Sait Terzi

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This research focused on creating a new tool to assess the importance of critical raw materials (CRMs) for car electronics. The tool was developed by gathering input from seven automotive companies in Europe and has been validated using nine different raw materials. It helps companies understand their supply chains better and meet new European regulations on raw materials, ensuring a more reliable supply for the automotive industry. Who this helps: This helps automotive manufacturers and suppliers.

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This study looked at two types of surgery for a rare tumor in the spine called chordoma: one that removes the tumor completely (en bloc resection) and one that removes the tumor partly followed by a type of radiation therapy (intralesional resection with charged-particle therapy). Researchers found no significant difference in the chance of the tumor returning between the two methods, as both had a local control rate of around 76%, and about 24% of patients experienced complications after surgery. The findings highlight that while the complete removal of the tumor is preferred, the newer radiation therapy can still effectively help control the disease after less extensive surgery. Who this helps: This benefits patients with mobile spine chordomas and their doctors making treatment decisions.

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This research paper explores how the textile industry, which consumes a lot of resources and contributes significantly to pollution, can adopt more sustainable practices. It reviewed 82 studies and found that cotton and polyester are the most frequently studied materials for recycling and waste management, while other materials like wool and silk have not been explored enough. This is important because improving sustainability in more textile materials can reduce environmental harm and promote better practices in the industry. Who this helps: This benefits manufacturers, environmental advocates, and consumers seeking eco-friendly clothing options.

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This study examined the education and training needed for workers in the manufacturing sector to support a circular economy, which aims to reduce waste and promote recycling. Researchers found that many existing courses mainly teach technical skills like circular product design, but neglect important soft skills and digital skills. By developing a new skills framework, this research helps guide educational programs to provide a more balanced skill set, ensuring workers are well-prepared for future demands. Who this helps: This benefits students and workers entering the manufacturing field, as well as educators and employers looking to close the skills gap.

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This study looked at the results of surgery for rare bone tumors located in the sacrum (the lower part of the spine) in 19 patients, mostly middle-aged, over time. It found that 65% of the surgeries successfully removed all the tumor tissue, but 25% of patients had their cancer come back locally and 20% developed distant metastases. The research highlights that while surgery can be effective, it also carries a significant risk of complications, affecting 60% of patients, with issues like slow healing and bowel problems being the most common. Who this helps: This information benefits surgeons and medical teams involved in treating patients with sacral bone tumors.

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This study looked at how surgery affects the quality of life for people with cancer that has spread to the spine. It included 169 patients and found that, on average, they lived about 22 months after surgery, with 61% surviving for at least a year. After surgery, patients showed significant improvements in walking, overall health, and pain levels, and these benefits lasted over time, highlighting the importance of surgical treatment in enhancing life quality for these patients. Who this helps: This helps patients with spinal metastases.

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This study looked at a specific enzyme called Paraoxonase 1 (PON1) in patients with a heart condition known as isolated coronary artery ectasia (CAE). Researchers found that patients with CAE had significantly lower levels of PON1 activity (127.5 U/L) compared to healthy individuals (177.0 U/L), indicating a possible link between low PON1 levels and the development of CAE. This is important because understanding the role of PON1 could help in early diagnosis and management of patients with this heart condition. Who this helps: Patients with coronary artery issues and their healthcare providers.

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This study looked at whether it is necessary to use a drain after a specific surgery called urethroplasty, instead using a pressure dressing to prevent complications. Researchers followed 152 patients who had the surgery without a drain, and found that not a single patient suffered from fluid collection or wound issues, even with 42% having risk factors like a history of smoking. This matters because it shows that using a pressure dressing can effectively eliminate the need for a drain, which can simplify post-operative care and reduce patient discomfort. Who this helps: This benefits patients undergoing urethroplasty, as well as their doctors.

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This study looked at how high levels of lactate in the blood after a heart valve replacement procedure (called TAVI) affect patient survival in the hospital. Among 284 patients, 19 (or 6.6%) died within 30 days of the procedure. Those who died were older and had significantly higher lactate levels after the procedure (5.4 mmol/L compared to 1.3 mmol/L for survivors), indicating that high lactate is a strong sign of increased risk of death. Who this helps: This research benefits doctors and healthcare teams managing patients undergoing heart valve procedures.

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This study looked at "tumor budding," which are small groups of cancer cells at the edge of tumors, in patients with head and neck cancers. Researchers found that patients with more than 4 tumor buds had a much lower chance of surviving five years after diagnosis (26.4%) compared to those with 4 or fewer buds (85.3%). This matters because identifying high tumor budding can help doctors decide on treatment strategies, like whether to remove neck lymph nodes, improving patient care. Who this helps: This helps patients with head and neck cancers and their doctors.

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This study looked at how well certain blood tests and MRI scans can help tell if a tumor in the salivary gland is cancerous or not. Researchers analyzed data from 138 patients and found that a combination of systemic inflammation markers and age were good at predicting if a tumor was malignant, reaching an accuracy rate of about 84%. These findings are important because they provide a non-invasive way to help doctors better diagnose the nature of parotid tumors before surgery. Who this helps: This helps patients with parotid tumors and their doctors by improving diagnosis decisions.

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This study looked at how changes in climate and land use affect water, energy, and food systems in the Adige River Basin in Northern Italy. Researchers found that, by 2050, the natural benefits provided by the environment could decline, especially in areas with highly intensified agriculture. To improve the situation, they recommend strategies like reducing chemical fertilizers, promoting reforestation, and maintaining healthy water flows. Who this helps: These findings can benefit policymakers and environmental managers focused on sustainable resource management.

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This study examined a new silver-coated titanium alloy device used in spinal surgery to reduce the risk of post-surgery infections. Researchers followed 34 patients who had experienced infections after surgery and found that only 4 of them (11.8%) developed infections again after using the new device, which means the method successfully controlled infections 88.2% of the time. These results are encouraging, as they indicate that this new approach could significantly lower the chances of reinfections, which is important for improving patient outcomes. Who this helps: This benefits patients undergoing spinal surgery.

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This study looked at factors that increase the length of hospital stays and the risk of complications in 336 patients who had spine surgery. Researchers found that using a specific system called SAVES V2 helped identify more adverse events (210) compared to traditional methods (97), which highlights the benefits of better tracking. Specifically, both cancer and non-cancer patients had longer hospital stays when complications occurred, with non-cancer patients experiencing significantly higher lengths of stay when complications were present. Who this helps: This benefits patients undergoing spine surgery by improving monitoring and care.

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This study looked at whether measuring carbon dioxide (CO2) levels in chest drainage can help doctors tell the difference between real and false air leaks after minimally invasive lung surgery. It involved 104 patients, and they found that those with actual air leaks had a significantly higher CO2 level in their pleural space (24 mmHg) compared to those without leaks. This method could help improve patient care by offering a quicker and more accurate way to diagnose air leaks, which can complicate recovery. Who this helps: This benefits patients recovering from lung surgery and their doctors.

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This study looked at factors that may cause kidney problems in patients who had a minimally invasive heart procedure called transcatheter aortic valve implantation (TAVI). Researchers found that about 42% of patients experienced acute kidney injury (AKI) after the procedure, with older patients, women, and those with high blood pressure being more affected. Understanding these risks helps doctors better identify which patients might face complications, ultimately improving their care. Who this helps: Patients undergoing TAVI and their doctors.

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This study examined the relationship between how long spinal surgery takes and the chance of complications occurring afterward. Out of 336 patients, 105 had complications related to their surgery, which breaks down to 38% of cancer patients and 28% of patients with degenerative issues. The research found that longer surgery times significantly increased the risk of both immediate and delayed complications, which means surgeons should aim to reduce operation times for better patient safety without sacrificing quality. Who this helps: This information is beneficial for patients undergoing spinal surgery and their doctors.

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This study looked at how patients feel about their health and quality of life after undergoing a specific type of surgery called en bloc resection for spinal tumors. Out of 70 patients who had the surgery, 38 were included in the analysis. The results showed that while there was a small improvement in health-related quality of life scores after surgery, there were no major changes, except that patients reported less pain two years later, and those over 50 or with complications experienced more difficulties. This matters because it helps understand the benefits and challenges of this intensive surgical procedure for treating spinal tumors. Who this helps: Patients with spinal tumors and their doctors.

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This study looked at three specific proteins (periostin, fibronectin, and tenascin-C) in nasal growths called sinonasal lesions, which include conditions like nasal polyps and inverted papillomas. Researchers analyzed tissue samples from 70 patients and found that nasal polyps had much higher levels of periostin in the surrounding tissue (stroma) and fibronectin overall compared to other types of lesions. This matters because these proteins might help doctors better diagnose these conditions and could also lead to new treatment options in the future. Who this helps: Patients with sinonasal lesions and their doctors.

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This study evaluated how well a computer model, known as COSMO-RS, predicts certain chemical properties related to the acidity and solubility of various compounds. The researchers found that their predictions for solubility (logD) were the most accurate in a competitive challenge, with a small error margin of 1.36 log units, and their pKa predictions ranked second with an error of 3.44 log units, improving to 1.42 log units when accounting for specific chemical behaviors. This accuracy in predicting chemical properties is important because it can aid in drug development by better understanding how substances behave in biological systems. Who this helps: This benefits researchers and pharmaceutical companies working on new medications.

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This study looked at 56 patients with lung cancer that had spread to the spine, treated with surgery between 2009 and 2019. It found that the average survival after surgery was 8.1 months, with more than a third of patients living for over a year. The surgery improved patients' quality of life by reducing pain and helping them regain independence, regardless of their overall illness outlook. Who this helps: This benefits patients with lung cancer that has spread to the spine.

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This study looked at the emotional strain, called moral distress, experienced by nurses working in pediatric emergency departments. Researchers found that these nurses had an average score of 58.96 on the moral distress scale, indicating moderate levels of distress. Factors like job satisfaction and the type of emergency services impacted their distress levels, with 93.7% of the nurses having received training on the topic. Who this helps: This helps pediatric nurses by highlighting the challenges they face so that hospitals can provide better support and working conditions.

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This study examined a new type of spinal instrument made from a material called Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) to treat patients with degenerative diseases of the lumbar spine. Out of 28 patients studied, 89% showed strong evidence of spinal fusion after 12 months, and they reported significant improvements in pain and overall health. This matters because it indicates that CFR-PEEK might be a better option than traditional titanium implants, offering patients enhanced recovery without complications. Who this helps: Patients with degenerative spine diseases.

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This study looked at how long-term exposure to a new type of Doppler ultrasound affected the hearing parts of developing rat fetuses. The researchers found that while the ultrasound didn't harm the cochlear tissue (the part that helps with hearing), there was a noticeable decrease in cochlear activity at certain high frequencies, especially between 2 kHz and 32 kHz. This is important because it suggests that while the ultrasound might not cause immediate damage, it could impact hearing development. Who this helps: This information helps doctors and researchers working with prenatal patients and developing ultrasound technologies.

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This study looked at a surgical technique called endoscopic butterfly inlay myringoplasty, specifically for patients who needed a second surgery after problems with their initial cartilage tympanoplasty. Out of 17 patients treated, all had their grafts successfully placed, resulting in a 100% success rate, and their hearing remained stable after the procedure. This is important because it shows that this approach is safe and effective for fixing ear issues, giving hope to patients who have previously had unsuccessful surgeries. Who this helps: This helps patients who need revision ear surgeries.

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This study looked at how well sublingual sufentanil, a pain relief option that is placed under the tongue, works for managing pain after lung surgery compared to traditional intravenous pain relief. Out of 80 patients, those using the sublingual method experienced less pain and required fewer additional medications in the first 24 hours, with 40% needing extra meds compared to 70% in the intravenous group. This finding is important because it shows that sublingual sufentanil can offer effective pain management without the invasiveness of needles. Who this helps: This helps patients recovering from major lung surgery.

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Researchers studied patients with narrow airways (bronchial stenoses) after lung transplants, which can lead to serious health problems. Out of 497 lung transplant patients, 35 (7%) developed these complications, and while most were treated successfully with less invasive methods, six patients needed more complex surgeries, such as bronchoplasty. Of those, two are still alive and breathing well a year later, while four passed away after several years from unrelated causes, highlighting that, although challenging, surgical options can effectively resolve airway blockages. Who this helps: This information benefits lung transplant patients who may face complications with their airways.

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This study looked at the outcomes of two types of lung surgery for patients with non-small-cell lung cancer: thoracoscopic segmentectomy (a smaller surgery) and lobectomy (removal of a larger lung section). They analyzed data from over 7,400 patients and found that both surgeries had similar risks for major complications and death within 30 days after surgery. However, lobectomy involved taking out more lymph nodes, which can be important for cancer staging, but both surgeries were found to be safe options for patients. Who this helps: This benefits patients with non-small-cell lung cancer and their doctors by providing information on safe surgical options.

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This study looked at how well bone marrow concentrated (BMC) injections worked for treating aneurysmal bone cysts (ABCs) in the spine. Fourteen patients, who were mostly teenagers, received BMC injections, and researchers found that the hardness of the cysts significantly increased from an average score of 43.5 to 161.7 over 37 months, which correlated with improved health outcomes. This finding is important because it suggests that BMC injections can be an effective alternative for treating spinal ABCs when other treatments are not suitable. Who this helps: This helps patients with spinal aneurysmal bone cysts.

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This study tested how well two substances, dexmedetomidine and amifostine, protect salivary glands from damage caused by radiation used in cancer treatment. The researchers found that rats treated with dexmedetomidine had less cell damage and better antioxidant levels after radiation exposure compared to those who only received radiation; specifically, malondialdehyde levels decreased and glutathione levels increased. This is important because it suggests that dexmedetomidine could help reduce harmful side effects in patients undergoing radiotherapy. Who this helps: Patients receiving radiation therapy for cancer.

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This study focused on creating and improving an extract of enzymes from a specific mutant using a method called Solid State Fermentation with wheat bran. The researchers successfully concentrated these enzymes, achieving high activity levels for key enzymes like protease (98.68%) and carboxymethylcellulase (98.93%). Understanding how to optimize conditions for these enzymes is important because it could lead to more efficient industrial processes in areas like biofuel production and food processing. Who this helps: This helps industries that rely on enzyme applications, such as biofuels and food manufacturing.

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This study looked at the ratio of monocytes to high-density lipoprotein (MHR) in patients with a serious condition called Stanford type-A aortic dissection who were admitted to the hospital. Researchers found that the patients who died during their hospital stay had a higher MHR (0.0285) than those who survived (0.0210), suggesting that MHR can help predict the risk of death in these patients. This finding is important because MHR is a simple and low-cost measure that doctors can use to identify patients who may be at greater risk during their hospital treatment. Who this helps: This helps doctors in making better assessments of patient risk for those with aortic dissection.

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This study focused on an 81-year-old man who developed a heart defect, called a ventricular septal defect, after receiving a new aortic valve. He initially showed no symptoms but returned to the hospital three weeks later with heart failure symptoms, and tests revealed an 8 mm defect in his heart. The doctors successfully closed this defect with a special device, and one year later, he had no symptoms. Who this helps: This helps elderly patients with heart valve replacement.

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This study looked at 98 patients with a condition called coronary slow-flow phenomenon, which affects blood flow to the heart. Researchers found that patients with a higher measure called the mean corrected TIMI frame count—specifically those over 36.68—experienced significantly more chest pain and serious heart problems during an average follow-up of nearly four years. This means that tracking this measure can help identify which patients are at greater risk for serious cardiovascular issues. Who this helps: Patients with coronary slow-flow phenomenon and their doctors.

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This study looked at how reliable and effective a voice analysis program is in distinguishing between people with voice disorders and those with normal voices. Out of 105 participants, the program showed good reliability for measuring factors like jitter and shimmer in normal voices and moderate reliability for those with voice disorders. These findings are important because they indicate that while the program can help assess voice quality, it should be used alongside other methods for the best results. Who this helps: This helps doctors and speech therapists working with patients who have voice disorders.

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This study looked at how muscle loss, known as sarcopenia, affects patients undergoing surgery for malignant pleural mesothelioma (MPM). Researchers found that two-thirds of patients had sarcopenia before surgery, and those with it were more likely to face complications and had a lower survival rate after three years (34.9% survival for those with sarcopenia compared to 57.6% for those without). Understanding sarcopenia helps doctors make better decisions about who should undergo surgery for this serious condition. Who this helps: This benefits patients with MPM and their doctors by improving surgery selection.

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This study focused on how certain medications used for treating COVID-19, specifically hydroxychloroquine (HCQ), favipiravir, and moxifloxacin, affect the heart's electrical activity, measured by the QT interval, in 193 hospitalized patients. Researchers found that using moxifloxacin, either alone or with HCQ, significantly altered the QT and QTc values, with a marked increase in one group (p=0.005 for QT and p=0.018 for QTc dispersion). This matters because changes in the QT interval can lead to serious heart issues, indicating that careful monitoring is needed for COVID-19 patients receiving these treatments, especially if they also have bacterial infections. Who this helps: This helps patients undergoing COVID-19 treatment and their doctors by highlighting the importance of monitoring heart health during treatment.

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This study looked at the surgical removal of spinal tumors in one piece, known as en bloc resection, in 298 patients over more than 40 years. It found that about 50% of patients experienced complications, with a total of 220 adverse events reported, but the procedure led to a 67% chance of surviving for at least ten years. Although complications are common, this surgery helps manage the disease effectively and is advised for certain patients when performed by skilled surgeons. Who this helps: This benefits patients with spinal tumors and the doctors treating them.

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This study looked at patients with clear cell renal cell carcinoma (ccRCC) that has spread to the spine and how different factors affect their survival after surgery. Researchers followed 69 patients for about 5.5 years and found that the average overall survival was about 34.7 months, with only 31.2% of patients alive after five years. Key factors that improved survival included having fewer metastases and undergoing more aggressive surgical treatments. Who this helps: This benefits patients with spinal metastases from ccRCC and their doctors in making treatment decisions.

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This study looked at the use of 3D-printed custom implants to help rebuild the front part of the upper spine in patients who had surgery to remove tumors. The researchers presented two specific cases where this technology was applied successfully after a type of tumor called chordoma was removed from the C2 vertebra. This is important because it offers a new way to address complex spinal reconstruction, improving outcomes for patients with difficult spinal issues. Who this helps: Patients recovering from spinal tumor surgery.

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This study looked at how Italy managed disasters during the COVID-19 pandemic, especially when combined with other emergencies like natural disasters. Researchers analyzed data from the Italian Red Cross and created a new model to improve disaster management for multiple hazards, proposing guidelines such as better use of slow-onset hazard periods for preparation and sharing more resources internationally. This is important because it can help countries plan more effectively for future crises, reducing the impact on communities. Who this helps: This benefits emergency responders, planners, and communities at risk of disasters.

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This study looked at patients with endometrial cancer who developed rare metastases, or spread of the cancer, to the vertebral bones. Out of 775 patients with bone metastasis, only 1.6% had it from endometrial cancer, with an average of 31.5 months passing between their initial diagnosis and the appearance of bone metastases. Patients often faced serious issues, as 46.2% had painful fractures and the average survival time after developing bone metastasis was only 11.5 months. Who this helps: This research helps doctors treating patients with endometrial cancer by providing important insights into managing bone metastases.

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This study looked at the effectiveness of fully oral antibiotic treatment for patients with a type of bone infection called native vertebral osteomyelitis (NVO), over a 10-year period. Researchers examined 249 patients and found that 13.3% had clinical failures, with a failure rate of 21.7% among those on oral therapy. Importantly, for patients not infected with multidrug-resistant germs, oral treatment was just as effective as traditional intravenous therapy. Who this helps: This benefits patients with vertebral infections who could receive simpler oral treatments instead of more complicated intravenous options.

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This study looked at how astaxanthin (ASX), a natural compound, can protect against hearing loss caused by the cancer drug cisplatin in rats. Researchers found that rats given ASX along with cisplatin showed better hearing test results and less damage to their inner ear structures compared to those given only cisplatin. Specifically, those receiving 25 mg/kg of ASX had higher antioxidant levels, while those on 75 mg/kg had lower oxidative stress, which is known to harm cells. This matters because it suggests that astaxanthin could help prevent hearing loss in patients undergoing cisplatin treatment for cancer. Who this helps: This helps cancer patients who are at risk of hearing loss from cisplatin.

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Researchers studied how malignant pleural mesothelioma (MPM), a type of cancer, returns after initial treatment and what the best options are for managing recurrence. They looked at 94 patients and found that most recurrences (71.3%) involved the cancer spreading to distant sites, particularly in patients who had undergone a specific surgical procedure called extrapleural pneumonectomy (EPP). The average survival time after recurrence was 12 months, with those who had EPP living 14 months and those who had pleurectomy/decortication (PD) living about 8 months. This research highlights that specific factors, like having a longer time without cancer and receiving follow-up treatment, can lead to better survival after recurrence, showing the importance of personalized treatment strategies. Who this helps: This helps patients with malignant pleural mesothelioma by informing treatment decisions after recurrence.

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This paper looks at how extracorporeal membrane oxygenation (ECMO) is used in lung transplants over the past 30 years. Researchers found that ECMO is an important tool for helping patients before, during, and after their lung transplant, showing benefits in preventing complications like graft dysfunction. For instance, different types of ECMO can be used depending on the patient's needs, which can improve their chances of a successful surgery and recovery. Who this helps: This research benefits patients undergoing lung transplantation and their healthcare providers.

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This study looked at patients with bone metastases caused by gynecological cancers, analyzing their clinical features, treatment options, and factors that could influence their outcomes. The researchers reviewed 31 studies involving a total of 2,880 patients and found that many had advanced cancer stages (III and IV). The average survival after diagnosis of bone metastases varied widely, ranging from 3 to 45 months, and the most common treatments were palliative care methods like radiotherapy and chemotherapy. Who this helps: This information benefits doctors and healthcare providers by improving their understanding of treatment and prognosis in patients with gynecological cancer that has spread to the bones.

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This study looked at how to identify if patients with malignant pleural mesothelioma, a type of cancer affecting the lung lining, can safely undergo surgery. Researchers analyzed data from 291 patients and found that about 26% of them had disease that was too advanced for surgery when they entered the operating room. They discovered that high disease burden and low lung capacity were key indicators that surgery would not be successful. Who this helps: This helps patients by avoiding unnecessary surgeries and allows doctors to start more appropriate treatments sooner.

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This study looked at a surgical method for removing a part of the lung in patients with cancer, specifically using a video-assisted technique. The researchers found that this approach allowed for a safe and successful operation, with the patient recovering well and leaving the hospital just four days after surgery, without any major complications. This is important because it shows that even complex surgeries can be done effectively with less pain and shorter hospital stays. Who this helps: This benefits patients with lung cancer and their doctors by providing a safer surgical option.