Dr. Vanderhave studies how to best manage joint issues, particularly in individuals with hemophilia—a condition that leads to bleeding into joints and chronic pain. She looks at preventive measures like administering clotting factor medications early in life to keep patients from experiencing severe joint damage. Additionally, she investigates surgical options, like hip replacements, for rare genetic disorders that cause severe joint deterioration. Her research highlights the importance of timely treatment to enhance mobility and reduce pain in affected patients.
Key findings
Preventive treatment with clotting factor medications in hemophilia patients significantly reduces the risk of severe joint damage, helping to avoid arthritis-like complications.
In a case study, total hip replacement surgery for two teenagers with camptodactyly-arthropathy-coxa vara-pericarditis syndrome resulted in major pain relief and improved mobility post-surgery.
Surgical interventions, when combined with careful medication management, can substantially improve outcomes for patients with severe joint damage.
Frequently asked questions
Does Dr. Vanderhave study hemophilia?
Yes, she focuses on the musculoskeletal care of hemophilia patients, particularly the management of joint issues caused by the disorder.
What treatments has Dr. Vanderhave researched?
Dr. Vanderhave has researched preventive treatments like clotting factor medications for hemophilia and surgical options, such as hip replacements for patients with severe joint damage.
Is Dr. Vanderhave's work relevant to adolescents with joint issues?
Yes, her research includes surgical interventions for young patients suffering from severe joint conditions, demonstrating effective pain relief and mobility improvement.
Publications in plain English
Interobserver and Intraobserver Agreement are Unsatisfactory When Determining Abstract Study Design and Level of Evidence.
2022
Journal of pediatric orthopedics
Patel NM, Schmitz MR, Bastrom TP, Ghag R, Janicki JA +8 more
Plain English This study looked at how consistently different reviewers could agree on the type of study design and the level of evidence for thirty-six research abstracts from a medical conference. Initially, their agreement was only fair, with a rating of 0.28 for level of evidence, but improved to 0.43 when they used a reference guide. This matters because accurate ratings help ensure that the right research gets highlighted for its clinical importance, which can lead to better patient care.
Who this helps: Doctors and researchers in the medical field.
Plain English This study looked at bone and joint infections in older children and teenagers, finding that many had delays in diagnosis, averaging 9.2 days, often after seeing at least one doctor. Of the 30 patients studied, 55% could walk when they arrived at the hospital, and over one-third experienced serious health issues or complications. Recognizing these infections quickly is vital, as delays can lead to worse medical outcomes and longer hospital stays.
Who this helps: This helps doctors and young patients by improving awareness and diagnosis of serious infections.
Orthopaedic Manifestations of Sickle Cell Disease.
2018
The Journal of the American Academy of Orthopaedic Surgeons
Vanderhave KL, Perkins CA, Scannell B, Brighton BK
Plain English This research paper looks at how sickle cell disease (SCD) affects bones and joints. It found that serious issues like osteonecrosis (bone death) and osteomyelitis (bone infection) are common in SCD patients and can lead to significant health problems. Understanding these complications is important for providing the right treatments and ensuring patient safety during surgeries.
Who this helps: This helps patients with sickle cell disease and their doctors.
Blood Loss Trends and Financial Implications in Adolescent Idiopathic Scoliosis.
2018
Clinical spine surgery
Alamanda VK, Massengill DL, Rozario N, Moore CG, Scannell B +2 more
Plain English This study looked at blood loss during surgery for adolescent idiopathic scoliosis, focusing on which factors contribute to increased blood loss and the costs of managing that blood loss. Researchers analyzed data from 134 patients aged 10 to 18 who had spinal fusion surgery and found that younger males with lower body weight tended to lose more blood during surgery. They also noted that using intraoperative cell salvage (ICS) helped recover about 133 mL of blood for the patients, with costs for these procedures averaging around $1,037.
Who this helps: This research benefits surgeons and adolescents undergoing scoliosis surgery by helping to improve care and manage costs.
Adolescent Distal Humerus Fractures: ORIF Versus CRPP.
2017
Journal of pediatric orthopedics
Bell P, Scannell BP, Loeffler BJ, Brighton BK, Gaston RG +5 more
Plain English This study looked at how two different surgical methods for treating broken arm bones (distal humerus fractures) in teenagers affect recovery. It found that teenagers treated with a less invasive method called percutaneous fixation had better movement outcomes and fewer complications compared to those treated with open surgery. Specifically, those who received percutaneous fixation regained motion more quickly (2.8 months versus 3.9 months) and experienced fewer complications, such as nerve problems and the need for follow-up surgeries.
Who this helps: This research benefits teenagers with arm fractures and their doctors by providing clear treatment options that lead to better recovery outcomes.
Weightbearing Versus Nonweightbearing After Meniscus Repair.
2015
Sports health
VanderHave KL, Perkins C, Le M
Plain English This research looked at how different rehabilitation methods after meniscus repair surgery—either allowing patients to put weight on their knee or not—affect recovery. The findings showed that success rates for both approaches were quite high, ranging from 70% to 96%, with newer rehab methods allowing early weightbearing achieving results from 64% to 96%. This matters because it helps determine the best rehabilitation approach for patients recovering from this type of knee surgery.
Who this helps: Patients recovering from meniscus repair.
Distal femoral physeal fixation: are smooth pins really safe?
2014
Journal of pediatric orthopedics
Dahl WJ, Silva S, Vanderhave KL
Plain English This study looked at how different methods of fixing fractures in the growth plate of the thigh bone (femur) might contribute to potential complications, particularly the formation of a "physeal bar" which can affect bone growth. Researchers used a rabbit model and found that only a small number of animals (seven percent for one pin type and 13% for another) developed these bars, showing that different pin placements did not significantly change the risk. This is important because it indicates that using smooth pins can safely stabilize fractures in a way that minimizes damage, helping to preserve normal growth in young patients.
Who this helps: This helps patients, particularly children with distal femoral fractures, by reducing the risk of complications affecting their growth.
Evaluation of a Novel Method for Determining Transverse Plane Pelvic Obliquity.
2014
Spine deformity
Torretti JA, Segal LS, Brenneman RE, Shrader MW, Chinchilli VM +1 more
Plain English This study looked at a new way to measure pelvic tilting in children with cerebral palsy and scoliosis using their X-rays. Researchers found that the measurements taken with this new method were not consistent; the agreement between different observers was poor, with a highest reliability score below the level considered acceptable. This is important because accurate measurement of pelvic position is crucial for planning effective treatment for these patients.
Who this helps: This helps doctors treating children with cerebral palsy and scoliosis.
Applications of musculoskeletal ultrasonography in pediatric patients.
2014
The Journal of the American Academy of Orthopaedic Surgeons
Vanderhave KL, Brighton B, Casey V, Montijo H, Scannell B
Plain English This study looked at how ultrasound can be used to check for bone and joint problems in children. Researchers found that ultrasound is particularly useful because it can help detect issues like hip problems and nerve injuries without using radiation, making it safer and often more effective than other imaging methods. This is important because it provides doctors with a tool that can improve diagnosis and treatment for young patients.
Who this helps: This helps pediatric patients and their doctors.
Postoperative spine and VEPTR infections in children: a case-control study.
2014
Journal of pediatric orthopedics
Farley FA, Li Y, Gilsdorf JR, VanderHave KL, Hensinger RN +3 more
Plain English This study looked at infections that can happen after spine surgery for children with scoliosis. Among the 20 kids who got infections, 14 had a specific type of scoliosis related to muscle disorders. The research found that having a higher curvature of the spine before and after surgery, being unable to walk, and staying longer in the hospital all increased the chances of getting an infection. This is important because it helps doctors understand which patients are at greater risk and how to better prepare for surgery to prevent infections.
Who this helps: This helps doctors and families of children undergoing spine surgery, especially those with neuromuscular scoliosis.
Outcomes following removal of instrumentation after posterior spinal fusion.
2014
Journal of pediatric orthopedics
Alpert HW, Farley FA, Caird MS, Hensinger RN, Li Y +1 more
Plain English This study looked at the outcomes for young patients who had spinal hardware removed after a type of back surgery called posterior spinal fusion, specifically focusing on pain relief and infection. Researchers found that only 40% of the patients who had hardware removed due to pain reported feeling better afterward, and those with infections experienced more significant changes in their spinal curve compared to those without infections. This is important because it highlights that removing spinal hardware might not solve pain issues and could lead to worsening curvature of the spine, especially if an infection was present.
Who this helps: This study benefits patients dealing with back pain after spinal surgery and their doctors.
Plain English This study looked at how obesity affects the severity of arm fractures in children aged 2 to 11 who had surgery for a specific type of elbow fracture. Out of 354 children, it was found that obese kids were nine times more likely to have complex fractures and significantly more likely to experience nerve issues both before and after surgery. Understanding this connection is important because it highlights the need for addressing childhood obesity to reduce serious injuries and complications from falls.
Who this helps: This information benefits doctors and parents by emphasizing the importance of maintaining a healthy weight in children to prevent severe injuries.
Plain English The study examined the modified Dunn procedure, a surgical treatment for unstable slipped capital femoral epiphysis (SCFE), in 27 patients over an average follow-up of about 22 months. It found that 15% of patients had broken implants shortly after surgery, and 26% developed osteonecrosis, which caused worse outcomes, such as more pain and lower satisfaction scores. This research highlights the effectiveness of the procedure in restoring hip function while also noting the risks of complications.
Who this helps: This information benefits patients with SCFE and their doctors by providing insights into the potential risks and outcomes of the modified Dunn procedure.
Osteochondral injury after acute patellar dislocation in children and adolescents.
2013
Journal of pediatric orthopedics
Seeley MA, Knesek M, Vanderhave KL
Plain English This study looked at the injuries that can happen to the knee in children and teenagers who experience a first-time dislocation of the kneecap (patella). Out of 122 young patients, 46 were found to have osteochondral injuries, meaning damage to the bone and cartilage, which often went unnoticed on initial X-rays. The findings showed that injuries to certain areas of the knee, especially those on weight-bearing surfaces, led to worse recovery scores, with patients who had damage to the lateral femoral condyle scoring an average of 72.3, compared to 91.1 for those with patellar injuries.
Who this helps: This research benefits doctors and orthopedic specialists treating young patients with knee injuries.
Flexible cavovarus foot in children and adolescents.
2013
Foot and ankle clinics
VanderHave KL, Hensinger RN, King BW
Plain English This study looked at flexible cavovarus feet, a condition where the foot is shaped in an abnormal way, in children and teenagers. The researchers found that a careful assessment of each patient is crucial for effective treatment, as different children may need different approaches. Proper timing of treatments can help slow down the worsening of the condition over time.
Who this helps: This research benefits children and adolescents with flexible cavovarus feet and their healthcare providers.
Cervical arterial injury after blunt trauma in children: characterization and advanced imaging.
2013
Journal of pediatric orthopedics
Tolhurst SR, Vanderhave KL, Caird MS, Garton HL, Graziano GP +3 more
Plain English This research focused on how often children and teens suffer from cervical vascular injury (CVI) after experiencing blunt trauma in the neck, such as from car accidents. Among the 61 patients studied, 7 were found to have CVI, giving an overall rate of 11.5%. Additionally, certain types of neck fractures increased the risk of having CVI, which highlights the need for advanced imaging tests to better detect these injuries and guide treatment.
Who this helps: This benefits pediatric patients and their doctors by improving diagnosis and management of potential neck injuries after trauma.
Comparison of titanium elastic nail and plate fixation of pediatric subtrochanteric femur fractures.
2013
Journal of pediatric orthopedics
Li Y, Heyworth BE, Glotzbecker M, Seeley M, Suppan CA +5 more
Plain English This study looked at two ways to treat broken thigh bones (femurs) in children: using titanium elastic nails or plates. The researchers found that while both methods generally worked well, those who had plate fixation had better recovery scores and a lower complication rate (14% compared to 48% for nails). This is important because it suggests that plates may be a safer and more effective option for treating these specific fractures in young patients.
Who this helps: This benefits pediatric patients with femur fractures and their doctors.
Serial ultrasound evaluation of pediatric trigger thumb.
2013
Journal of pediatric orthopedics
Verma M, Craig CL, DiPietro MA, Crawford J, VanderHave KL +2 more
Plain English This study looked at children with a condition called trigger thumb, where the thumb gets stuck in a bent position. Researchers followed 28 children, observing that 10 thumbs healed on their own, while 9 thumbs needed surgery to fix the problem. They discovered that the thumb's tendon was normal but sometimes got too thick, causing it to get stuck; resolving this thickness led to improvement.
Who this helps: This helps children with trigger thumb and their parents.
Reliability of measurements of clavicle shaft fracture shortening in adolescents.
2013
Journal of pediatric orthopedics
Silva SR, Fox J, Speers M, Seeley M, Bovid K +3 more
Plain English This study examined how reliable different methods are for measuring the shortening of clavicle fractures in teenagers. The researchers found that different observers had a fair level of agreement when measuring the fractures, but none of the methods was clearly better than the others. The average difference in measurements was about 3 mm, which is small enough that it shouldn't significantly affect treatment decisions for these injuries.
Who this helps: This benefits doctors treating adolescents with clavicle fractures by providing insights into measurement reliability.
Magnetic resonance imaging of acute patellar dislocation in children: patterns of injury and risk factors for recurrence.
2012
Journal of pediatric orthopedics
Seeley M, Bowman KF, Walsh C, Sabb BJ, Vanderhave KL
Plain English This study looked at knee injuries in children who experienced their first dislocation of the kneecap, focusing on the patterns of damage visible in MRI scans. Out of 111 children analyzed, 78.4% had injury to the medial patellofemoral ligament (MPFL), and over half showed signs of muscle damage, while 34% had bone injuries. Understanding these injury patterns is important because it can guide better treatment options and help doctors know when surgery might be needed.
Who this helps: This research benefits doctors and surgeons who treat young patients with knee dislocations.
Utility of electrodiagnostic testing and computed tomography myelography in the preoperative evaluation of neonatal brachial plexus palsy.
2012
Journal of neurosurgery. Pediatrics
Vanderhave KL, Bovid K, Alpert H, Chang KW, Quint DJ +2 more
Plain English This study looked at how effective two tests, electrodiagnostic studies (EDSs) and CT myelography (CTM), are at identifying nerve injuries in babies with neonatal brachial plexus palsy (NBPP). Out of 21 infants analyzed, EDSs correctly identified nerve ruptures 92.8% of the time, while CTM identified them 58.3% of the time. This is important because accurately diagnosing the type of nerve injury helps doctors decide on the best treatment, which can lead to better recovery outcomes for the infants.
Who this helps: This helps infants with NBPP and their families by improving treatment options.
Perioperative pain control in pediatric patients undergoing orthopaedic surgery.
2012
The Journal of the American Academy of Orthopaedic Surgeons
Nowicki PD, Vanderhave KL, Gibbons K, Haydar B, Seeley M +3 more
Plain English This research focused on how to effectively manage pain in children undergoing orthopedic surgery. It found that using a mix of pain relief methods—like non-opioid medications, local anesthetics, and regional therapies—improves recovery and satisfaction. Clear communication with the child and their parents about the pain management plan before surgery is crucial for better outcomes.
Who this helps: This helps pediatric patients and their families.
Reliability of digital radiographs for pediatric lower extremity alignment.
2012
Journal of pediatric orthopedics
Nowicki PD, Vanderhave KL, Farley FA, Kuhns LR, Dahl W +1 more
Plain English This study looked at how reliable two different methods (computer-based and manual) are for measuring the alignment of kids' legs using digital X-rays. Researchers examined 32 X-ray images and found that while both methods produced fair to good results, the manual method was generally more reliable for certain measurements. Notably, the measurement of the mechanical axis deviation (MAD) had excellent reliability, which means it's very consistent.
Who this helps: This benefits pediatric patients and doctors making decisions about how to treat leg alignment issues.
A comparison of hip dislocation rates and hip containment procedures after selective dorsal rhizotomy versus intrathecal baclofen pump insertion in nonambulatory cerebral palsy patients.
Plain English This study looked at how often hip dislocations and surgeries happen in children with cerebral palsy who are unable to walk, comparing two treatments: selective dorsal rhizotomy (SDR) and intrathecal baclofen pump (ITBP). Researchers found that 10.6% of patients who had SDR experienced hip dislocation compared to 7.4% of those treated with ITBP, but the difference was not significant, indicating that both treatments resulted in similar outcomes. Despite having these procedures, 25% of hips from the SDR group and 32% from the ITBP group still needed reconstruction surgery, suggesting that the L1 nerve root may not significantly affect hip problems after these treatments.
Who this helps: This information benefits doctors and caregivers of children with cerebral palsy when deciding on treatment options.
Total hip arthroplasty in adolescents with severe hip arthropathy and dysplasia associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome.
2012
The Journal of arthroplasty
Murphy JM, Vanderhave KL, Urquhart AG
Plain English Two teenage siblings with a rare genetic condition called CACP syndrome developed severe arthritis in their hips at a young age, causing significant pain and disability. The doctors replaced both of their hip joints with artificial ones, and the surgery worked well—the patients experienced major pain relief and improved mobility, with one sibling doing especially well at follow-up visits. This case shows that hip replacement surgery is a viable option for young people with this rare condition when their hips become too damaged to function normally.
The Journal of the American Academy of Orthopaedic Surgeons
Vanderhave KL, Caird MS, Hake M, Hensinger RN, Urquhart AG +2 more
Plain English Hemophilia is a bleeding disorder caused by missing blood clotting proteins, and people with it bleed into their joints repeatedly, which damages them over time. The best treatment is giving patients clotting factor medications regularly starting in infancy to prevent these joint bleeds, and when bleeds do happen, doctors should drain the joint and give more medication immediately. Patients who don't receive this preventive treatment develop severe arthritis-like damage in multiple joints with poor outcomes, though surgery combined with careful medication management can help those with advanced damage.
Meniscus tears in the young athlete: results of arthroscopic repair.
2011
Journal of pediatric orthopedics
Vanderhave KL, Moravek JE, Sekiya JK, Wojtys EM
Plain English This study looked at how well surgery to fix meniscus tears works in children and young athletes. Researchers examined 49 knee repairs in 45 patients under 18 years old and found that 43 of them had excellent outcomes after an average follow-up of 27 months. Although those who also had surgery to fix their ACL took longer to return to activity (about 8 months) compared to those who didn't need that surgery (about 5.5 months), all young patients showed great potential for recovery, making it clear that surgery can be effective for these types of injuries.
Who this helps: Young athletes with meniscus tears and their doctors.
Bilateral unstable slipped capital femoral epiphysis: a look at risk factors.
2011
Orthopedics
Herrera-Soto JA, Vanderhave KL, Gordon E, Fabregas J, Phillips JH +2 more
Plain English This study looked at young girls who experienced a serious hip condition called unstable slipped capital femoral epiphysis (SCFE) on both hips. Out of seven patients, most had severe slips, with an average time between slips of about four months. The findings emphasize that it's important for doctors to monitor patients closely for hip problems on both sides, especially if the initial slip is severe, to prevent further complications.
Who this helps: This helps doctors and families understand the risks and necessary precautions for young patients with this hip condition.
Facet violation with the placement of percutaneous pedicle screws.
2011
Spine
Patel RD, Graziano GP, Vanderhave KL, Patel AA, Gerling MC
Plain English This study examined how often a specific type of spine surgery, called percutaneous pedicle screw placement, accidentally damages a part of the spine known as the facet joint. Out of 48 screws placed in cadaver specimens, 28 (about 58%) caused some level of damage, with 8 of those actually entering the joint. This is important because such injuries can lead to pain and instability after surgery, so understanding this risk could help improve surgical techniques.
Who this helps: This benefits patients undergoing spine surgery and their doctors by highlighting risks and improving surgical practices.
Plain English This study looked at a device called the Vertical Expandable Prosthetic Titanium Rib (VEPTR) that is used to help children with breathing problems due to chest deformities. Researchers found that while the device did improve scoliosis (curvature of the spine) angles by about 29%, with preoperative angles going from 64.7 degrees to 46.1 degrees, it did not significantly improve lung function or lung volume, as patients' breathing test scores remained largely unchanged. This matters because it indicates that while the device helps with spinal alignment, it does not help kids breathe better.
Who this helps: This helps children with thoracic insufficiency syndrome and their doctors.
Cervical spine trauma in children and adults: perioperative considerations.
2011
The Journal of the American Academy of Orthopaedic Surgeons
Vanderhave KL, Chiravuri S, Caird MS, Farley FA, Graziano GP +2 more
Plain English This study looked at how cervical spine injuries are treated in both children and adults, focusing on the important steps needed before, during, and after surgery. It highlighted that effective treatment involves understanding the spine's structure, managing the patient's airway, and ensuring proper positioning during surgery—particularly since children are more at risk for serious injuries. These insights are crucial for improving patient outcomes and making sure that both adult and pediatric patients receive the best care possible.
Who this helps: This helps doctors and medical teams treating patients with cervical spine injuries.
Lyme disease presenting as popliteal cyst in children.
2006
Journal of pediatric orthopedics
Magee TH, Segal LS, Ostrov B, Groh B, Vanderhave KL
Plain English This study looked at children who had Lyme disease but were initially misdiagnosed with a popliteal cyst—a swelling behind the knee. The authors discussed four cases where Lyme disease was the underlying cause of the cyst, emphasizing that recognizing this connection can lead to quicker treatment and better outcomes. This is important because early treatment of Lyme disease can prevent serious health issues down the line.
Who this helps: Children with Lyme disease and their doctors.
Frances A Farley Michelle S Caird Robert N Hensinger Brian K Brighton Mark Seeley Brian P Scannell Brian Scannell Ying Li Selina Silva Gregory P Graziano
Physician data sourced from the
NPPES NPI Registry
.
Publication data from
PubMed
.
Plain-English summaries generated by AI.
Not medical advice.