F. Ingravalle studies several important health areas, primarily focusing on inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Their research explores how nutritional factors, such as micronutrient levels, and treatment strategies affect disease activity, surgical needs, and overall patient quality of life. In addition to IBD, they investigate the relationship between the immune system and the vaginal microbiota, shedding light on how these interactions can influence gynecological health issues such as preterm labor, bacterial vaginosis, and miscarriages. Overall, Ingravalle's work seeks to enhance patient care and treatment outcomes through a deeper understanding of these health challenges.
Key findings
In IBD patients, significant differences in hemoglobin, iron, ferritin, and vitamin D levels were observed between those with active disease and those with inactive disease, indicating that monitoring these nutrients can aid disease management.
As of 2021, 218 out of every 100,000 people were affected by IBD, with 36% of Crohn's patients and 20% of ulcerative colitis patients requiring surgery within six years of diagnosis.
Biological therapies initially delayed surgery for Crohn's disease patients, but after adjusting for other factors, there was no significant long-term difference in surgery-free survival compared to conventional therapy.
Approximately one third of IBD patients were found to have sarcopenia, which negatively impacted their quality of life compared to healthy individuals, emphasizing the need for regular muscle health evaluations in these patients.
The research identified key pathways linking gut health and muscle function, providing insights into potential therapies for muscle-wasting conditions related to intestinal diseases.
Frequently asked questions
Does Dr. Ingravalle study inflammatory bowel disease?
Yes, Dr. Ingravalle focuses extensively on inflammatory bowel disease, exploring its epidemiology, treatment strategies, and associated health challenges.
What treatments has Dr. Ingravalle researched for Crohn's disease?
Their research compares biological therapies with conventional treatments in terms of their effects on surgery-free survival in Crohn's disease patients.
Is Dr. Ingravalle's work relevant to women with gynecological issues?
Yes, Dr. Ingravalle studies the immune system and microbiota balance, which is crucial for women's health, particularly during pregnancy and menopause.
What nutritional factors does Dr. Ingravalle highlight for IBD patients?
Dr. Ingravalle emphasizes monitoring levels of iron and vitamin D as critical for managing disease activity in IBD patients.
How does Dr. Ingravalle's research help improve patient outcomes?
Their work informs better management strategies and treatment options for patients with IBD and gynecological health issues, potentially leading to improved quality of life.
Publications in plain English
Understanding Health Literacy and eHealth Literacy in Nursing Students: A Cross-Sectional Cluster Analysis.
2026
Nursing reports (Pavia, Italy)
Zerilli I, Bulfone G, Capizzello D, Gambera A, Fazzino V +4 more
Plain English This study looked at the levels of health literacy and eHealth literacy in nursing students at a university in Italy. Researchers found four different groups among the students, each with unique literacy levels and experiences. For example, some students had much higher literacy skills than others, indicating that these differences could be influenced by their background and education. This matters because understanding these variations can help develop better training programs tailored to the needs of different student groups.
Who this helps: This helps nursing educators and students improve learning outcomes.
Introduction to the Operation Room Management technology: Interrupted Time Series analysis in an urban acute care hospital facility in Rome, Italy.
2025
Annali di igiene : medicina preventiva e di comunita
Marte M, Piunno G, Furia G, Vinci A, Ingravalle F +6 more
Plain English Researchers studied the impact of a new digital system called the Operation Room Management (ORM) in a hospital in Rome, Italy. They found that, by June 2023, nearly all surgeries (91%) were managed digitally, which led to shorter surgery times—an average decrease of about 9 minutes for orthopedics and 8.5 minutes for general surgery. This matters because it shows that digital tools can improve efficiency in hospitals without harming patient care.
Who this helps: This benefits patients and hospital staff by improving surgery scheduling and reducing wait times.
Open surgical repair as gold standard for acute Achilles tendon ruptures: Systematic review and network meta-analysis.
2025
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Pisano A, Boxler M, Gambuti E, Falco F, Trierweiler M +7 more
Plain English This study looked at different treatments for ruptured Achilles tendons, including open surgery, minimally invasive procedures, and non-surgical options, while also considering how weight-bearing timing affects healing. It found that open surgical repair combined with waiting to bear weight has the lowest chance of re-rupture at just 2%, compared to 12% for non-surgical treatments. This is important because it confirms that surgical options not only reduce re-injury risk but also lead to faster recoveries, making surgery the best choice for many patients.
Who this helps: This helps patients with Achilles tendon injuries.
Evaluation of sexual dysfunction among women with primary Sjögren's syndrome using a Female Sexual Function Index: a systematic review and meta-analysis.
2025
The journal of sexual medicine
D'Andrea S, Vinci A, Navarini L, Sansone A, Marino A +12 more
Plain English This study looked at sexual dysfunction in women with primary Sjögren's syndrome (pSS) and found that these women are five times more likely to experience sexual problems compared to those without the condition. The research analyzed data from 16 studies and showed that all areas of sexual function were negatively affected in women with pSS, not just those related to vaginal dryness. This finding highlights the need for healthcare providers to routinely assess and address sexual health in these patients.
Who this helps: This helps women with primary Sjögren's syndrome and their doctors.
Effectiveness of Plastic Stent for the Treatment of Incomplete Clearance of Common Bile Duct Stone: A Systematic Review and Meta-analysis.
2025
Journal of gastrointestinal and liver diseases : JGLD
Valvano M, Vinci A, Antonini F, Montale A, Capannolo A +9 more
Plain English This study looked at how effective a temporary plastic stent is for patients who still have stones in their bile ducts after a common treatment called ERCP. Out of 902 patients, the stent helped clear the bile duct stones in 79% of the cases. This finding is important because it shows that using a plastic stent can significantly help patients who struggle with stubborn bile duct stones.
Who this helps: Patients with persistent bile duct stones.
Substance use and academic performance among university students: systematic review and meta-analysis.
2025
BMC medical education
Bulfone G, Ingravalle F, Scerbo F, Mazzotta R, Simonelli I +7 more
Plain English This research paper examined how using different substances, including alcohol, affects college students' academic performance. It analyzed 21 studies and found that students who used drugs or other illegal substances had lower academic achievement, with an average effect size of -0.61, indicating a notable impact. While alcohol use also appeared to be negatively related to academic performance, the effect was smaller and not statistically significant, with an effect size of -0.24.
Who this helps: This helps university students and educators understand the potential risks of substance use on academic success.
The Frequent Use of Emergency Departments Among the Pediatric Population: A Retrospective Analysis in Rome, Italy.
2025
Epidemiologia (Basel, Switzerland)
Furia G, Ingravalle F, Vinci A, Papini P, Barbara A +4 more
Plain English This study looked at how often children in Rome visited emergency departments (EDs) in 2022. Out of 35,691 visits, only 3.5% of patients were responsible for more than 10% of the visits, but most were deemed unnecessary. It highlights that certain factors, like being very young or having severe health issues, lead to appropriate ED use, suggesting a need for better education for parents on when to use emergency services wisely.
Who this helps: This helps parents and caregivers of young children understand when to seek emergency care.
Time Trends in Prevalence and Antimicrobial Resistance of Respiratory Pathogens in a Tertiary Hospital in Rome, Italy: A Retrospective Analysis (2018-2023).
2025
Antibiotics (Basel, Switzerland)
Ingravalle F, Maurici M, Vinci A, Di Carlo S, D'Agostini C +2 more
Plain English This study looked at respiratory infections in patients at a hospital in Rome from 2018 to 2023, focusing on the types of germs causing these infections and their resistance to antibiotics. Researchers found that over 54,000 cases showed consistently high rates of resistance to multiple antibiotics, with about 20% of the germs identified being fungi that resist common antifungal treatments. These findings highlight the urgent need for ongoing monitoring of infections and resistance patterns to improve treatment strategies and infection control practices.
Who this helps: This benefits patients, doctors, and healthcare systems by informing better treatment decisions and infection management.
CBRNe Personal Protective Equipment Is Not a Hindrance to Lifesaving Procedures in Prehospital Settings: A Prospective, Repeated-Measures Observational Study.
2025
Epidemiologia (Basel, Switzerland)
Innocenzi S, Ingravalle F, Maurici M, Di Rienzo D, Casciani D +6 more
Plain English This study looked at how wearing special protective gear for hazardous materials affects emergency workers' ability to perform lifesaving medical procedures. They found that overall success rates for procedures remained high, but using the gear initially slowed down tasks like inserting IVs and made intubation a bit harder, dropping success rates by about 10%. With practice, responders improved noticeably, getting close to their normal success rates, but only about 61% managed to finish all drills while wearing the gear.
Who this helps: This benefits emergency medical workers and the patients they serve by ensuring effective training with protective gear.
A Six-Step Protocol for Monitoring Antimicrobial Resistance Trends Using WHONET and R: Real-World Application and R Code Integration.
2025
Methods and protocols
Ingravalle F, Vinci A, Ciotti M, Fontana C, Pica F +8 more
Plain English This paper studied how to effectively track antimicrobial resistance (AMR) trends using two free software tools, WHOnet and R. It showed that by following a six-step protocol and using real data from an Italian hospital, healthcare providers can easily analyze and visualize AMR patterns. This is important because timely and accurate data can help doctors make better treatment decisions, ultimately improving patient outcomes.
Who this helps: This helps patients and doctors by improving treatment strategies for infections.
β-Actin as an Endogenous Control Gene in Real-Time PCR for Detection of West Nile and Usutu Virus in Mosquitoes.
2025
Microorganisms
Lai J, Tessarolo C, Ercole E, Gallo M, Lo Faro M +15 more
Plain English This study focused on improving the way scientists detect mosquito-borne viruses, specifically West Nile virus (WNV) and Usutu virus (USUV), using a specific testing method called Real-Time PCR. Researchers tested over 1,000 samples of mosquitoes in Italy and found that this new detection method was 100% accurate, identifying six pools infected with either virus. This is important because it helps monitor and respond quickly to potential outbreaks of these diseases, especially as climate change affects mosquito populations.
Who this helps: Patients at risk of infection and public health officials tracking mosquito-borne diseases.
Space-time distribution of classical scrapie in Italian sheep: assessing the effectiveness of the National Genetic Selection Plan.
2025
Veterinary research
Desiato R, Ingravalle F, Bertolini S, Aiassa E, Barzanti P +3 more
Plain English The study looked at the spread of scrapie, a brain disease in sheep, across Italy and evaluated how effective the National Genetic Selection Plan (NGSP) has been in controlling it. Researchers found that scrapie cases initially increased from 2005 to 2015 but then dropped significantly from 2016 to 2022. Specifically, the prevalence ratio decreased to 0.88, while the number of susceptible rams also fell steadily over the same timeframe, indicating that the NGSP is successfully reducing the disease in sheep populations.
Who this helps: This benefits sheep farmers and veterinary professionals working to control scrapie in their flocks.
Evaluating the accuracy, reliability, and agreement of the İşcan and Hartnett age estimation methods on a contemporary European skeletal sample of fourth ribs.
2025
Forensic sciences research
Marella GL, Ceccobelli G, Reitano C, Tavone AM, Vella R +6 more
Plain English This study looked at two methods for estimating the age of adults by analyzing their fourth ribs in a sample of 127 rib pairs from European individuals. The İşcan method was more accurate, correctly estimating age 62% of the time, while the Hartnett method only succeeded 38% of the time. These findings emphasize the need for proper training for those using these methods and highlight the importance of standardizing techniques to improve accuracy in forensic investigations.
Who this helps: This helps forensic scientists and investigators who rely on accurate age estimations in their work.
Inflammatory Bowel Disease in the Post-STRIDE II Era: Epidemiology and Long-Term Clinical Outcomes from a Population-Based Study.
2025
Medical sciences (Basel, Switzerland)
Ingravalle F, Valvano M, Barbara A, Bardhi D, Latella G +7 more
Plain English This study looked at how inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, has changed since the introduction of new treatment strategies. Researchers found that in 2021, about 218 out of every 100,000 people had IBD, with surgery needed for 36% of Crohn's patients and 20% of ulcerative colitis patients within six years of diagnosis. Although more treatments are available, hospitalization rates have remained steady at around 16.5%, indicating that current management techniques have had a limited impact on altering the disease's course.
Who this helps: This helps patients with inflammatory bowel disease and their doctors.
The Relationship Between Nutritional Status, Micronutrient Deficiency, and Disease Activity in IBD Patients: A Multicenter Cross-Sectional Study.
2025
Nutrients
Valvano M, Faenza S, Cortellini F, Vinci A, Ingravalle F +6 more
Plain English This study looked at how nutritional status, particularly micronutrient levels, relates to disease activity in patients with inflammatory bowel diseases (IBD). Researchers found that levels of hemoglobin, iron, ferritin, and vitamin D varied significantly between patients with active and inactive disease, with specific numbers indicating that iron and vitamin D were particularly useful for assessing disease activity. The findings matter because they suggest that monitoring these nutrients could help manage IBD, although their effectiveness in clearly distinguishing between active and inactive disease is not perfect.
Who this helps: This research benefits patients with IBD and their doctors by highlighting important nutritional factors to monitor for better disease management.
Bone mineral density and body mass composition measurements in premenopausal anorexic patients: the impact of lean body mass.
2024
Journal of bone and mineral metabolism
Villa P, Cipolla C, Amar I, Sodero G, Pane LC +3 more
Plain English This study looked at bone density and body composition in young women with anorexia, comparing them to healthy peers. Researchers found that a high percentage of anorexic patients had low bone density, with 20% showing signs of osteoporosis in their lower back and 18% in their hip. The study highlighted that lower muscle mass is linked to weaker bones, emphasizing the importance of addressing muscle health in anorexic patients.
Who this helps: This research benefits patients with anorexia, healthcare providers, and those involved in treatment planning for eating disorders.
Burden of delayed discharge on acute hospital medical wards: A retrospective ecological study in Rome, Italy.
2024
PloS one
Vinci A, Furia G, Cammalleri V, Colamesta V, Chierchini P +10 more
Plain English This study looked at how delays in discharging patients from Santo Spirito Hospital in Rome affected the hospital's efficiency and costs. Researchers found that 16% of the 1,222 patients admitted had prolonged stays, with an average delay of 6.3 days. These delays create overcrowding in emergency departments, increase costs, and indicate that the reasons for holding patients are often linked to organizational and social issues rather than their medical conditions.
Who this helps: This helps hospitals and healthcare planners improve patient flow and resource management.
Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1pigs.
2024
Experimental neurology
Golia MT, Frigerio R, Pucci S, Sironi F, Margotta C +18 more
Plain English This study looked at how certain brain cells called glial cells operate in specially bred pigs that have a gene linked to ALS, a disease that causes nerve cell degeneration. The researchers found that changes in these glial cells happened before the pigs showed any symptoms of the disease, specifically noting an early increase in activity in oligodendrocytes and more later in astrocytes and microglia. This matters because it highlights potential early warning signs of ALS that could lead to better diagnosis and treatment options.
Who this helps: This helps patients with ALS and researchers looking for early detection methods.
Performance Evaluation of a Commercial Real-Time PCR Method for the Detection of Lupin Traces in Food.
2024
Foods (Basel, Switzerland)
Tramuta C, Decastelli L, Ingravalle F, Barcucci E, Fragassi S +1 more
Plain English This study tested a lab method to find small amounts of lupin, a type of legume that can cause allergies, in various foods like cookies and salads. The researchers found that the method was effective, able to detect lupin at very low levels of 0.5 parts per million. This is important because it helps ensure food safety for people allergic to lupin by allowing for accurate labeling and monitoring of foods.
Who this helps: This benefits patients with lupin allergies.
Is there any relationship between scoliosis, cervical pain and postural imbalance in Parkinson's disease? A cross-sectional pilot study.
2024
European journal of translational myology
Ronconi G, Gatto DM, Ariani M, Codazza S, Ingravalle F +3 more
Plain English This study looked at the connection between scoliosis (curvature of the spine), neck pain, and balance issues in people with Parkinson's disease. Out of 16 patients, 50% with scoliosis reported neck pain, compared to 37% without scoliosis. Additionally, neck pain was notably more common in those who had Parkinson's for less than 48 months, affecting 75% of them.
Who this helps: This research benefits patients with Parkinson's disease, particularly those experiencing neck pain and balance problems.
Moral Distress and Its Determinants among Nursing Students in an Italian University: A Cross-Sectional Study.
2024
Nursing reports (Pavia, Italy)
Bulfone G, Bressan V, Zerilli I, Vinci A, Mazzotta R +2 more
Plain English This study examined moral distress (MD) among nursing students at an Italian university, focusing on how different factors like career choice and personal circumstances affect their experiences. The research found that students who chose nursing as their first career, had children, and were employed reported lower levels of moral distress, while those who were separated or divorced experienced higher levels. This is important because moral distress can negatively impact students’ well-being and their future practice as nurses, highlighting the need for better training in ethics and stress management in nursing education.
Who this helps: Patients and nursing students.
Approaches for Selective Vaccinations in Cirrhotic Patients.
2023
Vaccines
Casella G, Ingravalle F, Ingravalle A, Andreotti S, Bonetti F +3 more
Plain English Researchers studied how selective vaccinations can help patients with cirrhosis, a serious liver disease that makes people more vulnerable to infections. They found that patients with advanced cirrhosis are 3.75 times more likely to die from bacterial infections, with a 30% chance of dying within a month and 63% within a year after an infection. This is important because effective vaccinations may reduce these risks and improve patient outcomes.
Who this helps: This helps cirrhotic patients and their doctors.
Validation of p53 Immunohistochemistry (PAb240 Clone) in Canine Tumors with Next-Generation Sequencing (NGS) Analysis.
2023
Animals : an open access journal from MDPI
Brunetti B, de Biase D, Dellapina G, Muscatello LV, Ingravalle F +2 more
Plain English This study looked at a method called p53 immunohistochemistry (IHC) to find mutations in tumors from dogs. Researchers tested 176 tumors, and when they did deeper genetic testing (NGS) on 41 of them, they found that the IHC test correctly identified mutations in 60% of cases. However, it also had a 25% margin of error in its predictions, meaning it wasn't always accurate.
Who this helps: This research is beneficial for veterinarians and dog owners dealing with tumor diagnoses.
Unemployment Status Subsequent to Cancer Diagnosis and Therapies: A Systematic Review and Meta-Analysis.
2023
Cancers
Chimienti M, Morlino G, Ingravalle F, Vinci A, Colarusso E +11 more
Plain English This study looked at how a cancer diagnosis and its treatments affect people's jobs. Researchers found that patients with cancer are over 7 times more likely to lose their jobs or have changes in their employment status after treatment. Factors such as older age, being overweight, and lower education levels increase the risk of unemployment for these individuals, especially for those receiving chemotherapy or radiation, and those with brain or colorectal cancers.
Who this helps: This helps cancer patients and their families, as well as healthcare providers and employers.
Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle.
2023
Animals : an open access journal from MDPI
Favole A, Testori C, Bergagna S, Gennero MS, Ingravalle F +23 more
Plain English This study looked at the health of dairy cows by measuring certain biological markers in cows raised in three different farming conditions: one that allowed more space (semi-intensive free-stall), one with less space (non-intensive tie-stall), and one that is highly intensive (intensive free-stall). Researchers found that cows in tie-stall conditions showed significant changes in their blood chemistry and brain markers, suggesting they may experience more stress or discomfort. Specifically, tie-stall cows had higher levels of a precursor protein linked to depression compared to those in free-housing systems, which could indicate poorer mental health.
Who this helps: This research helps farmers and veterinarians improve cow welfare on dairy farms.
Improving clinical diagnostic accuracy and management of False penile fractures characterizing typical clinical presentation: a systematic review and meta-analysis.
2023
World journal of urology
Agostini E, Vinci A, Bardhi D, Ingravalle F, Muselli M +1 more
Plain English The study examined false penile fractures (FPF), which can look like true fractures but do not involve serious damage. Researchers identified key symptoms, such as the absence of a "snap" sound, slow loss of an erection, and penile bending, which help distinguish FPF from true fractures. They found that when one of these symptoms is present, doctors can diagnose FPF with about 86% accuracy, and using multiple symptoms together can boost accuracy to nearly 100%, improving how surgeons decide on treatment options.
Who this helps: This helps patients dealing with penile trauma and their doctors by reducing unnecessary surgeries.
Celiac disease: experience of general practitioners in Brianza Area- Monza- Milan-Italy.
2023
Gastroenterology and hepatology from bed to bench
Casella G, Bardella MT, Ingravalle F, Ingravalle A, Andreotti S +4 more
Plain English This study looked at how well general practitioners in the Monza-Brianza and Milan areas of Italy understand and diagnose celiac disease, a common condition that often goes undetected due to unusual symptoms. The research found that while doctors’ knowledge was similar to that in other countries, it was still not enough to ensure that all patients could get diagnosed early; 84.7% of doctors agreed that ongoing training is essential to improve their understanding. Younger doctors, specifically those under 40, were much more enthusiastic about further training.
Who this helps: This benefits patients with celiac disease by potentially leading to earlier diagnosis and better treatment.
The long-term effect on surgery-free survival of biological compared to conventional therapy in Crohn's disease in real world-data: a retrospective study.
2023
BMC gastroenterology
Valvano M, Vinci A, Cesaro N, Frassino S, Ingravalle F +4 more
Plain English This study looked at how biological therapies compared to traditional treatments affect the time patients with Crohn's disease can avoid having surgery. It found that while patients on biological treatments experienced longer periods without surgery initially, after adjusting for other factors, there was no significant long-term difference in surgery-free survival between the two groups. The findings suggest that biological therapies might delay surgery but don’t greatly change the overall chances of needing it in the long run.
Who this helps: This benefits patients with Crohn's disease and their doctors in choosing effective treatment options.
Processed animal proteins (PAPs) in animal nutrition: Assessment of the chemical risk of essential and non-essential elements.
2022
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Pederiva S, Crescio MI, Ingravalle F, Abete MC, Marchis D +1 more
Plain English This study examined processed animal proteins (PAPs) to see if they can be a safe and nutritious alternative to regular protein supplements for animal feed. Researchers looked at 55 samples and found that they contained useful essential elements like iron, zinc, and copper in significant amounts, while only one sample exceeded safe levels for lead. This is important because it shows that PAPs could provide necessary nutrients for animals while helping to recycle by-products, but careful checks on their safety are needed.
Who this helps: This benefits farmers and the livestock industry by providing safer and more sustainable feed options.
Detection of Peanut Traces in Food by an Official Food Safety Laboratory.
2022
Foods (Basel, Switzerland)
Tramuta C, Decastelli L, Barcucci E, Ingravalle F, Fragassi S +2 more
Plain English The study focused on a new testing method to find tiny amounts of peanut in various food products, which is crucial for those with peanut allergies. The researchers discovered they could reliably detect peanut traces as low as 0.5 parts per million in most food types tested, ensuring a high level of accuracy and no interference from other common allergens. This matters because it helps food safety labs guarantee that foods are safe for people with peanut allergies.
Who this helps: Patients with peanut allergies.
Validation of serum paraoxonase/arylesterase 1 (PON1) as a protein marker of illicit dexamethasone treatment in veal calves.
2022
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
Guglielmetti C, Brusadore S, Pezzolato M, Baioni E, Ingravalle F +3 more
Plain English This study focused on finding a reliable way to detect illegal use of the drug dexamethasone in veal calves. Researchers confirmed that a specific protein marker called PON1 disappears in the blood of calves treated with dexamethasone, suggesting its potential as a reliable indicator of illicit treatment. PON1 can help identify farms where illegal drug use occurs, especially within 3 to 10 days after treatment, which is crucial for ensuring food safety and animal welfare.
Who this helps: This helps farmers, regulators, and consumers by identifying illegal practices in livestock production.
Discrimination between Wild and Farmed Sea Bass by Using New Spectrometry and Spectroscopy Methods.
2022
Foods (Basel, Switzerland)
Esposito G, Sciuto S, Guglielmetti C, Pastorino P, Ingravalle F +3 more
Plain English This study focused on finding reliable ways to tell apart wild sea bass from farmed sea bass, which is important for preventing misleading labeling in the market. Researchers used two techniques: mass spectrometry and Near-Infrared spectroscopy, finding that they could accurately distinguish between the two types of fish based on certain fatty acid ratios, achieving perfect sensitivity and specificity of 100%. This is important because it helps ensure that consumers are getting what they pay for and can help combat food fraud.
Who this helps: This benefits consumers and regulatory bodies monitoring food labeling.
Cannabinoid Therapeutic Effects in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
2022
Biomedicines
Vinci A, Ingravalle F, Bardhi D, Cesaro N, Frassino S +2 more
Plain English This study looked at the effects of adding cannabinoids to the treatment of Inflammatory Bowel Disease (IBD) to see if they could help patients better respond to standard therapies. The researchers analyzed data from six studies involving 208 patients and found that those treated with cannabinoids experienced a greater improvement in their symptoms compared to those who received a placebo, with a reduction in disease activity score (CDAI) by an average of about 36.6 points. However, cannabinoids were not recommended for Ulcerative Colitis, and it seemed that lower doses might be more effective for Crohn's Disease during the initial treatment phase.
Who this helps: This helps patients with Crohn's Disease looking for additional treatment options.
Using network analysis to identify seasonal patterns and key nodes for risk-based surveillance of pig diseases in Italy.
2021
Transboundary and emerging diseases
Crescio MI, Mastrantonio G, Bertolini S, Maurella C, Adkin A +6 more
Plain English This study looked at how pigs move between farms in Italy from 2013 to 2016, helping to understand the spread of diseases among pigs. Researchers found that most pig movements happen in spring and autumn and that a small number of farms, just 0.47% of all pig holdings, can spread diseases more quickly. The study highlights the importance of focusing disease surveillance efforts during these peak movement times and identifying these "super-spreader" farms to better control outbreaks.
Who this helps: This helps farmers and veterinarians monitor and prevent the spread of pig diseases effectively.
General practitioners' management of symptomatic uncomplicated diverticular disease of the colon by using rifaximin, a non-adsorbable antibiotic.
2021
European review for medical and pharmacological sciences
De Bastiani R, Sanna G, Bertolusso L, Casella G, De Polo M +22 more
Plain English This study looked at how general practitioners (GPs) can manage a condition called symptomatic uncomplicated diverticular disease (SUDD) using a specific antibiotic called rifaximin. Out of 286 patients treated, almost half (135 patients or 47.2%) reported they had no abdominal pain after three months, and very few experienced any serious side effects. This is important because it shows that GPs can effectively use rifaximin to help many patients with SUDD manage their symptoms without needing to see a specialist.
Who this helps: This benefits patients with SUDD who can receive effective treatment from their primary care doctors.
Local ultra-low-dose estriol gel treatment of vulvo-vaginal atrophy: efficacy and safety of long-term treatment.
2020
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Villa P, Tagliaferri V, Amar ID, Cipolla C, Ingravalle F +3 more
Plain English This study focused on treating vulvo-vaginal atrophy (VVA), a condition that affects many women after menopause, using a low-dose estriol gel. Out of 99 women who finished the treatment, 43% reported complete relief from symptoms, and 65% experienced milder symptoms after 30 weeks of using the gel. The treatment significantly improved symptoms without causing any serious side effects, making it a safe option for long-term relief from VVA.
Who this helps: This helps postmenopausal women suffering from vulvo-vaginal atrophy.
Real-time PCR assay for detecting illicit steroid administration in veal calves allows reliable biomarker profiling of formalin-fixed, paraffin-embedded (FFPE) archival tissue samples.
2020
Food chemistry
Benedetto A, Pezzolato M, Beltramo C, Audino V, Ingravalle F +4 more
Plain English This study examined a new method for detecting illegal steroid use in veal calves by analyzing preserved tissue samples. Researchers found that measuring progesterone receptor levels in the tissue effectively indicated steroid administration, showing it to be a reliable technique compared to traditional methods. This is important because it provides a way to ensure food safety and animal welfare in the meat industry.
Who this helps: This benefits regulators, veterinarians, and consumers concerned about food safety.
Wild rats as urban detectives for latent sources of asbestos contamination.
2020
The Science of the total environment
Ingravalle F, Ceballos LA, D'Errico V, Mirabelli D, Capella S +11 more
Plain English This study investigated the presence of asbestos in urban areas by using wild rats as indicators of contamination in Casale Monferrato, Italy, a city with a history of asbestos manufacturing. Researchers found asbestos fibers in the lungs of rats from 11 out of 16 sampling sites, indicating potential hazards for non-workers in those areas. These findings are important because they highlight locations where further investigation and cleanup are needed to protect public health.
Who this helps: This benefits residents living in contaminated areas and health officials working to ensure safer environments.
COVID emergency: an opportunity to increase the interaction between hepatologist and primary care physician.
2020
Minerva gastroenterologica e dietologica
Casella G, Ingravalle F, Ingravalle A, Monti C, Bonetti F +1 more
Plain English This study looked at how the COVID-19 pandemic created a chance for primary care doctors and liver specialists (hepatologists) to work more closely together. It found that using telemedicine, or remote healthcare, helped treat liver disease patients safely while reducing the risk of infection, especially for vulnerable groups like the elderly and those with weakened immune systems. This collaboration is important because it allows patients to get necessary care without having to travel, which can be risky during a pandemic.
Who this helps: Patients with liver diseases and other high-risk individuals.
Evaluation of the effects of hydroxyethyl starch (130/0.4) administration as a constant rate infusion on plasma colloid osmotic pressure in hypoabluminemic dogs.
2020
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Borrelli A, Maurella C, Lippi I, Ingravalle F, Botto A +2 more
Plain English This study looked at how a substance called hydroxyethyl starch (HES) affected blood pressure in dogs with low levels of albumin, a protein important for keeping blood within the vessels. The researchers infused 24 dogs with HES at two different rates: 1 mL/kg/h for 15 dogs and 2 mL/kg/h for 9 dogs. They found that neither infusion significantly changed blood pressure, although some individual dogs responded differently, and there were notable changes in other blood measurements.
Who this helps: This research benefits veterinarians treating dogs with low albumin levels.
The interplay between immune system and microbiota in gynecological diseases: a narrative review.
2020
European review for medical and pharmacological sciences
Villa P, Cipolla C, D'Ippolito S, Amar ID, Shachor M +5 more
Plain English This research looks at how the balance of bacteria in the vagina and the immune system affects gynecological health. It found that a healthy balance, dominated by Lactobacillus bacteria, is crucial, but factors like menopause can disrupt this, leading to issues like bacterial vaginosis, preterm labor, and miscarriage. For example, a decrease in Lactobacilli is linked to higher chances of preterm labor and issues with the immune response are associated with miscarriages.
Who this helps: This benefits women facing gynecological issues, including those dealing with menopause, pregnancy complications, or infections.
Serum indirect immunofluorescence assay and real-time PCR results in dogs affected by Leishmania infantum: evaluation before and after treatment at different clinical stages.
2019
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Bruno B, Romano A, Zanatta R, Spina S, Mignone W +4 more
Plain English This study looked at how two tests – one measuring antibodies in the blood and another measuring parasites in the body – differed in dogs affected by leishmaniasis at various stages of the disease. They found that sick dogs had higher antibody levels and parasite counts compared to those that were just infected or exposed, and the health of the dogs improved significantly after treatment, with 41 dogs showing partial recovery and 37 fully recovering within a few months. These results highlight the importance of monitoring both antibody levels and parasite loads in understanding a dog's health status and recovery progress after treatment.
Who this helps: This helps veterinarians and dog owners by providing better ways to monitor and treat dogs with leishmaniasis.
GR CALUX assay detects synthetic glucocorticoids in calf urine: a validation study.
2019
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
Pitardi D, Meloni D, Olivo F, Loprevite D, Cavarretta MC +8 more
Plain English This study focused on a test that detects synthetic drugs, specifically glucocorticoids, in the urine of calves. Researchers validated this test using common drugs at low concentrations and found it reliable, able to detect levels as low as 2 nanograms per milliliter for some substances. This is important because it helps ensure that farmers are not misusing growth-promoting drugs, which can affect food safety and animal health.
Who this helps: This benefits regulators, farmers, and ultimately consumers by promoting safer food sources.
Casella G, Ingravalle F, Abbate G, Monti C, Bonetti F +4 more
Plain English This study looked at how celiac disease (CD) affects patients' risk of severe illness from a bacterial infection called pneumococcal disease. Researchers found that people with CD are at higher risk for this infection because their immune response may be weakened, especially if their spleen isn’t functioning well. Vaccinating these patients can significantly reduce their risk of serious illness from pneumococcal bacteria, but it’s not yet clear how to best select which patients should receive the vaccine based on their spleen health.
Who this helps: This helps patients with celiac disease and their doctors.
Villa P, Amar ID, Shachor M, Cipolla C, Ingravalle F +1 more
Plain English This study looked at how menopausal hormone therapy (MHT) affects heart health in women, especially focusing on when they start the treatment. It found that women under 60, or within ten years of menopause, who use MHT can actually reduce their risk of heart disease and overall death. For example, using low doses of oral estrogen or applying hormones through the skin lowers the risk of dangerous blood clots compared to traditional methods.
Who this helps: This helps women going through menopause and their doctors in making informed treatment decisions.
Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep.
2019
PloS one
Zetterberg H, Bozzetta E, Favole A, Corona C, Cavarretta MC +4 more
Plain English This study looked at the levels of a protein called neurofilament light (NfL) in the blood of sheep to find a way to identify a deadly brain disease called scrapie. Researchers found that scrapie-infected sheep had NfL levels that were over 15 times higher than healthy sheep, with a specific average of 56.2 pg/ml compared to 3.4 pg/ml in controls. This discovery may help develop a reliable blood test to screen sheep for scrapie early on, potentially protecting flocks from this contagious disease.
Who this helps: This helps farmers and veterinarians prevent the spread of scrapie in sheep populations.
Characterization of Sarcopenia in an IBD Population Attending an Italian Gastroenterology Tertiary Center.
2019
Nutrients
Pizzoferrato M, de Sire R, Ingravalle F, Mentella MC, Petito V +14 more
Plain English This study looked at the loss of muscle mass, known as sarcopenia, in patients with inflammatory bowel disease (IBD) at a hospital in Italy. It found that about one third of these patients had sarcopenia, with significant reductions in muscle mass and lower quality of life compared to healthy individuals. This matters because it highlights the need for doctors to regularly check muscle health in IBD patients to improve their overall well-being.
Who this helps: This helps patients with IBD and their healthcare providers.
A cross-sectional study to identify a set of risk factors for caprine herpesvirus 1 infection.
2018
BMC veterinary research
Bertolini S, Rosamilia A, Caruso C, Maurella C, Ingravalle F +5 more
Plain English This study looked at factors that increase the risk of goats getting an infection from caprine herpesvirus 1 (CpHV-1), which can lead to deaths in newborn goats and reproductive issues. Researchers tested blood samples from 4,542 goats across 255 farms in Italy and found that 13.9% of the goats were infected. Certain factors, like the age of the goats, the size of the herds, and the presence of certain breeds or additional infections, were associated with a higher risk of infection.
Who this helps: This helps goat farmers and veterinarians manage and prevent CpHV-1 infections in their herds.
Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases.
2018
Minerva gastroenterologica e dietologica
de Sire R, Rizzatti G, Ingravalle F, Pizzoferrato M, Petito V +7 more
Plain English This study looked at how the gut and muscles are connected, especially in conditions like sarcopenia (muscle loss) and cachexia (severe weight loss and muscle wasting). Researchers identified key pathways that link gut health to muscle function, including specific signaling systems that can be disrupted in diseases such as cancer and chronic lung disease. Understanding these connections can lead to new therapies that might improve muscle health and quality of life for affected individuals.
Who this helps: Patients suffering from muscle-wasting conditions and their healthcare providers.