Sottini studies the process of transvenous lead extraction (TLE), which is a way to remove heart devices from patients. His research particularly targets elderly patients, specifically those aged 80 and older, who may need such procedures due to complications from their heart devices. He uses advanced techniques like bidirectional rotational mechanical sheaths to enhance the safety and success rates of these procedures, providing valuable insights for healthcare providers who care for older adults with cardiac devices.
Key findings
The success rate of transvenous lead extraction in octogenarians was 93.9%.
Among 83 patients studied, the 30-day mortality rate was 6%.
The study indicates that specialized techniques can safely manage higher complication risks in older patients.
Frequently asked questions
Does Dr. Sottini study heart device removals?
Yes, Dr. Sottini specifically studies transvenous lead extraction for removing heart devices.
What age group does Dr. Sottini focus on?
He focuses on patients who are 80 years old and older.
How successful is the lead extraction procedure Dr. Sottini studies?
The procedure has a success rate of 93.9% in elderly patients according to his research.
What is the mortality rate after the procedure?
The 30-day mortality rate after the procedure in his study was 6%.
Are there specific techniques Dr. Sottini uses?
Yes, he employs advanced tools like bidirectional rotational mechanical sheaths to improve outcomes.
Publications in plain English
Magnetic anisotropy and structural flexibility in the field-induced single ion magnets [Co{(OPPh)(EPPh)N}], E = S, Se, explored by experimental and computational methods.
2023
Dalton transactions (Cambridge, England : 2003)
Ferentinos E, Tzeli D, Sottini S, Groenen EJJ, Ozerov M +4 more
Plain English Researchers studied a group of cobalt complexes to see how their structure affects their ability to act as magnets at the atomic level. They found that the specific atoms used in the complexes didn’t significantly change their magnetic properties, and they observed that these complexes behave like magnets when exposed to an external magnetic field, with slow magnetization relaxation. This matters because understanding these materials can help in developing better magnetic storage devices or quantum computing technologies.
Who this helps: This helps scientists and engineers working on advanced materials and technology applications.
Outcomes of transvenous lead extraction in octogenarians using bidirectional rotational mechanical sheaths.
2023
Pacing and clinical electrophysiology : PACE
Migliore F, Pittorru R, Dall'Aglio PB, De Lazzari M, Falzone PV +9 more
Plain English This study looked at the outcomes of a procedure called transvenous lead extraction (TLE) in patients aged 80 and older, specifically using advanced tools to help with the process. Out of 83 patients, the procedure was successful in 93.9% of cases, with a 30-day mortality rate of 6%. The findings show that, although older patients have higher risks of complications, the extraction can be done safely and effectively using specialized methods, helping doctors make better decisions about heart device removals for this age group.
Who this helps: This research benefits elderly patients with heart devices, as well as their healthcare providers.
Study of manganese binding to the ferroxidase centre of human H-type ferritin.
2018
Journal of inorganic biochemistry
Ardini M, Howes BD, Fiorillo A, Falvo E, Sottini S +8 more
Plain English This study looked at how manganese and iron bind to a specific site in human ferritin, a protein that helps regulate iron in the body. The researchers found that both minerals can attach to ferritin, forming a cofactor that enhances the protein's ability to oxidize iron; specifically, manganese increases this activity. This is important because it suggests that manganese might play a significant role in how cells, especially glial cells, use iron.
Who this helps: Patients with conditions related to iron metabolism or manganese imbalance.
Sensing the quantum behaviour of magnetic nanoparticles by electron magnetic resonance.
2016
Physical chemistry chemical physics : PCCP
Fittipaldi M, Mercatelli R, Sottini S, Ceci P, Falvo E +1 more
Plain English Researchers studied tiny magnetic particles made of iron oxide, around 8 nanometers in size, which were encapsulated in a protein structure called ferritin. They used a technique called Electron Magnetic Resonance (EMR) to measure how these particles behave under different conditions, finding that temperature significantly affects their magnetic properties. This research matters because understanding these quantum behaviors can help in developing new medical technologies or treatments.
Who this helps: This helps researchers and developers working on advanced medical treatments and technologies.
Magnetic Anisotropy of Tetrahedral CoSingle-Ion Magnets: Solid-State Effects.
2016
Inorganic chemistry
Sottini S, Poneti G, Ciattini S, Levesanos N, Ferentinos E +3 more
Plain English This study looked at two cobalt complexes that act like tiny magnets and analyzed their properties at very low temperatures. Researchers found that despite both having similar structures, one complex (CoS) showed more disorder and larger magnetic differences than the other (CoSe), with both having similar magnetic characteristics. Understanding how these materials behave is important for developing better magnetic technologies.
Who this helps: This helps scientists and engineers working on advanced magnetic materials for various applications.
The β-subunit of cholera toxin has a high affinity for ganglioside GM1 embedded into solid supported lipid membranes with a lipid raft-like composition.
2014
Lipids
Margheri G, D'Agostino R, Trigari S, Sottini S, Del Rosso M
Plain English This study examined how well a specific part of the cholera toxin (the β-subunit) binds to a molecule called GM1, which is found in cell membranes. The researchers created membranes that mimic the natural environment of GM1 and found that the binding strength was very close to what occurs in living cells, with a dissociation constant (K(D)) that is only slightly different. This is important because it shows that these lab-made membranes can be useful for studying how cholera toxin interacts with cells, which can help develop better treatments or vaccines for cholera.
Who this helps: This benefits researchers and medical professionals working on cholera prevention and treatment.
The type 1 copper site of pseudoazurin: axial and rhombic.
2014
Journal of inorganic biochemistry
Gast P, Broeren FG, Sottini S, Aoki R, Takashina A +3 more
Plain English This study looked at a specific copper site in a protein called pseudoazurin, identifying two different shapes it can take. Researchers found that in various types of pseudoazurin, the shapes occur in different proportions, with some having as much as 91% of one shape and only 9% of the other. This finding is important because it suggests that having different shapes may be a common feature in similar proteins, which could influence how they function in biological processes.
Who this helps: This helps researchers studying protein functions and potentially improves our understanding of related diseases.
Copper sulfide nanocrystals with tunable composition by reduction of covellite nanocrystals with Cu+ ions.
2013
Journal of the American Chemical Society
Xie Y, Riedinger A, Prato M, Casu A, Genovese A +7 more
Plain English This study focused on creating copper sulfide nanocrystals with adjustable compositions from a starting material called covellite. The researchers found that they could change the properties of these nanocrystals by varying the amount of copper, leading to different optical responses; for instance, starting with covellite at Cu1.1S resulted in other forms up to Cu2S. This work is important because it helps develop materials with tailored properties for applications in electronics and photonics.
Who this helps: This helps scientists and engineers working on advanced materials.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Sottini S, Groenen EJ
Plain English This study looked at how to better describe certain magnetic properties of materials, particularly high-spin systems that have specific arrangements of electron states. The researchers found a more accurate way to analyze the electron-nuclear interactions by using a new method based on first-order perturbation theory, leading to clearer results in their experiments with a cobalt complex. This is important because it improves our understanding of how these materials behave, which can impact various applications in technology and medicine.
Who this helps: This benefits researchers and scientists working with magnetic materials and their applications.
High-frequency EPR study of the high-spin FeII complex Fe[(SPPh2)2N]2.
2012
Journal of magnetic resonance (San Diego, Calif. : 1997)
Mathies G, Chatziefthimiou SD, Maganas D, Sanakis Y, Sottini S +2 more
Plain English This study looked at a specific iron complex called Fe[(SPPh2)2N]2 using a technique called electron paramagnetic resonance (EPR). Researchers found that this complex can exist in different shapes, with two key shapes having specific measurements: one with a value of D=9.17 cm-1 and another with D=8.87 cm-1. Understanding these shapes and their properties is important because it helps scientists learn more about how such complexes behave, which could be useful in areas like materials science or medicine.
Who this helps: This helps researchers and scientists working with metal complexes in various fields.
Involvement of Tyr108 in the enzyme mechanism of the small laccase from Streptomyces coelicolor.
2012
Journal of the American Chemical Society
Gupta A, Nederlof I, Sottini S, Tepper AW, Groenen EJ +2 more
Plain English This study explored how a specific enzyme (small laccase) from the bacteria Streptomyces coelicolor works and examined a key part called Tyr108. Researchers discovered that Tyr108 is crucial for the enzyme's action, helping it process oxygen, which is important for its efficiency. The findings highlight that this enzyme operates differently from similar ones, showing a lower activity level, which may relate to its environment.
Who this helps: This benefits researchers studying enzymes and their potential applications in biotechnology and medicine.
Theoretical analysis of the spin Hamiltonian parameters in Co(II)S4 complexes, using density functional theory and correlated ab initio methods.
2011
Inorganic chemistry
Maganas D, Sottini S, Kyritsis P, Groenen EJ, Neese F
Plain English This study looked at certain cobalt (Co) compounds to understand their magnetic properties better. Researchers used advanced computer simulations to calculate key parameters, like the "zero-field splitting" (D), which was found to be within about 10% of experimental values when complex computational methods were used. This is important because it helps clarify the electronic structure of these complexes and can improve our understanding of their behavior in magnetic fields, which is useful in fields like materials science.
Who this helps: This helps researchers and scientists working with magnetic materials and coordination chemistry.
Sottini S, Gast P, Blok A, Canters GW, Cavazzini D +2 more
Plain English This study focused on the protein azurin, specifically looking at how protons interact with a particular part of its structure, which contains copper. Researchers used advanced technology to measure the interactions and found detailed information on these interactions, which helps to better understand the protein's properties. This research matters because it lays the groundwork for further studies that could improve our knowledge of proteins that play important roles in biological processes.
Who this helps: This helps researchers studying proteins and their functions in health and disease.
A multifrequency high-field electron paramagnetic resonance study of Co(II)S(4) coordination.
2010
Inorganic chemistry
Maganas D, Milikisyants S, Rijnbeek JM, Sottini S, Levesanos N +2 more
Plain English This research focused on studying two cobalt(II) complexes, which are chemical structures containing cobalt, using advanced techniques to better understand their properties. The researchers found that the two complexes had slightly different structures due to variations in their surrounding chemical groups, leading to specific energy differences of 24 cm-1 and 30 cm-1 for each complex. Understanding these properties is important because it can help in the development of materials and technologies that rely on cobalt compounds.
Who this helps: This research benefits chemists and materials scientists working on new technologies and materials.
A W-band pulsed EPR/ENDOR study of Co(II)S(4) coordination in the Co[(SPPh(2))(SP(i)Pr(2))N](2) complex.
2009
Physical chemistry chemical physics : PCCP
Sottini S, Mathies G, Gast P, Maganas D, Kyritsis P +1 more
Plain English This study looked at a cobalt compound that is organized around four sulfur atoms to understand how it works at a molecular level. The researchers used advanced techniques to analyze how the cobalt interacts with its surroundings, revealing important details about the structure and behavior of the compound. These findings can help in developing new materials and therapies that mimic natural processes.
Who this helps: This helps researchers developing new treatments and materials in medicine and chemistry.
Identification of a radical intermediate in the enzymatic reduction of oxygen by a small laccase.
2009
Journal of the American Chemical Society
Tepper AW, Milikisyants S, Sottini S, Vijgenboom E, Groenen EJ +1 more
Plain English Researchers studied a specific enzyme called small laccase (SLAC) from bacteria to understand how it interacts with oxygen. They discovered a new intermediate form of the enzyme that has two unpaired electrons, indicating a complex interaction involving copper and a special protein radical. This finding is important because it could provide insights into how enzymes work, which may help in developing new treatments or improving existing ones.
Who this helps: This benefits researchers and developers in the fields of biochemistry and drug development.
Förster resonance energy transfer (FRET) with a donor-acceptor system adsorbed on silver or gold nanoisland films.
2009
Physical chemistry chemical physics : PCCP
Giorgetti E, Cicchi S, Muniz-Miranda M, Margheri G, Del Rosso T +6 more
Plain English This study looked at how a special light transfer process, called Förster resonance energy transfer (FRET), works when two different types of molecules are attached to tiny metal films made of silver or gold. Researchers found that the tiny metal films significantly boosted the signal strength of the light emitted, helping them understand how these molecules attach to the metal surfaces. This finding is important because it can lead to better light-based technology applications in medicine and materials science.
Who this helps: This helps researchers and developers working on advanced medical imaging and diagnostic tools.
A modification of the commercial ESR900 cryostat to enable three-dimensional electron-paramagnetic-resonance studies of crystals.
2008
The Review of scientific instruments
Milikisyants S, Sottini S, Disselhorst JA, van der Meer H, Groenen EJ
Plain English This study focuses on improving a commercial device called a cryostat, which helps scientists study the magnetic properties of crystals at very low temperatures. The researchers modified the cryostat so it can measure the magnetic spectrum of crystals in any direction without having to take them out and reposition them, making the process easier and more efficient. This advancement allows for more accurate and detailed studies, which is important for understanding materials better.
Who this helps: This benefits researchers and scientists working with magnetic materials and crystals.
All optical switches based on the coupling of surface plasmon polaritons.
2008
Optics express
Margheri G, Del Rosso T, Sottini S, Trigari S, Giorgetti E
Plain English Researchers explored a new type of technology called All Optical Switches (AOS) that can efficiently control light using a thin metal film. They found that these switches can operate with minimal loss (only 1.5 dB) and can differentiate signals very well, achieving a 20 dB extinction ratio—meaning they can clearly turn on and off light signals. This is significant because it could lead to faster and more efficient data transmission in optical communication systems.
Who this helps: This helps industries involved in telecommunications and data centers.
UV polymerization of self-assembled monolayers of a novel diacetylene on silver: a spectroscopic analysis by surface plasmon resonance and surface enhanced Raman scattering.
2006
Langmuir : the ACS journal of surfaces and colloids
Giorgetti E, Muniz-Miranda M, Margheri G, Giusti A, Sottini S +3 more
Plain English This study looked at a new compound called carbazolyl-diacetylene (CDS9) that forms a thin layer on silver surfaces and how it changes when exposed to UV light. The researchers found that this exposure enhances the properties of the material, with specific changes observable in its structure, including an increase in certain chemical bonds. These findings are important because they can lead to better materials for sensors or electronic devices that rely on light interaction.
Who this helps: Patients and doctors involved in improving diagnostic tools and treatments that utilize advanced materials.
Acid-induced unfolding of myoglobin triggered by a laser pH jump method.
2006
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Abbruzzetti S, Sottini S, Viappiani C, Corrie JE
Plain English This study examined how a special method using lasers can quickly cause myoglobin, a protein important for oxygen transport in muscles, to unfold due to acid exposure. Researchers found that releasing a high concentration of protons in just one nanosecond led to complete unfolding of myoglobin, and they could track this unfolding process over time using specific light measurements. This method is significant because it allows scientists to study protein behavior under acidic conditions very quickly, which can improve our understanding of various biological processes and diseases.
Who this helps: This benefits researchers studying muscle function and diseases related to protein folding.
Kinetics of proton release after flash photolysis of 1-(2-nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solution.
2005
Journal of the American Chemical Society
Abbruzzetti S, Sottini S, Viappiani C, Corrie JE
Plain English The study examined how quickly protons (which are positively charged particles) are released after using a laser on a special compound called caged sulfate in water. Researchers found that protons are released very rapidly at a rate of about 15.8 million protons per second when the solution is at neutral pH, and they identified that the compound acts more strongly acidic at lower pH levels. Understanding these kinetics is important because it provides insights into how certain chemical reactions can occur quickly in biological systems.
Who this helps: This research benefits scientists studying chemical reactions in biological environments.
Light-induced protein-matrix uncoupling and protein relaxation in dry samples of trehalose-coated MbCO at room temperature.
2005
Cell biochemistry and biophysics
Abbruzzetti S, Giuffrida S, Sottini S, Viappiani C, Cordone L
Plain English This research looked at how light affects a specific protein (carboxy-myoglobin) when coated with trehalose in dry and humid conditions. The study found that in dry samples, shining light beforehand allowed carbon monoxide molecules released from the protein to move more freely, which resulted in a more disorganized structure. This is important because it helps us understand how proteins behave under different conditions, which could have implications for biological processes in cells.
Who this helps: This benefits researchers studying protein behavior and potential applications in medical treatments.
Geminate rebinding in R-state hemoglobin: kinetic and computational evidence for multiple hydrophobic pockets.
2005
Journal of the American Chemical Society
Sottini S, Abbruzzetti S, Spyrakis F, Bettati S, Ronda L +2 more
Plain English This study explored how carbon monoxide (CO) binds to human hemoglobin within a special gel, finding that it binds in two distinct phases, similar to myoglobin. Researchers identified specific hydrophobic pockets in the hemoglobin structure that facilitate this process and discovered that the binding characteristics change slightly when glycerol is added, suggesting that these pockets play a crucial role in how hemoglobin interacts with gases. Understanding these binding processes is important because they can affect how effectively hemoglobin transports oxygen and carbon dioxide in the body.
Who this helps: This benefits patients with respiratory issues and doctors treating them.
Evidence for two geminate rebinding states following laser photolysis of R state hemoglobin encapsulated in wet silica gels.
2005
The journal of physical chemistry. B
Sottini S, Abbruzzetti S, Viappiani C, Bettati S, Ronda L +1 more
Plain English This study examined how carbon monoxide (CO) attaches again to hemoglobin, the protein in red blood cells, after being exposed to light. Researchers found that in a thick gel made of silica and glycerol, CO rebounded to hemoglobin from two different sites. They identified the speeds at which this rebinding occurs and measured the energy needed for these processes.
Who this helps: This research benefits medical professionals studying blood gas transport and therapies involving hemoglobin.
Determination of microscopic rate constants for CO binding and migration in myoglobin encapsulated in silica gels.
2005
The journal of physical chemistry. B
Sottini S, Abbruzzetti S, Viappiani C, Ronda L, Mozzarelli A
Plain English This study looked at how carbon monoxide (CO) binds and moves in a protein called myoglobin, which was placed inside silica gel. The researchers found that after exposing it to light, the CO took two different paths to reattach to the myoglobin, allowing them to measure specific rates of binding and the energy needed for each path. This is important because understanding how CO interacts with myoglobin can help improve our knowledge about how oxygen and similar gases behave in biological systems.
Who this helps: This helps researchers studying respiratory proteins and their functions.
Photobleaching of polydiacetylene waveguides: a characterization of the process and patterning of optical elements.
1997
Applied optics
Palchetti L, Li Q, Giorgetti E, Grando D, Sottini S
Plain English This study examined how a certain type of waveguide material (poly-3BCMU) changes when exposed to ultraviolet light and a specific laser, focusing on how oxygen affects this change. The researchers found that the rate at which oxygen moves plays a key role in the process. They successfully used this method to create patterns for optical devices and holograms on the material, which is important for improving the functionality of optical elements.
Who this helps: This benefits researchers and engineers working on advanced optical devices and technology.
Optical fiber monitored by a directional coupler for delivering laser radiation in medical treatments.
1995
Applied optics
Sottini S, Lombardo S, Russo V
Plain English This study looked at how to improve the safety of laser treatments by monitoring the fiber used to deliver the laser in real time. Researchers found that using special tools called directional couplers allowed them to detect changes in the laser delivery system due to fiber damage, which could happen during treatments. For example, they found that monitoring can be effective even when the fiber tip is in direct contact with tissue, as long as it is properly pushed against the target.
Who this helps: This benefits patients undergoing laser treatments by potentially making the procedures safer.
Thermal annealing of K(+)-Na(+) ion-exchanged waveguides.
1995
Optics letters
Giorgetti E, Grando D, Palchetti L, Sottini S
Plain English This study looked at a process called thermal annealing, which changes how certain types of glass waveguides handle light. Researchers found that when they used a specific kind of glass, the loss of light was very low, measuring just 0.4 decibels when connected to standard fibers. This is important because it means that the waveguides can be made more effective for various applications, including communication technology.
Who this helps: This benefits engineers and companies working on advanced communication technologies.
Probe for laser angioplasty radiating a corolla shaped beam.
1989
Applied optics
Sottini S, Russo V, Marghe G, Crea F
Plain English This study looked at a new type of laser probe designed for a procedure called laser angioplasty, which helps open blocked blood vessels. The probe has a unique shape that spreads the laser light in a way that reduces the chances of damaging the blood vessels. Early tests on cadaver aorta showed that this new probe lowers the risk of serious complications, making it safer for use in areas like the coronary arteries.
Who this helps: This study benefits patients needing heart procedures.
Reflection holographic filters for compacting optical processors.
1974
Applied optics
Righini GC, Russo V, Sottini S
Plain English This study focused on improving how optical processors recognize characters by using reflection holographic filters, which are created from special photographic materials. Researchers found that these filters are very effective at distinguishing between similar characters and can be used in smaller, cheaper processors—cutting both size and cost in half compared to older methods. This is important because it makes character recognition technology more accessible and efficient, which can enhance various optical devices.
Who this helps: This benefits manufacturers of optical devices and their users.
Plain English Researchers studied a new type of lens designed for use in optical systems, which could make them easier to integrate into existing technologies. They created and tested two optical lenses that have flat input and output surfaces, which can be added to thin film circuits without complicating the manufacturing process. This advancement is significant because it allows for precise lens production similar to glass optics, potentially improving the performance of various optical devices.
Who this helps: This benefits engineers and manufacturers working on advanced optical technologies.