Division of Vaccine Development, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, 212 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungcheongbuk-do, 28160, Republic of Korea.
Hyunki In studies gastrointestinal cancers, including gastric and pancreatic cancers. He investigates innovative diagnostic methods, like analyzing DNA from stomach fluid, which has shown promise in identifying gastric cancer early. He also examines trends in surgical treatments for these cancers, especially how the COVID-19 pandemic affected surgical procedures and outcomes, ensuring that patients receive timely care even during crises.
Key findings
In a study of over 1,000 patients, DNA levels in stomach fluid were significantly higher in those with gastric cancer compared to those with benign or precancerous conditions.
Patients with higher DNA levels in their stomach fluid exhibited longer progression-free survival due to potentially greater immune cell activity, indicating a complex relationship between DNA levels and tumor behavior.
During the COVID-19 pandemic, pancreatic cancer surgeries continued at normal rates, while liver cancer surgeries temporarily dropped before quickly recovering, demonstrating effective management of cancer care during the crisis.
Analysis of nearly 96,000 operations found that esophageal and rectal cancer surgeries significantly declined throughout the pandemic, highlighting potential risks of delayed treatment for these cancers.
Frequently asked questions
Does Dr. In study gastric cancer?
Yes, Dr. In focuses on gastric cancer, specifically exploring diagnostic methods and treatment outcomes.
What innovative techniques has Dr. In researched?
He has researched the use of DNA content from stomach fluid as a possible biomarker for diagnosing gastric cancer.
How did COVID-19 affect surgeries for gastrointestinal cancer?
His research indicates that while some surgeries were delayed, pancreatic surgeries remained stable, and stomach and colon surgeries quickly returned to normal levels after initial declines.
Is Dr. In's work important for cancer patients?
Yes, his findings are crucial for improving early detection and understanding treatment timelines during challenging situations like the pandemic.
Publications in plain English
Characteristics of a Measles Outbreak in a Pediatric Hospital in the Honam Region, 2025.
2026
Jugan geon-gang gwa jilbyeong
Kim S, Kim EY, Kim SY, Yun S, Lee YU +3 more
Plain English In March 2025, a measles outbreak at a children’s hospital in the Honam region began with an unvaccinated child who had traveled to Vietnam, leading to nine confirmed cases, mostly among healthcare workers. The study found that 80.2% of healthcare workers had immunity to measles, but this was lower (64.0%) in those aged 25-34. This outbreak shows how measles can spread in hospitals and emphasizes the need for better vaccination practices, especially for multicultural families and travelers.
Who this helps: This information benefits healthcare workers and patients by improving outbreak prevention measures.
Design and immunogenicity evaluation of pan-recombinant vaccines based on the consensus sequence of severe acute respiratory syndrome coronavirus-2 spike protein.
2026
Scientific reports
Na YJ, Choi EB, Kim K, Kim S, Moon SY +2 more
Plain English Researchers created and tested three new vaccines designed to provide broad protection against different versions of the SARS-CoV-2 virus, which causes COVID-19. In lab mice, these vaccines showed they could trigger strong immune responses, producing important antibodies and reducing virus levels in the lungs, especially against variants like Delta and Omicron. This is important because it means these vaccines could help protect against ongoing and future mutations of the virus.
Who this helps: This helps patients by offering more effective protection against COVID-19 and its variants.
Racial/ethnic differences in risk factors for non-cardia gastric cancer: an analysis of the Multiethnic Cohort (MEC) Study.
2025
Cancer causes & control : CCC
Adams A, Gandhi A, Friedmann P, Sarkar S, Rana B +4 more
Plain English This study looked at how different racial and ethnic groups in the U.S. experience varying risks for a specific type of stomach cancer called non-cardia gastric cancer (NCGC). The researchers analyzed data from over 1,100 people with NCGC and nearly 191,000 without it, finding that factors like family history, education level, and lifestyle choices significantly impacted risk. For instance, Latino individuals with a family history of gastric cancer had a risk increase of about 75% to 98%, while daily alcohol consumption raised the risk for African Americans by 56%.
Who this helps: This information helps doctors and healthcare providers better understand cancer risks in diverse patient populations, leading to more tailored prevention and detection strategies.
Cost-Effectiveness of Serum Pepsinogen as a Gastric Cancer Targeted Screening Strategy in the United States.
2025
Gastro hep advances
Oh A, Rustgi SD, Hur C, In H
Plain English This study looked at using a blood test called serum pepsinogen (PG) to screen for gastric cancer in the United States, as current screening methods are invasive and costly. The researchers found that one-time PG screening at age 40 could reduce lifetime gastric cancer cases by 10.9% and decrease mortality by 10.8%, costing about $4,913 for each year of healthy life gained. This really matters because it shows that a simple blood test could help catch gastric cancer earlier, potentially saving lives and reducing healthcare costs.
Who this helps: This helps patients by providing an easier and less expensive way to detect gastric cancer early.
Immune Cell Engagers: Advancing Precision Immunotherapy for Cancer Treatment.
2025
Antibodies (Basel, Switzerland)
In H, Park M, Lee H, Han KH
Plain English This study looks at a new type of cancer treatment called immune cell engagers (ICEs), which help the body’s immune system fight tumors more effectively. Since 2014, nine ICEs have been approved by the FDA, helping to tackle some tough challenges in cancer care. Current research aims to improve these therapies, making them safer and more effective for various types of cancer.
Who this helps: This helps cancer patients seeking personalized treatment options.
Squeeze-EnGAN: Memory Efficient and Unsupervised Low-Light Image Enhancement for Intelligent Vehicles.
2025
Sensors (Basel, Switzerland)
In H, Kweon J, Moon C
Plain English This study looked at a new method called Squeeze-EnGAN, which helps improve images taken in low-light conditions for smart vehicles like self-driving cars and drones. Researchers found that Squeeze-EnGAN is both efficient and capable of enhancing images without needing lots of paired low-light and bright-light images, making it easier to use. By using this method, images were enhanced enough to improve object detection accuracy, which is crucial for safe driving and navigating.
Who this helps: This benefits developers of autonomous vehicles and their users by improving navigation and safety in low-light environments.
Consensus guideline for the management of gastric cancer with synchronous peritoneal metastases.
2025
Cancer
Butensky SD, Bansal VV, Su DG, Waheed MT, Nikiforchin A +15 more
Plain English This study updated guidelines for treating stomach cancer that has spread to the lining of the abdomen at the same time. The researchers found that a careful assessment before surgery is important and that a combination of surgery and direct chemotherapy into the abdomen can significantly improve survival, reducing the risk of death by about 48%. This matters because it helps doctors make better treatment decisions, ultimately improving outcomes for patients with this challenging condition.
Who this helps: Patients with stomach cancer and their doctors.
Consensus Guideline for the Management of Gastric Cancer with Synchronous Peritoneal Metastases.
2025
Annals of surgical oncology
Butensky SD, Bansal VV, Su DG, Waheed MT, Nikiforchin A +15 more
Plain English This study updated guidelines for managing gastric cancer that has spread to the lining of the abdomen, a condition known as synchronous peritoneal metastases (GCPM). Researchers found that a combination of surgery and special local chemotherapy can improve survival rates, with patients showing nearly a 50% better survival chance when treated with this approach. These updated guidelines provide important recommendations for doctors, helping them make better treatment decisions for patients facing this challenging disease.
Who this helps: This helps patients with gastric cancer and their doctors.
In vivo antibody library screening identifies PKM2-targeting M1 antibody with antitumor activity in melanoma.
2025
American journal of cancer research
In H, Choi YH, Kang S, Han KH
Plain English This research focused on finding new antibodies that can stop the growth of melanoma, a type of skin cancer. The scientists discovered an antibody called M1 that successfully targets a protein called PKM2, which is important for tumors to grow. The M1 antibody inhibited melanoma cell growth in mice by 70%, showing it could lead to new treatments for this aggressive cancer.
Who this helps: This helps patients with melanoma by paving the way for new therapies.
[The History of Tuberculosis Prevention Day and National Strategic Plan for Tuberculosis Control in Republic of Korea].
2025
Jugan geon-gang gwa jilbyeong
Park JH, Jang AH, Lee EY, Ahn HJ, Kim JE +6 more
Plain English This study looks at how tuberculosis (TB) is prevented and managed in South Korea by reviewing the history of Tuberculosis Prevention Day and the national strategies in place to control the disease. It highlights that since 2013, South Korea has been following a five-year plan to combat TB, with the current plan addressing past challenges and focusing on better training and cooperation among healthcare workers. Raising awareness about TB is crucial as it highlights the disease's seriousness and the ongoing efforts of healthcare professionals to control it.
Who this helps: This benefits patients, healthcare workers, and public health officials.
Quality of Cancer Recurrence Data in the National Cancer Database: A Reappraisal of Reporting Readiness.
2025
Annals of surgical oncology
Chan K, Palis BE, Cotler JH, Janczewski LM, Zhu X +15 more
Plain English This study looked at how complete and accurate the information is about cancer recurrences in the National Cancer Database (NCDB) from 2004 to 2021. It found that the percentage of missing data decreased significantly for various cancers: breast cancer missing data went from 15.7% to 8.4%, colon from 19.8% to 9.3%, and lung from 20.5% to 7.4%. However, issues like poor doctor documentation still affect data quality, which can complicate research efforts.
Who this helps: This benefits researchers, doctors, and cancer patients as better data leads to improved treatment options and outcomes.
Plain English This study looked at how different levels of liver therapies aimed at curing colorectal cancer that has spread to the liver affected patients' survival rates. Researchers analyzed data from nearly 35,000 patients and found that increasing the rate of these therapies by just 5% led to a 1.2% increase in survival rates. This is important because it shows that getting more patients access to these curative treatments can significantly improve their chances of living longer.
Who this helps: This helps patients with colorectal cancer liver metastases.
Defining the surgical workforce for colorectal cancer liver metastases: Impact on access to curative care.
2025
Surgery
Tsagkalidis V, Handorf EA, Bates BA, Brauer DG, Verma C +11 more
Plain English This study looked at how many liver surgeons are available to treat older patients with colorectal cancer that has spread to the liver. Researchers found that there were only 421 surgeons for about 16,700 patients, meaning many people (42.4%) lived where there were no liver surgery options. Those living near a liver surgeon had a better chance of receiving an evaluation and a reduced risk of death, showing that access to surgeons directly affects patient survival.
Who this helps: This helps patients with colorectal cancer liver metastases by improving their chances of getting necessary treatments.
Role of Radiation Therapy for Biliary Tract Cancers.
2025
Current oncology (Toronto, Ont.)
Chakraborty MA, Kumar R, Ecker BL, In H, Langan RC +2 more
Plain English This study looked at how radiation therapy can help treat biliary tract cancers, which include types like cholangiocarcinoma and gallbladder cancer. The researchers found that radiation therapy can improve survival for patients, especially those with serious features of their disease; however, since these cancers are rare, most research so far has been small and not very rigorous. Improving radiation treatment could help more patients live longer and feel better, especially those who can’t have surgery.
Who this helps: This helps patients with biliary tract cancers and their doctors.
Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer.
2025
eLife
Cadoná FC, Bartelli TF, Pelosof AG, Sztokfisz CZ, Bueno AP +20 more
Plain English Researchers analyzed DNA collected from stomach fluid during routine upper endoscopy in over 1,000 patients and found that DNA levels were significantly higher in those with gastric cancer compared to those with benign or precancerous conditions. Higher DNA levels also correlated with more advanced tumors, and paradoxically, patients with elevated levels had longer progression-free survival, possibly because of greater immune cell activity in the tumor. This stomach fluid test could become a useful add-on to standard biopsy for diagnosing and tracking gastric cancer.
Usability study of a smart transfer-assistive robot with dual arms for care workers.
2024
Disability and rehabilitation. Assistive technology
Kim YS, Shin HR, Yoon HJ, Ban SW, Kim YG +2 more
Plain English Researchers studied a smart robot designed to help long-term care workers move patients more easily. They found that using the robot significantly reduced physical strain on workers, with the burden rated lower on a scale that measures perceived effort. On average, workers rated the robot positively for safety and ease of use, demonstrating its potential to lower work-related injuries among caregivers.
Who this helps: This benefits long-term care workers and the patients they assist.
DataMesh+: A Blockchain-Powered Peer-to-Peer Data Exchange Model for Self-Sovereign Data Marketplaces.
2024
Sensors (Basel, Switzerland)
Merlec MM, In HP
Plain English This research studied a new way to exchange data using a method called "DataMesh+", which is built on blockchain technology. The findings showed that this decentralized model can create fair and secure marketplaces for data trading, allowing users to have full control over their own data. This is important because it addresses common problems like lack of trust and transparency in traditional data markets.
Who this helps: This benefits data providers and consumers who want more control and security over their data.
Timing of maternal vaccination against COVID-19 for effective protection of neonates: cohort study.
2024
Frontiers in immunology
Nowakowska A, Lee SM, Kim M, Chun J, Kim S +13 more
Plain English This study looked at how maternal vaccination against COVID-19 affects newborns, focusing on the timing of the vaccine. Researchers found that mothers who were vaccinated before pregnancy passed stronger immunity to their babies, giving newborns better protection against COVID-19 compared to those whose mothers were vaccinated or infected after pregnancy. This is significant because it highlights the importance of vaccination before pregnancy in keeping babies safe.
Who this helps: This helps pregnant individuals and their newborns.
[Characteristics of Notified Tuberculosis Cases in the Republic of Korea, 2023].
2024
Jugan geon-gang gwa jilbyeong
Lee H, Kim J, Kim J, Park Y, Shin J +38 more
Plain English In 2023, South Korea reported a total of 19,540 tuberculosis (TB) cases, which is a 4.1% decrease from 2022 and represents a significant reduction of 61.3% over the last 12 years. However, the number of cases among people aged 65 and older increased slightly to 11,309, making up about 57.9% of all cases, and there was also a 3.3% rise in TB cases among foreign individuals. The ongoing challenge remains, as the number of multidrug-resistant TB cases was 551, showing a slight decrease from the previous year, and the government aims to reduce the overall TB incidence rate to fewer than 20 cases per 100,000 people by 2027.
Who this helps: This information benefits public health officials and healthcare providers working on TB prevention and treatment programs.
Gender Gap in Academic Surgery: Disparities in Early-Career Scholarly Productivity Sets the Stage for Unequal Academic Advancement.
2024
The Journal of surgical research
Kim G, Goodman E, Adams A, Skendelas J, Ward J +3 more
Plain English This study looked at the differences in career advancement between male and female surgeons in academic positions. It found that women in early-career roles were 40% less likely to get promoted compared to their male counterparts and published significantly fewer research papers, with only 30% of women reaching more than 30 publications compared to 50% of men. These findings highlight a clear gap in academic opportunities based on gender, which can be addressed by providing better support for female surgeons.
Who this helps: This helps female surgeons and academic institutions working to promote gender equality.
Oral Microbiome Signatures as Potential Biomarkers for Gastric Cancer Risk Assessment.
2024
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
In H, Perati SR, Usyk M, Yang J, Sarkar S +7 more
Plain English This study looked at the bacteria in the mouths of people with gastric cancer (GC), pre-cancerous conditions (Pre-GC), and healthy individuals to see if these bacteria could help identify who is at risk for gastric cancer. The researchers found significant differences in the bacterial communities: they identified 32 types of bacteria that were more common in gastric cancer patients compared to healthy individuals, and 23 types that were more common in those with pre-cancerous conditions. The findings indicate that mouth bacteria could serve as a useful tool to predict the risk of gastric cancer with high accuracy (an AUC of 0.880 for gastric cancer and 0.943 for pre-cancer).
Who this helps: This helps doctors and healthcare providers identify at-risk patients more effectively.
Development and clinical validation of passive shoulder exoskeleton with novel gravity compensation mechanism for stabilizing arm tremor of surgeons during minimally invasive surgery.
2024
Frontiers in bioengineering and biotechnology
Choi HS, Lee SJ, In H
Plain English This study developed a shoulder exoskeleton designed to help surgeons during minimally invasive surgeries by reducing muscle strain and arm tremors. The new device showed promising results, with muscle activation in the shoulder decreasing by an average of 14.55% while tremors were reduced by 9.85% on average, reaching a maximum reduction of 19.5%. This is important because less muscle fatigue and improved stability can lead to better surgical performance and outcomes for patients.
Who this helps: This benefits surgeons performing minimally invasive surgeries.
[Results of the Tuberculosis Epidemiological Investigation Conducted at a Community Self-sufficiency Center].
2024
Jugan geon-gang gwa jilbyeong
Jung J, Lee A, Kim J, Park H, In H
Plain English This study looked at how tuberculosis (TB) spreads in community self-sufficiency centers in South Korea. When a TB case was found in February 2023, researchers checked 50 people who had close contact with the patient. They discovered one additional person with active TB and 17 others with latent TB infections, showing that 44.7% of those tested had LTBI. This is important because it highlights the need for regular TB screenings in these centers, especially since the people there often come from more vulnerable socio-economic backgrounds where TB is more common.
Who this helps: Patients and communities at risk of tuberculosis.
Recurrence-free survival dynamics following adjuvant chemotherapy for resected colorectal cancer: A systematic review of randomized controlled trials.
2024
Cancer medicine
Vail E, Choubey AP, Alexander HR, August DA, Berry A +11 more
Plain English This study looked at how adjuvant chemotherapy affects patients with Stage II-IV colorectal cancer after they have had surgery to remove tumors. Researchers found that patients who received chemotherapy had significantly lower rates of cancer returning within the first year compared to those who only had surgery: 9% experienced a return of cancer within the first six months, compared to 22% in the surgery-only group. Chemo helped more in the short term, but the differences in outcomes became smaller after the first year.
Who this helps: This research benefits colorectal cancer patients by highlighting the importance of chemotherapy in preventing early recurrence.
Racial disparities in rates of invasiveness of resected intraductal papillary mucinous neoplasms in the United States.
2024
Surgery
Allen WE, Greendyk JD, Alexander HR, Beninato T, Eskander MF +10 more
Plain English This study looked at how race and ethnicity affect the likelihood of finding invasive tumors in patients undergoing surgery for a precancerous condition of the pancreas called intraductal papillary mucinous neoplasms. Out of 4,505 cases examined, 20.5% had invasive cancer, with Black patients at 24.2%, Asian patients at 23.7%, and Hispanic patients at 22.6%, compared to 19.9% for non-Hispanic White patients. This difference in invasive cases can't be explained by overall health or age factors, which means that non-White patients face higher risks, and recognizing this can help doctors improve early interventions and treatment strategies.
Who this helps: This helps patients from diverse racial and ethnic backgrounds facing pancreatic cancer risks.
Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma: a SEER Database Analysis of Mucinous and non-Mucinous Histologies.
2024
Annals of surgical oncology
Tsagkalidis V, Choe JK, Beninato T, Eskander MF, Grandhi MS +7 more
Plain English This study looked at two types of appendiceal cancer—mucinous and non-mucinous—and how much of the tumor needs to be surgically removed to improve survival. Out of nearly 4,700 patients, 68% had their entire colon removed, and while this helped patients with non-mucinous cancer (especially those with medium to high tumor grades), it didn't improve survival for those with mucinous cancer at all. This finding suggests that patients with mucinous appendiceal adenocarcinoma might not need such extensive surgery, which could reduce unnecessary procedures and their associated risks.
Who this helps: This helps patients with mucinous appendiceal cancer by potentially sparing them from more invasive surgery.
Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer.
2024
Surgery
Ko TM, Laraia KN, Alexander HR, Ecker BL, Grandhi MS +6 more
Plain English This study examined how neighborhood wealth affects young adults (under 50) with colorectal cancer. It found that those living in poorer neighborhoods were 13% more likely to have advanced cancer when diagnosed and had a 45% higher risk of dying compared to those from wealthier areas. Additionally, non-Hispanic Black patients faced more severe outcomes, including being less likely to have surgery and having lower survival rates.
Who this helps: This research benefits patients, particularly young adults with colorectal cancer and those from low-income or minority communities.
Operative trends for pancreatic and hepatic malignancies during the COVID-19 pandemic.
2024
Surgery
Manzella A, Ecker BL, Eskander MF, Grandhi MS, In H +6 more
Plain English Researchers tracked cancer surgeries for the pancreas and liver during COVID-19 to see if the pandemic disrupted treatment. They found that pancreatic cancer surgeries continued at normal rates throughout the pandemic, while liver cancer surgeries dropped briefly at the start but quickly returned to normal levels—and more pancreatic cancer patients received chemotherapy before surgery during the pandemic.
This matters because it shows hospitals prioritized cancer operations during COVID-19, meaning patients with these deadly cancers didn't face major treatment delays, though the increased use of pre-surgery chemotherapy suggests doctors may have changed their approach to managing these patients.
The order of surgery and chemotherapy matters: Multimodality therapy and stage-specific differences in survival in gastric cancer.
2023
Journal of surgical oncology
Ramos-Santillan V, Friedmann P, Eskander M, Chuy J, Parides M +1 more
Plain English This study looked at how the order of surgery and chemotherapy affects survival rates in patients with gastric cancer, focusing on those at various stages of the disease. Researchers found that patients with early-stage cancer (stage I) who received chemotherapy before surgery had worse survival rates compared to those who had it after surgery, while patients with later-stage cancer (stage III) had better survival with the same pre-surgery treatment. These findings highlight the importance of treatment timing, suggesting that stage-specific strategies could improve outcomes for gastric cancer patients.
Who this helps: This helps patients with gastric cancer by informing treatment decisions that could lead to better survival rates.
Controlling Gastric Cancer in a World of Heterogeneous Risk.
2023
Gastroenterology
Huang RJ, Laszkowska M, In H, Hwang JH, Epplein M
Plain English This paper looks at gastric cancer, which is a major cause of death worldwide, and explores how the risk of this cancer varies between different places. It found that preventing the disease mainly involves treating infections from Helicobacter pylori, and that countries with high rates of gastric cancer are using screening methods to catch it early. In places with lower rates, the focus is on monitoring people with early signs of the disease. Understanding these differences is crucial for improving treatment and prevention strategies.
Who this helps: This helps patients and doctors in different countries tailor their approaches to battling gastric cancer.
Association of smartphone use with abnormal social jetlag among adolescents in Korea before and after COVID-19.
2023
Addictive behaviors
Cho Y, In H, Park M, Park EC, Kim SH
Plain English This study looked at how smartphone use affects sleep patterns in teenagers in South Korea before and after the COVID-19 pandemic. It found that adolescents who used smartphones for 6 or more hours a day were 2.6 times more likely to experience abnormal sleep patterns, with this issue being especially noticeable in girls. The pandemic made this problem worse, indicating the need for better smartphone use practices to help teens sleep better.
Who this helps: This helps adolescents and their parents in managing smartphone use for better sleep health.
Multitier Web System Reliability: Identifying Causative Metrics and Analyzing Performance Anomaly Using a Regression Model.
2023
Sensors (Basel, Switzerland)
Kim S, Kim JS, In HP
Plain English This study looked at how to improve the reliability of complex web services that businesses rely on. Researchers identified 191 performance metrics related to service performance, and out of these, 62 key metrics were found to have the biggest impact on service quality. Their new method effectively detected performance issues and their root causes without needing to change the detection model, which is crucial for companies striving to maintain good customer experiences.
Who this helps: This helps businesses and their IT teams improve service reliability and customer satisfaction.
Humoral Immune Response of Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Prime-Boost Vaccination against SARS-CoV-2 Variants in Korea.
2023
Infection & chemotherapy
Lim H, Jang S, In HJ, Kim K, Choi EB +9 more
Plain English This study examined how well a mixed vaccination approach using two different COVID-19 vaccines—ChAdOx1 nCoV-19 and mRNA-1273—works against various SARS-CoV-2 variants, especially the omicron variant. Researchers found that the ability of these vaccines to neutralize the virus decreased over time, with antibody levels dropping significantly from 2 weeks to 3 months after the second dose, and that the omicron variant had the lowest level of antibody response compared to other variants. This information is important for improving vaccination strategies and ensuring effective protection against emerging variants in the future.
Who this helps: This helps public health officials and vaccine planners in developing better vaccination strategies.
Potentially Avoidable Admissions and Prolonged Hospitalization in Patients with Suspected Colon Cancer.
2023
Annals of surgical oncology
Tagerman DL, Ramos-Santillan V, Kalam A, Wang F, Schriner JB +5 more
Plain English This study looked at why some patients suspected of having colon cancer end up staying in the hospital longer than necessary after visiting the Emergency Department. Out of 97 patients, 12% had unnecessarily long admissions, mostly for cancer testing. Additionally, 78% of those who needed hospitalization for non-urgent reasons stayed longer than ideal, with an average extra stay of 12 days. This matters because it shows that there are gaps in how patients can be managed without needing extended hospital stays, highlighting a need for better outpatient care options.
Who this helps: This helps patients with suspected colon cancer by promoting more efficient care and reducing unnecessary hospital stays.
Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research.
2023
Current oncology (Toronto, Ont.)
Kumar R, Kim J, Deek MP, Eskander MF, Gulhati P +10 more
Plain English This research looked at how combining immunotherapy and radiation therapy can improve treatment for gastrointestinal cancers. The findings from various studies, including some larger studies, show that adding immunotherapy to standard treatments can lead to better survival rates, although the exact timing and ways to combine these treatments are still being worked out. This matters because it opens up new possibilities for more effective cancer treatments, potentially leading to longer lives for patients.
Who this helps: This helps patients with gastrointestinal cancers.
Interpretation of Tumor Response Grade following Preoperative Therapy for Gastric Cancer: An Overview.
2023
Cancers
Tsagkalidis V, Blaszczyk MB, In H
Plain English This study looks at how doctors measure the response of gastric cancer to preoperative chemotherapy using a system called Tumor Response Grade (TRG). It found that different TRG systems can produce inconsistent results, which makes it hard to predict how well a patient will do after treatment. Clearer and more accurate ways to assess treatment responses, including using scans and new imaging techniques, are needed to help guide treatment decisions.
Who this helps: This benefits patients with gastric cancer and their doctors by improving treatment planning.
A qualitative analysis of patients' experiences with an emergency department diagnosis of gastrointestinal cancer.
2023
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Adams A, Heinert S, Sanchez L, Karasz A, Ramos ME +3 more
Plain English This study looked at how patients felt about being diagnosed with gastrointestinal cancer in the emergency department (ED), where 23%-52% of these cancers are found. It found that patients often experienced negative feelings, such as denial and mistrust, and faced obstacles like misdiagnosis and delays in getting necessary tests. These struggles suggest that we need to improve public awareness about cancer symptoms and increase access to timely medical care.
Who this helps: This helps patients and healthcare providers by highlighting the importance of early detection and better support systems in the medical field.
Trends in the Development of Antibody-Drug Conjugates for Cancer Therapy.
2023
Antibodies (Basel, Switzerland)
Song CH, Jeong M, In H, Kim JH, Lin CW +1 more
Plain English This paper looks at the development of a type of cancer therapy called Antibody-Drug Conjugates (ADCs), which combine antibodies that target cancer cells with drugs that kill those cells. The research reviewed 12 existing ADCs and analyzed 71 studies and 128 clinical trial reports. It found that the latest ADCs are designed to improve how well they target cancer cells and tackle issues like drug resistance, which is crucial for making cancer treatments more effective and safer for patients.
Who this helps: This benefits cancer patients by providing more effective and targeted treatment options.
[Results of the Elderly Tuberculosis Screening Project 2022 in the Republic of Korea].
2023
Jugan geon-gang gwa jilbyeong
You S, Park A, Kim H, In H, Choi H +3 more
Plain English In 2022, South Korea conducted a tuberculosis (TB) screening program for older adults over 65, who are more likely to get serious TB infections. Out of nearly 188,000 individuals screened, 132 were found to have active TB, which is about 70 cases per 100,000 people, significantly higher than the general rate of 32 per 100,000. This information is important because it highlights that older adults have a greater risk for TB, and it emphasizes the need for targeted screening to help prevent serious illness and deaths from TB in this age group.
Who this helps: This benefits older adults and public health officials working to improve TB management.
Respondent Driven Sampling Method of Recruitment for a Case Control Study of Gastric Cancer Risk.
2023
Asian Pacific journal of cancer prevention : APJCP
Cassel K, In H, Sarkar S, Rapkin B, Umadat G
Plain English This study looked at how to recruit participants for research on gastric cancer, especially among ethnic minorities who are often underrepresented in such studies. Researchers aimed to use a social network method called Respondent Driven Sampling to bring in cases (people with gastric cancer) and controls (people without it) for a screening tool, but faced challenges. Out of an initial goal to recruit 120 participants, they only managed to get 5 gastric cancer patients to complete the survey, showing that the method was not very effective due to limited social networks and other barriers.
Who this helps: This helps researchers develop better screening tools for gastric cancer, potentially benefiting high-risk ethnic minority patients.
Evaluating the effectiveness of an active strap for wearable robot: A Mechanical and Physiological Study.
2023
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Lee S, In H
Plain English This research examined a new type of active strap used in wearable robots, specifically designed to support the hip joint. The study found that this strap could effectively help move the hip by tightening only when needed, which improved comfort compared to traditional straps. This is important because it can make wearable robotic devices more pleasant to use for those who need support while moving.
Who this helps: Patients using wearable robotic devices for mobility support.
Identification of dendritic cell precursor from the CD11ccells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand.
2023
Frontiers in immunology
In H, Park JS, Shin HS, Ryu SH, Sohn M +9 more
Plain English This research focused on identifying a new type of cell called a precursor for dendritic cells using mouse bone marrow treated with a specific growth factor. The scientists found that most cells in this culture had a distinct profile that showed they were immature precursors rather than fully developed dendritic cells. This matters because understanding these precursors can help improve immunotherapies, which are treatments that boost the body's immune response against diseases like cancer.
Who this helps: Patients undergoing immunotherapy treatments.
COVID-19 Effect on Surgery for Gastrointestinal Malignancies: Have Operative Volumes Recovered?
2023
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Manzella A, Eskander MF, Grandhi MS, In H, Langan RC +5 more
Plain English Researchers examined how COVID-19 affected surgery rates for gut cancers across the United States from 2019 to 2022, analyzing nearly 96,000 operations on the esophagus, stomach, colon, and rectum. They found that surgery for esophageal and rectal cancers dropped significantly and stayed low throughout the pandemic, while stomach and colon cancer surgeries initially fell but bounced back to normal levels within a few months. This matters because delays in cancer surgery can allow tumors to grow and spread, potentially worsening patient outcomes and survival rates.
The effects of operating height and the passage of time on the end-point performance of fine manipulative tasks that require high accuracy.
2022
Frontiers in physiology
Choi HS, In H
Plain English This study looked at how the height of a worktable affects people's performance on tasks that require precise hand movements, like those in surgery. Researchers found that when the table was set too high or too low, it led to muscle fatigue over time, causing performance to drop significantly. For example, the study measured changes in muscle activity and movement stability, showing that as fatigue increased, task performance declined.
Who this helps: This helps workers and medical professionals who rely on fine motor skills, particularly in surgery or other precision tasks.
Ankle strategy assistance to improve gait stability using controllers based on in-shoe center of pressure in 2 degree-of-freedom powered ankle-foot orthoses: a clinical study.
2022
Journal of neuroengineering and rehabilitation
Choi HS, Baek YS, In H
Plain English This study looked at how a special type of ankle-foot brace, called a powered ankle-foot orthosis (PAFO), can help improve balance and walking stability by supporting a technique called the "ankle strategy." The researchers found that when people used this brace, their stability improved significantly, as indicated by a specific measure of walking stability, and their muscle activity decreased, which suggests less effort was needed to maintain balance. However, while using the brace, there was an increase in some swaying, showing a complex relationship between stability and balance during walking.
Who this helps: This research benefits patients with mobility issues, particularly those at risk of falling, by providing insights into better rehabilitation technologies.
Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea - A problem of low coverage rate with current LTBI strategy.
2022
Frontiers in public health
Kim HW, Min J, Choi JY, Shin AY, Myong JP +12 more
Plain English This study looked at the rates of latent tuberculosis infection (LTBI) in South Korea among different groups of people, including workers in care facilities, high school students, and inmates. It found that 20.7% of workers, 2.0% of students, and 33.2% of inmates had LTBI. Unfortunately, only a tiny fraction of these individuals who tested positive for LTBI were covered by the current screening program, which indicates that the program needs to reach more high-risk groups to be effective.
Who this helps: This helps patients at risk for tuberculosis and healthcare providers seeking to improve screening efforts.