Kuni Ohtomo

Sumitomo Heavy Industries, Ltd., 2-1-1 Osaki, Shinagawa, Tokyo 141-6025, Japan.

50 publications 2017 – 2025

What does Kuni Ohtomo research?

Kuni Ohtomo studies advanced imaging techniques to diagnose and evaluate several medical conditions, focusing on the use of deep learning algorithms to improve the quality and speed of MRI scans. Their research addresses conditions like lumbar spinal stenosis, brain disorders, neuroforaminal stenosis, and prostate cancer, developing methods that provide clearer images and reduce the time patients spend in MRI machines. This research directly impacts doctors' abilities to identify issues such as nerve narrowing, tumors, and more, leading to better treatment plans for patients.

Key findings

  • Achieved 1.5 MeV kinetic energy for laser-driven protons and a concentration of over 17 trillion protons per square centimeter per second.
  • Super-resolution deep learning reconstruction improved interobserver agreement in evaluating lumbar spinal stenosis with a high score of 0.819.
  • The iterative motion correction technique improved brain MRI clarity, yielding a structural similarity score of 0.952 compared to 0.949 for standard images.
  • A study found that deep learning-based knee MRIs took only 3 minutes, compared to the 12 minutes required by traditional methods, with better image quality.
  • Images from a 1.5T MRI using deep learning showed significantly better quality and agreement among doctors for neuroforaminal stenosis evaluations, with a score increase from 0.410-0.542 to 0.422-0.571.

Frequently asked questions

Does Kuni Ohtomo study MRI techniques?
Yes, Kuni Ohtomo focuses on improving MRI techniques using deep learning to enhance image quality and reduce scan times.
What conditions does Kuni Ohtomo's research impact?
Their research impacts conditions like lumbar spinal stenosis, brain disorders, neuroforaminal stenosis, and prostate cancer.
Are Kuni Ohtomo's findings relevant for patients undergoing knee MRIs?
Yes, their work has improved knee MRI imaging techniques, resulting in quicker scans and clearer images for better diagnosis.
How does Kuni Ohtomo's work improve patient care?
By enhancing image quality and reducing scan times, their research leads to more accurate diagnoses and less time in the MRI machine for patients.
What technology does Kuni Ohtomo use in their research?
They use advanced deep learning techniques for image reconstruction and enhancement in MRI and other imaging modalities.

Publications in plain English

Super-resolution deep learning reconstruction to evaluate lumbar spinal stenosis status on magnetic resonance myelography.

2025

Japanese journal of radiology

Yasaka K, Asari Y, Morita Y, Kurokawa M, Tajima T +6 more

Plain English
This study looked at a new image enhancement technique called super-resolution deep learning reconstruction (SR-DLR) to evaluate lumbar spinal stenosis using MRI scans of the lower back from 40 patients, average age 59.4 years. Researchers found that the SR-DLR method provided clearer images and better agreement among doctors assessing the severity of the condition compared to traditional imaging methods, with a high interobserver agreement score of 0.819 for SR-DLR. These improvements matter because they can help doctors make more accurate diagnoses and treatment plans for patients with lumbar spinal stenosis. Who this helps: This helps doctors and patients with lumbar spinal stenosis.

PubMed

Demonstration and real-time non-destructive diagnosis of a high-flux laser-driven proton bunch.

2025

The Review of scientific instruments

Sakaki H, Kojima S, Suwada T, Dinh TH, Tsutui H +11 more

Plain English
This study focused on creating a powerful beam of protons using lasers, which can generate very short bursts of high-energy particles. Researchers achieved a kinetic energy of 1.5 MeV for these protons, measured their length to be less than 0.14 nanoseconds, and had a concentration of over 17 trillion protons per square centimeter per second. This technology is important because it allows researchers to investigate how materials are damaged at incredibly small time scales, which can improve our understanding of material integrity and safety. Who this helps: This benefits scientists and researchers working in materials science and engineering.

PubMed

Faster acquisition of magnetic resonance imaging sequences of the knee via deep learning reconstruction: a volunteer study.

2024

Clinical radiology

Akai H, Yasaka K, Sugawara H, Furuta T, Tajima T +5 more

Plain English
This study looked at using advanced deep learning technology to speed up MRI scans of the knee. Researchers tested images from 27 healthy volunteers and found that a faster imaging method using deep learning produced better quality images in less time—specifically, they obtained images in about 3 minutes compared to around 12 minutes with the standard method. This is important because quicker and clearer MRI scans can help doctors diagnose knee issues more efficiently. Who this helps: Patients needing knee MRIs and their doctors.

PubMed

Super-resolution Deep Learning Reconstruction Cervical Spine 1.5T MRI: Improved Interobserver Agreement in Evaluations of Neuroforaminal Stenosis Compared to Conventional Deep Learning Reconstruction.

2024

Journal of imaging informatics in medicine

Yasaka K, Uehara S, Kato S, Watanabe Y, Tajima T +6 more

Plain English
This study looked at whether a new method called super-resolution deep learning reconstruction (SR-DLR) for analyzing MRI scans of the neck is better than an older method (conventional deep learning reconstruction, or DLR) in helping doctors agree on diagnoses of nerve root narrowing (neuroforaminal stenosis). Researchers found that SR-DLR made it easier for different doctors to agree on their evaluations, with scores indicating agreement improving from 0.422-0.571 with SR-DLR compared to 0.410-0.542 with DLR. This matters because clearer and more consistent MRI readings can lead to better patient care and treatment decisions. Who this helps: This helps patients with neck pain and potential nerve issues, as well as their doctors.

PubMed

Super-resolution Deep Learning Reconstruction for 3D Brain MR Imaging: Improvement of Cranial Nerve Depiction and Interobserver Agreement in Evaluations of Neurovascular Conflict.

2024

Academic radiology

Yasaka K, Kanzawa J, Nakaya M, Kurokawa R, Tajima T +6 more

Plain English
This study looked at a new method called super-resolution deep learning reconstruction (SR-DLR) to see if it improves brain MR imaging, specifically how well cranial nerves are shown and how consistently different doctors agree on the images. The researchers found that SR-DLR provided clearer images and better agreement among doctors when assessing conflicts between blood vessels and nerves, with an agreement score for the degree of this conflict ranging from 0.429 to 0.923, compared to 0.175 to 0.689 with the older method. The improvements in image quality are important because clearer images can lead to better diagnoses and treatment plans for patients with cranial nerve issues. Who this helps: Patients with cranial nerve problems.

PubMed

Iterative Motion Correction Technique with Deep Learning Reconstruction for Brain MRI: A Volunteer and Patient Study.

2024

Journal of imaging informatics in medicine

Yasaka K, Akai H, Kato S, Tajima T, Yoshioka N +7 more

Plain English
This study looked at a new technique for improving brain MRIs by using a method called iterative motion correction (IMC), which helps reduce blurriness caused by movement during the scan. Researchers tested this on 40 people, including 10 volunteers and 30 patients, and found that IMC images had a structural similarity score of 0.952 compared to 0.949 for standard images, meaning IMC images looked clearer. It's important because better quality MRIs can lead to more accurate diagnoses and treatment plans for brain conditions. Who this helps: Patients needing brain imaging and their doctors.

PubMed

Commercially Available Deep-learning-reconstruction of MR Imaging of the Knee at 1.5T Has Higher Image Quality Than Conventionally-reconstructed Imaging at 3T: A Normal Volunteer Study.

2023

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

Akai H, Yasaka K, Sugawara H, Tajima T, Akahane M +4 more

Plain English
This study looked at the image quality of knee MRIs taken at two different strengths: 1.5 Tesla (1.5T) with advanced deep learning techniques and 3 Tesla (3T) without those techniques. The results showed that the 1.5T images provided a clearer view of most knee structures, with significantly better visibility of the meniscus and ligaments and less image noise compared to the 3T images. This matters because it means that doctors can potentially get better diagnostic information from a lower-strength MRI scan, which could be more accessible and less expensive for patients. Who this helps: This helps patients needing knee imaging and their doctors.

PubMed

Usefulness of deep learning-based noise reduction for 1.5 T MRI brain images.

2023

Clinical radiology

Tajima T, Akai H, Yasaka K, Kunimatsu A, Yamashita Y +5 more

Plain English
This study looked at improving the quality of brain MRI images taken with a lower strength magnet (1.5 Tesla) by using a new technology called deep learning-based noise reduction. Researchers found that the enhanced images had significantly better quality, with higher clarity in distinguishing different brain structures, making them comparable to images from stronger magnets (3 Tesla). This is important because it means that doctors can achieve high-quality brain scans using less expensive and more widely available MRI machines. Who this helps: This helps patients by providing better brain imaging options without the need for more powerful—and often more costly—MRI machines.

PubMed

The monitoring of oil production process by deep learning based on morphology in oleaginous yeasts.

2023

Applied microbiology and biotechnology

Kitahara Y, Itani A, Ohtomo K, Oda Y, Takahashi Y +7 more

Plain English
This study looked at how the shape of certain yeast types, used to produce oils, changes during their growth in large-scale production settings. Researchers found that they could categorize the yeast into 7 different groups based on their shape, and this was closely linked to how well the yeast produced oil. This finding is important because it offers a new way to monitor and improve oil production in these microorganisms using advanced technology. Who this helps: This benefits patients and industries looking for sustainable oil alternatives.

PubMed

Acceleration of knee magnetic resonance imaging using a combination of compressed sensing and commercially available deep learning reconstruction: a preliminary study.

2023

BMC medical imaging

Akai H, Yasaka K, Sugawara H, Tajima T, Kamitani M +6 more

Plain English
This study looked at whether a new imaging technique using deep learning can make knee MRIs faster while still providing clear images. Researchers tested this by comparing images taken with one scan (1NSA-DLR) to those taken with four scans (4NSA), finding that the 1NSA-DLR images had much better clarity and less noise. Specifically, 1NSA-DLR images had significantly higher signal-to-noise ratios, showing clearer details of knee structures like ligaments and cartilage, which could improve diagnostic accuracy. Who this helps: This helps patients needing knee evaluations and the doctors interpreting those images.

PubMed

Clinical Impact of Deep Learning Reconstruction in MRI.

2023

Radiographics : a review publication of the Radiological Society of North America, Inc

Kiryu S, Akai H, Yasaka K, Tajima T, Kunimatsu A +4 more

Plain English
This research paper examined the use of deep learning technology to improve MRI image quality. The findings showed that deep learning reconstruction (DLR) can significantly enhance the clarity of images produced by lower-strength MRI machines, matching the quality typically seen with higher-strength machines without requiring longer scanning times. This is important because it decreases discomfort for patients and reduces costs for MRI facilities. Who this helps: Patients and healthcare providers who rely on MRI for diagnosis and treatment.

PubMed

Comparison of 1.5 T and 3 T magnetic resonance angiography for detecting cerebral aneurysms using deep learning-based computer-assisted detection software.

2023

Neuroradiology

Tajima T, Akai H, Yasaka K, Kunimatsu A, Yoshioka N +4 more

Plain English
This study looked at how well two types of MRI machines (1.5 T and 3 T) could find brain aneurysms using a computer program designed to help with detection. They analyzed scans from 90 patients and found that both machines were good at identifying aneurysms, with a sensitivity of about 88% to 100%. However, the 3 T machine had more false positives—2.6 per case compared to 1.5 for the 1.5 T machine—meaning it mistakenly identified problems more often. Who this helps: This helps doctors who are diagnosing brain aneurysms, especially those with less experience using these imaging tools.

PubMed

Impact of deep learning reconstruction on intracranial 1.5 T magnetic resonance angiography.

2022

Japanese journal of radiology

Yasaka K, Akai H, Sugawara H, Tajima T, Akahane M +6 more

Plain English
This study examined how a new deep learning technique improves MRI scans of the brain's blood vessels, specifically focusing on a method known as magnetic resonance angiography (MRA) using a 1.5 Tesla machine. Researchers analyzed images from 40 patients and found that the new technique significantly enhances image quality—showing up to twice the improvement in important visual measurements compared to traditional methods. This matters because clearer images help doctors better see and understand blood flow in the brain, which can lead to better diagnoses and treatments for patients with brain-related conditions. Who this helps: This benefits patients undergoing brain scans and doctors interpreting those images.

PubMed

Deep learning reconstruction for 1.5 T cervical spine MRI: effect on interobserver agreement in the evaluation of degenerative changes.

2022

European radiology

Yasaka K, Tanishima T, Ohtake Y, Tajima T, Akai H +3 more

Plain English
This study looked at how a technology called deep learning reconstruction (DLR) improves MRI images of the neck (cervical spine) taken with a 1.5 T machine, focusing on how well doctors can spot age-related changes in the spine. Researchers found that images produced using DLR were clearer, leading to a better agreement between doctors when assessing issues like spinal canal stenosis, with agreement scores improving significantly from around 0.778 to 0.874. This is important because clearer images help doctors make more accurate diagnoses and treatment plans for patients with spine problems. Who this helps: Patients with neck pain or degenerative spinal conditions.

PubMed

Clinical feasibility of an abdominal thin-slice breath-hold single-shot fast spin echo sequence processed using a deep learning-based noise-reduction approach.

2022

Magnetic resonance imaging

Tajima T, Akai H, Yasaka K, Kunimatsu A, Akahane M +4 more

Plain English
This study looked at a new method for taking MRI images of the pancreas using a technique called "deep learning-based noise reduction" to improve image quality while reducing scan time. Researchers found that using this technique (called BH-dDLR-FASE) significantly improved the quality of the images compared to traditional methods, and reduced the scan time from an average of 122 seconds to just 30 seconds. This matters because faster and clearer imaging of the pancreas can help doctors diagnose and treat pancreatic diseases more effectively. Who this helps: This helps patients suspected of having pancreatic diseases by providing quicker and clearer MRI results.

PubMed

Feasibility of accelerated whole-body diffusion-weighted imaging using a deep learning-based noise-reduction technique in patients with prostate cancer.

2022

Magnetic resonance imaging

Tajima T, Akai H, Sugawara H, Furuta T, Yasaka K +6 more

Plain English
This study looked at whether a new technique could speed up whole-body imaging for prostate cancer patients while still delivering clear images. Researchers tested two different imaging methods on 17 patients and found that the faster method (taking 3 minutes and 30 seconds) provided better image quality and clearer details of cancer spread compared to the traditional method that took almost 10 minutes. This is important because quicker imaging can mean less time for patients in the MRI machine, making the process more efficient without sacrificing quality. Who this helps: Patients with prostate cancer and the doctors treating them.

PubMed

Deep learning reconstruction for the evaluation of neuroforaminal stenosis using 1.5T cervical spine MRI: comparison with 3T MRI without deep learning reconstruction.

2022

Neuroradiology

Yasaka K, Tanishima T, Ohtake Y, Tajima T, Akai H +3 more

Plain English
This study examined how well two different types of MRI machines could detect narrowing of the spinal canal (neuroforaminal stenosis). The researchers found that images from a 1.5T MRI with deep learning technology had significantly better image quality and consistency among doctors (with a quality score of 8.4 compared to 10.3 for the 3T MRI without this technology) and higher agreement in diagnosis (0.920 vs. 0.894). This matters because better image quality leads to more accurate diagnoses, ultimately improving patient care. Who this helps: Patients with spinal issues.

PubMed

Isolation, Structure Determination, and Total Synthesis of Hoshinoamide C, an Antiparasitic Lipopeptide from the Marine Cyanobacterium.

2021

Journal of natural products

Iwasaki A, Ohtomo K, Kurisawa N, Shiota I, Rahmawati Y +3 more

Plain English
This study focused on a compound called hoshinoamide C, which is found in marine cyanobacteria and is known to fight parasites. The researchers determined its structure and confirmed that it successfully inhibits the growth of malaria and African sleeping sickness parasites at very low concentrations—0.96 micromolar for malaria and 2.9 micromolar for the other disease—without harming human cells. This discovery is important because it could lead to new treatments for these serious diseases. Who this helps: Patients suffering from malaria and African sleeping sickness.

PubMed

Severe Cytomegalovirus anterior uveitis and corneal endotheliitis after use of topical tacrolimus.

2021

International journal of ophthalmology

Tsubota Y, Fujino Y, Ohtomo K, Ueda K, Yoshida J +3 more

PubMed

Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model.

2021

Radiology

Akai H, Miyagawa K, Takahashi K, Mochida-Saito A, Kurokawa K +9 more

Plain English
This study looked at how a contrast agent called gadolinium, used in medical imaging, affects brain function and behavior in mice. The researchers found that while gadolinium deposited in the brains of some mice, there were no noticeable changes in their movement, anxiety levels, or memory. This is important because it suggests that the newer type of gadolinium (macrocyclic) may be safer than older forms when used in medical tests. Who this helps: This benefits patients undergoing imaging tests and doctors administering gadolinium-based contrast agents.

PubMed

Breath-hold 3D magnetic resonance cholangiopancreatography at 1.5 T using a deep learning-based noise-reduction approach: Comparison with the conventional respiratory-triggered technique.

2021

European journal of radiology

Tajima T, Akai H, Sugawara H, Yasaka K, Kunimatsu A +5 more

Plain English
This research compared two methods of a specific type of MRI called magnetic resonance cholangiopancreatography (MRCP) to see which produced better images of the bile and pancreatic ducts. The study found that a new breath-hold method using deep learning noise reduction (BH-dDLR-MRCP) resulted in significantly clearer images than the regular breath-hold method without this technology, with noticeable improvements in visibility scores and image quality metrics. This matters because clearer images can lead to better diagnosis of disorders in the bile and pancreatic ducts, ultimately improving patient care. Who this helps: Patients needing imaging for bile and pancreatic issues.

PubMed

Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate.

2021

Micromachines

Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y +11 more

Plain English
Researchers created a new type of lab plate called a horizontal-type co-culture plate (HTCP) to improve how cells communicate and exchange substances. This device allows scientists to better observe and measure the movement of tiny particles, called extracellular vesicles (EVs), between cells, resulting in a two-fold increase in EV transfer compared to older methods. This advancement is important because it enhances our understanding of how cells interact, which could accelerate research in various areas, including drug development and disease treatment. Who this helps: This benefits researchers and scientists studying cell behavior and communication.

PubMed

Application of CT texture analysis to assess the localization of primary aldosteronism.

2020

Scientific reports

Akai H, Yasaka K, Kunimatsu A, Ohtomo K, Abe O +1 more

Plain English
This study looked at how to predict where primary aldosteronism (PA) occurs in patients by analyzing images from CT scans. Researchers examined data from 82 patients and found that certain features in the CT images, like the average gray level intensity and the number of positive pixels, could predict the location of the adrenal gland abnormalities in 67.1% of cases. This finding is important because it offers a less invasive way to determine where the problem is, which can help in making treatment decisions. Who this helps: Patients with primary aldosteronism.

PubMed

Embolization of visceral arterial aneurysms: Simulation with 3D-printed models.

2020

Vascular

Shibata E, Takao H, Amemiya S, Ohtomo K, Abe O

Plain English
This study looked at how effective 3D-printed models of blood vessels are for planning surgery to treat aneurysms in arteries supplying internal organs. Researchers used these models to simulate procedures for four patients, aged 40 to 71, with aneurysms averaging 16.5 mm in size. All four patients underwent successful treatment without complications, showing that these 3D models can help doctors create better treatment plans and improve patient outcomes. Who this helps: This benefits patients with visceral artery aneurysms.

PubMed

Incidence of Medial and Lateral Meniscal Tears After Delayed Anterior Cruciate Ligament Reconstruction in Pediatric Patients.

2020

Orthopaedic journal of sports medicine

Kawashima I, Hiraiwa H, Ishizuka S, Kawai R, Kusaka Y +2 more

Plain English
This study looked at how the timing of surgery for ACL injuries in children affects the likelihood of other knee injuries, specifically meniscal and cartilage tears. Researchers analyzed 207 knees and found that when surgery was delayed for more than 150 days, the rate of medial meniscal tears was much higher (59.2% vs. 25.6% for early surgery), while the rate of lateral meniscal tears was lower (22.2% vs. 50.0%). This is important because it shows that waiting too long for surgery can lead to more serious knee damage, particularly on the inside of the joint. Who this helps: This helps pediatric patients and their doctors by highlighting the importance of timely treatment for ACL injuries.

PubMed

Deep learning to differentiate parkinsonian disorders separately using single midsagittal MR imaging: a proof of concept study.

2019

European radiology

Kiryu S, Yasaka K, Akai H, Nakata Y, Sugomori Y +4 more

Plain English
This study explored how well a type of artificial intelligence called deep learning can differentiate between different Parkinson's-related disorders using brain scans (MRI). The researchers looked at scans from 419 people, including those with Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy, and found that the technology accurately identified these conditions with very high accuracy rates—up to 98.4% for detecting normal cases. This matters because better and faster diagnoses can lead to more effective treatments for these disorders. Who this helps: This helps patients with parkinsonian disorders by improving diagnostic accuracy.

PubMed

PEG-poly(L-lysine)-based polymeric micelle MRI contrast agent: Feasibility study of a Gd-micelle contrast agent for MR lymphography.

2018

Journal of magnetic resonance imaging : JMRI

Akai H, Shiraishi K, Yokoyama M, Yasaka K, Nojima M +4 more

Plain English
This study looked at a new type of MRI contrast agent called Gd-micelle to see if it could improve imaging of lymph nodes. In tests on mice, Gd-micelle provided better contrast than the standard agent, gadofluorine P, with a peak contrast ratio of 2.64 in normal lymph nodes and 3.48 in inflamed ones, showing it enhances imaging more effectively. These findings matter because they suggest Gd-micelle could help doctors get clearer images of lymph nodes, which is important for diagnosing and monitoring diseases like cancer. Who this helps: Patients requiring lymph node imaging, particularly those with cancer.

PubMed

Gadoxetate disodium-induced tachypnoea and the effect of dilution method: a proof-of-concept study in mice.

2018

European radiology

Akai H, Yasaka K, Nojima M, Kunimatsu A, Inoue Y +3 more

Plain English
This research studied the effects of a contrast agent called gadoxetate disodium on breathing in mice. The findings showed that mice injected with gadoxetate disodium experienced a significant increase in their breathing rate, rising by about 20 breaths per minute, compared to only 3 breaths per minute in the control group. This matters because it highlights that gadoxetate disodium causes a rapid increase in breathing without affecting oxygen levels or heart rate, showing its unique impact among the tested agents. Who this helps: This benefits patients undergoing medical imaging procedures that use contrast agents.

PubMed

Vaginal delivery-related changes in the pelvic organ position and vaginal cross-sectional area in the general population.

2018

Clinical imaging

Naganawa S, Maeda E, Hagiwara A, Amemiya S, Gonoi W +3 more

Plain English
This study looked at how having babies affects the position of pelvic organs and the size of the vaginal area in women. Researchers used MRI scans of 119 women and found that those who had given birth two or three times (bipara and tripara) had a larger vaginal area compared to those who had never given birth (nullipara), with significant changes noted (p<0.01). These findings are important because they provide insights into how vaginal delivery can change women's bodies, which can inform better care during and after childbirth. Who this helps: This helps women who are pregnant or have given birth, as well as healthcare providers.

PubMed

Imaging prediction of nonalcoholic steatohepatitis using computed tomography texture analysis.

2018

European radiology

Naganawa S, Enooku K, Tateishi R, Akai H, Yasaka K +5 more

Plain English
This study looked at using CT scans to help identify a liver condition called nonalcoholic steatohepatitis (NASH). Researchers analyzed images from 88 patients and found that when the scans showed no signs of liver damage (fibrosis), their method accurately predicted NASH 94% of the time. However, when there were signs of fibrosis, the accuracy dropped to 42%, indicating that liver damage can hide the signs of NASH. Who this helps: This helps doctors diagnose NASH more effectively in patients without liver damage.

PubMed

The relationship of waist circumference and body mass index to grey matter volume in community dwelling adults with mild obesity.

2018

Obesity science & practice

Hayakawa YK, Sasaki H, Takao H, Yoshikawa T, Hayashi N +4 more

Plain English
This study looked at how waist size and body mass index (BMI) affect the volume of grey matter in the brains of nearly 800 Japanese adults with mild obesity. The findings showed that while global grey matter volume didn't relate to waist size or BMI, specific brain regions had less grey matter when waist size and BMI were higher, with men showing this effect more broadly than women. Understanding these connections is important because it highlights how even mild obesity can affect brain health, especially in certain groups. Who this helps: This helps patients, particularly those dealing with mild obesity, and health professionals monitoring brain health.

PubMed

Quantitative computed tomography texture analyses for anterior mediastinal masses: Differentiation between solid masses and cysts.

2018

European journal of radiology

Yasaka K, Akai H, Abe O, Ohtomo K, Kiryu S

Plain English
This study looked at whether doctors can tell the difference between solid masses and cysts in the front part of the chest using detailed CT scans. Researchers analyzed 76 unenhanced CT scans and 84 contrast-enhanced CT scans and found that a specific combination of image analysis techniques successfully distinguished solid masses from cysts, achieving a high accuracy rate of 98% for the contrast-enhanced scans. This is important because accurately identifying these types of masses can help guide treatment decisions for patients. Who this helps: This benefits patients who have masses in the chest and need accurate diagnoses for effective treatment.

PubMed

Monoclonal immunoglobulin heavy chain gene rearrangement in Fuchs' uveitis.

2018

BMC ophthalmology

Nakahara H, Kaburaki T, Tanaka R, Matsuda J, Takamoto M +6 more

Plain English
Researchers studied five patients with Fuchs' uveitis (FU) who had undergone surgery to remove cloudy fluid in the eye, in order to determine if they might also have a type of lymphoma called primary vitreoretinal lymphoma (PVRL). They found that while monoclonal immunoglobulin heavy chain gene rearrangement, which indicates PVRL, was present in four of the patients, other tests showed no signs of lymphoma in any of the cases. This matters because it highlights the risk of misdiagnosing FU as PVRL based on these test results, indicating the need for careful evaluation to avoid errors in diagnosis. Who this helps: This helps ophthalmologists and patients with Fuchs' uveitis.

PubMed

The inhibitory effect of gadoxetate disodium on hepatic transporters: a study using indocyanine green.

2018

European radiology

Akai H, Yasaka K, Kunimatsu A, Nojima M, Inoue Y +3 more

Plain English
This study looked at how a drug called gadoxetate disodium affects liver transporters that help remove a substance called indocyanine green (ICG) from the body. Researchers found that, when gadoxetate disodium was given, the liver took up ICG more slowly compared to a control group, with significant slowdowns in both cold and normal conditions (logKe values of -6.52 vs. -5.87 in cold and -4.54 vs. -4.14 in normal). This matters because it shows that gadoxetate disodium can slow down liver function, potentially affecting how other medications work. Who this helps: This helps doctors and patients, especially those using gadoxetate disodium during imaging procedures.

PubMed

Clinical characteristics and ocular complications of patients with scleritis in Japanese.

2018

Japanese journal of ophthalmology

Tanaka R, Kaburaki T, Ohtomo K, Takamoto M, Komae K +3 more

Plain English
This study looked at 123 Japanese patients with scleritis to understand their symptoms and complications. It found that 41% of patients had high eye pressure, and one-third experienced vision loss, especially those with severe types of scleritis. Most patients were treated with systemic corticosteroids, and controlling eye pressure is crucial to prevent further vision problems. Who this helps: This benefits patients with scleritis and their doctors by providing insights for better management of the condition.

PubMed

Predicting prognosis of resected hepatocellular carcinoma by radiomics analysis with random survival forest.

2018

Diagnostic and interventional imaging

Akai H, Yasaka K, Kunimatsu A, Nojima M, Kokudo T +5 more

Plain English
This study looked at how analyzing medical images using a special computer method called random survival forest (RSF) can help predict the survival of patients with operable liver cancer (hepatocellular carcinoma or HCC). Researchers examined CT scans from 127 patients and found that specific features in the images could separate patients into high-risk and low-risk groups for survival. They discovered that having a higher predicted risk score increased the chance of poorer outcomes, with a notable risk ratio of 1.06 for every 1% increase in risk, and also identified vascular invasion as a significant concern. Who this helps: This research benefits doctors and patients by providing better tools for predicting cancer outcomes and guiding treatment decisions.

PubMed

Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy.

2018

Translational vision science & technology

Ohtomo K, Arita R, Shirakawa R, Usui T, Yamashita H +3 more

Plain English
This study looked at how S-1 chemotherapy affects small glands in the eyelids called meibomian glands, which are important for eye health. Researchers found that, after starting S-1 treatment, the area of these glands decreased significantly at both 3 and 6 months, indicating that the more S-1 a patient received, the more the glands shrank. This matters because it highlights a potential side effect of S-1 that can affect patients' eye health. Who this helps: This helps patients undergoing S-1 chemotherapy and their doctors by providing insight into potential eye-related side effects.

PubMed

Comparison of the cardiothoracic ratio between postmortem and antemortem computed tomography.

2017

Legal medicine (Tokyo, Japan)

Okuma H, Gonoi W, Ishida M, Shirota G, Kanno S +4 more

Plain English
This study examined the size of the heart compared to the chest in 147 people before and after death using CT scans. Researchers found that the heart appears larger after death (average ratio increased from 0.50 to 0.53) across all heart conditions evaluated. This is important because it shows that heart size measurements taken after death can be misleading, highlighting the need for updated criteria to accurately assess heart size in postmortem scans. Who this helps: This helps doctors, particularly those involved in forensic pathology and radiology.

PubMed

Computed tomography and magnetic resonance imaging of a plexiform angiomyxoid myofibroblastic tumor: a case report.

2017

BMC medical imaging

Akai H, Kiryu S, Shinozaki M, Ohta Y, Nakano Y +2 more

Plain English
This study looks at a rare type of stomach tumor called a plexiform angiomyxoid myofibroblastic tumor (PAMT) in a 55-year-old man who had a stomach growth for 10 years. Imaging tests revealed two unusual cysts in the tumor, and surgery confirmed the diagnosis of PAMT. This finding is important because it adds new information about how PAMT can appear, helping doctors recognize it better in the future. Who this helps: This helps doctors and patients facing diagnosis and treatment of rare gastric tumors.

PubMed

3D Printing of Preoperative Simulation Models of a Splenic Artery Aneurysm: Precision and Accuracy.

2017

Academic radiology

Takao H, Amemiya S, Shibata E, Ohtomo K

Plain English
This study focused on using 3D printing to create detailed models of splenic artery aneurysms to improve surgical planning for treatments. Researchers produced 10 models based on CT scans and found that the sizes of the aneurysms in the 3D models were very close to those in the original scans, with an average size of 3.90 cm and 4.33 cm compared to 4.14 cm and 4.66 cm in the scans. This is important because it shows that these 3D models can accurately represent real human anatomy, helping doctors prepare for complex surgeries. Who this helps: This helps doctors and surgeons preparing for procedures involving splenic artery aneurysms.

PubMed

Influence of Indocyanine Green on Hepatic Gd-EOB-DTPA Uptake: A Proof-of-Concept Study in Mice.

2017

Investigative radiology

Akai H, Yasaka K, Nojima M, Inoue Y, Ohtomo K +1 more

Plain English
This study looked at how different amounts of indocyanine green (ICG) affect the liver's ability to absorb a contrast agent called Gd-EOB-DTPA, used in MRI scans. In hypothermic mice, as more ICG was injected, the liver's ability to take up Gd-EOB-DTPA decreased significantly: the peak brightness dropped from 1.66 in the control group to 1.25 with the highest ICG dose. This information is important because understanding the impact of ICG on MRIs can help improve imaging techniques for liver conditions. Who this helps: This helps doctors and researchers working with liver imaging.

PubMed

Initial Trabeculectomy With Mitomycin-C for Secondary Glaucoma-associated With Uveitis in Behçet Disease Patients.

2017

Journal of glaucoma

Komae K, Takamoto M, Tanaka R, Aihara M, Ohtomo K +5 more

Plain English
This study looked at the effects of a surgical procedure called trabeculectomy combined with a drug, mitomycin-C, on patients with Behçet disease who also have glaucoma caused by uveitis. Researchers found that five years after the surgery, 76.1% of patients were able to keep their eye pressure at a safe level, and over half (54.4%) maintained a healthy filtering bleb, which is important for eye function. Importantly, the rates of uveitis attacks before and after surgery were similar, indicating that the surgery did not worsen the condition. Who this helps: This research benefits patients with Behçet disease and their doctors by providing insights into effective treatment options for glaucoma.

PubMed

Precision of quantitative computed tomography texture analysis using image filtering: A phantom study for scanner variability.

2017

Medicine

Yasaka K, Akai H, Mackin D, Court L, Moros E +2 more

Plain English
This study looked at how different CT scanners measure the texture of images taken of phantom objects (fake models) that represent tumors. Researchers found that most texture measurements were consistent across different machines, but certain measurements related to texture variability showed significant differences, with variability indexes reaching as high as 0.692. This is important because understanding how well these scans can reliably capture tumor characteristics helps improve cancer diagnosis and treatment planning. Who this helps: This helps doctors and healthcare providers in making better treatment decisions for cancer patients.

PubMed

Quantitative computed tomography texture analysis for estimating histological subtypes of thymic epithelial tumors.

2017

European journal of radiology

Yasaka K, Akai H, Nojima M, Shinozaki-Ushiku A, Fukayama M +3 more

Plain English
This study examined whether CT scans can help distinguish between high-risk thymic epithelial tumors (HTET) and low-risk thymic epithelial tumors (LTET) in 39 patients. The researchers found that specific measurements from the CT scans—like the average texture features—were effective in telling the two types apart, achieving accuracy scores (AUC) of up to 0.89 for certain measurements. This is important because identifying these tumor types can guide treatment decisions and improve patient outcomes. Who this helps: This helps doctors and patients with thymic epithelial tumors.

PubMed

Development of pancreatic cancer is predictable well in advance using contrast-enhanced CT: a case-cohort study.

2017

European radiology

Gonoi W, Hayashi TY, Okuma H, Akahane M, Nakai Y +5 more

Plain English
This research studied how certain imaging results from CT scans can predict the development of pancreatic cancer in patients already receiving treatment for liver cancer. Among 1,848 patients, those who later developed pancreatic cancer showed warning signs—like changes in the pancreas—up to 34 months before their cancer was diagnosed. These findings are important because they help identify high-risk patients earlier, potentially leading to better outcomes through timely intervention. Who this helps: This research helps patients at risk for pancreatic cancer and their doctors.

PubMed

Combined intravitreal methotrexate and immunochemotherapy followed by reduced-dose whole-brain radiotherapy for newly diagnosed B-cell primary intraocular lymphoma.

2017

British journal of haematology

Kaburaki T, Taoka K, Matsuda J, Yamashita H, Matsuda I +8 more

Plain English
This study looked at a new treatment approach for primary intraocular lymphoma, a type of eye cancer that can often spread to the brain. Researchers used a combination of eye injections, chemotherapy, and lower-dose whole-brain radiation therapy. They found that 74.9% of patients were free from disease progression four years later, and 86.3% were still alive, while only one patient showed signs of mild cognitive decline despite increased white matter changes in the brain scans. Who this helps: This benefits patients with primary intraocular lymphoma and their doctors by providing a more effective treatment option with fewer cognitive side effects.

PubMed

3D-Printed Visceral Aneurysm Models Based on CT Data for Simulations of Endovascular Embolization: Evaluation of Size and Shape Accuracy.

2017

AJR. American journal of roentgenology

Shibata E, Takao H, Amemiya S, Ohtomo K

Plain English
This study looked at how accurately 3D-printed models of visceral aneurysms match real-life sizes and shapes based on CT scans. Researchers tested models from 15 patients and found that the sizes of the aneurysms ranged from 6.1 to 35.7 mm in diameter, and the models were almost perfectly accurate with a shape accuracy rate of about 91%. These findings are important because they show that 3D-printed models can effectively help doctors plan for surgeries by providing precise anatomical details. Who this helps: This helps doctors and patients preparing for endovascular treatments.

PubMed

Influence of outflow-obstructed liver volume and venous communication development: A three-dimensional volume study in living donors.

2017

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Kawaguchi Y, Hasegawa K, Okura N, Maki H, Akamatsu N +5 more

Plain English
This study looked at how the size of blocked blood flow in the liver affects the recovery of living donors who give a part of their liver for transplantation. Researchers examined 119 donors and found that those with larger areas of blocked blood flow had worse liver function after surgery compared to those with smaller blockages. Specifically, 60 donors had significant outflow obstruction and experienced more complications than the 59 donors with smaller obstructions. Who this helps: This research benefits living liver donors by improving understanding of how liver function can be affected by outflow obstructions, leading to better care practices.

PubMed

Impact of hepatocellular carcinoma heterogeneity on computed tomography as a prognostic indicator.

2017

Scientific reports

Kiryu S, Akai H, Nojima M, Hasegawa K, Shinkawa H +3 more

Plain English
This study looked at how the differences in liver tumors, specifically hepatocellular carcinoma (HCC), can be seen in CT scans and how these differences relate to patient outcomes. Researchers examined CT images from 122 patients and found that certain measurements from the visual texture of these scans were linked to survival rates; for example, specific texture features showed a strong correlation with how long patients might live after treatment. This finding is important because it means that analyzing CT images can help doctors make better predictions about a patient's prognosis and tailor treatment plans more effectively. Who this helps: This helps doctors and patients by providing clearer insights into cancer prognosis.

PubMed

Atsuko Heshiki, MD.

2017

Radiology

Ohtomo K

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.