Hanjie Ying

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This study focused on improving the production of 3-fucosyllactose (3-FL), a valuable sugar found in human milk, using E. coli bacteria. Researchers tested nine different genes related to biofilm formation and found that a specific gene called pslA significantly enhanced the bacteria’s ability to form biofilms and increase 3-FL output by 38.4%. This is important because it establishes a more efficient way to produce a substance increasingly in demand for infant nutrition and other health products. Who this helps: This helps patients, especially infants who benefit from breast milk components, as well as companies producing infant formulas.

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This study looked at how effective a new testing method called metagenomic next-generation sequencing (mNGS) is for diagnosing septic arthritis compared to traditional cultures in 82 patients. The researchers found that mNGS identified pathogens in 65.9% of cases, while cultures only detected them in 33.3%. This method was particularly helpful for patients with low white blood cell counts, where it found pathogens in 50% of those cases compared to just 23.7% with culture. Who this helps: This benefits patients with suspected septic arthritis, especially those who have negative culture results or low white blood cell counts.

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This study focused on a protein called KDM4C, which is found in high levels in pancreatic cancer cells. Researchers found that removing KDM4C from these cells decreased their growth and increased the survival of cancer in mice, specifically showing that KDM4C helps keep a harmful signaling pathway active (ERK signaling) in these cancer cells. Targeting KDM4C with a drug showed promise in stopping cancer growth, highlighting it as a potential new treatment approach for pancreatic cancer. Who this helps: This helps patients with pancreatic cancer, especially those with KRAS mutations.

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This research examines how certain bacteria break down glucose using specific enzymes that convert it into products like gluconic acid, which can then be turned into other valuable substances. The study highlights methods to improve this process for producing items like vitamin C and tartaric acid more efficiently. This is important because it shows how we can make useful compounds sustainably from sugar. Who this helps: This benefits manufacturers looking for eco-friendly ways to produce chemicals and nutrients.

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This study looked at how a protein called SHP2 affects heart changes during heart failure, specifically focusing on its relationship with another protein, AMPK, which is important for mitochondrial function. Researchers found that when SHP2 was blocked, it helped restore AMPK's function, leading to improved heart structure and function. Their results showed that inhibiting SHP2 reduced heart enlargement and damage caused by stress hormones, making it a potential new target for treating heart failure. Who this helps: This helps patients with heart failure by offering new treatment options.

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This study looked at a protein called CCT3, which is found in higher amounts in lung cancer patients. Researchers discovered that CCT3 helps lung cancer cells grow and spread by activating certain pathways in the body. In tests with 714 people, higher levels of CCT3 in the blood were able to effectively identify lung cancer cases, with a diagnostic accuracy of 87.3%. Who this helps: This research benefits lung cancer patients and doctors by providing a potential new way to diagnose the disease early and target treatment.

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This study looked at how inflammation in cancer affects the effectiveness of a treatment called bevacizumab (Bev) for patients with advanced colorectal cancer. It found that patients with a high fibrinogen-to-prealbumin ratio (FPR-H) had worse outcomes, including a 2.18 times lower chance of controlling their disease and a 2.86 times higher risk of dying within a year compared to those with a low ratio (FPR-L). Understanding the FPR can help doctors tailor treatments and track disease progression better. Who this helps: This helps patients with metastatic colorectal cancer and their doctors.

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This study looked at how hypothyroidism affects the risk of a liver condition during pregnancy called intrahepatic cholestasis of pregnancy (ICP). Researchers analyzed data from over 42,000 pregnant women and found that those with clinical hypothyroidism had more than three times the risk of developing ICP compared to women with normal thyroid function. Additionally, women with a specific type of hypothyroidism (identified by thyroid peroxidase antibodies) faced an even higher risk, and the risk increased with lower thyroid hormone levels and higher thyroid-stimulating hormone levels. Who this helps: This information is crucial for pregnant women with hypothyroidism and their doctors, enabling better monitoring and care during pregnancy.

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This research focused on improving the treatment of bone defects by using advanced materials to deliver nitric oxide (NO), which helps bones heal better. The study found that new polymer-based nanoparticles can control how and when NO is released, which is important because delivering NO effectively can enhance bone repair and reduce infection risks after surgery. For example, these new methods improve how NO interacts with bone tissue while avoiding harmful side effects seen with high concentrations. Who this helps: This benefits patients with bone injuries or conditions needing surgical repair.

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This study focused on creating a new type of adhesive using lignin, a natural substance from plants, in place of harmful chemicals commonly found in traditional adhesives. The researchers developed an improved lignin-based adhesive that is 23 times tougher, over 6 times stronger in bonding, and more than 5 times better at staying strong when wet compared to regular lignin adhesives. This is important because it offers a safe and effective alternative for the wood industry, helping to reduce reliance on harmful materials and promoting sustainability. Who this helps: This benefits manufacturers in the wood industry and the environment by providing safer, high-performing adhesives.

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This study focused on improving the way long-acting injectable microspheres are made, especially for drugs that don't dissolve well in water. Researchers developed a new manufacturing process that quickly removes solvents, leading to microspheres that can hold more drug and have consistent quality. They found that this method allows for accurate predictions of how the drug will behave in the body, with a reliability rate of 98.89%, meeting strict industry standards for accuracy. Who this helps: This benefits patients who rely on injectable medications, as it can lead to more effective and reliable treatments.

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This research paper looks at methods for extracting valuable compounds from the Ganoderma lucidum mushroom, which are in demand for health products. It analyzes different techniques for separating these compounds and finds that new methods like high-speed counter-current chromatography can improve purity while being more cost-effective and environmentally friendly. This matters because it helps ensure that high-quality mushroom extracts can be produced efficiently, meeting growing market needs. Who this helps: This benefits manufacturers of health supplements and their customers seeking high-quality products.

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This study focused on a new method for predicting survival in patients with liver cancer, specifically hepatocellular carcinoma (HCC), by looking at the expression of a protein called AKR1B10. Researchers found that high levels of AKR1B10 were linked to worse survival rates, with a risk increase of over two times (HR = 2.187), and developed a radiomics model that accurately predicted the presence of this protein with an accuracy score of 0.83. This new approach helps connect medical imaging results to important biological factors, improving how doctors can assess risks and outcomes before surgery. Who this helps: Patients with hepatocellular carcinoma and their doctors.

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This study looked at how aging affects muscle stem cells, which are crucial for muscle repair and growth. Researchers found that a protein called MRG15 decreases in older or injured muscle stem cells, making it harder for these cells to grow and repair muscle tissue. Specifically, when MRG15 was removed in mice, muscle regeneration suffered significantly, showing a direct link between MRG15 and the ability of muscles to recover after injury. Who this helps: This research benefits patients and doctors dealing with age-related muscle loss and injuries.

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Researchers studied a new type of communication system for satellites that can withstand radiation from space. They found that a system made from very thin materials successfully operated in low Earth orbit for nine months with fewer than one error in every billion bits transmitted, showing it is highly resistant to radiation damage. This is important because it means satellites can communicate reliably without failing from exposure to harsh space conditions for an estimated 271 years. Who this helps: This benefits satellite manufacturers and space agencies.

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This study looked at how a fatty acid called palmitic acid affects a protein known as SRPK1, which plays a role in cell function and stability. The researchers found that palmitic acid leads to the breakdown of SRPK1, which then influences the activity of another important protein, p53, helping to prevent cell death in the context of high fat levels. They also discovered that a compound called 4'-O-Methylochnaflavone can stabilize SRPK1 and reduce cell death caused by palmitic acid. Who this helps: This research can benefit patients suffering from erectile dysfunction related to high-fat diets.

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This paper looks at how hyperthermia, a treatment that heats up tumor cells to kill them, can improve the results of radiotherapy and chemotherapy in treating tumors. It found that combining hyperthermia with radiotherapy leads to better treatment outcomes by damaging tumor cells more effectively and helping to overcome issues like low oxygen levels in tumors. Overall, studies show that this combination method can significantly enhance the effectiveness of cancer treatments. Who this helps: This approach benefits cancer patients undergoing radiotherapy.

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This study looked at a new drug called A5S, which targets a specific pathway involved in inflammation related to diabetes, to see if it could help prevent damage to the kidneys and heart. Researchers found that A5S significantly improved kidney function and reduced heart and kidney tissue damage in diabetic mice over eight weeks. This is important because it shows that A5S can block harmful inflammatory responses, suggesting that it might be a promising treatment option for diabetic patients at risk of heart and kidney problems. Who this helps: Patients with diabetes who suffer from heart and kidney complications.

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This study looked at how a lack of a protein called connexin43 (Cx43) affects heart rhythms. Researchers found that without Cx43, there were lower levels of an amino acid called proline, leading to serious heart rhythm problems in mice. They discovered that giving extra proline to these mice helped fix their heart rhythm issues, showing that changing proline levels could be a new way to treat these dangerous heart conditions. Who this helps: This benefits patients with heart rhythm disorders and doctors looking for new treatment options.

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Researchers studied how tiny silicon particles can help rice plants cope with difficult growing conditions like drought and high salt levels. They found that these silicon particles enhance the plants’ ability to handle stress, improve vital functions such as photosynthesis, and protect against damage from toxic metals. Specifically, the silicon treatment boosted the plants' antioxidant defenses and overall resilience, offering a promising way to make rice farming more sustainable given the global demand for this staple food. Who this helps: This benefits rice farmers and ultimately, consumers who rely on rice as a key food source.

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Researchers studied how adding halogen elements like chlorine, bromine, or iodine to metal sulfide materials can improve their stability and effectiveness in chemical reactions. They found that this treatment helped a particular metal sulfide (CdS) remain stable and function effectively, allowing it to achieve a remarkable 90% yield in activating methanol, significantly better than untreated CdS, which barely worked. This finding is important because it enhances the potential for using these materials in creating valuable chemicals efficiently and sustainably. Who this helps: This benefits researchers and industries involved in chemical manufacturing and renewable energy.

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This study examined how certain inflammatory markers could help predict which patients with advanced colorectal cancer would benefit most from a specific chemotherapy treatment that includes bevacizumab. Researchers looked at data from 364 patients and found that a particular marker, called FPSIR, was strongly linked to how well patients responded to the treatment and their survival rates. Specifically, higher FPSIR scores indicated a worse chance of survival, with those in the highest group being over twice as likely to have poor outcomes. Who this helps: This research benefits patients with metastatic colorectal cancer and their doctors by improving treatment decisions.

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This study looked at a Virtual Reality (VR) therapy program designed to help Cantonese-speaking adults in Hong Kong who are dealing with mild to moderate depression and anxiety. They found that participants experienced significant improvements in their mental health, such as reduced depression and increased self-compassion, especially in one VR scenario called "Crying Girl." The research highlights that this VR therapy can be effective and culturally relevant, but it also identified some technical challenges that need to be addressed for better accessibility. Who this helps: This benefits patients experiencing depression and anxiety, especially in Hong Kong.

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This study explored how certain carbon molecules form in the environment around stars, specifically looking at carbon chains that are important for creating more complex molecules in space. Researchers found that long carbon chain molecules, or polyynes, are produced through quick reactions between simple molecules and more complex hydrocarbons. They demonstrated this process in the lab, which helps explain how these molecules form in space and sheds light on the chemistry occurring around stars. Who this helps: This benefits astronomers and scientists studying interstellar chemistry.

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This study looked at 1,828 women who were pregnant with twins to see if their iron levels, measured by ferritin in the first trimester, affected their risk of developing gestational diabetes (GDM). They found that 19.25% of these women developed GDM, and those with higher ferritin levels were nearly twice as likely to have GDM compared to those with the lowest levels. This is significant because understanding the risk factors for GDM in twin pregnancies can help in managing the health of both mothers and babies. Who this helps: This research benefits pregnant women carrying twins and their healthcare providers.

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This study focused on a new treatment using an antibody that targets a protein called Syndecan-1 in pancreatic cancer, which is a very deadly disease with only a 13% five-year survival rate. The researchers found that this antibody not only stopped cancer cells from growing in the lab but also significantly reduced tumor growth in animal models when combined with standard treatments. This matters because it could improve outcomes for patients with pancreatic cancer and similar tumors that are difficult to treat. Who this helps: Patients with pancreatic cancer and other related cancers.

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This study looked at how Simvastatin, a medication commonly used to lower cholesterol, affects liver fibrosis, which is the thickening and scarring of liver tissue. The researchers found that Simvastatin helped reduce harmful processes in liver cells, specifically by blocking two metabolic pathways that contribute to liver damage, leading to a decrease in cell activity associated with fibrosis. This is important because it shows a new way that Simvastatin may help protect the liver and could guide future treatments for liver diseases. Who this helps: Patients with liver fibrosis.

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This study looked at whether combining certain targeted therapies with chemotherapy could improve outcomes for patients with a tough type of ovarian cancer that doesn't respond well to standard treatments. The research analyzed 22 clinical trials with over 3,400 patients and found that adding drugs like bevacizumab, sorafenib, or adavosertib to chemotherapy significantly increased survival and the time patients lived without the disease getting worse. Bevacizumab together with paclitaxel was highlighted as the best option, offering a good mix of effectiveness and manageable side effects. Who this helps: This research benefits ovarian cancer patients who have limited treatment options.

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This study examined a rare condition called MASTUMP, which involves multiple ureteral fibroepithelial polyps, narrowed ureters, and complex ureter shapes in nine patients. The researchers discovered that all patients had previously unsuccessful treatments and noted that surgical removal of the polyps, using personalized approaches, had no recurrences over a follow-up period of about 46 months. This information is crucial because it can lead to better treatment strategies for patients with similar complex ureteral issues. Who this helps: This benefits patients with complex ureteral conditions and their doctors by offering effective surgical management options.

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This study focused on sarcopenia, which is the loss of muscle mass and function that often occurs as people age. Researchers analyzed data from multiple studies and used advanced techniques to identify changes in gene expression related to muscle function. They found three specific genes (CHCHD10, SAMM50, and MDH2) that are significantly altered in people with sarcopenia, and a model based on these genes was 88.3% accurate in identifying individuals at risk for this condition. Who this helps: This benefits older adults at risk for sarcopenia, as well as healthcare providers looking for better ways to diagnose and treat this condition early.

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Researchers developed a new system for producing 5'-cytidine monophosphate (5'-CMP), an important ingredient used in food and medicine. They created a modified strain of bacteria that could produce 5'-CMP 5.98 times more efficiently than previous methods, achieving a production rate of 1.77 mmol/L/hour while maintaining high conversion and yield rates. This advancement could significantly lower production costs and improve the availability of 5'-CMP for various industries. Who this helps: This benefits manufacturers in the food and pharmaceutical industries.

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This study looked at how different cleaning and treatment methods affect the surfaces of single-crystal aluminum nitride (AlN) materials, which are important for electronic devices. Researchers found that while some cleaning methods removed surface contaminants, they introduced new issues like fluorine residues. Using hydrogen during the treatment helped clean the surface of carbon and oxygen and led to better growth patterns for the material. This is important because it can improve the performance of electronic devices made from AlN. Who this helps: Patients and consumers who rely on better electronics and optoelectronic devices.

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This study looked at improving how we predict cancer survival by creating a new method called DeReF, which helps combine different types of medical information more effectively. The researchers found that their approach leads to better predictions by allowing for more varied combinations of data, which improves understanding among different cancer features. In tests, their method performed significantly better on various datasets, including liver cancer data. Who this helps: This helps doctors and researchers who need more accurate predictions for cancer patient survival.

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This study compared two treatment options for advanced bladder cancer: one using enfortumab vedotin plus pembrolizumab (EV+P) and the other using nivolumab with gemcitabine-cisplatin (N+GC). In the US, EV+P costs about $1.86 million and results in 3.34 quality-adjusted life years (QALYs), while N+GC costs around $882,000 for 2.36 QALYs, making N+GC the more cost-effective option. In China, EV+P costs approximately $485,000 and provides 2.95 QALYs compared to N+GC's cost of about $204,000 for 2.15 QALYs, again favoring N+GC for value. Who this helps: This information helps doctors and healthcare planners make better decisions regarding treatment options for patients with advanced bladder cancer.

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Researchers studied how artificial intelligence (AI) can improve the process of ovarian stimulation during in vitro fertilization (IVF), which is crucial for success. They found that their AI models were much better at predicting how patients would respond to stimulation than traditional methods, with accuracy scores ranging from 0.89 to 0.95. This is important because better predictions can lead to more personalized treatment plans, improving the chances of successful IVF outcomes. Who this helps: This helps patients undergoing IVF by providing more tailored and effective treatment options.

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This study looked at a new type of electrolyte made from ethanolamine that helps zinc batteries work better. Researchers found that this electrolyte can improve the lifespan of zinc batteries to over 1800 hours while keeping the battery's components stable. This is important because it means longer-lasting and more reliable batteries, which can benefit a range of electronic devices and electric vehicles. Who this helps: Patients and consumers who rely on better battery technology for devices and electric vehicles.

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This study looked at how tomato plants respond to both heat and carbon dioxide (CO) simultaneously. Researchers discovered that a protein called βCA2 plays a key role in this process by working with another protein, PSKR1. They found that when both heat and CO stress occur, PSKR1 activates βCA2 by adding a phosphate group to a specific site on the protein, which in turn helps the plant produce a protective molecule, aiding its survival under stress. Who this helps: This research benefits farmers and agricultural scientists focused on developing crops that can withstand climate challenges.

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This study looked at how nerve compression, which causes neuropathic pain, affects inflammation throughout the body using mice and rats. Researchers found that this type of pain triggered a wide range of inflammatory responses and changes in various organs, including the heart, liver, and lungs, indicating that neuropathic pain is not just local but can affect the entire body. Specifically, they discovered increased levels of certain inflammatory genes and altered metabolic processes in these organs. Who this helps: This research benefits patients with chronic neuropathic pain by identifying potential new treatments to manage their inflammation and pain.

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This study looked at a protein called SERINC2 to see if it can help predict outcomes for patients with pancreatic cancer, a very aggressive type of cancer. The researchers found that high levels of SERINC2 were linked to worse survival, with patients showing high levels living less than 20 months on average, compared to those with lower levels. This matters because it could lead to new tests to identify patients at higher risk and new treatments that target SERINC2. Who this helps: Patients with pancreatic cancer.

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This study looked at how bile acids in the body affect liver fat buildup, particularly in cases of liver steatosis, which is an excess of fat in the liver. Researchers found that higher bile acid levels are linked to increased liver fat, with a specific finding that a high-fat diet raises these bile acids while reducing liver autophagy (the process that helps break down fats). This matters because understanding how bile acids and certain genetic factors influence liver fat could lead to better treatments for liver diseases. Who this helps: This helps patients with liver disease and healthcare providers managing metabolic conditions.

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This study looked at improving the production of cytidine, an important compound used in medicines. Researchers created a special strain of bacteria that forms tiny minicells and found that using this strain in a different fermentation method increased cytidine production to 1.74 grams per liter, which is 114% more than traditional methods. This matters because it shows a new way to make cytidine more efficiently, which can benefit pharmaceutical manufacturing. Who this helps: This helps pharmaceutical companies and researchers working on drug development.

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This study looked at the role of Epstein-Barr Virus (EBV) DNA levels in predicting outcomes for patients with advanced nasopharyngeal cancer who received specific chemotherapy and radiation treatments. Researchers found that patients with higher EBV DNA levels (≥450 copies/ml) had worse progress-free survival rates after two years (74.7%) compared to those with lower levels (92.6%). This finding is important because measuring EBV DNA could help doctors better identify which patients need more intensive treatment. Who this helps: This helps patients with advanced nasopharyngeal cancer and their doctors.

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This study looked at how well outpatient medical staff at a maternity and childcare hospital understand and practice infectious disease prevention and control. Out of 168 staff surveyed, they scored an average of about 70 points on a scale of 0 to 100, showing significant gaps in knowledge and practices, especially among those with less experience or education. For instance, staff with fewer than 10 years of experience were more likely to have lower knowledge scores. Who this helps: This information is valuable for improving training programs for medical staff, ultimately benefiting patients and their families.

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This study looked at how weight gain during pregnancy affects the health of babies born to mothers with gestational diabetes. It found that over half (52.67%) of pregnancies had adverse outcomes, such as complications during delivery or the need for intensive care for newborns, with risks increasing for heavier mothers (44.28% in normal-weight women compared to 67.08% in those with severe obesity). The research suggests that women who are underweight should gain 12 to 20 kg, normal-weight women should gain 8 to 16 kg, and those who are overweight or obese should aim for weight loss or minimal gain to reduce these risks. Who this helps: This information benefits pregnant individuals with gestational diabetes and their healthcare providers.

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This study developed a new method to create and dye fabrics using indigoid colors in a single step. By engineering a process that combines dye creation and application, the researchers reduced water use significantly compared to traditional methods, achieving high efficiency and making dyeing possible on synthetic materials like nylon. This is important because it offers a more sustainable way to color textiles, reducing environmental impact. Who this helps: This benefits textile manufacturers and environmentally-conscious consumers.

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This study examined how two different viruses that infect a common type of ocean bacteria called SAR11 affect the bacteria's metabolism. The researchers found that one virus caused changes in 460 genes, while the other virus affected 136 genes, showing that each virus has a unique impact. Understanding these effects is important because it can help us learn more about how these bacteria function in the ocean, which is crucial for global carbon and nutrient cycling. Who this helps: This research benefits marine scientists and environmentalists studying ocean ecosystems.

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This study looked at a rare condition called immune checkpoint inhibitor-related ureteritis and cystitis (ICI-UC) that occurs in some cancer patients receiving specific immunotherapy treatments. Out of 1,239 patients treated, only 12 (about 1%) developed this condition, which caused significant urinary symptoms and required treatment, often with steroids, leading to rapid improvement in most cases. The findings help better understand the condition and introduce a new way to classify its severity and possible treatments, making it easier for doctors to recognize and manage it. Who this helps: This helps cancer patients undergoing immunotherapy and their doctors.