N P Zinoveva studies the use of Revelise (alteplase), a medication designed to treat ischemic strokes, which occur when a blood clot blocks a blood vessel in the brain. Their research involves analyzing how this treatment performs in everyday clinical settings, particularly among older patients and those with existing health conditions. Zinoveva aims to understand the benefits of this therapy in reducing disabilities caused by strokes and improving patient care.
Key findings
In the International PRIMA Study involving 2,202 patients, 49.9% had good outcomes upon discharge after receiving Revelise.
The percentage of patients who experienced favorable outcomes increased to 66.4% after 90 days.
The study demonstrated that Revelise effectively reduces stroke-related disabilities among diverse patient groups.
Frequently asked questions
Does Dr. Zinoveva study ischemic strokes?
Yes, Dr. Zinoveva focuses on the treatment of ischemic strokes using thrombolytic therapy.
What treatments has Dr. Zinoveva researched?
Dr. Zinoveva has researched the use of Revelise (alteplase) for treating ischemic strokes.
Is Dr. Zinoveva's work relevant to older stroke patients?
Yes, Dr. Zinoveva's research specifically includes older patients and those with other health issues.
Publications in plain English
[Thrombolytic Therapy for Ischemic Stroke with Revelise: Results of a Two-Year Follow-Up in the International PRIMA Study].
2025
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Shamalov NA, Khasanova DR, Marchenko SV, Soldatov MA, Azarova AG +46 more
Plain English This study looked at how well and safely Revelise (alteplase), a medication for treating ischemic stroke (IS), works in real-life situations. It involved 2,202 patients, mostly around 68 years old, and found that nearly half (49.9%) of them had good outcomes when discharged, rising to 66.4% after 90 days. The results showed that Revelise effectively reduces stroke-related disabilities, even in older patients and those with other health issues.
Who this helps: This benefits patients who suffer from ischemic strokes and the doctors treating them.
[Plenary Session of the Human Ecology and Environmental Hygiene Research Board of the Russian Academy of Medical Sciences and the Ministry of Health of the Russian Federation].
2004
Gigiena i sanitariia
Kir'ianova LF, Maksimova VA, Zinov'eva NP, Fedotova NA
[Main results of researches by the state institution A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences, in 2003].
[Evaluation of maximal permissible concentration of 2-allyl oxyethanol in the atmospheric air].
1995
Gigiena i sanitariia
Pinigin MA, Tepikina LA, Safulin AA, Zinovéva NP, Skvortsova EL +3 more
Plain English This study looked at the safe levels of a chemical called 2-allyl oxyethanol (2-AOE) in the air. Researchers found that people can start to feel irritation at a concentration of 0.68 mg/m3, while long-term exposure could lead to health issues at 0.075 mg/m3. They propose that the daily safe limit should be set at 0.01 mg/m3 to protect people’s health.
Who this helps: This helps communities and environmental health officials to keep the air safe for everyone.
[Toxicologic and hygienic evaluation of benzyl acetate as an atmospheric air pollutant].
1993
Gigiena i sanitariia
Tepikina LA, Zinovéva NP, Shipulina ZV
Plain English This study looked at benzyl acetate, a chemical that can pollute the air, and found that a dangerous dose (LD50) for it is 2500 mg per kilogram of body weight. The researchers also developed a method to detect benzyl acetate in the air at very low levels, between 0.008 and 0.01 mg per cubic meter, and identified that the maximum acceptable concentration for this pollutant in the air is 0.01 mg/m3, which puts it in a category of moderate danger. Understanding these levels is important for keeping air safe and protecting health.
Who this helps: This helps patients, particularly those with respiratory issues, and environmental health advocates.
Plain English Researchers developed a way to measure how much nitrogen dioxide (NO2) people are exposed to in their homes and outside in Moscow. They found that, in general, NO2 levels were lower indoors than outdoors, but when there were gas appliances in homes, the indoor levels were higher. This matters because understanding where people are exposed to NO2 can help manage health risks associated with air pollution.
Who this helps: This helps patients, particularly those in urban areas with gas appliances.