Jane C-J Chao

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

50 publications 2021 – 2026 ORCID

What does Jane C-J Chao research?

Dr. Chao studies how health insurance policies, like Medicaid expansion, affect access to surgical care for thyroid and parathyroid conditions. Her research specifically looks into thyroid cancer surgeries, comparing techniques where only part of the thyroid is removed versus complete removal. She also investigates the legal aspects of thyroid surgery, including malpractice cases, to understand the factors that influence outcomes for both patients and surgeons.

Key findings

  • Medicaid expansion increased access to high-quality surgical centers for patients, with Medicaid patients in expansion states being 12-21 times more likely to have surgery at the best hospitals compared to those in non-expansion states.
  • Patients undergoing half-thyroid removals for low-risk cancer had fewer immediate second surgeries after the 2015 guidelines, showing that this less-invasive technique is safe and effective.
  • Surgeons won 78% of malpractice cases related to thyroid surgery, with an increased success rate of 92% in academic hospitals, highlighting the influence of hospital type on litigation outcomes.

Frequently asked questions

Does Dr. Chao study thyroid cancer?
Yes, Dr. Chao examines surgical techniques for thyroid cancer, focusing on the effectiveness of partial versus total thyroid removals.
What treatments has Dr. Chao researched?
Dr. Chao researches parathyroid surgeries and various techniques for thyroid surgery, including the impact of health insurance on access to these treatments.
Is Dr. Chao's work relevant to patients with low-income or uninsured?
Yes, her research highlights the disparities in surgical access and quality of care for low-income and uninsured patients, particularly those needing thyroid or parathyroid surgery.

Publications in plain English

Comparative analysis of two analytical methodologies for deriving dietary patterns associated with vitamin D insufficiency and anemia among expectant mothers.

2026

International journal of medical sciences

Das A, Hsu CY, Bai CH, Chang JS, Huang YL +4 more

Plain English
This study looked at how different diets affect vitamin D levels and anemia in pregnant women. Researchers analyzed the eating habits of 1,502 expectant mothers and found that those following a plant and marine-based diet had a 30% lower chance of vitamin D deficiency, while those with a diet high in convenience foods had a 46% higher risk of low vitamin D levels. Understanding these dietary connections is important for improving the health of mothers and their babies during pregnancy. Who this helps: This helps expectant mothers by providing guidance on healthy eating.

PubMed

Effect ofon cognition and microbiota in post-stroke patients: a single-blinded, controlled trial.

2026

International journal of medical sciences

Lin ST, Tung TH, Lin YN, Chang FH, Lian YZ +5 more

Plain English
This study looked at how a specific probiotic called OLP-01 affects brain function and gut bacteria in patients who have had a stroke. Researchers found that patients taking OLP-01 for 12 weeks showed improved cognitive abilities, with scores on cognitive tests increasing from an average of 19.1 to 23.7 on the Montreal Cognitive Assessment. Although the probiotic improved brain function and changed gut bacteria, it did not significantly affect physical performance levels. Who this helps: This study benefits post-stroke patients looking to improve their cognitive function.

PubMed

Preventive Effect ofKoidz. on Dextran Sulfate Sodium-Induced Chronic Colitis in Mice.

2026

Nutrients

Yeh HJ, Chao HM, Chang CC, Kao WY, Yang SC +2 more

Plain English
Researchers studied the effects of a cereal crop called djulis on mice with a type of bowel inflammation known as chronic colitis. They found that mice fed different amounts of djulis experienced less disease activity, with the highest dose group showing a significant improvement in their condition, including a notable reduction in inflammation markers and a restoration of colon length. This is important because it suggests that djulis could be a natural treatment option for people suffering from inflammatory bowel disease. Who this helps: Patients with inflammatory bowel disease.

PubMed

Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model.

2025

Asian Pacific journal of allergy and immunology

Huang WC, Liou CJ, Shen SC, Hu S, Chao JC +2 more

Plain English
This study looked at whether oleuropein, a compound found in olive leaves, can help reduce inflammation in a mouse model of atopic dermatitis (a skin condition). The researchers found that applying oleuropein decreased levels of certain inflammatory proteins and cytokines linked to allergic reactions, leading to less swelling and skin thickening in the mice. This matters because it shows that oleuropein could be a potential new treatment for atopic dermatitis by improving the immune response. Who this helps: This helps patients with atopic dermatitis.

PubMed

Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats.

2025

International journal of medical sciences

Wu YC, Lian YZ, Zhao H, Wang L, Ning D +1 more

Plain English
This study looked at how a special mixture of ingredients from Chinese herbs can help fight fatigue in rats after intense exercise. The results showed that rats given a high dose of this herbal mixture were able to exercise longer before getting tired, with the time to exhaustion increasing significantly. Specifically, those rats were able to go longer and had lower levels of lactic acid in their blood, which is linked to fatigue. Who this helps: This research benefits athletes and anyone looking to improve their endurance and exercise performance.

PubMed

Effectiveness of diet modification on dietary nutrient intake, aspiration, and fluid intake for adults with dysphagia: a meta-analysis of randomized controlled trials.

2025

The journal of nutrition, health & aging

Chu YH, Chao JC

Plain English
This study looked at how changing diets helps adults with swallowing difficulties, known as dysphagia. Researchers reviewed 16 past studies and found that special diets made with softer foods helped increase energy and protein intake, while using thicker liquids reduced the risk of choking (aspiration) and improved fluid consumption. These findings matter because they show that modifying diets can make eating and drinking safer and more nutritious for individuals with dysphagia. Who this helps: Patients with dysphagia.

PubMed

Treatment of Gingival Recession Using the Pinhole Surgical Technique With Collagen Membrane Vs Coronally Advanced Flap Technique With Connective Tissue Graft: A Split-Mouth Randomized Clinical Trial.

2025

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)

Shibly O, Chao JC, Albandar JM, Almehmadi N, Al-Sabbagh M

Plain English
This study looked at two different ways to treat gum recession: one method uses a flap and a graft (CAF + CTG), while the other uses a pinhole technique with a collagen membrane (PST + CM). After a year, both methods showed similar results in reducing gum recession by about 2 mm and covering around 65% of the exposed root surface. However, the flap method increased the thickness of healthy gum tissue significantly more, indicating that both treatments work well, but one may provide extra benefits in some areas. Who this helps: This benefits patients dealing with gum recession.

PubMed

Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity.

2025

International journal of medical sciences

Nguyen NTH, Bai CH, Chang JS, Chen YC, Huang YL +4 more

Plain English
This study examined how the diets of pregnant Taiwanese women who were overweight or obese before pregnancy affected their levels of folate and iron, which are important for health during pregnancy. Researchers found that women who ate more dairy and plant-based foods had higher folate levels and a lower risk of low folate, while those consuming more animal products had higher iron and vitamin B-12 levels. These findings highlight the importance of healthy dietary patterns in improving micronutrient levels for pregnant women with prior obesity. Who this helps: This benefits pregnant women, especially those who are overweight or obese, by providing insights into how their diet can improve their health and that of their babies.

PubMed

Associations of dietary patterns with serum 25(OH) vitamin D and serum anemia related biomarkers among expectant mothers: A machine learning based approach.

2025

International journal of medical informatics

Das A, Bai CH, Chang JS, Huang YL, Wang FF +3 more

Plain English
This study looked at how different eating habits among pregnant women relate to their iron levels and vitamin D levels. Researchers analyzed information from 1,423 expectant mothers and found that those who followed a balanced diet with moderate plant foods and low animal products had a 55% lower chance of having low iron and a 73% lower chance of having low ferritin levels compared to those with less diverse diets, but they were also more likely to have low vitamin D. Understanding these dietary patterns can help improve the health of pregnant women and their babies. Who this helps: This helps expectant mothers and their healthcare providers.

PubMed

Trace Element and Mineral Content in Medicinal Plants Collected in the Altai Mountains Foothills.

2025

Biological trace element research

Tinkov AA, Korobeinikova TV, Baranova OV, Chang JS, Chao JC +4 more

Plain English
This study looked at 21 medicinal plants collected from the Altai Mountains to see how much trace elements and minerals they contained. Researchers found that the roots of the plant Rhaponticum carthamoides had the highest levels of toxic elements like aluminum and lead, while Hippophae rhamnoides fruits had the highest levels of the essential mineral zinc. This information is important because it helps identify which plants can be beneficial for health and which may pose risks due to toxic elements. Who this helps: This benefits patients looking for safe and effective medicinal plants.

PubMed

Interactive effects of sleep duration and dietary patterns on obesity moderated by age.

2025

Scientific reports

Lin LY, Hsu CY, Chao JC, Chien YN, Chiou HY

Plain English
This study looked at how sleep duration and eating habits affect obesity in adults in Taiwan. Researchers found that people who slept less had 21% higher chances of being obese. Additionally, diets high in processed foods and protein were linked to even higher obesity rates, while eating more dairy and complex carbs helped reduce obesity risk. This is important because it shows that both sleep and diet play significant roles in weight management and that younger adults are especially affected. Who this helps: Patients looking to manage their weight and improve their health.

PubMed

Impact of social media addiction on anxiety symptoms as modified by social support and its subscales.

2025

Digital health

Yeh CR, Vo HT, Lin CY, Lai CF, Tran Le TC +4 more

Plain English
This study looked at how social media addiction affects anxiety levels in young adults in Taiwan, focusing on the role of social support. Out of 1,324 participants, 21.4% showed signs of social media addiction, which was linked to higher anxiety scores. Those with strong family and partner support had lower anxiety symptoms, suggesting that social support helps reduce anxiety for those struggling with social media use. Who this helps: This helps young adults who use social media excessively and may struggle with anxiety, as well as their families and friends.

PubMed

Global prevalences of erythropoiesis-associated micronutrient deficiencies (iron, folate, and vitamin B) among pregnant women: a systematic review and meta-analysis.

2025

Annals of medicine

Nguyen NTH, Chen YC, Nhu NT, Bao HB, Hsu CY +2 more

Plain English
The study looked at how common deficiencies in iron, folate, and vitamin B12 are among pregnant women around the world. It found that 28.4% of pregnant women have iron deficiency, 11.1% lack folate, and 17.1% are deficient in vitamin B12. Additionally, more than half (53.1%) of women have either iron or folate deficiency, which can lead to serious health risks for both mothers and their babies. Who this helps: This helps pregnant women and healthcare providers working to improve maternal and child health.

PubMed

The association of Medicaid expansion and parathyroidectomy for benign disease: Insurance status remains an important factor in access to high-volume centers.

2025

Surgery

Kheng M, Ko T, Manzella A, Chao JC, Laird AM +1 more

Plain English
Researchers examined whether expanding Medicaid (government health insurance for low-income people) helped patients get parathyroid surgery at the best hospitals. They analyzed data from nearly 32,000 patients and found that Medicaid expansion significantly improved access—Medicaid patients in expansion states were 12-21 times more likely to receive surgery at high-quality, high-volume centers compared to those in non-expansion states. However, the study revealed a troubling gap: uninsured and Medicaid patients overall were still much more likely to have surgery at lower-quality, low-volume hospitals compared to privately insured patients, even after expansion. Medicare patients fared reasonably well at high-volume centers. The bottom line is that while Medicaid expansion helped, insurance status remains a major barrier to accessing the best surgical care—and patients without insurance or with Medicaid still face significant disadvantages compared to the privately

PubMed

Role of vitamins beyond vitamin Din bone health and osteoporosis (Review).

2024

International journal of molecular medicine

Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A +9 more

Plain English
This research reviewed how various vitamins (A, C, E, K, and B vitamins) affect bone health and the risk of osteoporosis. It found that getting the right amount of these vitamins helps build strong bones, while too much vitamin A can actually harm bone formation. Proper intake of vitamins can lower the risk of osteoporosis, making it important for overall bone health. Who this helps: This benefits patients at risk for osteoporosis.

PubMed

Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway.

2024

International immunopharmacology

Huang WC, Liou CJ, Shen SC, Hu S, Chao JC +2 more

Plain English
This study looked at how punicalagin, a compound found in pomegranate peel, affects inflammation in skin cells (HaCaT cells) when exposed to certain inflammatory signals. Researchers found that treating these cells with as little as 3 micromoles of punicalagin reduced key inflammatory substances by significant amounts, including interleukin-6 and interleukin-8, and enhanced protective pathways in the cells. These findings suggest punicalagin could be a helpful anti-inflammatory agent for treating skin inflammation. Who this helps: Patients with inflammatory skin conditions.

PubMed

Socioeconomic status as a predictor of post-operative mortality and outcomes in carotid artery stenting vs. carotid endarterectomy.

2024

Frontiers in cardiovascular medicine

Baxi J, Chao JC, Dewan K, Yang NK, Pepe RJ +6 more

Plain English
This study looked at how a patient's socioeconomic status (SES) affects their recovery after two types of procedures to open blocked carotid arteries: carotid artery stenting (CAS) and carotid endarterectomy (CEA). The researchers found that low SES doubles the risk of death after CEA (with an increased risk ratio of 2.07), but it does not significantly affect outcomes after CAS. Additionally, low SES patients had a slightly higher stroke rate after CEA (1.5% compared to 1.2% for high SES), while bleeding issues were more common in high SES patients undergoing CAS (7.1% vs. 5.3%). Who this helps: This research benefits patients undergoing these procedures, especially those from low-income backgrounds.

PubMed

Rheumatic fever and long-term use of benzathine penicillin as possible risk factors for extensive macular atrophy with pseudodrusen in a Brazilian cohort.

2024

International journal of retina and vitreous

Moreira-Neto CA, Schmidt Andujar RA, Chao JCT, Vasconcelos H, Alves FEE +7 more

Plain English
This study looked at the connection between rheumatic fever (RF) and long-term use of benzathine penicillin (BP) in Brazilian patients with a condition called extensive macular atrophy with pseudodrusen (EMAP), which affects vision. Researchers found that 90.9% of the patients had RF and that each additional year of BP treatment was linked to a significant area reduction of atrophy in the eye. Specifically, older age at RF diagnosis appeared to lower the presence of certain eye conditions in these patients. Who this helps: This research helps eye doctors and patients by identifying potential risk factors for vision loss related to rheumatic fever and penicillin treatment.

PubMed

A ferritin-related dietary pattern is positively associated with iron status but negatively associated with vitamin D status in pregnant women: a cross-sectional study.

2024

European journal of nutrition

Das A, Bai CH, Chang JS, Huang YL, Wang FF +3 more

Plain English
This study looked at the eating habits of pregnant women and how their diets affected their iron and vitamin D levels. Researchers found that a diet high in certain foods like fish, nuts, and organ meat was linked to better iron levels; specifically, women with the healthiest diets had a 35% lower chance of having low iron. However, these same women were also 79% more likely to have low vitamin D levels. This is important because while good iron levels help prevent anemia, low vitamin D can lead to other health issues. Who this helps: This helps pregnant women by highlighting the importance of balancing their diet for both iron and vitamin D.

PubMed

Accuracy of intraoral scanners in maxillary multiple restorations: Anstudy.

2024

Journal of dental sciences

Aung HMM, Linn TY, Lee WF, Chao JC, Teng NC +2 more

Plain English
This study looked at how accurate two different intraoral scanners, Trios 3 and Virtuo Vivo, are when used to create multiple dental restorations. The researchers found that while Trios 3 was more accurate in measuring a specific type of dental bridge, Virtuo Vivo performed better overall in consistency. The findings help dentists choose the right scanner for different types of dental work, which can lead to better results for patients. Who this helps: This helps dentists and dental technicians.

PubMed

Malpractice litigation after thyroid surgery: What factors favor surgeons?

2024

Surgery

Chao JC, Kheng M, Manzella A, Beninato T, Laird AM

Plain English
Researchers analyzed 68 lawsuits filed against surgeons for malpractice after thyroid surgery between 1949 and 2022, looking at what factors determined whether surgeons won or lost. Surgeons won about 78% of cases overall, and won even more often (92%) when cases were tried at academic hospitals or handled by surgeons with specialized endocrine training—they also won more frequently in states with legal protections for doctors. The most common problem leading to lawsuits was nerve damage during surgery, and when patients did win, they received damage awards averaging around $570,000.

PubMed

Reoperation Rates After Initial Thyroid Lobectomy for Patients with Thyroid Cancer: A National Cohort Study.

2024

Thyroid : official journal of the American Thyroid Association

Kheng M, Manzella A, Chao JC, Laird AM, Beninato T

Plain English
Researchers compared how often patients needed a second surgery after having either half their thyroid removed (lobectomy) or their entire thyroid removed for cancer, before and after 2015 guidelines made the less-invasive half-removal option more acceptable. They found that while doctors increasingly chose the half-removal option after 2015, patients who had it needed fewer immediate second surgeries (likely because doctors got better at doing the procedure right the first time), and they weren't any more likely to need surgery later for cancer recurrence compared to patients who had their whole thyroid removed. The finding matters because it shows that the less-invasive surgery can be a safe and effective option for patients with low-risk thyroid cancer, potentially allowing them to avoid the side effects of removing their entire thyroid while not compromising their long-term outcomes.

PubMed

Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia.

2023

European journal of nutrition

Hu TY, Mayasari NR, Cheng TM, Bai CH, Chao JC +5 more

Plain English
This study looked at how different genetic forms of a protein called haptoglobin affect the risk of iron-deficiency anemia during pregnancy, especially in relation to dietary iron intake. Among 1,430 pregnant women, those with the haptoglobin 1-1 form had the lowest iron levels and the highest rates of iron deficiency. Women not taking recommended prenatal supplements were 4 times more likely to have iron deficiency anemia, with higher risks for those carrying specific haptoglobin forms. Who this helps: This information is beneficial for pregnant women and healthcare providers to better manage iron levels during pregnancy.

PubMed

Interactive Effects of Obesity and Hypertension on Patterns of Hair Essential Trace Element and Mineral Content in Adult Women.

2023

Biological trace element research

Skalny AV, Korobeinikova TV, Zabroda NN, Chang JS, Chao JC +4 more

Plain English
This study looked at how obesity and high blood pressure (hypertension) affect the levels of important minerals and trace elements in the hair of adult women. Researchers analyzed hair samples from 607 women and found that those with obesity, hypertension, or both had lower levels of minerals like calcium, magnesium, and zinc compared to healthy women. This is important because it suggests that obesity and high blood pressure may be linked to deficiencies in these essential nutrients, which could affect women's overall health. Who this helps: This helps patients, particularly women with obesity and hypertension, by highlighting potential nutritional deficiencies related to their conditions.

PubMed

A Wi-Fi-Based Passive Indoor Positioning System via Entropy-Enhanced Deployment of Wi-Fi Sniffers.

2023

Sensors (Basel, Switzerland)

Chan PY, Chao JC, Wu RB

Plain English
This study focused on creating a system that can determine the location of devices indoors using Wi-Fi signals without the device needing to do anything special. By cleverly placing 20 Wi-Fi Sniffers, the system achieved an accuracy of about 2.2 meters when determining a device's position. This is important because it allows for precise tracking within buildings, which can enhance various applications from navigation to safety. Who this helps: This benefits patients in hospitals by improving location-based services and ensuring better tracking of devices and equipment.

PubMed

Effects of Climate, Sun Exposure, and Dietary Intake on Vitamin D Concentrations in Pregnant Women: A Population-Based Study.

2023

Nutrients

Huang YL, Pham TTM, Chen YC, Chang JS, Chao JC +1 more

Plain English
This study looked at how climate, sunlight exposure, and dietary intake affect vitamin D levels in pregnant women across Taiwan. Researchers found that about 30.1% of pregnant women had a vitamin D deficiency, with the highest rates in the northern regions. The findings showed that eating enough red meat, taking vitamin D or calcium supplements, getting sun exposure, and having blood tests during sunny months significantly reduced the risk of deficiency, suggesting that both diet and sunlight are important for maintaining healthy vitamin D levels depending on the local climate. Who this helps: Pregnant women and healthcare providers.

PubMed

Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan.

2023

Nutrients

Das A, Bai CH, Chang JS, Huang YL, Wang FF +2 more

Plain English
This study looked at the diets of pregnant women in Taiwan to see how different eating patterns affected their vitamin D and iron levels. Researchers found that women who primarily ate plant-based diets had lower chances of having low vitamin D and folate levels, while those with higher meat consumption were more likely to have low iron levels but also had better vitamin B and vitamin D levels. This matters because ensuring healthy vitamin and mineral levels in pregnant women is crucial for their health and the development of their babies. Who this helps: This helps pregnant women by guiding them on dietary choices that can improve their vitamin and iron levels.

PubMed

Relationships between Dietary Patterns and Erythropoiesis-Associated Micronutrient Deficiencies (Iron, Folate, and Vitamin B) among Pregnant Women in Taiwan.

2023

Nutrients

Mayasari NR, Bai CH, Chao JC, Chen YC, Huang YL +3 more

Plain English
This study examined the eating habits of pregnant women in Taiwan and how they relate to deficiencies in important nutrients like iron, folate, and vitamin B, which are crucial for healthy blood production. Researchers found that 38.2% of women had one nutrient deficiency, while 18.6% had two, and 7.5% had three deficiencies. Notably, women with lower incomes and anemia were particularly vulnerable, with 32.5% having two deficiencies and 15.8% having three. Eating more fruits, vegetables, nuts, whole grains, soy, and dairy can significantly decrease the chances of these deficiencies by up to 67%. Who this helps: This research benefits pregnant women, especially those from low-income backgrounds.

PubMed

Ambulatory Electrocardiography Monitoring for Early Discharge After Minimally Invasive Valve Surgery.

2023

The Journal of surgical research

Laraia KN, Pepe RJ, Sabatino ME, Dewan KC, Yoo J +8 more

Plain English
This study looked at patients who had minimally invasive valve surgery and were discharged early, analyzing whether those with irregular heartbeats before leaving the hospital faced different health outcomes than those without such issues. Among the 41 patients, 17 (41.5%) had irregular heartbeats before discharge, and most (92.7%) experienced rapid heartbeats during home monitoring, but there were no deaths, and readmission rates were similar for both groups. This research shows that patients can safely go home earlier without risking their health, allowing them to recover more comfortably. Who this helps: This helps patients recovering from heart surgery.

PubMed

Minimally invasive approach associated with lower resource utilization after aortic and mitral valve surgery.

2023

JTCVS open

Yang NK, Soliman FK, Pepe RJ, Palte NK, Yoo J +10 more

Plain English
The study looked at how minimally invasive cardiac surgery (MICS) compared to traditional open-heart surgery affects costs, hospital stays, and recovery in patients undergoing heart valve operations. It found that patients who had MICS had a lower rate of high resource use (31.25% compared to 61.29% for open surgery) and spent fewer days in the hospital (4 days vs. 6 days). MICS also cost less on average ($22,900 vs. $31,900), and patients undergoing open surgery had higher rates of complications like heart rhythm issues and kidney failure. Who this helps: This benefits patients undergoing heart valve surgery, as they can have a quicker recovery and lower costs.

PubMed

CombinedPolysaccharides with Plasmon-Activated Water Affect IFN-γ/TNF-α Induced Inflammation in Caco-2 Cells.

2023

Pharmaceuticals (Basel, Switzerland)

Lian YZ, Liu YC, Chang CC, Nochi T, Chao JC

Plain English
This study looked at how a natural substance called polysaccharides (specifically LBP) and a special type of water (plasmon-activated water, or PAW) can reduce inflammation in human colon cells. Researchers found that combining LBP with PAW significantly lowered harmful substances that cause inflammation and cell death, with the best results seen at higher doses of LBP (500 µg/mL). This matters because it shows a potential way to treat inflammation in the gut, which is important for people with conditions like inflammatory bowel disease. Who this helps: This helps patients with inflammatory bowel diseases.

PubMed

Outcomes of minimally invasive aortic valve replacement in patients with obese body mass indices.

2022

Journal of cardiac surgery

Sabatino ME, Yang N, Soliman FK, Chao JC, Ikegami H +3 more

Plain English
This study looked at how obesity affects the outcomes of a specific type of heart surgery called minimally invasive aortic valve replacement (mini-AVR) in patients with different levels of obesity. Researchers found that in a group of 206 obese patients, factors like hospital stay length and mortality rates after surgery were similar across three obesity classes, with hospital stays averaging about 5 to 6 days and 30-day mortality rates ranging from 2.44% to 7.89%. These results show that mini-AVR is a safe option for obese patients, no matter how obese they are. Who this helps: This helps patients with obesity who need heart valve surgery.

PubMed

The effects of medications for treating COPD and allied conditions on stroke: a population-based cohort study.

2022

NPJ primary care respiratory medicine

Shen AL, Lin HL, Lin HC, Chao JC, Hsu CY +1 more

Plain English
This study looked at how different medications affect the risk of stroke in patients with chronic obstructive pulmonary disease (COPD) and similar conditions. Out of over 48,000 patients, those with COPD had a higher stroke rate of 4.2%, compared to 1.6% in those without COPD. Patients over 65, men, and those with high blood pressure, diabetes, or heart issues had an even greater risk, but using certain medications like mucolytics or a combination of specific inhalers lowered the stroke risk. Who this helps: This information benefits COPD patients and their doctors in managing stroke risk.

PubMed

Polysaccharides and Capsaicin Inhibit Oxidative Stress, Inflammatory Responses, and Pain Signaling in Rats with Dextran Sulfate Sodium-Induced Colitis.

2022

International journal of molecular sciences

Chen YS, Lian YZ, Chen WC, Chang CC, Tinkov AA +2 more

Plain English
This study looked at how two substances, polysaccharides and capsaicin, affected ulcerative colitis (UC) in rats. The researchers found that these treatments significantly reduced signs of disease, including inflammation and pain, and improved overall gut health. For example, the combination treatment lowered levels of harmful proteins related to inflammation and oxidative stress. Who this helps: This research benefits patients with ulcerative colitis by providing new potential treatment options.

PubMed

Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-κB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.

2022

International journal of molecular sciences

Huang WC, Liou CJ, Shen SC, Hu S, Chao JC +2 more

Plain English
This study looked at the effects of a compound called urolithin A on inflammation caused by a molecule that mimics viral infection. The researchers found that a low dose of 1 micromolar of urolithin A significantly reduced inflammation in immune cells, lowering levels of inflammatory proteins by more than 50%. This matters because it shows that urolithin A could help combat inflammation and strengthen the body's defense against viral infections. Who this helps: Patients with viral infections or inflammatory diseases.

PubMed

Association of Angiotensin Receptor Blockers with Incident Parkinson Disease in Patients with Hypertension: A Retrospective Cohort Study.

2022

The American journal of medicine

Lin HC, Tseng YF, Shen AL, Chao JC, Hsu CY +1 more

Plain English
This study looked at whether angiotensin receptor blockers (ARBs), which are often used to treat high blood pressure, can also lower the risk of developing Parkinson's disease. Out of over 107,000 patients, those who used ARBs had only 1.1% developing Parkinson's, compared to 2.2% of those who didn't use ARBs. This suggests that using ARBs can significantly reduce the risk of Parkinson's disease for newly diagnosed patients with hypertension. Who this helps: This benefits patients with high blood pressure, particularly those concerned about the risk of Parkinson's disease.

PubMed

Combined Low Plant and High Animal Dietary Pattern Is Associated with a Lower Risk of Anemia among Dyslipidemic Adult Women in Taiwan: A Retrospective Study from 2001 to 2015.

2022

International journal of environmental research and public health

Purnamasari SD, Hsu CY, Chen YT, Kurniawan AL, Lee HA +1 more

Plain English
This study looked at the diets of over 22,000 women in Taiwan who have high cholesterol issues and explored how their eating habits relate to anemia, a condition where you lack enough healthy red blood cells. The findings showed that women who followed a low-plant and high-animal diet had a 24% lower risk of moderate to severe anemia compared to those with a low plant and low animal diet. This is important because preventing anemia can improve overall health and energy levels for these women. Who this helps: This helps dyslipidemic adult women by providing dietary insights to reduce their risk of anemia.

PubMed

An Intelligent Cardiopulmonary Training System and Adherence to Training Intensity: A Feasibility Study.

2022

International journal of environmental research and public health

Wei L, Chi JY, Chao JC, Lin YN

Plain English
This study looked at how well an intelligent training system for the heart and lungs works for people who don't exercise much. Nine participants completed 12 sessions of cycling for 30 minutes three times a week, and after four weeks, their ability to exercise and oxygen intake improved significantly—by about 14 watts and 1.5 mL/kg/min. The study also found that participants spent a good amount of their training time in the right heart rate zone, which is important for effective training. Who this helps: This benefits patients who are starting to exercise again, particularly those in rehabilitation programs.

PubMed

Association of Dietary Pattern with Cardiovascular Risk Factors among Postmenopausal Women in Taiwan: A Cross-Sectional Study from 2001 to 2015.

2022

Nutrients

Aliné S, Hsu CY, Lee HA, Paramastri R, Chao JC

Plain English
This study looked at how eating habits affect heart health in postmenopausal women in Taiwan. Researchers found that women who ate a diet high in processed foods and certain meats had a higher likelihood of high blood pressure, increased triglycerides, and higher blood sugar levels. Specifically, those with the worst diets had a 38% higher risk of high triglycerides and a 45% greater risk of elevated blood sugar compared to those with better eating patterns. These findings highlight the importance of healthy eating for reducing heart disease risk in these women. Who this helps: This helps postmenopausal women looking to improve their heart health.

PubMed

Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast.

2022

Nature communications

Swamy KBS, Lee HY, Ladra C, Liu CJ, Chao JC +2 more

Plain English
This study looked at how the mixing of genes from two different types of yeast affects their ability to reproduce. Researchers found that when yeast from one species (Saccharomyces bayanus var. uvarum) has chromosomes mixed with another species (Saccharomyces cerevisiae), it causes problems in protein complexes, leading to cell division issues. They discovered that the more chromosomes that were swapped, the greater the problems, which could either be lessened or worsened by adjusting the yeast's protein management system. Who this helps: This helps scientists studying yeast genetics and speciation, as well as agricultural researchers working with yeast strains.

PubMed

polysaccharides and capsaicin modulate inflammatory cytokines and colonic microbiota in colitis rats induced by dextran sulfate sodium.

2022

Journal of clinical biochemistry and nutrition

Lian YZ, Chang CC, Chen YS, Tinkov AA, Skalny AV +1 more

Plain English
This study looked at how two natural substances, polysaccharides and capsaicin, affect inflammation and gut bacteria in rats with colitis, a type of inflammatory bowel disease. The researchers found that both treatments improved the rats' health, with the disease activity scores dropping by a significant amount, and they also lowered levels of inflammatory signals in the colon. These findings suggest that using polysaccharides and capsaicin may help manage ulcerative colitis by reducing inflammation and improving gut health. Who this helps: This helps patients with ulcerative colitis.

PubMed

C-Phycocyanin andPolysaccharides Protect against Aspirin-Induced Inflammation and Apoptosis in Gastric RGM-1 Cells.

2022

Nutrients

Liu YC, Chang CC, Matsui H, Chao JC

Plain English
This study looked at how two substances, C-phycocyanin (CPC) from blue-green algae and polysaccharides from wolfberries, could protect stomach cells from damage caused by aspirin. Researchers found that these substances helped reduce inflammation and cell death when aspirin was applied to stomach cells. Specifically, CPC and LBP increased levels of a protective substance called IL-10 and decreased harmful proteins, showing their potential to help manage aspirin's negative effects on the stomach. Who this helps: This benefits patients who use aspirin, particularly those at risk of stomach damage.

PubMed

Surgery is Associated With Improved Overall Survival in Patients With Metastatic Gastric Cancer: A National Cancer Database Analysis.

2022

The American surgeon

Greco SH, Chao JC, Heath NG, Lin Y, Gall VA +6 more

Plain English
This study examined how surgery impacts survival for patients with advanced gastric cancer that has spread to other parts of the body. Researchers analyzed data from nearly 19,000 patients and found that those who had surgery on the primary tumor or distant sites lived longer, with a median survival of about 15.8 to 15.9 months, compared to just 8.6 months for patients who did not have surgery. This is important because it shows that surgery can significantly improve survival, encouraging more exploration of surgical options for these patients. Who this helps: This helps patients with metastatic gastric cancer and their healthcare providers.

PubMed

Associations of Food and Nutrient Intake with Serum Hepcidin and the Risk of Gestational Iron-Deficiency Anemia among Pregnant Women: A Population-Based Study.

2021

Nutrients

Mayasari NR, Bai CH, Hu TY, Chao JC, Chen YC +5 more

Plain English
This research studied how the foods pregnant women eat influence their iron levels and the risk of iron-deficiency anemia during pregnancy. The study with 1,430 women found that eating more Chinese dim sum and dark leafy vegetables raised iron-regulating hepcidin levels, while eating noodles reduced them. It also showed that higher protein and fiber intake lowered the risk of anemia, while increased carbohydrate consumption could raise the risk. This matters because understanding these dietary links can help prevent anemia in pregnant women, ensuring better health for them and their babies. Who this helps: Pregnant women at risk of iron-deficiency anemia.

PubMed

Synergistic Interaction of Dietary Pattern and Concordance Lifestyle with Abnormal Liver Function among Young Adults in Taiwan: A Population-Based Longitudinal Study.

2021

Nutrients

Paramastri R, Hsu CY, Chuang YK, Lee HA, Wiratama BS +1 more

Plain English
This study looked at how certain diets and lifestyle choices affect liver health in young adults in Taiwan. Researchers found that those who consumed a diet high in soy sauce, sugary drinks, and processed foods, while avoiding seafood, fruits, and vegetables, had a higher risk of abnormal liver function. Specifically, having both a poor diet and an unhealthy lifestyle more than doubled the chances of liver problems (with an increased risk of 114%). Who this helps: This helps young adults, healthcare providers, and nutritionists in understanding the importance of dietary and lifestyle choices for liver health.

PubMed

Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3-5 chronic kidney disease patients in Taiwan.

2021

BMC nephrology

Kurniawan AL, Yang YL, Hsu CY, Paramastri R, Lee HA +3 more

Plain English
The study looked at over 2,000 patients with chronic kidney disease (stages 3-5) in Taiwan to understand how certain metabolic factors like blood pressure and blood sugar levels relate to anemia and electrolyte issues. It found that high blood pressure and elevated blood sugar levels were linked to a greater risk of anemia, while high blood sugar also increased the risk of low sodium and high calcium levels. This information is important because managing these metabolic factors could help prevent serious complications in kidney disease patients. Who this helps: This helps patients with chronic kidney disease.

PubMed

Phytochemistry, Pharmacology, and Nutraceutical Profile ofSpecies: An Updated Review.

2021

Molecules (Basel, Switzerland)

Dhatwalia J, Kumari A, Verma R, Upadhyay N, Guleria I +10 more

Plain English
This study looks at the genus Carissa, a group of plants used traditionally in various regions to treat illnesses like chest pain, headaches, and diabetes. Researchers reviewed 155 papers and found that these plants have beneficial properties, including being antioxidant, antimicrobial, and possibly helpful in treating cancer and inflammation, thanks to 121 different chemical compounds identified in them. This matters because it supports the traditional use of these plants in medicine and highlights their potential for developing new treatments. Who this helps: Patients seeking alternative or complementary treatments for various health issues.

PubMed

Reproducibility and Validity of a Food Frequency Questionnaire (FFQ) Developed for Middle-Aged and Older Adults in Semarang, Indonesia.

2021

Nutrients

Syauqy A, Afifah DN, Purwanti R, Nissa C, Fitranti DY +1 more

Plain English
This study looked at a food survey tool called a Food Frequency Questionnaire (FFQ) to see how accurately it can measure what middle-aged and older adults in Semarang, Indonesia eat. Researchers tested the FFQ with 259 participants by having them fill it out twice and also complete detailed 24-hour food recalls, finding that the FFQ correlates reasonably well with these recalls, with accuracy rates of 81.1% to 94.6%. This is important because reliable food surveys can help understand dietary patterns and health in older adults. Who this helps: This helps patients and health professionals understand and improve nutrition for older adults.

PubMed

Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues.

2021

International journal of molecular sciences

Skalny AV, Aschner M, Lei XG, Gritsenko VA, Santamaria A +7 more

Plain English
This study looked at how zinc (Zn) affects gut bacteria and overall health. Researchers found that zinc is important for maintaining a diverse range of gut bacteria, which helps keep the gut lining strong and prevents harmful substances from entering the bloodstream. However, too much zinc can disrupt gut bacteria, leading to issues like inflammation and various health problems, including obesity and attention disorders. Who this helps: This helps patients looking for ways to improve gut health and manage related conditions.

PubMed

Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults.

2021

Medicina (Kaunas, Lithuania)

Kurniawan AL, Hsu CY, Chao JC, Paramastri R, Lee HA +1 more

Plain English
This study looked at how two indicators of insulin resistance, called the TyG index and TG/HDL-C ratio, relate to abnormal liver function in over 133,000 Taiwanese adults aged 30 and older. The results showed that higher levels of these indicators were linked to increased risks of liver issues: for example, those in the highest category of the TyG index had a 45% higher risk of elevated AST levels and an 85% higher risk for elevated ALT levels compared to those in the middle range. Understanding these relationships can help detect liver problems early and potentially prevent more serious liver disease. Who this helps: This benefits patients at risk for liver disease and their doctors.

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.