomy, focusing on over 290 patients from 2012 to 2021. Researchers found that while most patients were very positive about aspects like their medical team, appearance, and self-esteem, they had significant worries about pain and recovery. Understanding these varied expectations is important because it highlights the need for better patient education before surgery, aiming to improve their overall outcomes and quality of life. Who this helps: This benefits patients considering breast reconstruction and their healthcare providers.

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This study looked at the use of anti-Ro and anti-La autoantibody tests in pregnant women to see how often they are ordered, why they are done, and if they make financial sense. Out of 47 patients tested, only 11 (23%) had positive results, and the tests were deemed necessary for 26 patients (55%), leading to a total cost of €1644.96 for the tests. The findings show that while testing was done according to guidelines, most patients did not need it, highlighting potential savings and fewer check-ups for those who tested negative. Who this helps: This benefits pregnant women and their healthcare providers by optimizing testing and monitoring strategies.

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This study looked at a specific abnormality in cervical screening results called ASC-H, which occurs rarely but can be concerning. Researchers found that about 3.6% of women referred to a colposcopy clinic had ASC-H, and more than half (53.3%) of these cases ended up having high-grade cervical changes. Effective treatment was achieved in up to 96.8% of cases, showing that quick follow-up and appropriate management are crucial for women with ASC-H results. Who this helps: This benefits patients with abnormal cervical screening results and their doctors by providing clear guidance on managing their care.

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This study looked at the fungus Aspergillus sojae, which is used in making foods like miso and shochu. Researchers found that A. sojae has evolved from a related fungus, A. parasiticus, and has a unique genetic makeup that allows it to thrive in soy fermentation without producing harmful aflatoxins, which can be toxic. This research is important because it helps us understand how specific fungi are adapted for safe use in food production and how they affect the flavors and safety of fermented soy products. Who this helps: This benefits food producers and consumers who want safer and tastier fermented soy products.

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This study looked at how a specific antibody, CR9114, works to protect against influenza virus when given through different methods, either intravenously or through the nose. Researchers found that when CR9114 was given through the nose, it was up to 50 times more effective in protecting against various strains of the flu compared to when it was injected into the bloodstream, and this nasal protection didn’t rely on the antibody's Fc part. This research is important because it highlights a more effective way to use antibodies for preventing flu infections, particularly through the nose, which could lead to better vaccination strategies. Who this helps: This benefits patients at risk for influenza, including young children and the elderly.

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This study looked at whether a technique called supramaximal walkouts (where a person lifts a weight heavier than their maximum for a short time) helps improve performance in repeated back squats. The researchers found that after doing an SMW with 110% of their max weight, the participants didn't experience a drop in their performance for the first set of back squats, while those who didn’t do the SMW showed decreased power and speed in all three sets. This is important because maintaining performance in multiple sets can be beneficial for strength training. Who this helps: This helps weightlifters and trainers looking to improve their training results.

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This study focused on improving how scientists create PDMS materials, which are used in laboratory settings to grow cells. Researchers developed a standardized method that allows these materials to be made with varying stiffness, mimicking the conditions found in real tissues. By ensuring consistency and minimizing contamination, this new approach helps improve cell culture experiments, making them more reliable and relevant to real-life health conditions. Who this helps: This benefits researchers and doctors working on cell-based therapies and mechanobiology studies.

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This study looked at the publication rates of research presented at two medical conferences in 2022, focusing on the European Urogynaecological Association (EUGA) and Junior Obstetrics and Gynecology Society (JOGS). Out of 304 abstracts, only 21.1% were published as full-text articles by August 2024, with EUGA having a publication rate of 31.9% compared to JOGS's 12.7%. This highlights that conferences are important for sharing research, but emphasizes that only a small fraction of studies are published, and that having more authors increases the chances of publication. Who this helps: This helps researchers and medical professionals looking to publish their findings.

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This study looked at how cells in the brain's protective layers, called leptomeningeal cells (LMCs), react to different levels of stiffness in their environment compared to brain cells called astrocytes. Researchers found that LMCs are very sensitive to changes in stiffness, especially when it's different from what they're used to, while astrocytes can handle a wider range without significant changes. This matters because understanding how these cells respond to their mechanical environment could lead to better insights into their role in brain health and disease. Who this helps: This helps researchers and doctors studying brain function and related disorders.

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This study looked at how well Obstetrics and Gynaecology trainees in Ireland understand pelvic floor dysfunction (PFD), a condition that greatly affects women's health. Out of 113 trainees surveyed, most (96.5%) participated, revealing that the average knowledge score was just 9.32 out of 25. The study found that those with more experience and specific training in urogynaecology had higher scores, indicating that more focused training programs could improve understanding and treatment of PFD. Who this helps: This benefits trainees and ultimately leads to better care for women experiencing pelvic floor issues.

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This study looked at how cervical glandular intraepithelial neoplasia (CGIN) is managed over five years in a group of patients. Out of 109 patients diagnosed, the average age was about 35, and while many had abnormal smear results, 15.6% needed a hysterectomy. The research highlights the importance of thorough testing and follow-up care since CGIN can lead to more serious conditions like cervical cancer, which is increasing. Who this helps: This benefits patients at risk of cervical cancer and healthcare providers managing their care.

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This study looked at the connection between abnormal fetal heart rates and problems in the placenta in babies born with a serious brain injury called hypoxic-ischemic encephalopathy (HIE). Researchers found that babies with HIE whose placentas showed signs of chorioamnionitis had longer periods of abnormal heart rates, specifically a significant link with a p-value of 0.013, indicating a strong association. Understanding this relationship could help doctors assess risks during labor, potentially improving outcomes for infants. Who this helps: This benefits infants with HIE and their healthcare providers.

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This study examined how a specific surgical technique, called the fibula free flap, has been used over 21 years to reconstruct parts of the jaw after cancer surgery. Out of 401 patients, 97.8% had successful flaps, but more than half faced complications, including almost 30% needing further surgery. These findings highlight that while new technologies and methods can improve outcomes, reconstructive surgery for the jaw still carries significant risks. Who this helps: This research benefits patients who need jaw reconstruction after cancer treatment.

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This study looked at complications from two types of tissue expanders—textured and smooth—used in breast reconstruction after mastectomy. Researchers analyzed data from 3,526 expanders and found that smooth tissue expanders had more issues with infections and malposition, particularly when placed in front of the chest muscle. However, the overall rate of expander loss was the same for both types. This information is important for helping doctors and patients choose the best type of tissue expander to minimize complications during breast reconstruction. Who this helps: Patients undergoing breast reconstruction.

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This study looked at how inflammation in the placenta affects women with gestational diabetes, a type of diabetes that occurs during pregnancy. Researchers found that women with gestational diabetes had higher levels of a marker related to mitochondrial damage, with a significant increase of mitochondrial DNA (cf-mtDNA) in their blood compared to those without diabetes (30 in the normal group vs. 27 in the diabetes group). Importantly, by using an antioxidant called L-ergothioneine, they were able to reduce inflammation in the placenta, indicating this could be a promising treatment option. Who this helps: This research benefits pregnant women with gestational diabetes by identifying a potential new way to reduce placental inflammation and improve health outcomes.

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This study looked at how body fat, specifically a type called visceral adipose tissue (VAT), affects pregnant women with gestational diabetes (GDM), a condition that can impact glucose control during pregnancy. Researchers found that women with GDM, particularly those who are obese, had difficulty adapting their fat tissue, leading to higher insulin resistance and increased levels of certain hormones compared to those without GDM. For example, GDM-obese women had much lower activity of key insulin signaling proteins and higher levels of leptin, a hormone related to fat storage. Who this helps: This research helps healthcare providers understand metabolic challenges in pregnant women with GDM, aiming to improve patient care and outcomes.

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This study looked at a rare type of cancer called anaplastic large-cell lymphoma (BIA-ALCL) that can occur in patients with textured breast implants. Researchers reviewed hundreds of articles and found that textured implants are associated with a significantly increased risk of developing this cancer, and they provided guidelines for how doctors should diagnose and manage it. These findings are important because they help ensure patients receive better care and monitoring, reducing the risks associated with breast implants. Who this helps: This helps patients with breast implants and their doctors.

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This study looked at how to prepare fresh biological tissues for creating accurate 3D models that mimic the natural environment in which cells live. Researchers found that using a mixture of 2.5% agarose and 1.5% gelatin is the best way to securely hold tissue slices in place without damaging them, allowing for quick preparation. This matters because it improves the accuracy of tissue models, which can lead to better research and treatments. Who this helps: This helps researchers working with biological tissues, including those developing new therapies.

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This study investigated how high levels of a protein called alpha-synuclein (αSyn), which is linked to Parkinson's disease (PD), affect aging in brain cells using rat models. The researchers found that overexpression of αSyn increased levels of a gene called SKOR1, which can harm the cells that produce dopamine—a key factor in PD. This matters because understanding the relationship between aging, αSyn, and SKOR1 could help identify ways to prevent or slow down the progression of PD. Who this helps: This helps patients at risk for Parkinson's disease and their doctors.

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This study explored how a protein called sFlt-1, which increases during pre-eclampsia, affects brain cell development. The researchers found that sFlt-1 significantly reduced the growth of neurites (the parts of neurons that help them communicate) and limited the maturation of neurons when tested at levels as high as 100 ng/ml. Understanding how sFlt-1 influences brain cell development helps clarify why children exposed to pre-eclampsia may be at greater risk for neurodevelopmental disorders. Who this helps: This research benefits doctors, researchers, and eventually parents of children affected by pre-eclampsia.

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This study looked at how a team of specialists works together to help pregnant women with complicated health issues at a specialized maternity hospital. Over seven years, there were 575 discussions about 486 patients, with an average of 13 women talked about at each meeting, which included various specialists like hematologists and neurologists. This collaboration is important because it shows how different experts can come together to provide better care for women during pregnancy, especially those facing serious medical challenges. Who this helps: This benefits pregnant patients with complex health conditions requiring specialized care.

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This research looked at the connection between changes in gut bacteria and pre-eclampsia, a pregnancy complication that can harm both mothers and babies. The study found that women with pre-eclampsia often have noticeable changes in their gut microbiome, although it's still unclear if these changes cause the condition or are a result of it. Understanding this relationship could lead to new treatments, like diet changes or supplements, to help manage pre-eclampsia. Who this helps: This helps pregnant women at risk of pre-eclampsia and their healthcare providers.

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This study looked at how simulated lack of blood flow followed by its restoration (known as ischaemia/reperfusion) affects the function of trophoblast cells, which are critical for a healthy pregnancy. The researchers found that after one hour of ischaemia and 24 hours of reperfusion, these cells produced more harmful compounds and showed reduced ability to move and grow. Specifically, there was a significant drop in a key enzyme called MMP-9, which is essential for the cells' ability to invade, indicating different ways that ischaemia impacts trophoblast function. Who this helps: This helps patients at risk of early-onset pre-eclampsia and their doctors.

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This study examined the mechanical properties of tissue from the cheek (buccal mucosa) and the ureter (the tube that carries urine from the kidney) taken from pigs. Researchers found that the ureter is stronger and more directional in its strength, with a higher average strength of 498 kPa when pulled lengthwise, compared to 264 kPa across its width. In contrast, the buccal mucosa showed consistent strength regardless of the direction it was tested. These findings are important because they influence how doctors can use buccal mucosa in surgical repairs of the ureter. Who this helps: This helps patients needing reconstructive surgery for urinary issues.

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This study focused on improving how often breast cancer patients used the BREAST-Q, a tool for measuring their experiences and satisfaction with breast reconstruction. After implementing a quality improvement plan, the completion rate of BREAST-Q surveys jumped from about 43% to nearly 88% between 2011 and 2019. This is important because it means healthcare providers can better understand patients' needs and experiences, leading to improved care. Who this helps: This benefits breast cancer patients by ensuring their voices and experiences are considered in their treatment.

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This study looked at the health issues related to the capsule that forms around breast implants, especially problems that can occur years after surgery. Researchers highlighted several rare conditions that might cause swelling or masses, like a specific type of cancer known as BIA-ALCL, and emphasized the importance of correctly diagnosing these issues. By improving the understanding and management of these conditions, doctors can provide better care for patients with complications from breast implants. Who this helps: This helps patients who have breast implants and may experience complications.

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This study looked at the mechanical properties of fresh and frozen pig colon tissue to better understand how tissues behave in their natural environment. Researchers found that fresh tissue was significantly more elastic than frozen tissue, with differences in stiffness of up to ten times across different layers of the colon. These results are important because they show that fresh tissue provides a better way to study how cells react to their surroundings, which can improve the development of treatments and biomaterials for various diseases. Who this helps: This research benefits patients and medical professionals involved in tissue engineering and regenerative medicine.

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This study looked at whether patients who briefly used textured tissue expanders (TE) for breast reconstruction are at risk for developing a rare type of cancer called breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). Out of 3,310 patients monitored over an average of 6.8 years, none developed BIA-ALCL, suggesting that the risk is lower with short-term use of textured TEs compared to permanent textured implants. These findings are important for reassuring patients who previously used textured TEs about their cancer risk. Who this helps: This benefits patients who are worried about the safety of their breast reconstruction devices.

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This study examined a surgical method called right axillary thoracotomy for fixing congenital heart defects in 37 children, with an average age of 6.5 years. The surgeries were successful, with no complications like deaths or the need for additional surgeries in the early period after the procedure, and most children had a short hospital stay of about 3 days. This approach is beneficial because it is safe, effective, and leaves less visible scars compared to other methods. Who this helps: This helps children with congenital heart defects and their families.

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This study examined the link between breast implants and a rare type of cancer called anaplastic large-cell lymphoma (ALCL) in the U.S. From 2012 to 2020, the research recorded 330 cases of ALCL connected to breast implants, with patients typically diagnosed 11 years after getting the implants. Most patients experienced local symptoms like fluid buildup, and all had received textured implants, showing a clear connection between textured implants and ALCL. Who this helps: This research benefits patients who have breast implants, as well as healthcare providers involved in their care.

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This study looked at why some attempts at assisted vaginal delivery (where tools like vacuum pumps are used) didn’t succeed in a maternity hospital in Ireland. Out of 595 assisted deliveries, 28 (about 4.7%) were unsuccessful, and these often involved first-time mothers with an average age of 30. The research found that women who had unsuccessful deliveries were more likely to face complications like excessive bleeding afterward and their babies were more likely to need special care in the hospital. Who this helps: This information helps doctors and expectant mothers understand the risks associated with assisted deliveries, especially for first-time mothers.

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This study compared two methods of reconstructing large chest wall defects: microvascular free flaps (MVFFs) and pedicled flaps (PFs). Researchers examined 536 patients who had chest wall surgery and found that those with MVFFs covered larger defects (average 172 cm compared to 109 cm for PFs) and had a lower local recurrence rate (4% with MVFFs versus 12% with PFs). This matters because it highlights that MVFFs are effective for reconstructing larger defects with good outcomes. Who this helps: Patients undergoing chest wall surgery.

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The study looked at how to better manage women diagnosed with a pregnancy of unknown location (PUL), a scenario that can cause distress and may require many medical tests. Out of 394 cases reviewed, only about 10% (39 women) ended with a viable pregnancy, while 18% (83 women) needed medical treatment. The researchers found that one prediction model (M1) was better at identifying ectopic pregnancies than another (M6NP), which wrongly identified many viable pregnancies. This research helps improve care for women experiencing PUL by making the diagnosis process more efficient and focused. Who this helps: Patients facing uncertain pregnancy situations.

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This study looked at the recovery outcomes for 438 patients who had chest wall surgeries using either biologic or synthetic prostheses between 2000 and 2022. Researchers found that the chance of needing additional surgery due to complications was about the same for both types: 4% for biologic and 9% for synthetic after properly comparing similar groups of patients. This finding is important because it shows that patients can choose either option without a significant difference in the risk of complications, helping in the decision-making process for surgeries. Who this helps: Patients needing chest wall reconstruction.

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This study explored what influences medical students in Ireland to choose a career in obstetrics and gynecology (O&G). Out of 195 students surveyed, 134 responded, and only 30.8% indicated a strong interest in pursuing this specialty. Positive experiences during their clinical training, especially with hands-on opportunities and direct engagement with consultants, encouraged interest, while concerns about work-life balance and legal issues made them hesitant. Who this helps: This research is beneficial for medical students and educators aiming to improve recruitment into O&G.

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This study describes a case of a pregnant woman who developed serious health issues, including fever and neurological symptoms, while in her third trimester. Doctors discovered she had herpes simplex virus type 2 (HSV-2), which led to inflammation of the brain and liver. After 14 days of treatment with antiviral medication, she fully recovered, and her baby was healthy. Who this helps: This information benefits pregnant women and healthcare providers by highlighting the risks of rare infections during pregnancy.

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This study looked at the experiences of women who had their labor induced at a hospital in Ireland over three months. Out of 1,084 deliveries, 499 women (46%) were induced, with first-time mothers being more likely to undergo induction than those who had given birth before. The findings show that many women were induced before 40 weeks of pregnancy and those with certain medical reasons for induction had shorter delivery times, which is crucial for understanding how to better support these women during their labor process. Who this helps: This information benefits patients, especially expectant mothers, and healthcare providers involved in maternity care.

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This study looks at a case where a pregnant woman in her third trimester suffered from a serious condition called aortic dissection and had to be moved 160 kilometers for emergency treatment. The successful outcome relied on a coordinated effort among various medical teams, including heart specialists and maternity staff, highlighting how important teamwork and communication are in handling complex medical situations. This matters because effective collaborative care can greatly improve emergency response and patient safety. Who this helps: This helps pregnant women facing emergencies and the medical teams involved in their care.

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This study looked at serious health problems that pregnant women faced at a maternity hospital in Ireland over eight years. It found that 504 out of 81,504 pregnancies (about 6.1 per 1,000 cases) involved severe maternal issues, with the rate increasing from 6 to 9 per 1,000 over the study period. Most severe cases happened in the third trimester or after giving birth, with the main problems being high blood pressure, heavy bleeding after birth, and infections; these findings can help improve healthcare planning and resources. Who this helps: This information helps hospitals and healthcare providers to better care for pregnant women and plan resources effectively.

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This study looked at the difficulties that obstetricians and gynecologists in Ireland face when trying to hire and keep staff. Researchers interviewed 17 experienced doctors and found that issues like low morale, lack of resources, and training gaps were significant concerns. They suggested that better training programs and more support for doctors could help improve the situation, which is important for ensuring that women get the healthcare they need. Who this helps: This helps doctors and women's health patients.

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This study looked at how the blood serum from mothers with pre-eclampsia (a pregnancy complication affecting 3% to 5% of first-time pregnancies) impacts nerve cell growth and energy function. It found that the serum from mothers with pre-eclampsia boosts nerve growth by 25% and enhances cell respiration, which is crucial for brain development. These findings suggest that a molecule called IL-6, found in higher levels in these mothers, plays a role in this increased nerve growth and cellular energy, highlighting a potential link to neurodevelopmental issues in their children. Who this helps: This research helps expectant mothers and healthcare providers by providing insights into the effects of pre-eclampsia on child development.