Dr. Kelly A Ross studies how nitric oxide impacts pancreatic beta-cells, which are responsible for producing insulin. Her research highlights that nitric oxide can inhibit these cells' ability to take in glucose by disrupting their energy supply. This malfunction happens because nitric oxide interferes with the cells' energy-producing structures, leading to a state where they cannot absorb glucose effectively. This research is particularly relevant for understanding diabetes, as it uncovers a specific vulnerability of insulin-producing cells that could inform future treatment approaches.
Key findings
Nitric oxide inhibits glucose uptake in pancreatic beta-cells by significantly reducing ATP levels, which are crucial for energy.
The study found that this effect puts insulin-producing cells into a dormant state, affecting their function in insulin regulation.
Understanding this mechanism may lead to new treatment strategies for diabetes by targeting the specific vulnerabilities of pancreatic cells.
Frequently asked questions
Does Dr. Kelly A Ross study diabetes?
Yes, Dr. Ross's research focuses on pancreatic cells that produce insulin, which are critical in diabetes management.
What impact does nitric oxide have on glucose uptake?
Nitric oxide decreases the ability of insulin-producing cells to take in glucose by blocking their energy production, leading to reduced glucose absorption.
How could Dr. Ross's findings help improve diabetes treatments?
Her findings identify specific vulnerabilities in insulin-producing cells that could be targeted in developing new treatments for diabetes.
Publications in plain English
Coronary Artery Calcium Status, Body Composition, Blood Lipids, and Fitness Among Firefighters Participating in a Health and Wellness Program.
2026
Journal of strength and conditioning research
Sanchez KJ, Baruch T, Ross KA, Coburn JW, Costa PB +3 more
Plain English This study looked at the heart health and fitness levels of 45 male firefighters by checking their coronary artery calcium (CAC) status, which can indicate the risk of heart disease. Researchers found that 10 firefighters had abnormal CAC levels, while 35 had normal levels; those with normal CAC had lower blood pressure and performed better on fitness tests, showing 9-14% better results in vertical jumps and aerobic capacity. These findings highlight the hidden risk of heart disease in firefighters who appear fit and emphasize the importance of comprehensive health programs that include both exercise and medical screenings.
Who this helps: This helps firefighters and their health professionals.
Real-Time Automated pH Control within Batch Processes Relying on Raman pH Measurement.
2025
ACS omega
Serrano T, Espley AF, Potter SM, Ross KA, Tse P +9 more
Plain English This research studied how to better control the acidity levels (pH) during the chemical processing of used nuclear fuel, which is crucial for recycling valuable materials. The researchers found that using a method called Raman spectroscopy, combined with advanced data analysis, could effectively keep the solution's pH stable at about 2.8, even when changes occurred, ensuring accurate measurements and reducing errors. This method is more reliable than traditional pH probes and can help make recycling used nuclear fuel more efficient and safer.
Who this helps: This helps nuclear power plants and companies involved in nuclear fuel recycling.
Biddle Physical Ability Test (BPAT) Performance by Attempt in Southern California Structural Firefighter Candidates.
2025
International journal of exercise science
Lockie RG, Dulla JM, Meloni J, Ross KA, Orr RM +2 more
Plain English This study looked at how previous attempts at the Biddle Physical Ability Test (BPAT) affected the performance of firefighter candidates in Southern California. Among 1,507 candidates, those taking the test for the first, second, or third time were significantly slower and had higher failure rates (up to 13%) compared to those taking the test for the fourth time or more, who passed at rates of 98% or higher. This matters because it shows that more practice leads to better performance, suggesting candidates should participate in training sessions to improve their chances of passing the test.
Who this helps: This helps firefighter candidates improve their chances of passing the BPAT.
Compositional analysis and characterization of black huckleberry and soapberry: Two culturally significant berries for Indigenous communities of the Pacific Northwest.
2025
Food chemistry: X
Ross KA, DeLury NC, Fukumoto L, Gill D, Lindley R
Plain English This study examined the nutritional and chemical properties of black huckleberries and soapberries, which are important to Indigenous communities in the Pacific Northwest. The researchers found that black huckleberries are larger and contain higher levels of calcium and magnesium, while soapberries have more potassium and protein. These findings are significant because they highlight the different health benefits and uses of these berries, which can aid in traditional diets and nutrition.
Who this helps: This helps Indigenous communities and nutritionists who focus on traditional foods.
Patient-reported hip pain and function are worse among elite Nordic ski athletes competing in ski jumping versus Nordic combined: a cross-sectional analysis.
2024
Journal of ISAKOS : joint disorders & orthopaedic sports medicine
Vasavada KD, Shankar DS, Ross KA, Avila A, Buzin S +6 more
Plain English This study looked at hip pain and function in elite Nordic ski athletes, comparing those who compete in ski jumping (SJ) with those in Nordic combined (NC). Researchers found that ski jumpers reported significantly worse hip symptoms and function, with a lower quality of life related to their hips than the Nordic combined athletes. Specifically, SJ athletes had poorer scores for hip symptoms, stiffness, and function in sports activities, showing they struggled more with hip issues despite being similar in other characteristics.
Who this helps: This information benefits coaches, sports medicine professionals, and elite ski athletes, particularly those specializing in ski jumping.
Current and Emerging Techniques in Articular Cartilage Repair.
2024
Bulletin of the Hospital for Joint Disease (2013)
Ross KA, Ferati SR, Alaia MJ, Kennedy JG, Strauss EJ
Plain English This study looked at different ways to repair damaged cartilage in the knee, especially when lesions don’t heal well on their own. Researchers found that while some methods like microfracture offer temporary relief, they often don't provide lasting solutions like true natural cartilage. New techniques are being developed that might reduce recovery time and improve how well the repair integrates with existing cartilage, but they are not yet widely used.
Who this helps: This helps patients with knee injuries and osteoarthritis.
Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection.
2024
NPJ vaccines
Lopez CE, Zacharias ZR, Ross KA, Narasimhan B, Waldschmidt TJ +1 more
Plain English Researchers studied a new type of vaccine, called a polyanhydride nanovaccine, designed to protect against different strains of the influenza A virus, specifically H3N2. They found that this vaccine effectively triggered strong immune responses, developing both antibodies and T cells that could protect against not just H3N2 but also other flu strains. This is important because it could lead to a more effective and long-lasting flu vaccine, helping to tackle the constant evolution of the virus.
Who this helps: This benefits patients who are at risk of influenza, particularly those vulnerable to severe illness.
Next-generation nanovaccine induces durable immunity and protects against SARS-CoV-2.
2024
Acta biomaterialia
Ross KA, Kelly S, Phadke KS, Peroutka-Bigus N, Fasina O +5 more
Plain English Researchers studied a new type of vaccine called a nanovaccine, designed to provide long-lasting protection against COVID-19 and its variants. They found that this nanovaccine created strong and durable immune responses that lasted over 62 weeks, effectively neutralizing multiple SARS-CoV-2 variants and protecting mice from severe illness caused by the virus. This new approach could make vaccines more effective against future strains of COVID-19.
Who this helps: Patients and healthcare providers looking for stronger and more durable vaccines against COVID-19.
Characterizing femoroacetabular impingement in professional Nordic Skiers.
2023
The Physician and sportsmedicine
Vasavada K, Ross KA, Lott A, Shankar D, Marulanda D +4 more
Plain English This study looked at how common a condition called femoroacetabular impingement (FAI) is among professional Nordic skiers, compared to non-athletes. The researchers found that Nordic skiers were more likely to show signs of FAI on X-rays, with 19 skiers showing more hip issues than a similar group of non-skiers, but they also had better hip movement in certain directions. Understanding the high prevalence of FAI in these athletes helps doctors monitor their long-term hip health and manage any related pain or complications.
Who this helps: This helps athletes, doctors, and sports medicine specialists.
Augmented baseplates yield optimum outcomes when compared with bone graft augmentation for managing glenoid deformity during reverse total shoulder arthroplasty: a retrospective comparative study.
2023
Journal of shoulder and elbow surgery
Colasanti CA, Lin CC, Ross KA, Luthringer T, Elwell JA +5 more
Plain English This study looked at different methods for fixing a shoulder joint issue during reverse total shoulder surgery. It found that using augmented glenoid baseplates led to better patient outcomes than traditional bone grafts. Specifically, patients who received the augmented baseplates reported more improvement in shoulder function and satisfaction, with 77.6% achieving significant benefits compared to only 55% in the bone graft group, along with 50% less surgery time and 33% less blood loss.
Who this helps: This benefits patients undergoing reverse total shoulder arthroplasty.
Characterization of pincer-type Hip impingement in professional women's ice hockey players.
2023
The Physician and sportsmedicine
Ross KA, Mojica ES, Lott A, Carter C, Gonzalez-Lomas G
Plain English This study looked at a specific type of hip issue called pincer-type impingement in female professional ice hockey players. They found that 32% of the players had this condition in one or both hips, compared to 9% in a matched control group, although these differences were not statistically significant. Additionally, a high 84% of the players had another type of hip issue called cam morphology. Understanding the prevalence of these hip problems in athletes is important because it can help in their diagnosis and treatment, potentially leading to better outcomes.
Who this helps: This information benefits female ice hockey players and their medical teams.
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines.
2023
Immunity & ageing : I & A
Ross KA, Tingle AM, Senapati S, Holden KG, Wannemuehler MJ +3 more
Plain English This study looked at new materials that could improve how vaccines work for older adults, who often don't respond as well to vaccines. Researchers tested different types of these materials on immune cells from younger and older people. They found that polyanhydride nanoparticles could boost certain immune responses with less inflammation compared to standard boosters, while some materials had little effect at all. This matters because better vaccines for older adults could lead to improved protection against diseases in this age group.
Who this helps: Older adults who need effective vaccines to protect against illnesses.
The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation.
2023
bioRxiv : the preprint server for biology
Posey AE, Bagheri M, Ross KA, Lanum EN, Khan MA +6 more
Plain English This study examined a part of the Drp1 protein, which helps control the shape of mitochondria, the energy-producing structures in cells. The researchers discovered that this part, known as the variable domain, can change its structure in crowded environments, turning into a liquid-like state that helps Drp1 attach better to a specific mitochondrial lipid called cardiolipin. This finding is important because it suggests a new way that Drp1 can quickly adapt its function, which is crucial for normal cellular energy production.
Who this helps: This benefits patients with mitochondrial diseases and doctors who treat them.
The variable domain from dynamin-related protein 1 promotes liquid-liquid phase separation that enhances its interaction with cardiolipin-containing membranes.
2023
Protein science : a publication of the Protein Society
Posey AE, Ross KA, Bagheri M, Lanum EN, Khan MA +6 more
Plain English This study looked at a part of a protein called dynamin-related protein 1 (Drp1) that helps in the process of dividing mitochondria, the powerhouses of our cells. Researchers found that a specific area of this protein, known as the variable domain, can form a liquid-like state when certain conditions are present, which helps it bind better to mitochondrial membranes. This finding is important because it helps explain how Drp1 can quickly assemble and disassemble, which is crucial for maintaining healthy cell function.
Who this helps: This research benefits doctors and scientists studying cell health and mitochondrial diseases.
The Use of Computer Navigation and Robotic Technology in Complex Total Hip Arthroplasty.
2023
Bulletin of the Hospital for Joint Disease (2013)
Ross KA, Wiznia DH, Long WJ, Schwarzkopf R
Plain English This study looked at how computer navigation and robotic technology can help in complex hip surgeries, specifically total hip arthroplasty (THA), which is when doctors replace damaged hip joints. The findings suggest that these advanced techniques can improve the accuracy of positioning hip components, especially in challenging cases like hip dysplasia, where the hip is misshaped. Although there is promising evidence for their benefits, the research is not yet comprehensive enough to determine the overall advantages compared to standard methods.
Who this helps: This benefits patients with complex hip issues who need surgery, as well as surgeons looking for more precise tools.
β-cell-selective inhibition of DNA damage response signaling by nitric oxide is associated with an attenuation in glucose uptake.
2023
The Journal of biological chemistry
Yeo CT, Kropp EM, Hansen PA, Pereckas M, Oleson BJ +5 more
Plain English Researchers studied how nitric oxide (a molecule produced in the body) affects insulin-producing cells in the pancreas, and found that it shuts down the cells' ability to take in and process glucose (sugar) by depleting their energy supply. The nitric oxide specifically blocks the cells' energy-making machinery in their mitochondria, causing ATP (the cell's fuel) to drop so low that the cells can no longer absorb glucose, putting them into a dormant state. This matters because it reveals a unique vulnerability of pancreatic insulin cells compared to other cell types, which could help explain problems with blood sugar control and potentially lead to new treatments for diabetes.
The effect of specialization and level of competition on injury in elite male ice hockey players.
2022
The Physician and sportsmedicine
Ross KA, Fried JW, Bloom DA, Gonzalez-Lomas G
Plain English This study looked at whether young ice hockey players who specialize early in the sport get injured more often or achieve greater career success. Researchers surveyed 101 male players from different competitive levels and found that the average age when players specialized was about 13 years old. They discovered that early specialization did not lead to more injuries or better professional outcomes, but professional players had more concussions and surgeries related to ice hockey injuries.
Who this helps: This information benefits coaches and parents of young athletes, guiding them on the risks of early specialization in sports.
Counseling Veterans with Chronic Pain During the COVID-19 Pandemic: A Secondary Analysis of a Randomized Controlled Trial.
2022
Pain medicine (Malden, Mass.)
Lazar CM, Rosen MI, Sellinger J, Mattocks K, Navarra L +2 more
Plain English This study looked at how the COVID-19 pandemic affected veterans with chronic pain who were receiving brief counseling for pain management. Researchers found that the pandemic disrupted pain management services but also led to opportunities for personal growth and highlighted the importance of addressing mental health issues. By focusing on resilience, counselors can help veterans adopt better coping strategies and improve their overall quality of life.
Who this helps: This helps veterans with chronic pain and the counselors who support them.
Structural Stability and Antigenicity of Universal Equine H3N8 Hemagglutinin Trimer upon Release from Polyanhydride Nanoparticles and Pentablock Copolymer Hydrogels.
2022
ACS biomaterials science & engineering
Siddoway AC, Verhoeven D, Ross KA, Wannemuehler MJ, Mallapragada SK +1 more
Plain English This study focused on a new type of flu vaccine using a protein from equine (horse) viruses, designed to produce better and longer-lasting protection against influenza A. Researchers tested how well this protein could maintain its structure and effectiveness when delivered through special materials called nanoparticles and hydrogels. They found that these delivery systems help keep the vaccine stable and effective, paving the way for a universal flu vaccine that could protect against multiple strains.
Who this helps: This benefits patients by potentially providing better flu protection.
RNA Nanovaccine Protects against White Spot Syndrome Virus in Shrimp.
2022
Vaccines
Phanse Y, Puttamreddy S, Loy D, Ramirez JV, Ross KA +6 more
Plain English Researchers developed a new type of vaccine for shrimp that protects them from a deadly virus called white spot syndrome virus (WSSV), which has caused billions of dollars in losses in shrimp fisheries. The vaccine, which uses tiny particles to deliver double-stranded RNA, showed about 80% effectiveness in preventing the virus when tested on shrimp. This is important because it offers a promising way to safeguard shrimp populations and the fisheries that depend on them.
Who this helps: This helps shrimp farmers and the seafood industry by providing a tool to prevent major disease outbreaks.
Long-Lasting Protection Induced by a Polyanhydride Nanovaccine against Respiratory Syncytial Virus in an Outbred Mouse Model.
2022
Journal of virology
Stephens LM, Ross KA, McLellan JS, Narasimhan B, Varga SM
Plain English In this study, researchers developed a new vaccine called RSVNanoVax to protect against Respiratory Syncytial Virus (RSV), a virus that causes serious infections, especially in children. They tested this vaccine on a type of mouse called Swiss Webster, which has a diverse genetic background, and found that it could generate strong immune responses and protect the mice from RSV for at least one year. This is important because there is currently no approved vaccine for RSV, and a successful vaccine could help reduce illness and deaths caused by this virus.
Who this helps: This benefits children and elderly adults at risk for RSV infections, as well as healthcare providers seeking effective preventive measures.
Body Composition and Fitness Characteristics of Firefighters Participating in a Health and Wellness Program: Relationships and Descriptive Data.
2022
International journal of environmental research and public health
Lockie RG, Dulla JM, Higuera D, Ross KA, Orr RM +2 more
Plain English This study looked at the body composition and fitness levels of 270 firefighters who were part of a health and wellness program. It found that about 52% were overweight, 25% had obesity, and around 76% were at increased risk for heart disease. Despite having good fitness levels in exercises like push-ups and leg presses, many firefighters still showed signs of being unhealthy, highlighting the need for better health programs to reduce heart disease risk.
Who this helps: This helps firefighters and health program designers.
Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.
2021
Current topics in microbiology and immunology
Grego EA, Siddoway AC, Uz M, Liu L, Christiansen JC +5 more
Plain English This research looked at vaccine technology that uses tiny particles made from polymers to boost the body's immune response and deliver vaccines more effectively. The study found that these polymeric nanoparticles not only help create strong and lasting immunity but can also be stored longer and administered in various ways, improving overall patient experience. This is important because it can lead to safer and more effective vaccines for diseases like respiratory infections and cancer.
Who this helps: Patients needing vaccines, especially for respiratory infections and cancer.
Néel ordering in the distorted honeycomb pyrosilicate: C-ErSiO.
2021
Journal of physics. Condensed matter : an Institute of Physics journal
Hester G, DeLazzer TN, Lim SS, Brown CM, Ross KA
Plain English This study focused on a specific compound called C-ErSiO, which is part of a group of rare-earth materials that can have interesting magnetic properties. The researchers found that C-ErSiO exhibits a type of magnetic ordering called antiferromagnetic ordering at a very low temperature of 2.3 Kelvin. They determined that the arrangement of magnetic moments resembles a collinear pattern with a strength of 6.61, tilted slightly off from a certain axis.
Who this helps: This research benefits scientists and materials researchers exploring new magnetic materials.
Prefusion F-Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus.
2021
Journal of immunology (Baltimore, Md. : 1950)
Stephens LM, Ross KA, Waldstein KA, Legge KL, McLellan JS +2 more
Plain English Researchers developed a new vaccine called RSVNanoVax to protect against the respiratory syncytial virus (RSV), which sickens many young children and older adults but currently has no licensed vaccine. In tests on mice, this vaccine significantly reduced weight loss and lung problems after RSV exposure, with protection lasting for at least six months and rapid virus clearance within two days. This matters because it offers a promising new way to prevent RSV infections and their serious health impacts.
Who this helps: This helps young children, older adults, and healthcare providers.
The Use of Computer Navigation and Robotic Technology in Complex Total Knee Arthroplasty.
2021
JBJS reviews
Ross KA, Wiznia DH, Long WJ, Schwarzkopf R
Plain English This study looked at how computer navigation and robotic technology can help doctors perform complex knee surgeries, especially in patients with deformities or those who have had previous surgeries. The findings show that using these technologies can improve the alignment of the knee joint, leading to quicker recoveries, less need for physical therapy, and reduced blood loss. Although the initial results are promising, more research is needed to fully understand their long-term benefits.
Who this helps: Patients requiring total knee replacements, particularly those with complicated conditions.
Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles.
2021
Journal of visualized experiments : JoVE
Hasibuzzaman MM, Ross KA, Salem AK, Narasimhan B, Simons AL
Plain English This study looked at a new way to deliver an immune-boosting protein called IL-1α to treat head and neck cancer in mice. Researchers found that using nanoparticles to carry IL-1α helped control tumor growth better while aiming to reduce unpleasant side effects, like flu-like symptoms. The method showed promise in triggering a strong immune response against the tumors, which is crucial for improving cancer therapies.
Who this helps: This helps cancer patients, especially those with head and neck cancers.
Magnetic properties of the Ising-like rare earth pyrosilicate: D-ErSiO.
2021
Journal of physics. Condensed matter : an Institute of Physics journal
Hester G, DeLazzer TN, Yahne DR, Sarkis CL, Zhao HD +3 more
Plain English This study explored the magnetic properties of a material called D-ErSiO, which belongs to a group of rare earth compounds. Researchers found that it has a complex magnetic structure and identified specific behaviors when exposed to different magnetic fields. Notably, at 0.1 Kelvin and with a strong magnetic field, a transition occurred at 2.65 Tesla, which is higher than some other measures they observed, indicating that the magnetic behavior is sensitive to the direction of the magnetic field.
Who this helps: This helps scientists and researchers studying quantum materials and magnetic properties.
Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production.
2021
Science advances
Senapati S, Darling RJ, Ross KA, Wannemeuhler MJ, Narasimhan B +1 more
Plain English This research studied a new type of synthetic material that helps boost the body's immune response by improving how B cells recognize and respond to infections. The scientists created special micelles that help produce antibodies more effectively while causing less inflammation than traditional methods. They demonstrated that these micelles can generate antibodies for various targets, including those related to COVID-19, which is important for quickly developing treatments for infectious diseases.
Who this helps: This benefits patients, especially older adults and those needing effective vaccines and therapies.
Associations of Air Pollution and Pediatric Asthma in Cleveland, Ohio.
2021
TheScientificWorldJournal
Khatri SB, Newman C, Hammel JP, Dey T, Van Laere JJ +8 more
Plain English This study examined the link between air pollution and asthma in children in Cleveland, Ohio, by analyzing emergency department visits for asthma along with air quality data related to vehicle and industrial emissions. It found that higher levels of certain pollutants, particularly those from motor vehicles and steel production, are linked to more asthma-related emergency visits, with significant increases noted for fine and coarse particulate matter. This research is important because it highlights specific sources of pollution that can worsen asthma symptoms, enabling targeted actions to improve air quality for children.
Who this helps: Patients, especially children with asthma, and their families.
Understanding Reentrance in Frustrated Magnets: The Case of the Er_{2}Sn_{2}O_{7} Pyrochlore.
2021
Physical review letters
Yahne DR, Pereira D, Jaubert LDC, Sanjeewa LD, Powell M +5 more
Plain English This study looked at a unique type of magnetic material called Er_{2}Sn_{2}O_{7}, focusing on a behavior known as reentrance, where the material changes from an ordered state to a less ordered one and back again under different conditions. Researchers found that this material shows multiple instances of reentrance when tested with varying magnetic fields and temperatures. Understanding this behavior is important because it can help scientists learn more about similar phenomena in other materials.
Who this helps: This helps researchers and scientists studying advanced materials and their magnetic properties.
A National Survey on Depression, Internalized Homophobia, College Religiosity, and Climate of Acceptance on College Campuses for Sexual Minority Adults.
2020
Journal of homosexuality
Heiden-Rootes K, Wiegand A, Thomas D, Moore RM, Ross KA
Plain English This study looked at how attending religiously conservative colleges affects the mental health of sexual minority adults, particularly in terms of depression. Researchers surveyed 384 sexual minority adults and found that those at more conservative colleges reported higher levels of depression. This was mainly due to these colleges being less accepting of sexual minority identities, which increased feelings of internalized homophobia.
Who this helps: This helps sexual minority adults attending conservative colleges.
Realization of the kagome spin ice state in a frustrated intermetallic compound.
2020
Science (New York, N.Y.)
Zhao K, Deng H, Chen H, Ross KA, Petříček V +4 more
Plain English This study looked at a special type of material called HoAgGe to see how its magnetic spins behave when arranged in a specific pattern called a kagome lattice. Researchers found that this material can actually display a unique magnetic state known as the kagome spin ice state, showing a mix of different ordered and disordered magnetic configurations. These findings are important because they enhance our understanding of complex magnetic materials, which could lead to new technologies in computing and data storage.
Who this helps: This benefits scientists and researchers working on developing advanced materials for tech applications.
Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.
2019
The Journal of pharmacology and experimental therapeutics
Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B +1 more
Plain English This study looked at a new type of vaccine made from polyanhydride particles to see how well it can protect against tumors. Researchers found that a single dose of this vaccine produced strong immune responses in mice, offering similar tumor protection as a two-dose regimen given several days apart. Importantly, while the single dose was effective for cellular immunity, the two-dose approach was better for building up antibodies.
Who this helps: This benefits cancer patients by exploring more efficient vaccination strategies.
Lesion Size Measured on MRI Does Not Accurately Reflect Arthroscopic Measurement in Talar Osteochondral Lesions.
2019
Orthopaedic journal of sports medicine
Yasui Y, Hannon CP, Fraser EJ, Ackermann J, Boakye L +4 more
Plain English This study looked at how well MRI measurements of cartilage damage in the ankle match the measurements taken during surgery. Researchers found that MRIs often overestimated the size of these lesions, with an average difference of 42.2 mm on MRI compared to 28.6 mm during surgery. This matters because inaccurate measurements can lead to improper treatment decisions.
Who this helps: Patients needing ankle surgery.
Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.
2019
Journal for immunotherapy of cancer
Espinosa-Cotton M, Rodman Iii SN, Ross KA, Jensen IJ, Sangodeyi-Miller K +9 more
Plain English This study looked at how a protein called interleukin-1 alpha (IL-1α) affects the effectiveness of the cancer drug cetuximab in patients with a type of throat and neck cancer. Researchers found that boosting IL-1α levels while using cetuximab improved the immune system's ability to fight tumors, which led to better outcomes for patients; specifically, patients with detectable IL-1α levels had improved survival when treated with cetuximab. This is important because it suggests a new approach to treating this cancer that might enhance long-term survival for patients.
Who this helps: This helps patients with head and neck squamous cell carcinoma.
Quantum Spin Ice Dynamics in the Dipole-Octupole Pyrochlore Magnet Ce_{2}Zr_{2}O_{7}.
2019
Physical review letters
Gaudet J, Smith EM, Dudemaine J, Beare J, Buhariwalla CRC +11 more
Plain English This study looked at a special type of magnet called Ce2Zr2O7 to understand its magnetic properties. Researchers found that instead of behaving as expected at low temperatures—where it should have a stable magnetic order—it shows a dynamic and fluctuating state called a quantum spin ice. They measured specific magnetic interactions, with a value of θ_{CW} equal to -0.4K, and noted that sample disorder, like oxidation, affects its behavior significantly.
Who this helps: This benefits researchers and scientists studying magnets and quantum materials.
Banerjee K, Gautam SK, Kshirsagar P, Ross KA, Spagnol G +7 more
Plain English This study examined a new cancer vaccine made from a protein called MUC4, which is linked to pancreatic cancer. The researchers found that their MUC4-based vaccine, when delivered in a special form using nanoparticles, significantly boosted the immune response by activating important immune cells and increasing the production of specific antibodies. This is important because it offers a promising approach to improving treatment for pancreatic cancer patients, who currently have limited options.
Who this helps: Patients with pancreatic cancer.
Effective mosaic-based nanovaccines against avian influenza in poultry.
2019
Vaccine
Kingstad-Bakke BA, Chandrasekar SS, Phanse Y, Ross KA, Hatta M +5 more
Plain English This study looked at a new type of vaccine for avian influenza (bird flu) in chickens, using a "mosaic" approach that targets various virus strains. Researchers found that their H5 mosaic vaccine, when combined with special nanoparticles, not only generated strong immune responses in the chickens but also effectively protected them from infection and reduced virus spread eight weeks after vaccination. This is important because current vaccines often fail to protect against different strains of the virus, which can lead to outbreaks that affect both poultry and potentially humans.
Who this helps: This benefits poultry farmers and the public by helping prevent avian influenza outbreaks.
Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine.
2019
Nanomedicine : nanotechnology, biology, and medicine
Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B +1 more
Plain English This study examined how combining a substance called pentaerythritol lipid A (PELA) with a cancer vaccine could boost its effectiveness against tumors. The researchers found that when mice received this combined treatment, their immune responses improved significantly, leading to faster growth of immune cells and stronger antibody production. As a result, tumors grew more slowly in these mice compared to those that received the vaccine without PELA.
Who this helps: This helps cancer patients by potentially improving the effectiveness of cancer vaccines.
Plain English Researchers studied a new type of quantum dimer magnet called Yb₂Si₂O₇ to understand its magnetic properties. They found that it has a special ground state without an energy gap at zero magnetic field and transitions into a magnetically ordered state at low magnetic fields (around 0.4 and 1.4 Tesla). This new material shows unusual behavior that could change our understanding of magnetism in similar materials.
Who this helps: This research benefits scientists and engineers working on new magnetic materials and quantum technologies.
Evaluation of CpG-ODN-adjuvanted polyanhydride-based intranasal influenza nanovaccine in pigs.
2019
Veterinary microbiology
Dhakal S, Ghimire S, Renu S, Ross KA, Lakshmanappa YS +6 more
Plain English This study focused on a new vaccine for swine influenza that uses special nanoparticles to improve its effectiveness. Researchers found that this vaccine led to significantly stronger immune responses in pigs, including an increase in specific antibodies in their noses and a remarkable 80-fold reduction in the amount of virus in their lungs compared to a traditional vaccine. This improvement is important because it not only protects pigs from the flu but also helps prevent the virus from spreading to humans, which can cause economic losses in the pig industry.
Who this helps: This benefits farmers and the swine industry, as well as public health by reducing the risk of zoonotic transmission.
Author Correction: Thermogenesis-triggered seed dispersal in dwarf mistletoe.
2018
Nature communications
deBruyn RAJ, Paetkau M, Ross KA, Godfrey DV, Church JS +1 more
Plain English This paper discusses a correction to earlier research about how dwarf mistletoe seeds are spread. The study showed that these seeds are released when the plant generates heat, helping them move away to grow in new locations. This is important because it affects how mistletoe spreads in forests, which has implications for forest ecology and management.
Who this helps: This helps forest managers and ecologists.
Prediction of tibial nonunion at the 6-week time point.
2018
Injury
Ross KA, O'Halloran K, Castillo RC, Coale M, Fowler J +7 more
Plain English This study looked at how to predict whether a broken tibia (shinbone) would heal properly after surgery using a specific type of nail for fixation. Researchers analyzed data from 323 patients and found that infection within six weeks, a specific scoring system called RUST, and another score called NURD were important indicators of healing issues. They found that in patients with severe initial healing indications (high RUST), everyone healed well, while in patients with lower initial scores (low RUST), 69% with higher NURD scores had problems healing.
Who this helps: This helps doctors better assess the healing outlook for patients with tibial fractures.
Seminal plasma does not aid in the transport of phenolsulfonphthalein across the uterotubal junction in mares.
2018
The Canadian veterinary journal = La revue veterinaire canadienne
Ross KA, Kolb DS, Macedo A, Anderson M, Klein C
Plain English This study looked at whether a substance called prostaglandin E2 in male horse semen could help transport a dye (phenolsulfonphthalein or PSP) through the reproductive tract of female horses (mares). The researchers found that PSP did not show up in the urine or blood samples of the mares after they were treated with either the dye alone or with the dye mixed in semen, indicating that the seminal plasma did not assist in moving the dye as expected. This matters because understanding how substances move through the reproductive system can help in improving breeding practices in horses.
Who this helps: This research benefits veterinarians and horse breeders.
Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections.
2018
Frontiers in immunology
Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B +2 more
Plain English This research focused on a new type of flu vaccine called IAV-nanovax, which is given through the nose instead of an injection. The study found that this vaccine effectively triggered strong immune responses in the lungs, creating memory cells that help protect against not just the same flu strains but also different ones. This is important because it could lead to a more effective and universal flu vaccine, which is especially needed as new strains of the virus emerge.
Who this helps: This helps patients, particularly those who are at higher risk for severe flu infections.
Single Crystals of Cubic Rare-Earth Pyrochlore Germanates: REGeO(RE = Yb and Lu) Grown by a High-Temperature Hydrothermal Technique.
2018
Inorganic chemistry
Sanjeewa LD, Ross KA, Sarkis CL, Nair HS, McMillen CD +1 more
Plain English This study focuses on creating large, single crystals of a material called YbGeO using a special high-temperature process. Researchers found that these crystals have unique magnetic properties that may lead to interesting quantum behaviors. This discovery is important because these high-quality crystals can be used in advanced scientific experiments to better understand their properties.
Who this helps: This benefits researchers and scientists studying quantum materials.
Behavior of the breathing pyrochlore lattice BaYbZnOin applied magnetic field.
2018
Journal of physics. Condensed matter : an Institute of Physics journal
Rau JG, Wu LS, May AF, Taylor AE, Liu IL +7 more
Plain English This study looked at a material called BaYbZnO, which behaves uniquely under certain conditions, specifically at very low temperatures and in magnetic fields. Researchers found that at a magnetic field of about 3 Tesla, there were changes in how the material's spins interacted, but they didn't see major changes in the spin behaviors with higher magnetic fields. Importantly, they noted a peak in heat capacity at very low temperatures, which may indicate complex interactions or hidden issues within the material.
Who this helps: This research benefits scientists and researchers studying magnetism and materials science.