E Pacciani

Retired Authority for Archaeological Heritage of the Tuscany Region, Florence, Italy.

22 publications 1986 – 2024 ORCID

What does E Pacciani research?

E Pacciani studies the historical aspects of celiac disease, a condition where the body reacts negatively to gluten, a protein found in wheat and other grains. By analyzing ancient bone remains, they investigate the diets of individuals who may have suffered from celiac disease, revealing how these diets influenced their health over time. This research helps us understand not only the origins of celiac disease but also how it has affected people throughout history, providing insights that can inform current treatments and patient care.

Key findings

  • Research on a young woman from ancient Italy revealed significant differences in bone chemistry, indicating a unique diet linked to chronic malnutrition potentially related to celiac disease.
  • Analysis of DNA from remains dated to the first century AD showed the presence of the HLA DQ 2.5 genetic marker, associated with an increased risk of celiac disease, suggesting the condition has existed for thousands of years.

Frequently asked questions

Does Dr. Pacciani study celiac disease?
Yes, Dr. Pacciani specifically studies the historical aspects and origins of celiac disease through archaeological research.
What techniques does Dr. Pacciani use in their research?
They use stable isotope analysis of ancient bone remains and genetic analysis to understand dietary habits and health conditions in ancient individuals.
Who can benefit from Dr. Pacciani's research?
Patients with celiac disease and healthcare providers can benefit from this research, as it provides insights into the condition's history and its impact on health.

Publications in plain English

The feasibility of the adult age estimation 3D-CBCT method on ancient human remains.

2024

The Journal of forensic odonto-stomatology

Bianchi I, Vitale GG, Focardi M, Capasso E, Galli A +4 more

Plain English
This study focused on using a new method to estimate the ages of ancient human remains from two archaeological sites in Italy. By analyzing the dental structure of 37 skeletons, researchers found that the method was more accurate for remains from Mont'e Prama, estimating ages from about 18 to 28 years with a maximum error of just over 6 years, compared to a wider age range of 16 to 43 years with up to 7.85 years of error for the remains from Florence. This research is important because it provides a reliable way to determine the ages of ancient individuals, which can offer insights into the historical demographics of past populations. Who this helps: This helps archaeologists and anthropologists studying ancient societies.

PubMed

Multiproxy bioarchaeological data reveals interplay between growth, diet and population dynamics across the transition to farming in the central Mediterranean.

2023

Scientific reports

Parkinson EW, Stoddart S, Sparacello V, Bertoldi F, Fonzo O +7 more

Plain English
This study looked at how the shift to farming affected people's growth, diet, and health over 30,000 years in the central Mediterranean. Researchers analyzed data from skeletal remains and found that as people transitioned to farming, their life strategies changed significantly, with notable impacts on diet and population dynamics, using information from nearly 2,000 human and animal samples. These findings help us understand the long-term effects of agricultural practices on human societies. Who this helps: This benefits researchers studying human evolution and health in ancient societies.

PubMed

Exploring mobility in Italian Neolithic and Copper Age communities.

2021

Scientific reports

De Angelis F, Pellegrini M, Martínez-Labarga C, Anzivino L, Scorrano G +19 more

Plain English
This study looked at how people moved around in central and southern Italy during the late Neolithic and Copper Age by examining the chemical composition of teeth from 126 individuals. The findings showed that most people lived a more settled lifestyle, with little evidence of extensive mobility; in fact, only a few individuals were identified as having moved around significantly. This matters because it helps us understand the social structure and lifestyle of ancient communities in Italy, showing a clear difference from later Bronze Age populations. Who this helps: This helps researchers and historians understanding ancient human behaviors and societal development.

PubMed

The origin and legacy of the Etruscans through a 2000-year archeogenomic time transect.

2021

Science advances

Posth C, Zaro V, Spyrou MA, Vai S, Gnecchi-Ruscone GA +33 more

Plain English
This study looked at the DNA of 82 people from the ancient Etruscan civilization in Italy over nearly 2,000 years to understand their origins and changes over time. Researchers found that, while the Etruscans initially had a mix of different ancestries, including Indo-European roots, there was a significant shift during the Roman Empire, leading to about 50% new genetic influences from the eastern Mediterranean. This research highlights how the Etruscan population evolved and contributed to the genetics of modern Italians. Who this helps: This helps historians and archaeologists understand the cultural and genetic history of Italy.

PubMed

Assessing the Parasitic Burden in a Late Antique Florentine Emergency Burial Site.

2019

The Korean journal of parasitology

Roche K, Pacciani E, Bianucci R, Le Bailly M

Plain English
Researchers studied ancient graves found in Florence, Italy, which were believed to be part of an emergency burial site from the late 4th to early 5th centuries CE. They found that nearly 28% of the individuals examined had signs of roundworm infection, suggesting that such parasitic infections were common in this population due to poor living conditions during a time of crisis. Understanding these infections helps us learn about the health and challenges faced by people in history. Who this helps: This helps historians, archaeologists, and modern public health experts.

PubMed

Integrative approach usinggenomes to revisit the historical landscape of plague during the Medieval Period.

2018

Proceedings of the National Academy of Sciences of the United States of America

Namouchi A, Guellil M, Kersten O, Hänsch S, Ottoni C +11 more

Plain English
This research studied the genetic makeup of the plague bacteria from the 14th century to understand how the disease spread during the Medieval Period. The researchers analyzed five ancient genomes and found that the plague likely entered Western Europe through various trade routes, particularly fur trading, which helped the disease circulate among people. This matters because it sheds light on how historical pandemics unfolded and can inform our understanding of disease transmission today. Who this helps: This helps historians and public health officials understand disease patterns and improve future epidemic responses.

PubMed

Palaeodiet reconstruction in a woman with probable celiac disease: a stable isotope analysis of bone remains from the archaeological site of Cosa (Italy).

2014

American journal of physical anthropology

Scorrano G, Brilli M, Martínez-Labarga C, Giustini F, Pacciani E +5 more

Plain English
Researchers examined the bones of a young woman from ancient Italy to learn about her diet and how it might connect to celiac disease. They found that her bone chemistry showed significant differences, indicating she had a unique diet that likely contributed to chronic malnutrition linked to celiac disease. This study highlights how analyzing ancient bones can provide insight into health issues related to diet and may help us understand the historical impact of celiac disease. Who this helps: This helps patients with celiac disease and healthcare providers.

PubMed

MRI neurography findings in patients with idiopathic brachial plexopathy: correlations with clinical-neurophysiological data in eight consecutive cases.

2013

Internal medicine (Tokyo, Japan)

Luigetti M, Pravatà E, Colosimo C, Sabatelli M, Masciullo M +7 more

Plain English
This study looked at eight patients with idiopathic brachial plexopathy, a condition that causes sudden shoulder pain and weakness in the arm. Researchers found that traditional clinical exams and nerve tests were crucial for diagnosis, but MRI neurography also proved valuable for identifying inflammation and ruling out other causes like tumors. This is important because it provides a clearer understanding of the condition and helps ensure patients receive the right treatment. Who this helps: This helps patients with idiopathic brachial plexopathy and their doctors.

PubMed

Origin of celiac disease: how old are predisposing haplotypes?

2012

World journal of gastroenterology

Gasbarrini G, Rickards O, Martínez-Labarga C, Pacciani E, Chilleri F +4 more

Plain English
This study looked at the remains of a young woman from the first century AD who showed signs of malnutrition, which might indicate celiac disease. Researchers analyzed her DNA and found she had a specific genetic marker (HLA DQ 2.5) that is strongly linked to an increased risk of celiac disease. This discovery is important because it suggests that celiac disease has been present for thousands of years, which can reshape our understanding of the condition's history. Who this helps: This helps researchers and medical professionals understand the long-term history of celiac disease.

PubMed

Craniofacial morphometric variation and the biological history of the peopling of Sardinia.

2010

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen

D'Amore G, Di Marco S, Floris G, Pacciani E, Sanna E

Plain English
This study looked at the differences in skull and facial features among prehistoric groups in Sardinia, covering a time span from the Late Neolithic to the Bronze Age. The researchers found that these groups became more distinct from populations in mainland Italy over time, while still showing similarities among Sardinians from different ancient times. Importantly, some of the features from ancient Sardinians are still present in today's Sardinian population, indicating a deep biological connection that has lasted for thousands of years. Who this helps: This helps researchers and historians understand the ancestry of Sardinian populations.

PubMed

Unusual morphological features in a presumably Neolithic individual from Riparo della Rossa, Serra San Quirico (Ancona, Italy).

2007

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen

D'Amore G, Pacciani E, Frederic P, Caramella Crespi V

Plain English
This study looked at ancient human bones found in a rock shelter in Italy to learn more about their age and characteristics. Researchers found that the bones exhibited unusual features not typically seen in modern humans and dated them to be between about 5,690 to 10,000 years old, concluding that they likely belonged to a male from the Neolithic period. Understanding these ancient remains helps shed light on human evolution and the lifestyles of early cultures. Who this helps: This benefits researchers studying human history and evolution.

PubMed

[Congenital spinal malformations: issues of anthropological ancient samples].

2006

Medicina nei secoli

Boano R, Catalano P, Pacciani E, Fulcheri E, Massa ER

Plain English
This study looked at ancient bones to understand how often and in what ways congenital spinal problems occurred in children who lived a long time ago. Researchers examined the remains of 132 children and found two cases of spinal malformations that contributed to early deaths. These findings reveal important information about the health challenges faced by children in the past and could help us understand factors affecting child mortality over centuries. Who this helps: This helps researchers and historians studying child health and mortality in ancient societies.

PubMed

Symptomatic cervicogenic headache.

2000

Clinical and experimental rheumatology

Delfini R, Salvati M, Passacantilli E, Pacciani E

Plain English
This study focuses on cervicogenic headaches, which are headaches that arise from neck issues. Researchers found that sometimes the cause of these headaches is clear, such as after an injury, but other times it can be difficult to figure out the reason, especially if there are neck or skull problems. Proper evaluation can help identify the cause quickly and reduce discomfort and costs for patients and their families. Who this helps: Patients suffering from cervicogenic headaches and their healthcare providers.

PubMed

Diagnostic imaging of the early slipped capital femoral epiphysis.

1998

La Radiologia medica

Magnano GM, Lucigrai G, De Filippi C, Castriota Scanderberg A, Pacciani E +1 more

Plain English
This study looked at how well different imaging methods can detect early slipped capital femoral epiphysis (ESCFE) in overweight children. Among 21 patients, the study found that ultrasound was the most accurate method, correctly identifying ESCFE 95% of the time, compared to 66% for regular X-rays and 88% for MRI. This is important because catching ESCFE early allows for successful surgical treatment, which can prevent further complications. Who this helps: This helps children with hip pain and their doctors by improving diagnosis and treatment options.

PubMed

[Clinico-radiologic correlations in common neck pain].

1996

La Radiologia medica

Pacciani E, Salsano ML, Donnetti L, Urso S

Plain English
The study looked at 130 patients with neck pain, headaches, dizziness, and upper limb pain, finding strong connections between specific radiographic signs in the neck and their symptoms. The most common finding was vertebral rotation, seen in 79 cases, which correlated with clinical symptoms in 70 of those instances. This research highlights that understanding these spine images can help doctors better diagnose and treat neck pain, especially since degenerative changes were less impactful than other signs. Who this helps: This benefits doctors and patients experiencing neck pain.

PubMed

Associated dental anomalies in an Etruscan adolescent.

1995

The Angle orthodontist

Baccetti T, Franchi L, Cecchi JM, Pacciani E

Plain English
Researchers examined three pieces of the upper jaw from a 6th-century B.C. Etruscan teenager and found three specific dental issues: two permanent teeth were missing, one tooth was shaped unusually, and another tooth grew in the wrong position. These findings help us understand how different dental problems can be linked to one another. This matters because it sheds light on dental health in ancient populations and may inform modern dental studies. Who this helps: This helps dental researchers and historians studying ancient health and diseases.

PubMed

[Nonspecific osteomyelitis in childhood and adolescence. The contribution of imaging diagnosis].

1995

La Radiologia medica

Urso S, Pacciani E, Fariello G, Colajacomo M, Fassari FM +4 more

Plain English
This research studied nonspecific osteomyelitis, a bone infection in children aged 2 to 16 years, looking at how well different imaging methods can diagnose it. The study examined 40 patients and found that imaging techniques like CT and MRI were effective in identifying the condition, with MRI revealing important details about the lesions in most cases. For example, in acute osteomyelitis, CT and MRI detected bone involvement and soft tissue changes in most patients, showing the importance of using multiple imaging types for accurate diagnosis and treatment. Who this helps: This research helps pediatricians and radiologists in diagnosing osteomyelitis in children and adolescents.

PubMed

Enamel hypoplasia and age at weaning in 19th-century Florence, Italy.

1994

American journal of physical anthropology

Moggi-Cecchi J, Pacciani E, Pinto-Cisternas J

Plain English
This study looked at children's tooth enamel in 19th-century Florence to find out when enamel problems occurred. Researchers found that the most significant enamel defects happened in children aged between 1.5 and 3.5 years, especially showing stress-related issues as they were weaned off breast milk, which typically happened around 12 to 18 months. This information helps us understand better how the weaning process and diet affected children's health during that time. Who this helps: This helps historians and healthcare professionals understand historical child health and nutrition.

PubMed

[Static-dynamic computerized tomography in the diagnosis of traumatic lesions of alar ligaments. Preliminary results].

1994

La Radiologia medica

Urso S, Pacciani E, Ascani E, Salsano ML, Randisi F +1 more

Plain English
This study looked at 25 patients with neck injuries who experienced pain, headaches, and dizziness despite no broken bones being found. The researchers used specialized CT scans to check for injuries in the alar ligaments, which support the neck, and found that 14 patients had changes indicating trauma, with 12 showing thinning of the ligaments and 2 showing complete absence of the ligaments. These findings are important because they help doctors better understand and diagnose neck injuries that don’t show up on regular scans, potentially leading to more effective treatment for patients. Who this helps: This helps patients suffering from neck injuries and their doctors.

PubMed

"Orthodontistry" and dental occlusion in Etruscans.

1989

The Angle orthodontist

Corruccini RS, Pacciani E

Plain English
This research studied the dental characteristics of the Etruscans, an ancient civilization from around the 8th Century B.C. The findings indicate that while the Etruscans used orthodontic bands to align teeth, their remains showed very good tooth alignment and little crowding, suggesting they didn’t have the severe dental issues (malocclusion) that became common later in industrial societies. This matters because it helps us understand the history of dental health and practices over time. Who this helps: This helps historians, dentists, and researchers studying dental evolution and public health.

PubMed

[Osteoid osteoma and osteoblastoma of the vertebrae].

1987

La Radiologia medica

Urso S, Alessi G, Risi D, Migliorini A, Pacciani E

Plain English
The study looked at ten patients who had bone tumors in their spine, specifically osteoid osteoma and osteoblastoma. Surgery was performed on all patients, and imaging techniques routinely confirmed the tumors' presence and location. The findings highlight the importance of using imaging tests like X-rays and CT scans to accurately diagnose these conditions, ensuring that patients receive the right treatment. Who this helps: This helps patients with spinal tumors and their doctors.

PubMed

The radiological diagnosis of spinal stenosis in the lumbar canal.

1986

Italian journal of orthopaedics and traumatology

Urso S, Pacciani E, Donnetti L

Plain English
This study looked at 132 patients with a condition called lumbar spinal stenosis, which narrows the spinal canal in the lower back. The researchers created a straightforward system to help surgeons identify the type and location of the problem so they can plan surgery more effectively. Understanding this condition better is important because it can lead to better treatment for patients suffering pain and mobility issues. Who this helps: This helps patients with lumbar spinal stenosis and their doctors.

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.