R Pervez studies inflammatory arthritis, particularly how certain proteins in the body can trigger this condition. Their research highlights the role of a protein called CD13, which enters the bloodstream and activates a receptor known as B1R on immune and joint cells. This activation is linked to increased inflammation, especially in patients suffering from rheumatoid arthritis. By exploring ways to block this receptor, their work aims to develop treatments that can alleviate symptoms and reduce inflammation without harming the overall immune response.
Key findings
Blocking the B1R receptor significantly reduced inflammation in human tissue samples from arthritis patients.
In mouse models of arthritis, inhibiting the B1R receptor led to a decrease in disease severity.
The study showed that the B1R receptor is overactive in patients with rheumatoid arthritis, identifying it as a potential drug target.
Frequently asked questions
Does Dr. Pervez study rheumatoid arthritis?
Yes, Dr. Pervez focuses on rheumatoid arthritis and how specific proteins in the body contribute to this condition.
What treatments has Dr. Pervez researched for arthritis?
Dr. Pervez's research targets the B1R receptor, suggesting that blocking this receptor could be a new treatment approach for inflammatory arthritis.
Is Dr. Pervez's work relevant to other inflammatory diseases?
Yes, the findings regarding the B1R receptor may also apply to other inflammatory diseases beyond rheumatoid arthritis.
Publications in plain English
Effect of botanicals, organic nutrient sources, and bio-control agents on root-knot nematode () infecting tomato.
2025
Frontiers in plant science
G V, Machal M, Rana VS, Gowda Ap A, Kumar V +6 more
Plain English This study looked at natural ways to control root-knot nematodes, which are tiny worms that can damage tomato plants and cause up to 30% loss in yield. Researchers tested various plant extracts, essential oils, and organic fertilizers and found that these treatments significantly reduced nematode populations and boosted tomato growth compared to traditional chemical treatments. Specifically, the combined natural methods worked similarly well as a chemical product called Velum Prime, while also improving soil quality.
Who this helps: This helps farmers and agricultural workers looking for sustainable methods to protect tomato crops.
Trends and Disparities in Mortality due to Diabetes Mellitus and Sepsis in the US Adults: 1999-2023.
2025
Endocrinology, diabetes & metabolism
Rao AG, Shahid S, Pervez N, Pervez R, Ahmed R
Plain English This study looked at how diabetes affects death rates from sepsis among adults in the U.S. from 1999 to 2023. Researchers found that over 483,000 adults with diabetes died from sepsis during this time, with a notable increase in deaths during the COVID-19 pandemic, particularly among Hispanic populations (up 22.49%) before declining again. The findings highlight significant disparities in mortality rates, especially among older adults and specific racial groups, showing the need for better healthcare strategies to manage diabetes and prevent sepsis.
Who this helps: This helps patients with diabetes, healthcare providers, and public health officials.
Strengthening Canada's Health Workforce: The Role of Pan-Canadian Data.
2025
Healthcare quarterly (Toronto, Ont.)
Pirie T, Logvin A, Pervez R, Weir-Seeley S, Salter L +5 more
Plain English This study looked at how better data collection can improve the Canadian healthcare workforce. It found that there are significant gaps in the current data, but new standards from the Canadian Institute for Health Information (CIHI) and the creation of Health Workforce Canada aim to fix these issues. Improving data on healthcare workers is crucial for making informed policies and ensuring everyone gets the care they need.
Who this helps: This helps patients and healthcare providers by ensuring better staffing and resources in the health system.
Spatiotemporal trends and index-based assessment of beach litter abundance and pollution status on Shantou beaches, China.
2025
Marine pollution bulletin
Pervez R, Jia C, Sardar M, Lai Y, Jattak ZU +1 more
Plain English This study looked at the amount and types of litter on 10 beaches in Shantou, China, across different seasons. Researchers found that beaches had the most litter in summer, with 40% being considered "dirty," while winter had the least litter. Notably, plastic made up most of the trash, and during summer, all beaches were classified as "extremely dirty."
Who this helps: This research benefits environmentalists, beachgoers, and policy-makers aiming to improve beach conditions.
Patterns of thoracic injury in bomb blast victims: A retrospective radiological review.
2025
The Journal of international medical research
Ahmad MN, Abdullah M, Shaikh RH, Pervez R, Uddin MMZ +3 more
Plain English This study looked at the types of lung injuries suffered by 130 people who were victims of bomb blasts over a 20-year period. Researchers found that nearly 70% of these injuries were caused by the blast itself, and common issues included foreign objects in the lungs, areas of collapsed lung, and lung swelling. Understanding these injury patterns is important for improving emergency care and treatment for victims in the aftermath of bomb blasts.
Who this helps: This helps doctors and emergency responders who treat bomb blast victims.
Spatial variation in iodine content with relation to soil physicochemical properties in lower Himalayan region.
2024
Environmental research
Ali J, Mohiuddin M, Wang X, Hussain Z, Irshad M +4 more
Plain English This study looked at how different soil types in the lower Himalayan region of Pakistan affect iodine levels in the soil. Researchers found that iodine levels were higher in the flat areas of Haripur and decreased in the hilly areas of Mansehra, with specific numbers showing that higher soil pH and lower organic matter in Mansehra contributed to lower iodine levels. Understanding these differences is important because iodine is essential for health, and low levels can lead to serious health problems.
Who this helps: This helps patients at risk of iodine deficiency, particularly those living in the hilly areas studied.
Evaluating the feasibility and potential impacts of a recovery-oriented psychosocial rehabilitation toolkit in a health care setting in Kenya: A mixed-methods study.
2023
Psychiatric rehabilitation journal
Casey R, Wiener JC, Krupa T, Lysaght R, Le Ber MJ +7 more
Plain English This study looked at how well a mental health support program called the Psychosocial Rehabilitation (PSR) Toolkit worked for people with serious mental illnesses in Kenya. Over 14 weekly group sessions, 23 patients and their family members participated, and the patients showed a moderate improvement in managing their illness. However, family members had a mixed experience, feeling less positive about recovery afterwards, even though participants reported feeling more hopeful and less stigmatized.
Who this helps: This benefits patients with serious mental illnesses and their families by providing them with tools and support for recovery.
Impact of microplastic pollution on coastal ecosystems using comprehensive beach quality indices.
2023
Marine pollution bulletin
Pervez R, Lai Y, Song Y, Li X, Lai Z
Plain English This study looked at the pollution from microplastics on beaches in China, using special measures to evaluate the level and impact of this pollution. Researchers found that all tested beaches had extremely high levels of microplastics, averaging about 664 pieces per kilogram of sand, with most of these being tiny fibers. These findings highlight the serious environmental threat posed by microplastics to coastal ecosystems and emphasize the need for action to address this pollution.
Who this helps: This helps environmental scientists, beach conservationists, and policymakers.
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.
2023
Annals of the rheumatic diseases
Knights AJ, Farrell EC, Ellis OM, Lammlin L, Junginger LM +10 more
Plain English This study looked at how certain cells in the inner lining of joints change their roles after a joint injury, specifically focusing on fibroblasts in osteoarthritis. Researchers found seven different types of these fibroblasts, with one type (Prg4lining fibroblasts) producing a protein called R-spondin 2, which contributes to unhealthy interactions between joint cells after an injury. Understanding these changes helps clarify the mechanisms behind joint problems after injuries, potentially leading to better treatments.
Who this helps: This helps patients with post-traumatic osteoarthritis.
Microplastic distribution within core sediments of beach and its responses to anthropogenic activities.
2022
Marine pollution bulletin
Pervez R, Wang Y
Plain English This study looked at how microplastics, tiny pieces of plastic, are distributed in the sand of five different beaches. The researchers found more microplastics closer to the surface, with an average of about 16.6 microplastics per 25 grams of sand at the deepest site compared to lower amounts at the other beaches, which had averages between 6.7 and 11.1. This rise in microplastics at the deeper levels shows that beach sediment has been collecting plastic for about 70 years, highlighting the ongoing impact of human activities on coastal environments.
Who this helps: This research benefits environmental scientists and beach conservationists who aim to understand and address pollution in marine settings.
Effects of Kinesio Taping Compared with Manipulation Therapy on Drooling and Speech Intelligibility in Children with Oral Dysphagia: A Pilot Study.
2022
Alternative therapies in health and medicine
Pervez R, Naz S, Babur N, Mumtaz N
Plain English This study looked at how two treatments, Kinesio Taping (KT) and Manipulation Therapy (MT), affect drooling and speech clarity in 20 children with oral dysphagia. After a month of treatment, both methods helped improve drooling and speech understanding; specifically, drooling and speech intelligibility improved significantly in both groups. However, there wasn’t enough difference between the two treatments to favor one over the other.
Who this helps: Patients with oral dysphagia and their families.
Spatio-temporal variations of litter on Qingdao tourist beaches in China.
2022
Environmental pollution (Barking, Essex : 1987)
Pervez R, Lai Z
Plain English This study looked at litter on ten popular tourist beaches in Qingdao, China, during summer and winter. Researchers found that there was more litter in the summer (0.13 items per meter) compared to winter (0.04 items per meter), with plastics making up about 24% of the total litter year-round. Most of the beaches were rated as "very clean" or "clean," but 85% had some hazardous trash, indicating a need for better management and awareness to protect these coastal environments.
Who this helps: This helps beachgoers and local wildlife by promoting cleaner, safer beaches.
Review: System transformation to enhance transitional age youth mental health - a scoping review.
2022
Child and adolescent mental health
Adu J, Oudshoorn A, Van Berkum A, Pervez R, Norman R +4 more
Plain English This study looked at how to improve mental health care for young people ages 15 to 25 in wealthy countries. Researchers reviewed 5,652 articles and found that, while there are some promising strategies, such as helping youth transition from pediatric to adult mental health services and focusing on community care, there are still gaps in how these systems work together. Improving these systems is crucial as young people face significant mental health challenges, and better support can lead to healthier futures for them.
Who this helps: This helps transitional age youth and mental health care providers.
Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
2022
The Journal of clinical investigation
Tsou PS, Lu C, Gurrea-Rubio M, Muraoka S, Campbell PL +26 more
Plain English Researchers discovered that a protein called CD13, which leaks into the bloodstream, causes inflammatory arthritis by activating a receptor called B1R found on joint cells. They confirmed this by showing that blocking B1R with drugs stopped the inflammation in multiple types of arthritis in mice and in human joint tissue samples.
This matters because B1R could be a new drug target to treat rheumatoid arthritis and other inflammatory diseases by preventing CD13 from triggering joint inflammation.
Infectivity of entomopathogenic nematodes against the legume pod-borer,Fabricius, infesting pigeon pea.
2021
Journal of helminthology
Pervez R, Rao U
Plain English This study focused on the effectiveness of specific types of microscopic worms, called entomopathogenic nematodes (EPNs), in controlling a major pest of pigeon pea, the legume pod-borer. The research found that two types of EPNs, Heterorhabditis sp. and Oscheius sp., could kill nearly all of the larvae (about 100% mortality) within 72 hours, making them highly effective. This is important because it offers a safer alternative to chemical pesticides, which can harm the environment.
Who this helps: This helps farmers and agricultural industries looking for eco-friendly pest control methods.
Using the WHO-AIMS to inform development of mental health systems: the case study of Makueni County, Kenya.
2020
BMC health services research
Mutiso VN, Musyimi CW, Gitonga I, Tele A, Pervez R +3 more
Plain English This study examined the state of mental health services in Makueni County, Kenya, using a tool called WHO-AIMS to assess what resources and practices are in place. Researchers found that there were no dedicated policies or governance specifically for mental health, despite officials recognizing its importance, and identified key issues like a lack of funding and trained professionals. Addressing these problems is crucial for building an effective mental health system in the area.
Who this helps: This study benefits patients in Makueni County who need better mental health services.
Validity of colour doppler sonography for evaluation of portal venous system in hepatocellular carcinoma.
2013
JPMA. The Journal of the Pakistan Medical Association
Alam S, Pervez R
Plain English This study looked at how well color Doppler ultrasound works to check for blood clots in the portal vein of patients with liver cancer. Out of 100 patients with liver cancer, 28 had blood clots in the portal vein. The ultrasound was found to be very accurate, correctly identifying 89.3% of cases of portal vein thrombosis compared to the more invasive CT scans. This finding is important because it shows that color Doppler ultrasound can be a useful, less invasive tool for doctors to evaluate patients with liver cancer and potentially improve their care.
Who this helps: This helps patients with liver cancer by providing a safer way to assess their conditions.
Paraganglioma of urinary bladder: an unusual presentation. pitfalls in diagnosis and treatment.
2012
JPMA. The Journal of the Pakistan Medical Association
Ghafoor AU, Yousaf I, Pervez R, Khan RU, Mir K
Plain English This study looked at a rare type of tumor called paraganglioma that can occur in the bladder. In the case reported, the symptoms were not typical, which caused doctors to misdiagnose the patient initially. Correct identification only happened after a detailed tissue examination, showing how important accurate diagnosis is for effective treatment.
Who this helps: This helps doctors in diagnosing rare bladder tumors correctly.
Asthma knowledge and approach among Pakistani family physicians and the impact of an educational programme.
2007
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Haque AS, Zubairi AB, Shiraz A, Zuberi F, Karim SI +2 more
Plain English This study looked at how much knowledge family doctors in Pakistan have about asthma and how an educational program could improve that knowledge. Before the program, only 57% of doctors had a good understanding of asthma, but after taking the course, this number rose to 78%. The findings are important because they show that ongoing education significantly boosts doctors' skills in managing asthma, which can lead to better care for patients.
Who this helps: This benefits patients with asthma by ensuring their doctors have up-to-date knowledge and skills for treatment.
Compliance with disposition to primary care physicians and psychiatrists in elderly homebound mentally ill patients.
1998
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Habib A, Sanchez M, Pervez R, Devanand DP
Plain English This study looked at elderly patients with mental health issues who are confined to their homes. Out of 65 patients, 36 were referred to primary care doctors, with 75% of them keeping their follow-up appointments, compared to only 41% of the 29 patients who were referred to psychiatrists. This matters because those who followed up with their doctors showed better improvement in their health, highlighting the need for primary care physicians to be better equipped to handle mental health in elderly patients.
Who this helps: This helps elderly patients with mental health issues.