P Schule

Department of Psychiatry, Maimonides Medical Center, Brooklyn, NY, 11219, USA.

6 publications 1977 – 2025

What does P Schule research?

Dr. P Schule studies the use of genetically modified pig organs, particularly kidneys and thymuses (a part of the immune system), for transplant purposes in humans. His research primarily examines how these pig organs can be engineered to reduce the chances of rejection by the human body, which is a major obstacle in organ transplantation. One specific focus of his studies is on a gene called alpha-1,3-galactosyltransferase, which is associated with immune reactions. By removing this gene from pig organs, he seeks to improve their compatibility and longevity when transplanted into non-human primates, paving the way for potential future applications in human transplants.

Key findings

  • In a study using pigs engineered to lack the alpha-1,3-galactosyltransferase gene, hyperacute rejection was completely prevented in organ transplants.
  • Despite the success in preventing immediate rejection, other immune mechanisms still led to organ failure, highlighting ongoing challenges in xenotransplantation.
  • The findings establish clear barriers that need to be overcome for successful xenotransplantation beyond just the issue of the Gal antigen.

Frequently asked questions

Does Dr. Schule study organ transplantation?
Yes, Dr. Schule specializes in organ transplantation, specifically using genetically modified pig organs to address organ rejection.
What treatments has Dr. Schule researched?
Dr. Schule's research focuses on xenotransplantation, where pig organs are used for transplant procedures in humans, aiming to improve compatibility and reduce rejection.
Is Dr. Schule's work relevant to patients needing organ transplants?
Yes, his research is highly relevant as it seeks to develop new solutions for organ shortage and improve outcomes for transplant patients.

Publications in plain English

Reassessment of the concept of Calomera decemguttata (Fabricius) with a description of Calomera paradecemguttata sp. nov. (Coleoptera: Cicindelidae).

2025

Zootaxa

Moravec J, Dheurle C, Schüle P, Wiesner J

Plain English
This study reevaluates a group of tiger beetles known as Calomera decemguttata and identifies a new species called Calomera paradecemguttata. Researchers discovered that the original type specimen of Calomera decemguttata is different from the specimens commonly referred to by that name, leading to the clarification of the species complex and the recognition of six other related species. This distinction is important for accurately classifying these beetles, which helps improve our understanding of biodiversity and how to conserve these species. Who this helps: This benefits researchers studying biodiversity and conservation efforts.

PubMed

Larval descriptions of threespecies with some bionomical remarks (Coleoptera, Cicindelidae).

2021

ZooKeys

Schüle P, Putchkov A, Markina T

Plain English
This research studied the larva stages of three types of tiger beetles: Dromica kolbei, Dromica alboclavata, and the first larval stage of Dromica helleri. The scientists detailed unique features of these larvae, such as the shape of part of their bodies and specific hair patterns, which can help to identify and differentiate these species from one another. This is important for understanding biodiversity and conservation efforts in ecosystems where these beetles live. Who this helps: This benefits entomologists and conservationists working to protect and study beetle species.

PubMed

Psychiatric Emergency Services - Can Duty-Hour Changes Help Residents and Patients?

2018

The Psychiatric quarterly

Brainch N, Schule P, Laurel F, Bodic M, Jacob T

Plain English
This study looked at how changing the work hours for psychiatric residents affects their well-being and the care patients receive in emergency settings. After switching to shorter "swing" shifts, residents reported better sleep, with 86% feeling rested, and patient wait times and length of stay in the emergency department improved significantly—from an average wait time of 169 minutes to 147 minutes and length of stay from 690 minutes to 515 minutes. These changes are important because they show that adjusting work hours can benefit both residents and patients, leading to better care overall. Who this helps: Patients and psychiatric residents.

PubMed

Results of gal-knockout porcine thymokidney xenografts.

2009

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Griesemer AD, Hirakata A, Shimizu A, Moran S, Tena A +9 more

Plain English
Pig organs engineered to lack the alpha-1,3-galactosyltransferase gene avoid the immediate antibody-mediated rejection seen in standard xenografts. This study transplanted these knockout pig kidney-thymus units into nonhuman primates and found that while hyperacute rejection was prevented, other immune mechanisms still caused organ failure. The results defined the next barriers to xenotransplantation beyond the Gal antigen.

PubMed

[Not Available].

1978

Musees de Geneve

Schulé P

PubMed

[Obituary: Marc Cramer (1892-1976)].

1977

Gesnerus

Schulé P

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.