Elisa Sacchini studies inflammatory bowel disease, which includes conditions like Crohn's disease and ulcerative colitis that affect the digestive system. Her research specifically examines how these diseases have changed over time in the Republic of San Marino, looking at rates of new diagnoses and existing cases. By analyzing the health data over the past few decades, she aims to understand the factors contributing to these diseases and their impact on patient care, helping to guide better treatment options for individuals affected by IBD.
Key findings
In 2014, the rate of Crohn's disease was 241 cases per 100,000 people in San Marino.
The rate of ulcerative colitis was found to be 311 cases per 100,000 people in the same year.
Both diseases have shown a significant increase in new cases over the past 35 years.
Frequently asked questions
Does Dr. Sacchini study inflammatory bowel disease?
Yes, Dr. Sacchini conducts research specifically on inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
What trends has Dr. Sacchini found in her research?
She has found that the rates of Crohn's disease and ulcerative colitis have significantly increased in San Marino over the past few decades.
How does Dr. Sacchini's work benefit patients?
Her research helps identify health needs related to inflammatory bowel disease, guiding healthcare providers in developing effective treatment strategies.
Publications in plain English
Increased fluid intake and blood pressure in healthy children: a randomized controlled trial. The SPA Project.
2026
Pediatric nephrology (Berlin, Germany)
Ardissino G, Viola L, Mancuso MC, Ria T, Tamburini G +8 more
Plain English This study investigated whether drinking more water can lower blood pressure in healthy children. Over a year, kids encouraged to increase their fluid intake showed lower blood pressure readings, with a median difference of 2 mmHg compared to those who did not increase their water consumption. This finding is important because it suggests that simply drinking more water could help prevent high blood pressure as children grow older, which is linked to various health issues.
Who this helps: This helps children and parents looking to promote better health habits.
Multiple office blood pressure monitoring for the diagnosis of hypertension in children.
2025
European journal of pediatrics
Dato L, Mancuso MC, Ria T, Viola L, Salice P +11 more
Plain English This study explored how different methods of measuring blood pressure (BP) in children compare to diagnose high BP, also known as hypertension. Researchers found that initial readings from regular office visits typically showed higher BP than a more thorough method called multiple office blood pressure monitoring (mOBPM). Specifically, in a group of 151 children, 29 were identified as having high BP based on the first readings, while only 6 were identified with mOBPM, indicating that earlier methods often overestimate BP.
Who this helps: This benefits doctors and healthcare providers in accurately diagnosing hypertension in children.
The impact of COVID-19 vaccination programme in the Republic of San Marino: Focus on effectiveness of Gam-Covid-Vac.
2022
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Tonnara G, Piselli P, Cimaglia C, Arlotti M, Sacchini E +9 more
Plain English This study looked at how effective the Gam-COVID-Vac (Sputnik V) vaccine was in the Republic of San Marino, where most vaccinations were with this vaccine. They found that out of the people who hadn't had COVID-19 before, those vaccinated had a 67.6% lower chance of getting infected and an 87.9% lower chance of being hospitalized due to COVID-19. Protection against serious illness remained strong over time, with no significant decline noted for hospitalizations.
Who this helps: This helps patients and the healthcare system by showing the vaccine's effectiveness in preventing severe COVID-19 outcomes.
Socioeconomic inequalities in overweight and obesity among 6- to 9-year-old children in 24 countries from the World Health Organization European region.
2021
Obesity reviews : an official journal of the International Association for the Study of Obesity
Buoncristiano M, Williams J, Simmonds P, Nurk E, Ahrens W +39 more
Plain English This study looked at how socioeconomic status (SES) affects overweight and obesity in children aged 6 to 9 in 24 European countries. Researchers analyzed data from over 123,000 children and found that in wealthy countries, children with less educated parents were more likely to be overweight or obese, while in many middle-income countries, the trends were reversed. Understanding these differences is important because it guides better policies and programs to fight childhood obesity that consider a country's economic situation.
Who this helps: This helps children, parents, and health officials by offering insights into better targeting of health initiatives.
Socioeconomic differences in food habits among 6- to 9-year-old children from 23 countries-WHO European Childhood Obesity Surveillance Initiative (COSI 2015/2017).
2021
Obesity reviews : an official journal of the International Association for the Study of Obesity
Fismen AS, Buoncristiano M, Williams J, Helleve A, Abdrakhmanova S +37 more
Plain English This study looked at how family income and education levels affect what children aged 6 to 9 eat in 23 countries. It found that children from families with lower education and perceived wealth tend to have unhealthier diets, consuming more sugary drinks and fewer fruits and vegetables. For example, unhealthy eating habits were linked to lower parental education levels, and this pattern was seen across many European and Asian countries.
Who this helps: This helps policymakers and health organizations working to improve children's nutrition.
Urban and rural differences in frequency of fruit, vegetable, and soft drink consumption among 6-9-year-old children from 19 countries from the WHO European region.
2021
Obesity reviews : an official journal of the International Association for the Study of Obesity
Heinen MM, Bel-Serrat S, Kelleher CC, Buoncristiano M, Spinelli A +36 more
Plain English The study looked at how often children aged 6-9 in urban and rural areas of 19 European countries eat fruits and vegetables and drink soft drinks. It found that between 30% to 90% of kids do not eat fruits or vegetables daily, and nearly 45% have soft drinks more than three times a week. This matters because these eating habits can lead to health issues like obesity, and the research highlights that rural children are at higher risk in some countries, indicating a need for better access to healthy foods.
Who this helps: This helps children and their families by highlighting the need for improved nutrition where they live.
Thinness, overweight, and obesity in 6- to 9-year-old children from 36 countries: The World Health Organization European Childhood Obesity Surveillance Initiative-COSI 2015-2017.
2021
Obesity reviews : an official journal of the International Association for the Study of Obesity
Spinelli A, Buoncristiano M, Nardone P, Starc G, Hejgaard T +50 more
Plain English This study looked at the weight and height of over 203,000 children aged 6 to 9 from 36 countries in Europe and Central Asia between 2015 and 2017. It found that 28.7% of boys and 26.5% of girls were overweight or obese, with the highest obesity rates in Cyprus (21.5% of boys and 19.2% of girls) and the lowest in Tajikistan (1.8% of boys and 1.1% of girls). This matters because childhood obesity can lead to serious health issues, and addressing these disparities is crucial for improving children's health across different regions.
Who this helps: This helps parents, healthcare providers, and policymakers focused on child health and nutrition.
Interatrial Shunting Through an Asymptomatic Patent Foramen Ovale in Thoracic Surgery.
2019
The Annals of thoracic surgery
Cagini L, Cardaioli G, Andolfi M, Savino K, Eusebi P +7 more
Plain English The study focused on patients with an asymptomatic condition called a patent foramen ovale (PFO) who were undergoing major lung surgery for cancer. Researchers found that 25% of these patients had a PFO before surgery, and those with a PFO were 2.5 times more likely to face complications after the operation, particularly atrial fibrillation, which increased their risk by 3.5 times. This finding is important because it suggests that even asymptomatic PFOs could lead to serious issues during recovery from surgery.
Who this helps: This helps patients undergoing lung surgery by identifying potential risks associated with PFO.
Prevalence of Severe Obesity among Primary School Children in 21 European Countries.
2019
Obesity facts
Spinelli A, Buoncristiano M, Kovacs VA, Yngve A, Spiroski I +30 more
Plain English This research examined the rates of severe obesity in primary school children across 21 European countries. It found that the prevalence of severe obesity ranged from 1.0% in Sweden and Moldova to 5.5% in Malta, with about 398,000 children in total expected to be severely obese based on the World Health Organization's definitions. Addressing severe obesity is crucial because it significantly impacts children's health, education, and overall well-being.
Who this helps: This helps parents, teachers, and public health officials working to improve children's health.
Validation of the Hemifacial Spasm Grading Scale: a clinical tool for hemifacial spasm.
2019
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Tambasco N, Simoni S, Sacchini E, Eusebi P, Marsili E +5 more
Plain English Researchers developed and tested a new grading scale for hemifacial spasm (HFS), a condition that causes involuntary facial muscle contractions. They found that the Hemifacial Spasm Grading Scale (HSGS) reliably measured HFS severity, with good agreement among different raters, and showed that treatment with botulinum neurotoxin effectively reduced symptoms over a month, as indicated by lower scores. This tool is significant because it provides an objective way for doctors to assess the condition and monitor treatment progress.
Who this helps: This benefits patients with hemifacial spasm and their doctors by providing a clear way to track treatment effectiveness.
Epidemiology of inflammatory bowel disease in the Republic of San Marino: The "EPIMICI - San Marino" study.
2019
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Piscaglia AC, Lopetuso LR, Laterza L, Gerardi V, Sacchini E +5 more
Plain English This study looked at the rates of Crohn's disease and ulcerative colitis in San Marino over the past 35 years. It found that as of 2014, there were 241 cases of Crohn's disease and 311 cases of ulcerative colitis per 100,000 people, with both diseases showing a significant increase in new cases over the decades. Understanding these trends is important because it helps identify health needs and guide treatment in this small nation.
Who this helps: Patients living with inflammatory bowel disease and their healthcare providers.
The validation of an Italian version of the Freezing of Gait Questionnaire.
2015
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Tambasco N, Simoni S, Eusebi P, Ripandelli F, Brahimi E +4 more
Plain English This study focused on validating an Italian version of the Freezing of Gait Questionnaire (FOG-Q), a tool used to assess the severity of freezing of gait in people with Parkinson's disease. The researchers tested this version on 51 patients and found that the questionnaire was reliable, with a high score reliability of 0.91, and the average score among patients was 12.6 out of 24. This matters because it provides healthcare professionals with a solid tool to better understand and manage a common and disabling symptom of Parkinson's disease.
Who this helps: This benefits patients with Parkinson's disease and their doctors.
Clinical aspects and management of levodopa-induced dyskinesia.
2012
Parkinson's disease
Tambasco N, Simoni S, Marsili E, Sacchini E, Murasecco D +3 more
Plain English This research focused on how to manage a movement disorder called dyskinesia that occurs in patients with Parkinson's disease after long-term treatment with a medication called levodopa. The study reviewed different strategies to reduce these involuntary movements, including adjusting levodopa doses and starting another type of medication called dopamine agonists earlier. The findings emphasize that using dopamine agonists can help manage symptoms effectively, improving the quality of life for patients.
Who this helps: This benefits patients with Parkinson's disease experiencing dyskinesia.