I Scoleri studies Crohn's disease, a serious inflammatory condition affecting the intestines. They investigate how different evaluation methods, including medical imaging and symptom tracking, can predict how patients will respond to treatments. For instance, Scoleri's research highlights the importance of endoscopic assessments in forecasting hospitalizations and necessary treatment adjustments. Additionally, they explore the role of intestinal gas production and its connection to various gastrointestinal symptoms, offering insights into potential diagnostic approaches for gut health.
Key findings
In one study, patients with higher initial disease activity in Crohn's disease faced more hospitalizations and treatment changes, with a p-value of less than 0.01 indicating strong significance.
In another study, 47% of patients showed clinical improvement after treatment, while 42% remained stable, demonstrating the potential of CT enterography to reflect treatment outcomes.
The research on intestinal gases indicated that changes in gas composition can impact overall health, and proper techniques are necessary for effective diagnostic measurements.
Frequently asked questions
Does Dr. Scoleri study Crohn's disease?
Yes, Dr. Scoleri focuses on Crohn's disease and investigates methods to predict patient outcomes and improve treatment strategies.
What imaging techniques has Dr. Scoleri researched?
Dr. Scoleri has studied CT enterography, a medical imaging technique, to assess the effectiveness of treatments in Crohn's disease patients.
Is Dr. Scoleri's work relevant to patients with gastrointestinal symptoms?
Yes, their research on intestinal gas production and gastrointestinal symptoms directly helps patients dealing with various gut health issues.
Publications in plain English
Systematic intraoperative cholangiography during elective laparoscopic cholecystectomy: Is it a justifiable practice?
2023
Annals of hepato-biliary-pancreatic surgery
Esposito F, Scoleri I, Cattan R, Cook MC, Sacrieru D +3 more
Plain English This study examined the use of a specific imaging test called intraoperative cholangiography (IOC) during gallbladder surgeries to see how effective it is in identifying complications like bile duct injuries or stones. Out of 303 patients, those who had IOC experienced longer surgery times—about 15 minutes more—and more complications, with 5.1% facing issues compared to none in the group that didn’t have the test. Although IOC successfully identified stones 77% of the time, the study found no clear advantages to routinely using it during these operations, suggesting it’s better only for select patients or when the anatomy is unclear.
Who this helps: This information benefits surgeons and patients considering gallbladder surgery.
Validation of the albumin-indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin-bilirubin score.
2019
Journal of hepato-biliary-pancreatic sciences
Russolillo N, Forchino F, Conci S, Mele C, Langella S +5 more
Plain English This study looked at a new method called the ALICE model to predict how well patients with liver cancer will do after surgery. Researchers tested this model on 400 patients and found it effectively predicts complications like fluid buildup and severe liver failure, showing a strong correlation with another method called ALBI. The findings indicate that the ALICE model can provide valuable insights about liver function after surgery, helping doctors make better decisions for their patients.
Who this helps: Patients with liver cancer and their doctors.
Comparison of the 7th and 8th editions of the American Joint Committee on Cancer Staging Systems for perihilar cholangiocarcinoma.
2018
Surgery
Ruzzenente A, Bagante F, Ardito F, Campagnaro T, Scoleri I +4 more
Plain English Researchers compared two systems used to stage perihilar cholangiocarcinoma (a type of bile duct cancer) to see which one better predicts patient survival after surgery. They studied 214 patients and found that while both systems indicated similar survival rates (for example, about 71% for stage I and 34% for stage II), the newer 8th edition performed slightly better in distinguishing between different stages of the disease. Overall, this study highlights that while the 8th edition is an improvement, both systems still struggle to accurately predict patient outcomes, indicating that further improvements are needed.
Who this helps: This helps doctors better understand how to assess and treat patients with perihilar cholangiocarcinoma.
Multiparametric Evaluation Predicts Different Mid-Term Outcomes in Crohn's Disease.
2018
Digestive diseases (Basel, Switzerland)
Laterza L, Piscaglia AC, Minordi LM, Scoleri I, Larosa L +8 more
Plain English This study looked at how different types of assessments—clinical, endoscopic, and radiological—can help predict outcomes for patients with Crohn's disease over the next three years. Researchers found that patients who showed more signs of disease activity at the start, especially through endoscopy, faced more hospitalizations and needed more treatment changes; for instance, those with higher activity levels were hospitalized significantly more often (p < 0.01). Understanding these predictions can help doctors tailor treatment plans more effectively and potentially improve outcomes for patients.
Who this helps: This helps patients with Crohn's disease and their doctors.
Rifaximin for the treatment of diarrhoea-predominant irritable bowel syndrome.
2015
Expert opinion on pharmacotherapy
Laterza L, Ianiro G, Scoleri I, Landi R, Bruno G +4 more
Plain English This study looked at rifaximin, an antibiotic that doesn't absorb well into the body but targets bacteria in the gut, to see how effective it is for treating diarrhea-predominant irritable bowel syndrome (IBS). The research found that rifaximin can improve symptoms of IBS by changing the gut bacteria, making it a good treatment option. This is important because it offers a way to manage IBS symptoms without affecting other medications.
Who this helps: This helps patients suffering from diarrhea-predominant IBS.
Comparison between clinical and radiological evaluation before and after medical therapy in patients with Crohn's disease: new prospective roles of CT enterography.
2015
La Radiologia medica
Minordi LM, Scaldaferri F, Larosa L, Marra R, Giordano F +9 more
Plain English Researchers studied how well CT enterography (a type of medical imaging) reflects the health changes in patients with Crohn's disease after they receive treatment. Out of 45 patients, 21 (47%) showed clinical improvement, while 5 (11%) got worse, and 19 (42%) remained stable. The study found that improvements in scans, like reduced bowel thickness, matched with clinical improvements, showing that CT enterography can reliably help evaluate therapy effectiveness.
Who this helps: This benefits patients with Crohn’s disease and their doctors by providing better assessment tools for treatment success.
Intestinal gas production and gastrointestinal symptoms: from pathogenesis to clinical implication.
2013
European review for medical and pharmacological sciences
Scaldaferri F, Nardone O, Lopetuso LR, Petito V, Bibbò S +9 more
Plain English This study looked at how gas produced by our gut can relate to various gastrointestinal problems. Researchers noted that certain gases, like hydrogen and methane, are created when our gut bacteria break down carbohydrates, and changes in gas composition can affect our overall health. They emphasized that measuring these gases in our breath can be a useful diagnostic tool, although proper techniques are needed for collecting and analyzing samples.
Who this helps: This benefits doctors and patients dealing with gastrointestinal issues.