Igor V Korobeinikov studies how medications, particularly Revelise (alteplase), can help people who have had ischemic strokes. An ischemic stroke occurs when blood flow to the brain is blocked, and timely treatment is crucial. His work involves looking at the effectiveness of these treatments in everyday medical settings, analyzing how well they reduce disabilities caused by strokes in older patients and those with other health conditions.
Key findings
In a study of 2,202 patients, nearly 50% (49.9%) experienced good outcomes at discharge after receiving Revelise for ischemic stroke.
The number of patients with good outcomes increased to 66.4% after 90 days following treatment.
Revelise proved effective in reducing stroke-related disabilities, even among older patients and those with significant pre-existing health issues.
Frequently asked questions
Does Dr. Korobeinikov study ischemic stroke?
Yes, Dr. Korobeinikov researches treatments for ischemic stroke, particularly focusing on the medication Revelise.
What outcomes does Revelise treatment provide?
His studies show that nearly 50% of patients have good outcomes at discharge, improving to around 66% after 90 days.
Is Dr. Korobeinikov's work relevant for elderly stroke patients?
Yes, his research highlights the effectiveness of treatments in older patients and those with other health issues.
Publications in plain English
[Thrombolytic Therapy for Ischemic Stroke with Revelise: Results of a Two-Year Follow-Up in the International PRIMA Study].
2025
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Shamalov NA, Khasanova DR, Marchenko SV, Soldatov MA, Azarova AG +46 more
Plain English This study looked at how well and safely Revelise (alteplase), a medication for treating ischemic stroke (IS), works in real-life situations. It involved 2,202 patients, mostly around 68 years old, and found that nearly half (49.9%) of them had good outcomes when discharged, rising to 66.4% after 90 days. The results showed that Revelise effectively reduces stroke-related disabilities, even in older patients and those with other health issues.
Who this helps: This benefits patients who suffer from ischemic strokes and the doctors treating them.
Ovsyannikov SV, Karkin AE, Korobeinikov IV, Morozova NV, Bykov M +2 more
Plain English This study looked at the electronic properties of a specific type of iron oxide, known as FeO, which was created under high-pressure and high-temperature conditions. Researchers found that this material behaved like a semimetal, with electrical conductivity coming from both electrons and holes in equal amounts, which is significant for its potential applications. Understanding these properties is crucial because it could lead to the development of advanced materials and improve our knowledge of similar iron oxides that could be used in various technologies.
Who this helps: This helps researchers and engineers working on new materials and technologies.
Tuning the electronic and vibrational properties of SnPSeand PbPScrystals and their metallization under high pressure.
2017
Dalton transactions (Cambridge, England : 2003)
Ovsyannikov SV, Morozova NV, Korobeinikov IV, Haborets V, Yevych R +2 more
Plain English This study investigated how the properties of two semiconductors, SnPSe and PbPS, change when they are exposed to high pressure. Researchers found that when pressure was applied, the electrical resistance of SnPSe dramatically decreased by about 100 million times at 10 gigapascals, indicating a change in its electronic properties, while PbPS showed little change in resistance even at much higher pressure (20 gigapascals). These findings matter because they suggest that these materials could be more useful in electronic and optical technologies, and they encourage further research into similar materials that may respond interestingly to pressure.
Who this helps: This benefits researchers and developers working on advanced electronic and optical devices.
Dramatic Changes in Thermoelectric Power of Germanium under Pressure: Printing n-p Junctions by Applied Stress.
2017
Scientific reports
Korobeinikov IV, Morozova NV, Shchennikov VV, Ovsyannikov SV
Plain English This study looked at how applying pressure affects the electrical properties of germanium, a common semiconductor used in electronics. Researchers found that when they increased the pressure up to 20 GPa (about 200,000 times normal atmospheric pressure), the electrical behavior changed significantly, allowing germanium to conduct electricity in a different way—specifically, it switched to a p-type conduction state at around 10 GPa, before transforming back to an n-type state when the pressure was released. This discovery could lead to new ways to create advanced electronic devices, like those with printed junctions made from germanium.
Who this helps: This benefits engineers and manufacturers in the electronics industry.
Structural and Magnetic Transitions in CaCoVOPerovskite at Extreme Conditions.
2017
Inorganic chemistry
Ovsyannikov SV, Bykova E, Pakhomova A, Kozlenko DP, Bykov M +11 more
Plain English Researchers studied the new material CaCoVO, focusing on how it behaves under extreme conditions like high pressure and low temperature. They found that while its crystal structure remained stable up to 60 GPa, an important change occurred around 30 GPa, where the bonds between cobalt and oxygen became much more compressible and cobalt ions shifted positions. This is significant because understanding these transitions can help in developing advanced materials for various applications, including electronics and energy storage.
Who this helps: This helps researchers and engineers working on new materials and technologies.