F COSENZA

Institute for Quantitative Genetics and Genomics of Plants, Heinrich Heine University, 40225 Düsseldorf, Germany.

14 publications 1962 – 2024 ORCID

What does F COSENZA research?

Dr. Cosenza studies liver cirrhosis, a serious liver condition where the organ becomes severely scarred and doesn’t function properly. One of the complications of liver cirrhosis is the buildup of certain substances in the blood that can lead to confusion and other cognitive issues. To address this, Dr. Cosenza has researched the use of rifaximin, a medication that targets bacteria in the gut, along with dietary changes and another treatment called lactulose, which helps in bowel movements. By examining the effects of these treatments, Dr. Cosenza aims to find effective ways to lower harmful blood compounds in patients with this condition.

Key findings

  • Patients taking rifaximin saw their levels of benzodiazepine-like compounds decrease from an average of 106 to 64 pmol DE/ml.
  • The study involved 18 patients, highlighting the potential of rifaximin as a beneficial treatment in this context.
  • No significant changes were observed in patients receiving lactulose or placebo, demonstrating the targeted efficacy of rifaximin.

Frequently asked questions

Does Dr. Cosenza study liver cirrhosis?
Yes, Dr. Cosenza conducts research specifically on liver cirrhosis and its complications.
What treatments has Dr. Cosenza researched for liver cirrhosis?
Dr. Cosenza has researched the use of rifaximin, lactulose, and dietary changes to manage blood compounds in patients with liver cirrhosis.
Is Dr. Cosenza's work relevant to patients with liver disease?
Absolutely, their work focuses directly on improving health outcomes for patients suffering from liver disease.

Publications in plain English

Genetic mapping reveals new loci and alleles for flowering time and plant height using the double round-robin population of barley.

2024

Journal of experimental botany

Cosenza F, Shrestha A, Van Inghelandt D, Casale FA, Wu PY +4 more

Plain English
This study examined the genetics behind flowering time and plant height in barley, which are important for crop yield. The researchers found new genetic variants and identified that environmental factors play a significant role, particularly affecting plant height. They discovered new genetic regions linked to these traits, suggesting that the genetics involved are more complicated than previously thought. Who this helps: This research benefits barley farmers and plant breeders looking to improve crop yields.

PubMed

Emotions at diagnosis in patients with bullous diseases.

2023

Italian journal of dermatology and venereology

Sampogna F, Battisti S, Scarpulla C, Battisti V, Cosenza F +3 more

Plain English
This study looked at how patients feel when they are diagnosed with bullous diseases, like pemphigus, a severe skin condition. Out of 105 patients, 48% reported feeling confused at diagnosis, while over 30% felt sadness and fear. The findings highlight the need for doctors to communicate more compassionately and listen to patients' emotions during such tough times to provide better support. Who this helps: This benefits patients and their families, as well as healthcare providers.

PubMed

Cloning the barley nec3 disease lesion mimic mutant using complementation by sequencing.

2022

The plant genome

Rosignoli S, Cosenza F, Moscou MJ, Civolani L, Musiani F +5 more

Plain English
This study focused on a group of barley plants that show disease-like symptoms without actually being infected by any pathogens. Researchers discovered that a specific gene, called CYP71P1, is responsible for these symptoms in some of these plants. By using an efficient new method, they were able to identify this gene, which helps improve our understanding of how plants defend themselves against diseases. Who this helps: This benefits plant scientists and farmers by providing insights for developing more disease-resistant barley crops.

PubMed

A lineage-specific Exo70 is required for receptor kinase-mediated immunity in barley.

2022

Science advances

Holden S, Bergum M, Green P, Bettgenhaeuser J, Hernández-Pinzón I +18 more

Plain English
This study examined how a specific part of barley's immune system helps protect it from wheat stripe rust, a harmful fungus. The researchers found that a gene called Exo70FX12 is essential for this defense mechanism, working alongside another gene, Pur1. They discovered that this Exo70FX12 gene is unique to certain grass types and highlights the importance of specialized proteins in plant immunity. Who this helps: This research benefits farmers and agricultural scientists focused on improving crop resistance to diseases.

PubMed

The double round-robin population unravels the genetic architecture of grain size in barley.

2022

Journal of experimental botany

Shrestha A, Cosenza F, van Inghelandt D, Wu PY, Li J +3 more

Plain English
This study focused on understanding the genetics behind the size and weight of barley grains, which are important for crop yield. Researchers examined 45 different barley strains and discovered that traits like grain length and weight show a lot of genetic variability, with over 84% heritability. Their findings reveal that the genetics of grain size in barley are more complicated than previously thought and highlight the role of specific genes that may influence these traits. Who this helps: This benefits farmers and agricultural scientists working to improve barley crop yields.

PubMed

Longitudinal melanonychia due to voriconazole therapy during treatment of chromoblastomycosis.

2018

Clinical and experimental dermatology

Criado PR, Cosenza FD, Junior WB, Ferreira PS

PubMed

Two-time Green's functions and spectral density method in nonextensive quantum statistical mechanics.

2008

Physical review. E, Statistical, nonlinear, and soft matter physics

Cavallo A, Cosenza F, De Cesare L

Plain English
This study looked at how to analyze complex systems in quantum physics using a method known as two-time Green's functions, modified to account for situations where traditional assumptions about systems (called "nonextensive" conditions) don’t hold. The researchers found that using this new approach, particularly for a model dealing with a dense gas of particles, allowed them to calculate important thermodynamic properties more accurately when the particles interact strongly. Their work showed specific effects of nonextensivity on these properties, revealing insights that are vital for understanding many-body systems at low temperatures. Who this helps: Patients and researchers working on advanced materials and quantum technologies.

PubMed

Evaluation of rifaximin, placebo and lactulose in reducing the levels of benzodiazepine-like compounds in patients with liver cirrhosis: a pilot study.

2005

Drugs under experimental and clinical research

Venturini I, Ferrieri A, Farina F, Cosenza F, Avallone R +3 more

Plain English
This study looked at whether the medication rifaximin, along with diet and lactulose, could lower levels of benzodiazepine-like compounds in the blood of patients with liver cirrhosis, which can lead to confusion and other serious problems. Researchers treated 18 patients and found that those taking rifaximin had a significant drop in these compounds from an average of about 106 to 64 pmol DE/ml, while those on lactulose or placebo showed no change. This matters because managing these compound levels could help prevent complications in patients with severe liver disease. Who this helps: This helps patients with liver cirrhosis.

PubMed

Peripheral benzodiazepine receptors in potatoes (Solanum tuberosum).

2004

Biochemical and biophysical research communications

Corsi L, Avallone R, Geminiani E, Cosenza F, Venturini I +1 more

Plain English
This study looked at a specific protein called peripheral benzodiazepine receptors (PBRs) in potatoes. Researchers found that PBRs are mostly located in the plant's growth areas and are more abundant in these regions compared to other tissues; specifically, the protein size is around 30-36 kDa and is increased in meristematic cells. This discovery is significant because it suggests that these receptors play a role in how potatoes grow and develop, which could impact agricultural practices. Who this helps: This helps farmers and agricultural scientists improve potato growth and yield.

PubMed

Extraction and purification from Ceratonia siliqua of compounds acting on central and peripheral benzodiazepine receptors.

2002

Fitoterapia

Avallone R, Cosenza F, Farina F, Baraldi C, Baraldi M

Plain English
This study examined the leaves and pods of carob (Ceratonia siliqua) to find compounds that interact with specific brain receptors linked to anxiety and sedation. The results showed that the leaves contain a very high concentration of active compounds, with 2,572.57 ng of a key substance per gram, which may help in reducing anxiety. This research highlights the potential for using carob extracts as natural remedies for anxiety and in preventing some diseases. Who this helps: Patients looking for natural alternatives to manage anxiety and health care providers seeking new treatment options.

PubMed

Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line.

2002

Fitoterapia

Corsi L, Avallone R, Cosenza F, Farina F, Baraldi C +1 more

Plain English
Researchers studied extracts from carob plants, specifically from the pods and leaves, to see how they affected the growth of liver cancer cells in mice. They found that these extracts significantly slowed down the cancer cells' growth, especially at a concentration of 1 mg/ml, and were effective in triggering cell death after 24 hours. The extracts contained important compounds known for their cancer-fighting properties, with the leaves having higher concentrations of these beneficial substances than the pods. Who this helps: This benefits patients with liver cancer and could inform new treatments.

PubMed

Two-time Green's functions and the spectral density method in nonextensive classical statistical mechanics.

2001

Physical review letters

Cavallo A, Cosenza F, De Cesare L

Plain English
This study looked at a specific mathematical method used to analyze systems in nonextensive classical statistical mechanics, which deals with complex systems that don’t follow normal patterns. The researchers found that this method could effectively describe the properties of materials, like a classical ferromagnetic spin chain, helping to understand how they behave. These findings are important because they provide new tools for researchers studying complex materials and their properties. Who this helps: This benefits scientists and researchers working in materials science and physics.

PubMed

Molar eruption and mandibular growth. II.

1965

The New York state dental journal

Rubin PL, Cosenza F, Biederman W

PubMed

Study of blood flow in the dental pulp by an electrical impedance technique.

1962

Physics in medicine and biology

LIEBMAN FM, COSENZA F

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.