D Buca studies how COVID-19 affects pregnant women, especially those who are considered high risk compared to those with lower risk factors. This includes looking into serious health issues, the need for hospital care, and the outcomes of pregnancies during the pandemic. By analyzing data on complications, treatments, and overall pregnancy health, Buca aims to help improve care for women and babies during these challenging times.
Key findings
High-risk pregnant women had a 52% higher chance of serious health problems due to COVID-19 compared to low-risk women.
5.3% of high-risk pregnancies ended in miscarriage, significantly higher than the 1.6% rate found in low-risk pregnancies.
High-risk pregnant women were more likely to require intensive treatments, such as mechanical ventilation.
Frequently asked questions
Does Dr. Buca study COVID-19 and pregnancy?
Yes, Dr. Buca specifically studies the effects of COVID-19 on pregnant women, focusing on both high-risk and low-risk groups.
What are the risks of COVID-19 for high-risk pregnant women?
High-risk pregnant women are at a significantly increased risk of serious health problems and complications, including a higher chance of needing intensive medical care.
What did Dr. Buca find about miscarriage rates during COVID-19?
Dr. Buca found that miscarriage rates were higher in high-risk pregnancies, with 5.3% ending in miscarriage compared to 1.6% in low-risk pregnancies.
Publications in plain English
Outcome of supracervical compared to total hysterectomy for emergency peripartum hemorrhage: a systematic review and meta-analysis.
2026
American journal of obstetrics and gynecology
Lucidi A, Jauniaux E, Buca D, Nieto-Calvache AJ, Khalil A +6 more
Plain English This study compared two types of emergency surgeries—supracervical hysterectomy and total hysterectomy—performed on women experiencing severe bleeding after childbirth. Researchers analyzed data from 25 studies involving 1,478 patients and found that supracervical hysterectomy led to fewer injuries to the urinary tract, less blood loss, fewer blood transfusions needed, and shorter surgery times, although it did not significantly affect overall maternal death rates or major complications. These findings are important because they suggest that supracervical hysterectomy may be a safer and more efficient option for managing postpartum hemorrhage.
Who this helps: This benefits patients recovering from childbirth, particularly those at risk for severe bleeding.
Adaptive Epitaxy of C-Si-Ge-Sn: Customizable Bulk and Quantum Structures.
2025
Advanced materials (Deerfield Beach, Fla.)
Concepción O, Devaiya AJ, Zoellner MH, Schubert MA, Bärwolf F +11 more
Plain English This study explored a new material called C(Si)GeSn, which is a mix of silicon, germanium, tin, and carbon. Researchers found that by adding a tiny amount of carbon (less than 1% of the material), they could improve its structure and increase the tin content to about 18%. This is significant because it allows for the creation of better infrared lasers and LEDs that work at room temperature and emit light at a useful wavelength of 2.54 micrometers.
Who this helps: These advancements benefit researchers and companies developing advanced lasers and electronic devices.
Epitaxial SiGeSn Alloys for CMOS-Compatible Thermoelectric Devices.
2025
ACS applied energy materials
Graziosi P, Marian D, Tomadin A, Roddaro S, Concepción O +6 more
Plain English This study looked at new materials called SiGeSn alloys that could be used in devices that generate electricity from heat, which could greatly benefit technology aimed at being more environmentally friendly. Researchers found that these materials showed strong thermoelectric properties, reaching a performance level that is favorable for practical use, with a measure known as the figure of merit exceeding 1, which is promising for both types of semiconductor materials (p-type and n-type) at temperatures typical for electronics. This finding is important because it suggests that these materials could be used in everyday electronic devices to improve energy efficiency.
Who this helps: Patients, doctors, and industries looking for more efficient electronic devices.
Shedding light on epitaxial SiGeSn alloys with Raman spectroscopy: local order and thermomechanical properties.
2025
Journal of physics. Condensed matter : an Institute of Physics journal
Corley-Wiciak AA, Zaitsev I, Concepción O, Buca D, Manganelli CL +2 more
Plain English This research focused on studying (Si)GeSn alloys, which are important materials for advanced electronics and photonics, using a technique called Raman spectroscopy. The findings revealed specific vibrational characteristics of these alloys and explored their properties under different conditions, such as temperature. This research is significant because it helps in understanding how these materials behave, which is crucial for their future applications in high-tech devices.
Who this helps: This helps engineers and researchers working on next-generation electronic devices.
Comparison between trans-vaginal and trans-abdominal ultrasound examination of the cervix in the second trimester of pregnancy: a prospective study.
2024
Journal of perinatal medicine
Calandra D, Mercaldi M, De Vito M, Buca D, Liberati M +3 more
Plain English This study looked at two methods of measuring the cervix during a routine second-trimester pregnancy ultrasound: trans-vaginal (TV) and trans-abdominal (TA). Researchers found that both methods gave very similar results—TA measurements averaged between 40.5 and 41.4 mm, and TV measurements were equally reliable—meaning both techniques are effective for assessing cervical length. This matters because it allows doctors to choose the ultrasound method they prefer without compromising accuracy, ultimately helping in the monitoring of pregnancy.
Who this helps: Patients and healthcare providers performing ultrasound examinations.
Room Temperature Lattice Thermal Conductivity of GeSn Alloys.
2024
ACS applied energy materials
Concepción O, Tiscareño-Ramírez J, Chimienti AA, Classen T, Corley-Wiciak AA +11 more
Plain English This study focused on a new type of semiconductor called GeSn alloys, looking specifically at how well they conduct heat at room temperature. The researchers found that as the amount of tin in the alloy increased, the thermal conductivity dropped dramatically—from 55 W/(m·K) for pure germanium to just 4 W/(m·K) for the GeSn alloys with higher tin content. This discovery is important because it shows that GeSn alloys could effectively harvest energy in temperature ranges where traditional silicon-based materials aren't suitable, potentially leading to more efficient energy use in devices like computers and IoT products.
Who this helps: This benefits engineers and developers working on energy-efficient technologies and electronics.
Full Picture of Lattice Deformation in a GeSnMicro-Disk by 5D X-ray Diffraction Microscopy.
2024
Small methods
Corley-Wiciak C, Zoellner MH, Corley-Wiciak AA, Rovaris F, Zatterin E +12 more
Plain English This study looked at how tiny crystal structures deform and how this affects their properties. Using a special X-ray method, the researchers mapped the strain in a specific type of microdisk made from germanium and tin, finding that small changes in shape were linked to defects and different materials within the structure. This technique allows scientists to understand these deformations without needing to prepare samples beforehand, which can be important for improving materials in various industries.
Who this helps: This helps scientists and engineers working in materials science and semiconductor development.
Treatments for cesarean scar pregnancy: a systematic review and meta-analysis.
2024
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Alameddine S, Lucidi A, Jurkovic D, Timor Tritsch I, Coutinho CM +6 more
Plain English This study examined how effective various treatments are for cesarean scar pregnancy (CSP), a condition where pregnancy occurs in a scar from a previous cesarean delivery. The researchers found that treatments like laparoscopy had a success rate of 96.1% and ultrasound guided suction curettage had a success rate of 100%, while other methods showed success rates ranging from about 72% to 91%. These findings matter because they help identify which methods are most effective and safe, guiding doctors in choosing the best treatment for women with this condition.
Who this helps: This helps patients experiencing cesarean scar pregnancy and their doctors make informed treatment decisions.
Continuous-wave electrically pumped multi-quantum-well laser based on group-IV semiconductors.
2024
Nature communications
Seidel L, Liu T, Concepción O, Marzban B, Kiyek V +12 more
Plain English Researchers developed a new type of laser that uses group-IV semiconductors, which are materials like silicon and germanium. This laser operates continuously and emits light at a near-infrared wavelength of 2.32 micrometers with a low current requirement of just 4 milliamps. This advancement could lead to better technology for optical communications, making devices faster and more efficient.
Who this helps: This benefits engineers and companies working on photonics technology.
Systematic review and meta-analysis on placenta accreta spectrum disorders in twin pregnancies: risk factors, detection rate and histopathology.
2023
Minerva obstetrics and gynecology
DI Girolamo R, Buca D, Galliani C, D'Amico A, CALì G +5 more
Plain English This study looked at complications related to the placenta in twin pregnancies, particularly conditions known as placenta accreta spectrum (PAS). Researchers found that nearly 42% of the women studied had previous cesarean deliveries, around 28% had placenta previa, and about 58% became pregnant through assisted reproductive technology. Notably, prenatal detection of these complications was low, happening in less than 28% of cases, which means that many women faced serious health risks, such as needing blood transfusions (31.67%) or hysterectomies (26.67%) during delivery.
Who this helps: This information is valuable for doctors and healthcare providers caring for pregnant women, especially those expecting twins.
Role of lactoferrin in preventing preterm birth and pregnancy complications: a systematic review and meta-analysis.
2023
Minerva obstetrics and gynecology
D'Amico A, Buca D, Tinari S, Oronzii L, Lucidi A +3 more
Plain English This study looked at whether taking lactoferrin, a protein found in milk, can help prevent preterm births in women who are at high risk. The analysis of six studies involving 333 pregnancies found that women who took lactoferrin had nearly half the risk of giving birth before 37 weeks compared to those who did not. Specifically, the odds ratio was 0.43, meaning they were 57% less likely to experience preterm birth. This is important because preventing preterm births can lead to healthier outcomes for both mothers and babies.
Who this helps: This helps high-risk pregnant women and their healthcare providers.
Monkeypox infection in pregnancy: a systematic review and metaanalysis.
2023
American journal of obstetrics & gynecology MFM
D'Antonio F, Pagani G, Buca D, Khalil A
Plain English This study looked at how monkeypox infection impacts pregnant women and their babies. It found that 39% of pregnancies ended in miscarriage, and 77% experienced fetal or newborn losses. Additionally, there was a 62% chance that the virus could be passed from the mother to the baby.
Who this helps: This research benefits pregnant women and healthcare providers managing their care.
Aspirin for prevention of preeclampsia and adverse perinatal outcome in twin pregnancies: a systematic review and meta-analysis.
2023
American journal of obstetrics & gynecology MFM
D'Antonio F, Khalil A, Rizzo G, Fichera A, Herrera M +7 more
Plain English This study looked at whether taking aspirin can lower the risk of preeclampsia and other problems during twin pregnancies. It found that aspirin treatment reduced the risk of preeclampsia by 36% in twin pregnancies compared to those who didn't take aspirin (with an odds ratio of 0.64). However, there was no significant difference in other pregnancy complications or overall birth outcomes.
Who this helps: This helps women expecting twins and their healthcare providers by providing insights into potential preventive measures for preeclampsia.
Letter to the authors regarding the timing of delivery for placenta accreta spectrum: the Pan-American Society for the Placenta Accreta Spectrum experience.
Placenta accreta spectrum disorders clinical practice guidelines: A systematic review.
2023
The journal of obstetrics and gynaecology research
Capannolo G, D'Amico A, Alameddine S, Di Girolamo R, Khalil A +9 more
Plain English This study looked at how well current guidelines help manage pregnancies affected by placenta accreta spectrum (PAS) disorders, which can complicate childbirth. Out of nine guidelines reviewed, most (about 78%) recommended a hysterectomy, and nearly 89% advised cesarean delivery between 34-37 weeks. However, there was less agreement on using certain imaging techniques and interventions before surgery, indicating that while the quality of guidelines is generally good, there are still gaps that need to be addressed.
Who this helps: Patients and doctors managing pregnancies at risk for PAS.
Isothermal Heteroepitaxy of GeSnStructures for Electronic and Photonic Applications.
2023
ACS applied electronic materials
Concepción O, Søgaard NB, Bae JH, Yamamoto Y, Tiedemann AT +5 more
Plain English This study focused on creating high-quality layers of a special alloy called GeSn, which combines germanium and tin, for use in advanced electronic and light-based technologies. Researchers successfully produced these layers with tin content between 6% and 15% using a new method that worked well in a typical manufacturing setup, allowing for better control in the production process. These findings are important because they can lead to improved performance in devices like sensors and quantum computers.
Who this helps: This helps engineers and researchers developing advanced electronic and photonic devices.
Extracellular vesicles during the three trimesters of pregnancy.
2023
Journal of reproductive immunology
Buca D, Lucidi A, Buca DV, Di Sebastiano F, D'Angelo E +4 more
Plain English This study examined tiny particles called extracellular vesicles (EVs) found in the blood of pregnant women during the first, second, and third trimesters to see how their levels changed and if they related to birth weight or ultrasound results. Researchers looked at blood samples from 64 women and found that while most EVs stayed consistent throughout pregnancy, levels of epithelial-derived EVs increased in the third trimester, and platelet-derived EVs decreased from 48.7% in the first trimester to 9.13% in the third trimester. These results help in understanding normal pregnancy development and could lead to better ways to detect pregnancy complications early using EVs.
Who this helps: This research benefits doctors and healthcare providers monitoring pregnant women.
Outcome of fetal Vein Galen aneurysmal malformations: a systematic review and meta-analysis.
2022
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
D'Amico A, Tinari S, D'Antonio F, Rizzo G, Liberati M +2 more
Plain English This study looked at the outcomes for fetuses diagnosed with a rare brain condition called Vein of Galen malformation, examining data from 226 cases. It found that 36.7% of babies showed abnormal brain development after birth, and only 29.7% were free from neurological issues. The study highlights the serious risks associated with this condition, including brain damage and heart problems, which can impact the child's development.
Who this helps: This helps parents and healthcare providers understand the potential risks faced by fetuses with this specific malformation.
Ovarian hyperstimulation syndrome and adverse pregnancy outcome.
2022
Minerva obstetrics and gynecology
Buca D, D'Antonio F, Liberati M, Tinari S, Pagani G +2 more
Plain English This study looked at how ovarian hyperstimulation syndrome (OHSS) affects pregnancy outcomes. Researchers found that women with OHSS experienced a significantly higher risk of complications; they were 8.8 times more likely to face serious maternal issues and 11.4 times more likely to have preterm births compared to women without OHSS. This matters because it highlights the serious risks associated with OHSS, which can lead to more complications during pregnancy.
Who this helps: This information benefits patients undergoing fertility treatments and their doctors.
Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.
2022
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Villalain C, Galindo A, Di Mascio D, Buca D, Morales-Rosello J +20 more
Plain English This study looked at how well two specific measurements (cerebroplacental ratio and umbilicocerebral ratio) can predict serious problems during childbirth in babies that are either growing normally or are late-term growth restricted. The researchers examined data from 646 pregnancies and found that 12.6% of normally growing babies and 24.3% of growth-restricted babies had adverse outcomes during delivery, with growth-restricted babies facing more risk. However, the measurements were not effective at predicting these problems, indicating that relying on them for assessments may not be useful.
Who this helps: This helps doctors make more informed decisions during labor for pregnant women and their babies.
Reference ranges for fetal brain structures using magnetic resonance imaging: systematic review.
2022
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Di Mascio D, Khalil A, Rizzo G, Kasprian G, Caulo M +8 more
Plain English This research examined how well past studies measured the sizes of fetal brain structures using MRI scanners. Out of 15 studies reviewed, they found that on average, the quality of the research was only 48.7%, with many studies showing weaknesses in their design and statistical methods. This is important because unreliable measurements can affect how fetal brain health is assessed, which may impact prenatal care.
Who this helps: This helps doctors and healthcare providers involved in prenatal care.
Blood Circulating CD133+ Extracellular Vesicles Predict Clinical Outcomes in Patients with Metastatic Colorectal Cancer.
2022
Cancers
Brocco D, Simeone P, Buca D, Marino PD, De Tursi M +11 more
Plain English This study looked at blood samples from 54 patients with metastatic colorectal cancer (mCRC) and 48 healthy individuals to see how certain tiny particles in the blood, called extracellular vesicles (EVs), can predict health outcomes. The researchers found that higher levels of these EVs, particularly ones carrying the CD133 marker, were linked to shorter overall survival and reduced response to initial treatment in patients. This is important because it shows that measuring these blood-based markers could help doctors better manage treatment plans for mCRC patients.
Who this helps: This benefits doctors and patients with metastatic colorectal cancer.
Placenta accreta spectrum disorders in twin pregnancies as an under reported clinical entity: a case series and systematic review.
2022
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Cali G, Labate F, Cucinella G, Fabio M, Buca D +3 more
Plain English This research looked at the occurrence of placenta accreta spectrum (PAS) disorders in pregnancies with twins, as this issue hasn't been deeply studied. The study examined 12 twin pregnancies complicated by PAS over five years and reviewed other research on this topic. The findings are important because they highlight that twin pregnancies have unique risks for PAS, which could lead to better monitoring and outcomes.
Who this helps: This helps doctors and healthcare providers who care for pregnant women, especially those expecting twins.
Methodological Quality of Fetal Brain Structure Charts for Screening Examination and Targeted Neurosonography: A Systematic Review.
2022
Fetal diagnosis and therapy
Di Mascio D, Buca D, Rizzo G, Khalil A, Timor-Tritsch IE +6 more
Plain English This study looked at how reliable existing charts for measuring fetal brain growth are, examining 60 research papers on the topic. The researchers found that the average quality of these studies was only 51.3%, with the worst quality related to neurosonography methods specifically. This matters because poor-quality charts could lead to inaccurate assessments, affecting the care given to pregnant patients and their babies.
Who this helps: This helps expectant mothers and healthcare providers by ensuring better assessment tools for fetal brain development.
Systematic review and critical evaluation of quality of clinical practice guidelines on the management of SARS-CoV-2 infection in pregnancy.
2022
American journal of obstetrics & gynecology MFM
Di Girolamo R, Khalil A, Rizzo G, Capannolo G, Buca D +4 more
Plain English This study looked at clinical guidelines for managing COVID-19 in pregnant women by reviewing 28 different guidelines from various sources. It found that many guidelines agreed on certain points, like only recommending hospitalization for severe cases, but there was a lot of variation in other areas, such as whether to suggest fetal growth scans or induce labor early. Overall, just 9 out of the 28 guidelines met the high-quality standard, showing that there's still a lot of uncertainty about how to care for pregnant women with COVID-19.
Who this helps: This benefits doctors and healthcare providers who treat pregnant women during the pandemic.
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
2022
European journal of obstetrics, gynecology, and reproductive biology
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F +7 more
Plain English This research examined how women with early-stage endometrial cancer or atypical hyperplasia responded to fertility-sparing treatments, looking specifically at their chances of getting pregnant and having healthy babies. The study included data from 1,036 women, showing that about 56% to 63% of these women became pregnant, depending on the treatment, with a live birth rate ranging from about 26% to 81%. This is important because it highlights that women who undergo these fertility-sparing treatments have a good chance of successfully achieving pregnancy and giving birth, which is essential for preserving their reproductive health.
Who this helps: This findings benefit women with endometrial cancer or atypical hyperplasia who want to preserve their fertility.
Erratum to systematic review and critical evaluation of quality of clinical practice guidelines on the management of SARS-CoV-2 infection in pregnancy.
2022
American journal of obstetrics & gynecology MFM
Di Girolamo R, Khalil A, Rizzo G, Capannolo G, Buca D +4 more
SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination.
2022
International journal of molecular sciences
Vespa S, Simeone P, Catitti G, Buca D, De Bellis D +10 more
Plain English This study looked at how people's immune systems react to the SARS-CoV-2 virus, either through natural infection or vaccination. Researchers tested 125 people, finding that those who had a natural infection had similar levels of protective antibodies as those who were vaccinated with certain vaccines, and all vaccinated individuals showed a strong immune response. This is important because understanding these immune responses can help improve future vaccines, especially against new virus variants.
Who this helps: This benefits patients and vaccine developers.
Extracellular Vesicles in pregnancy: Their potential role as a liquid biopsy.
2022
Journal of reproductive immunology
Buca D, D'Antonio F, Buca D, Di Sebastiano F, Simeone P +7 more
Plain English This study examined tiny particles called extracellular vesicles (EVs) in the blood of healthy pregnant women compared to non-pregnant women. The researchers found that pregnant women had significantly more platelet-derived EVs (about 2064) than non-pregnant women (about 701), while the number of EVs from other cells, like endothelial and leukocyte cells, was lower in pregnant women. This is important because these differences in EVs could help identify potential pregnancy complications, such as preeclampsia or premature birth.
Who this helps: This benefits pregnant patients and their healthcare providers.
Circulating Extracellular Vesicles: Their Role in Patients with Abdominal Aortic Aneurysm (AAA) Undergoing EndoVascular Aortic Repair (EVAR).
2022
International journal of molecular sciences
Serafini FL, Delli Pizzi A, Simeone P, Giammarino A, Mannetta C +9 more
Plain English This study looked at the blood cells known as extracellular vesicles (EVs) in patients with abdominal aortic aneurysms (AAA) who underwent a less invasive surgery called endovascular aortic repair (EVAR). The researchers found that patients who experienced a common complication called an endoleak had fewer activated platelets in their blood six months after the procedure and higher levels of certain EVs one month after the surgery. This matters because it indicates that these blood markers could provide safer, non-radiation-based ways to monitor patients for potential complications after EVAR.
Who this helps: This helps patients undergoing EVAR by providing a safer method for monitoring their recovery.
Risk factors, histopathology and diagnostic accuracy in posterior placenta accreta spectrum disorders: systematic review and meta-analysis.
2021
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Tinari S, Buca D, Cali G, Timor-Tritsch I, Palacios-Jaraquemada J +5 more
Plain English This research examined the factors that increase the risk of having a condition called posterior placenta accreta spectrum (PAS) during pregnancy, and how well ultrasound and MRI can detect it. The study found that 92.8% of women with posterior PAS had placenta previa, 76.1% had previous uterine surgeries (often C-sections), and 82.5% were mothers who had given birth before. Unfortunately, ultrasound only accurately detected 52.4% of cases, while MRI was more effective, spotting 73.5% of cases before birth. This information is crucial because understanding these risk factors and improving early detection can lead to better planning and management of pregnancies affected by PAS.
Who this helps: This research helps doctors and medical professionals working with pregnant women at risk of placenta accreta disorders.
Diagnostic accuracy of prenatal ultrasound in identifying the level of the lesion in fetuses with open spina bifida: A systematic review and meta-analysis.
2021
Acta obstetricia et gynecologica Scandinavica
Di Mascio D, Greco F, Rizzo G, Khalil A, Buca D +5 more
Plain English This study looked at how well prenatal ultrasound and MRI can identify the location of lesions in fetuses with open spina bifida. The researchers found that ultrasound accurately pinpointed the lesion level in about 40.9% of cases, and it was close (within one vertebral body) in 76.2% of cases. MRI performed slightly better, correctly identifying the lesion level in 42.5% of cases and being accurate within one vertebral body in 76.2%. This is important because knowing the precise level of the lesion can help doctors plan treatment more effectively for affected babies.
Who this helps: This benefits doctors and families preparing for the care of newborns with spina bifida.
Outcome of fetuses with congenital cytomegalovirus infection and normal ultrasound at diagnosis: systematic review and meta-analysis.
2021
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Buca D, Di Mascio D, Rizzo G, Giancotti A, D'Amico A +10 more
Plain English This study examined the outcomes for fetuses diagnosed with congenital cytomegalovirus (CMV) infection but found to have normal ultrasound scans. Among 1,178 cases, 4.4% had central nervous system issues that were caught in follow-up scans, 5.8% had anomalies only visible on MRI, and 3.1% had developmental problems after birth. This is important because it suggests that even if ultrasounds appear normal, there can still be serious issues that might be picked up later, highlighting the usefulness of MRI in these cases.
Who this helps: This benefits expectant parents and healthcare providers managing pregnancies affected by CMV.
Outcome of cesarean scar pregnancy according to gestational age at diagnosis: A systematic review and meta-analysis.
2021
European journal of obstetrics, gynecology, and reproductive biology
Timor-Tritsch I, Buca D, Di Mascio D, Cali G, D'Amico A +9 more
Plain English This study looked at how the timing of diagnosing a cesarean scar pregnancy (CSP) affects health outcomes for women. It found that women diagnosed at 9 weeks or earlier faced much lower risks of serious complications—only 5.9% had severe issues compared to 32.4% for those diagnosed later. This matters because early diagnosis can lead to better health outcomes and lower chances of complications during pregnancy.
Who this helps: Patients who have had a cesarean delivery.
Counseling in maternal-fetal medicine: SARS-CoV-2 infection in pregnancy.
2021
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Di Mascio D, Buca D, Berghella V, Khalil A, Rizzo G +5 more
Plain English This study looked at how SARS-CoV-2, the virus that causes COVID-19, affects pregnant women. It found that pregnant women are more likely to experience severe illness from the virus, including complications like pneumonia and the need for intensive care, but the risk of miscarriage or passing the virus to the baby is generally low. It matters because it helps manage the health of pregnant women during the pandemic, ensuring they receive appropriate care while protecting their babies.
Who this helps: This helps pregnant women and their healthcare providers.
Maternal outcomes of cesarean delivery performed at early gestational ages: a systematic review and meta-analysis.
2021
American journal of obstetrics & gynecology MFM
Cerra C, Morelli R, Di Mascio D, Buca D, di Sebastiano F +2 more
Plain English This study looked at the effects of cesarean deliveries performed before 34 weeks of pregnancy on mothers' health. Out of 8,378 women studied, 16.2% faced serious complications like severe bleeding, the need for blood transfusions, or even death. The risks increase significantly if the delivery happens even earlier—22.9% had complications at less than 28 weeks, and 24.8% at less than 26 weeks. These findings are important so doctors can better prepare and inform parents about the risks involved in early cesarean deliveries.
Who this helps: This helps patients and their families facing early cesarean deliveries.
Oronzii L, D'Antonio F, Tinari S, D'Amico A, DI Sebastiano F +3 more
Plain English This study looked at the challenges of starting labor in pregnancies where the baby isn't growing properly, known as late-onset fetal growth restriction (FGR). It found that special care is needed for these cases because traditional labor induction methods may increase risks for the baby. Knowing how to safely induce labor in these situations is crucial to better manage both the mother’s and baby's health.
Who this helps: This information benefits doctors and healthcare professionals managing pregnancies with late fetal growth restriction.
Outcomes of second stage cesarean section following the use of a fetal head elevation device: A systematic review and meta-analysis.
2021
European journal of obstetrics, gynecology, and reproductive biology
Di Girolamo R, Galliani C, Buca D, Liberati M, D'Antonio F
Plain English This research looked at women undergoing cesarean sections (C-sections) to see if using a fetal head elevation device (FHED) affected their recovery and the health of their babies. The study found that using FHED reduced the time from the surgical cut to delivery by about 52 seconds, decreased blood loss during surgery by roughly 131 milliliters, and led to a shorter hospital stay by almost 53 minutes. It also showed that women using FHED had a lower chance of needing blood transfusions and facing complications, while their babies had better blood acidity and a lower risk of severe infections and needing special care after birth.
Who this helps: This information benefits pregnant women undergoing C-sections, as well as the healthcare providers who support them.
Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study.
2021
Fetal diagnosis and therapy
Di Mascio D, Herraiz I, Villalain C, Buca D, Morales-Rosello J +20 more
Plain English This study looked at two measurement methods, the cerebroplacental ratio (CPR) and the umbilicocerebral ratio (UCR), to see how well they predict problems during and after birth in pregnancies affected by late fetal growth restriction. Researchers found that lower CPR values (1.11 compared to 1.22) were linked to worse outcomes, while higher UCR values (0.89 compared to 0.82) were observed in those with poor outcomes. However, neither measurement was very useful in predicting these adverse outcomes, showing low accuracy scores around 0.580.
Who this helps: This research benefits doctors and healthcare providers caring for pregnant patients with fetal growth issues.
Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
2021
American journal of obstetrics & gynecology MFM
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C +5 more
Plain English This research looked at health issues in the placenta of pregnant women infected with the SARS-CoV-2 virus. The study found that 30.7% of the placentas showed problems with blood flow to the mother, and 27.1% had issues with blood flow to the fetus; also, signs of inflammation appeared in about 23% to 26% of cases. Understanding these placental problems is important because they may affect pregnancy outcomes, and more studies are needed to connect these findings to how pregnancies progress.
Who this helps: This aids doctors and healthcare providers in managing pregnancies affected by COVID-19.
Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study.
2021
European journal of obstetrics, gynecology, and reproductive biology
Di Mascio D, Khalil A, Pilu G, Rizzo G, Caulo M +64 more
Plain English This study looked at how often additional brain problems are found in unborn babies diagnosed with isolated severe ventriculomegaly, which is swelling of the brain's ventricles. Researchers analyzed data from 187 fetuses and found that prenatal MRI revealed additional brain issues in 18.1% of cases. They discovered that severe malformations of brain development were most common, affecting 32.4% of the cases where additional problems were detected. This is important because it shows that MRI can uncover issues not seen on standard ultrasound, helping doctors make better decisions for the care of these babies.
Who this helps: This benefits parents and healthcare providers caring for fetuses with suspected brain conditions.
Diagnostic Impact of Radiological Findings and Extracellular Vesicles: Are We Close to Radiovesicolomics?
2021
Biology
Serafini FL, Lanuti P, Delli Pizzi A, Procaccini L, Villani M +11 more
Plain English This study looked at how combining advanced imaging techniques with the analysis of tiny cell components called extracellular vesicles could improve disease diagnosis. Researchers reviewed recent studies and found that, when these approaches work together, they could enhance the accuracy of diagnoses. For example, integrating these technologies could lead to earlier and more precise detection of diseases, which is important for timely treatment decisions.
Who this helps: Patients undergoing diagnostic tests.
Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019.
2021
American journal of obstetrics & gynecology MFM
D'Antonio F, Sen C, Mascio DD, Galindo A, Villalain C +126 more
Plain English This study looked at the effects of COVID-19 infection during pregnancy in women considered high risk compared to those with low-risk pregnancies. It found that high-risk pregnant women had a 52% higher chance of experiencing serious health problems related to COVID-19 than low-risk women, and they were also more likely to need hospital care and intensive treatments, such as mechanical ventilation. Additionally, there was a significant difference in miscarriage rates, with 5.3% of high-risk pregnancies ending in miscarriage compared to just 1.6% in low-risk pregnancies.
Who this helps: This research benefits pregnant women and their healthcare providers by providing insights into the risks associated with COVID-19 during pregnancy.
Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.
2020
Journal of perinatal medicine
Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A +200 more
Plain English This study looked at how factors like the timing of COVID-19 infection during pregnancy and the mother's health impacted the risk of negative outcomes for babies. It found that 4.2% of pregnant women with COVID-19 experienced serious issues, including miscarriage and neonatal death; important predictors of these adverse outcomes were being diagnosed earlier in pregnancy, lower birth weight, and requiring breathing support. Understanding these risks helps improve care for pregnant women with COVID-19, promoting healthier pregnancies and outcomes.
Who this helps: Patients and healthcare providers managing pregnancies complicated by COVID-19.
Role of Extracellular Vesicles in Epithelial Ovarian Cancer: A Systematic Review.
2020
International journal of molecular sciences
Lucidi A, Buca D, Ronsini C, Tinari S, Bologna G +7 more
Plain English This research paper looks at tiny particles released by cells, called extracellular vesicles (EVs), and their role in epithelial ovarian cancer (EOC). The study found that certain small RNA molecules from EVs could help in diagnosing EOC early. It also revealed that EVs play a significant role in helping cancer spread and resist treatment. This is important because better understanding and using these EVs could lead to improved diagnosis and treatment strategies for ovarian cancer.
Who this helps: This helps patients with ovarian cancer and their doctors.
GeSn/SiOMultilayers by Magnetron Sputtering Deposition for Short-Wave Infrared Photonics.
2020
ACS applied materials & interfaces
Slav A, Dascalescu I, Lepadatu AM, Palade C, Zoita NC +9 more
Plain English This study explored a way to create more efficient materials for short-wave infrared technology using a combination of germanium-tin (GeSn) alloys and silicon oxide (SiO). Researchers developed a method that produces tiny GeSn crystals with about 16% tin content and an average size of 9 nanometers, resulting in devices that respond well to light at wavelengths longer than 2200 nm. The new multilayer structures showed up to 50% higher photocurrent efficiency compared to traditional single-layer designs, which is crucial for applications like pollution monitoring and the Internet of Things.
Who this helps: This benefits developers of advanced sensors and photonic devices.