MRS. SANDRA M. KING

MONROE, NC

Research Active
Orthopaedic Surgery NPI registered 21+ years 50 publications 2018 – 2026 NPI: 1952385809

Practice Location

1310 NEW SALEM RD
MONROE, NC 28110-9696

Phone: (704) 242-0036

What does SANDRA KING research?

Sandra L King studies the use of advanced technologies to identify people from biological samples, such as calcified tissues and muscle. Specifically, she investigates a rapid DNA processing machine called the ANDE 6C, designed to make identifying individuals faster and easier after disasters, where traditional methods can take a long time. Her research aims to enhance how we can identify victims from difficult-to-analyze sources like bones and teeth, improving the speed and efficiency of forensic efforts.

Key findings

  • The ANDE 6C machine achieved a 50% success rate in identifying individuals using teeth samples.
  • The machine had a 0% success rate with muscle tissue samples, indicating limitations in its current application.
  • Overall, the rapid DNA system processed samples much quicker than traditional laboratory methods.

Frequently asked questions

Does Dr. King study identification methods for disaster victims?
Yes, Dr. King focuses on improving identification techniques for disaster victims using advanced DNA technologies.
What technologies has Dr. King researched?
Dr. King has researched the ANDE 6C rapid DNA system, which is designed to quickly identify individuals from bone and tooth samples.
Is Dr. King's work relevant to forensic science?
Yes, her work is significant for forensic science, particularly in identifying unknown remains and disaster victims efficiently.

Publications in plain English

Ontogenetic evidence of socially learned call sequences in Western Australian magpies.

2026

Proceedings. Biological sciences

Mason SL, King SL, Ridley AR

Plain English
Researchers studied young Western Australian magpies to see how they learn to combine their calls and create new sounds over time. They found that the fledglings learn their call sequences primarily from their social group, not from the larger population, and those who interacted more with others learned faster and had a wider variety of calls. This shows that social interaction plays a crucial role in developing their communication skills. Who this helps: This benefits researchers studying animal communication and understanding how social behavior influences learning in birds.

PubMed

What can we learn from bonobos and bottlenose dolphins about the evolution of between-group cooperation?

2026

Proceedings. Biological sciences

Samuni L, Connor RC, Surbeck M, King SL

Plain English
This study looked at how bonobos and bottlenose dolphins cooperate with individuals from other groups, even when there’s no immediate benefit to them. Researchers found that both species show similar traits, like being socially flexible and having advanced social skills, which enable this kind of cooperation. Understanding these behaviors helps us learn more about the roots of teamwork and social behavior in humans. Who this helps: This benefits researchers studying social behavior in animals and humans.

PubMed

APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice.

2025

Communications biology

Anderle S, Bonnar O, Henderson J, Shaw K, Chagas AM +5 more

Plain English
This study looked at how a specific gene variation (APOE4) and a lack of physical activity affect blood flow in the brains of mice, which can be relevant for understanding Alzheimer's disease. The researchers found that mice with the APOE4 gene had poorer blood flow response when active, showing only a 50% increase in blood flow compared to 100% in mice with another gene version (APOE3) during brain activity. Exercise improved blood flow and brain function, especially in mice with the APOE4 gene, suggesting that staying active is crucial for people with this genetic risk factor for reducing dementia risk. Who this helps: This helps patients, particularly those with the APOE4 gene variant at risk for Alzheimer's disease.

PubMed

PD-1 is requisite for skin Tcell formation and specification by TGFβ.

2025

Nature immunology

Devi KSP, Wang E, Jaiswal A, Konieczny P, Kim TG +25 more

Plain English
This study looked at the role of a protein called PD-1 in helping certain immune cells, known as CD8 T cells, develop properly in the skin. Researchers found that PD-1 is crucial for these T cells to effectively colonize skin areas and respond to signals that help them function well, which was confirmed through studies in both mice and humans. Understanding how PD-1 works can improve treatments that use immune therapies for conditions like cancer and autoimmune diseases. Who this helps: This research benefits patients with cancer and autoimmune diseases, as well as doctors treating these conditions.

PubMed

Social Interactions Are Related to Cognitive Development in Western Australian Magpie Fledglings.

2025

Ecology and evolution

Speechley EM, Ashton BJ, Thornton A, King SL, Simmons LW +1 more

Plain English
This study looked at how social interactions affect the brain development of young Western Australian magpies. Researchers found that magpies who interacted more with their peers, especially in large groups, learned better and solved problems faster at 300 days old. For example, magpies that responded to more vocal calls were better at learning tasks, requiring fewer attempts to succeed. Understanding these connections is important because it shows how social environments shape learning and cognitive skills in animals. Who this helps: This research benefits wildlife biologists and conservationists studying animal behavior and development.

PubMed

Allied male dolphins use synchronous displays to strengthen social bonds in a cooperative context.

2025

Movement ecology

Hill-Cousins S, Chereskin E, Allen SJ, Connor RC, Krützen M +2 more

Plain English
Researchers studied how male dolphins in Shark Bay, Australia, use synchronized movements to strengthen their social bonds while cooperating to attract female dolphins. They found that dolphins increased their synchronized displays after friendly interactions and that those with weaker bonds synchronized more precisely. This matters because it shows that dolphins communicate and maintain relationships similarly to humans, highlighting the complexity of their social structures. Who this helps: This helps researchers and conservationists better understand dolphin behavior and social dynamics.

PubMed

Social bonds decrease epigenetic age in male bottlenose dolphins.

2025

Communications biology

Gerber L, Peters KJ, King SL, Allen SJ, Connor RC +6 more

Plain English
This study looked at how social connections impact the biological age of male bottlenose dolphins in Shark Bay, Australia. Researchers found that dolphins with stronger social bonds had a lower biological age, meaning they appeared younger than their actual age. Specifically, they showed that closer bonds reduce biological age while being in larger groups also had a positive effect. This research is important because it helps us understand how social interactions can influence aging not just in dolphins, but potentially in other social animals, including humans. Who this helps: This helps researchers studying aging in social mammals, including healthcare professionals working with older patients.

PubMed

Road Users Fail to Appreciate the Special Optical Properties of Retroreflective Materials.

2024

Human factors

King SL, Szubski EC, Tyrrell RA

Plain English
This study looked at how well drivers and pedestrians understand the special way that certain reflective materials work, called retroreflective materials, which bounce light back toward its source. Researchers found that most people underestimate how bright these retroreflective materials can be, especially if they haven't seen them closely before. For instance, people often think these materials are dimmer than they really are, which might explain why pedestrians don't use these bright markings at night as much as they should. Who this helps: This benefits pedestrians and road safety organizations.

PubMed

Opportunities and Risks for Telehealth in Advancing Health Equity in Academic Medicine.

2024

Academic medicine : journal of the Association of American Medical Colleges

King SL, Rodriguez JA, Shipman SA

Plain English
This study looked at how telehealth can either improve or worsen healthcare access for underserved communities at academic medical centers. Researchers found that while telehealth has the potential to make healthcare more accessible, it also risks widening gaps for those without reliable internet or technology, known as the "digital divide." To make sure telehealth benefits everyone, it needs to be implemented with a focus on fairness and equal access. Who this helps: Patients from underserved communities.

PubMed

In pop pursuit: social bond strength predicts vocal synchrony during cooperative mate guarding in bottlenose dolphins.

2024

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Chereskin E, Allen SJ, Connor RC, Krützen M, King SL

Plain English
Researchers studied how the strength of social bonds affects vocal communication among male bottlenose dolphins when they work together to guard females. They found that dolphins with stronger social connections matched each other's vocal sounds more closely but did not change how often or how long they vocalized. This finding highlights that these vocalizations serve both to keep the females nearby and to strengthen the cooperation among the males. Who this helps: This helps scientists and wildlife conservationists understand animal behavior better.

PubMed

Aggressive interactions influence cognitive performance in Western Australian magpies.

2024

Proceedings. Biological sciences

Speechley EM, Ashton BJ, Thornton A, King SL, Simmons LW +2 more

Plain English
This study looked at how social interactions affect the thinking skills of wild Western Australian magpies. Researchers found that birds in larger groups did better on learning tasks, but the nature of their social interactions mattered too: magpies that faced aggression from others scored higher, while those that were more often aggressive with many birds did worse. Understanding these dynamics is important because it sheds light on how social environments can shape intelligence in animals. Who this helps: This research benefits wildlife biologists and conservationists studying animal behavior.

PubMed

Juvenile social play predicts adult reproductive success in male bottlenose dolphins.

2024

Proceedings of the National Academy of Sciences of the United States of America

Holmes KG, Krützen M, Ridley AR, Allen SJ, Connor RC +3 more

Plain English
This study looked at how playing with others as young dolphins can affect their success in mating when they grow up. Researchers found that male bottlenose dolphins that played more often in roles similar to those they would use in adult mating behavior ended up fathering more offspring. Specifically, males who practiced these "herding" behaviors during play had more paternities as adults, showing that early social play is crucial for their future reproductive success. Who this helps: This helps male bottlenose dolphins by highlighting the importance of social play for their future mating opportunities.

PubMed

Communication range predicts dolphin alliance size in a cooperative mating system.

2024

Current biology : CB

Sørensen PM, Connor RC, Allen SJ, Krützen M, Lebrec U +2 more

Plain English
This study looked at how the communication abilities of male bottlenose dolphins affect the size of their alliances when they are trying to mate. Researchers found that dolphins that could communicate effectively over longer distances formed larger groups of allies, with a direct link to improved mating opportunities. Specifically, the communication range helped determine the number of partners a male could work with, which significantly increased their chances of mating. Who this helps: This benefits dolphin researchers and conservationists studying dolphin behavior and social structures.

PubMed

Anthropogenic noise impairs cooperation in bottlenose dolphins.

2023

Current biology : CB

Sørensen PM, Haddock A, Guarino E, Jaakkola K, McMullen C +3 more

Plain English
This study looked at how noise from human activities affects the teamwork of bottlenose dolphins. Researchers found that when exposed to loud sounds, the dolphins had to use longer and louder whistles to communicate, but their ability to work together suffered significantly—success in their cooperative tasks dropped from 85% in quiet conditions to just 62.5% with high noise levels. This matters because it shows that noise pollution can harm important social behaviors in dolphins, which could impact their survival and well-being. Who this helps: This helps dolphins and conservationists working to protect marine life.

PubMed

An epigenetic DNA methylation clock for age estimates in Indo-Pacific bottlenose dolphins ().

2023

Evolutionary applications

Peters KJ, Gerber L, Scheu L, Cicciarella R, Zoller JA +7 more

Plain English
This study focused on developing a new method to accurately estimate the age of Indo-Pacific bottlenose dolphins using non-invasive skin samples instead of traditional methods that require invasive procedures. By analyzing genetic markers in 165 dolphin samples, researchers created an age prediction model that estimates ages within one year for many individuals, achieving an accuracy of 86% and a median error of just over two years. This is significant because knowing the age of dolphins can enhance our understanding of their populations, survival rates, and reproductive patterns. Who this helps: This benefits researchers studying dolphin populations and conservation efforts.

PubMed

Macronutrient composition of sea otter diet with respect to recolonization, life history, and season in southern Southeast Alaska.

2023

Ecology and evolution

LaRoche NL, King SL, Fergusson EA, Eckert GL, Pearson HC

Plain English
This study looked at what sea otters in Southeast Alaska eat and how their diet changes depending on the time of year and whether they are in areas where they are newly growing in number. The researchers observed thousands of sea otter dives and found that clams were the main food. They discovered that in newly recolonized areas, sea otters had a less varied diet but got more energy from their food compared to those in established areas. This information is important because understanding sea otter diets helps clarify how their population impacts local ecosystems and fishing industries. Who this helps: This benefits fishermen, wildlife managers, and conservationists.

PubMed

APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice.

2023

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Bonnar O, Shaw K, Anderle S, Grijseels DM, Clarke D +3 more

Plain English
This study looked at how a specific gene variant called APOE4 affects blood flow and brain function in the visual cortex and hippocampus of awake mice. The researchers found that while the overall blood vessel count and basic function remained normal in mice with the APOE4 gene, these mice showed lower responsiveness in their blood vessels and increased neuronal activity during visual tasks. This matters because it highlights that APOE4 can subtly change how the brain functions, potentially making individuals more vulnerable to problems like Alzheimer's disease later on. Who this helps: This helps patients at risk for Alzheimer's and their doctors in understanding the early impacts of the APOE4 gene.

PubMed

Inter-group alliance dynamics in Indo-Pacific bottlenose dolphins (Tursiops aduncus).

2023

Animal cognition

Friedman WR, Krützen M, King SL, Allen SJ, Gerber L +2 more

Plain English
This study looked at how male bottlenose dolphins in Shark Bay, Australia, form and maintain complex relationships, called alliances, over six years. Researchers observed 22 adult males and found that these dolphins created strong, distinct alliances, with some individuals taking on more important roles in keeping these partnerships alive. This research shows that dolphins, like humans, engage in strategic social behaviors that help them navigate their social groups, which is unique among animals. Who this helps: This benefits researchers studying animal behavior and social dynamics, as well as conservationists working to protect dolphin populations.

PubMed

α4-Containing GABAReceptors on DRD2 Neurons of the Nucleus Accumbens Mediate Instrumental Responding for Conditioned Reinforcers and Its Potentiation by Cocaine.

2023

eNeuro

Macpherson T, Dixon CI, Robertson J, Sindarto MM, Janak PH +4 more

Plain English
This study examined how certain receptors in the brain—specifically, GABA receptors that contain the α4 subunit—affect behavior related to rewards and the impact of cocaine. Researchers found that mice lacking these receptors responded more eagerly to food-related cues, showing a significant increase in reward-seeking behavior (higher rates of responding for rewards were noted). Additionally, the study highlighted that blocking these GABA receptors can reduce the way cocaine enhances reward-seeking behavior, underlining their critical role in how drugs like cocaine influence our responses to rewards. Who this helps: This research benefits patients struggling with addiction by providing insights into potential treatment strategies.

PubMed

Trends in Adoption and Maturation of Telehealth Programs at Teaching Hospitals and Health Systems.

2022

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

Baker MC, King SL, Sikka N, Krupinski EA, Shipman SA +1 more

Plain English
This study looked at how telehealth programs, which allow patients to receive medical care remotely, have developed in 165 major teaching hospitals and health systems between 2015 and 2018. Researchers found that while hospitals are using more telehealth services, the progression and capabilities of these programs vary widely, with those at higher levels of maturity showing better operational and financial performance. Understanding the different stages of telehealth program development is important for policymakers and healthcare leaders to improve and expand telehealth services. Who this helps: This helps patients and healthcare providers by improving access to telehealth services.

PubMed

Association patterns and community structure among female bottlenose dolphins: environmental, genetic and cultural factors.

2022

Mammalian biology = Zeitschrift fur Saugetierkunde

Marfurt SM, Allen SJ, Bizzozzero MR, Willems EP, King SL +6 more

Plain English
This study focused on how female bottlenose dolphins in Shark Bay, Western Australia, form social groups based on factors like family ties, shared hunting methods, and similar living environments. The researchers found that dolphins with close genetic relationships, as well as those using the same foraging techniques, tended to associate more with each other, and these connections were stronger within specific communities rather than between different groups. Understanding these social structures is important for improving dolphin conservation efforts. Who this helps: This helps researchers and wildlife conservationists working to protect dolphin populations.

PubMed

Social integration influences fitness in allied male dolphins.

2022

Current biology : CB

Gerber L, Connor RC, Allen SJ, Horlacher K, King SL +4 more

Plain English
This study looked at how social interactions among male dolphins in Shark Bay, Australia affect their success in reproducing. Researchers found that males with strong and stable social connections to their peers had more offspring, while those with inconsistent relationships had fewer; specifically, well-integrated dolphins fathered more young. This matters because it highlights the importance of teamwork and social bonds among males in competitive environments, which can influence their reproductive success. Who this helps: This helps researchers studying animal behavior and conservation efforts aimed at dolphin populations.

PubMed

Allied male dolphins use vocal exchanges to "bond at a distance".

2022

Current biology : CB

Chereskin E, Connor RC, Friedman WR, Jensen FH, Allen SJ +3 more

Plain English
This study looked at how male dolphins communicate using whistles to maintain their social bonds, particularly when they can't be close to each other. Researchers found that dolphins with weaker social connections use these vocal exchanges more often, indicating that talking helps them stay connected even if they don't spend much time together. This matters because it shows that vocal communication plays a crucial role in social bonding among dolphins, similar to how it does in some other animals. Who this helps: This helps researchers studying animal behavior and social dynamics in marine life.

PubMed

Characterizing User Experiences With an SMS Text Messaging-Based mHealth Intervention: Mixed Methods Study.

2022

JMIR formative research

King SL, Lebert J, Karpisek LA, Phillips A, Neal T +1 more

Plain English
This study looked at how users feel about a mental health service called Cope Notes, which sends helpful text messages to support people's mental well-being. Out of 14 users interviewed, they shared both positive experiences and suggestions for improvement, with strong feelings that accepting reality and trusting the service helped their experience. The findings show that many users find Cope Notes beneficial for their mental health, especially if the service can be more personalized to their needs. Who this helps: This helps patients looking for accessible mental health support.

PubMed

Bottlenose dolphin communication during a role-specialized group foraging task.

2022

Behavioural processes

Hamilton RA, Gazda SK, King SL, Starkhammar J, Connor RC

Plain English
This study looked at how bottlenose dolphins in Florida work together while hunting mullet fish using a strategy called "driver-barrier feeding." Researchers found that dolphins make more sounds, called whistles, just before they begin this cooperative hunting, with the driver dolphins using echolocation calls to coordinate with the barrier dolphins. This matters because it shows that dolphins can communicate in sophisticated ways, similar to what humans do during teamwork. Who this helps: This helps researchers, conservationists, and anyone interested in animal behavior and communication.

PubMed

Strategic intergroup alliances increase access to a contested resource in male bottlenose dolphins.

2022

Proceedings of the National Academy of Sciences of the United States of America

Connor RC, Krützen M, Allen SJ, Sherwin WB, King SL

Plain English
This study looked at how male bottlenose dolphins in Shark Bay, Australia, form strategic alliances to improve their chances of mating. Researchers found that these dolphins have the largest known alliance network among nonhuman species, with 121 adult males connected in complex ways. Males who built strong ties with rival groups were more successful at mating, showing that these alliances help them compete for females. Who this helps: This research helps scientists understand the social behaviors of dolphins and may provide insights into human social evolution.

PubMed

Social and vocal complexity in bottlenose dolphins.

2022

Trends in neurosciences

King SL, Connor RC, Montgomery SH

Plain English
This study looked at the social interactions and communication patterns of bottlenose dolphins, known for their intelligence and advanced vocal skills. Researchers found that these dolphins have complex social structures and use a variety of sounds to communicate, reflecting their high brain capacity. This understanding helps us appreciate the cognitive abilities of dolphins and the importance of their social behavior. Who this helps: This benefits researchers studying animal behavior and conservationists working to protect dolphin habitats.

PubMed

Immediate Effects of Cervical Spine Manipulation Compared With Muscle Energy Technique on Neck Muscle Activity and Range of Motion in Asymptomatic Participants: A Randomized Study.

2022

Journal of chiropractic medicine

King SL, Docrat A, Abdul-Rasheed A

Plain English
This study looked at how two different techniques for treating the neck—a method called cervical spine manipulation and another called muscle energy technique—affect neck muscle activity and flexibility in people without neck issues. Researchers found that both techniques improved neck movement immediately, but there was no significant difference between the two methods and no changes in muscle activity for either group. This is important because it shows that both techniques can quickly help improve neck mobility, which could be beneficial for therapies aimed at enhancing neck function. Who this helps: This helps patients seeking neck pain relief and chiropractors or therapists offering these treatments.

PubMed

Expert Consensus: Telehealth Skills for Health Care Professionals.

2021

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

Galpin K, Sikka N, King SL, Horvath KA, Shipman SA +1 more

Plain English
This study looked at the important skills that healthcare professionals need to effectively provide care through telehealth, especially as virtual visits became more common during the COVID-19 pandemic. Experts identified a clear set of essential skills needed for clinicians, aimed at ensuring high-quality care through telehealth. This is important because it helps prepare healthcare providers for both current and future demands for virtual care. Who this helps: Patients and healthcare professionals.

PubMed

Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways.

2021

Journal of autoimmunity

Chakraborty A, Staudinger C, King SL, Erickson FC, Lau LS +4 more

Plain English
This study explored how a protein called galectin-9 (Gal-9) impacts the behavior of B cells, which play a critical role in our immune system. Researchers found that Gal-9 is highly present in certain blood vessels in human tonsils and lymph nodes, and it helps B cells attach to these vessels but slows down their movement through the blood vessel walls. This is important because it shows how Gal-9 not only aids in positioning B cells where they need to be but also signals them to be less active, which helps prevent overreactions in the immune response. Who this helps: This benefits patients by improving our understanding of immune regulation and potential treatments for autoimmune diseases.

PubMed

Cooperative partner choice in multi-level male dolphin alliances.

2021

Scientific reports

Gerber L, Wittwer S, Allen SJ, Holmes KG, King SL +5 more

Plain English
This study looked at how male bottlenose dolphins choose their partners for social alliances, focusing on two key periods: adolescence and adulthood. Researchers found that strong social bonds during adolescence helped predict which dolphins would stay together as partners in adulthood. They also discovered that males prefer to ally with those of the same age or older, and that these social connections are more important than being related when it comes to forming cooperative relationships. This research matters because it shows that, like humans and chimpanzees, dolphins also rely on strong friendships rather than just family ties to work together effectively. Who this helps: This benefits researchers studying animal behavior and social structures in marine mammals.

PubMed

Cooperation-based concept formation in male bottlenose dolphins.

2021

Nature communications

King SL, Connor RC, Krützen M, Allen SJ

Plain English
This study looked at how male bottlenose dolphins in Shark Bay, Australia, form complex social groups when working together to chase and protect females. Researchers found that these dolphins have a unique understanding of their alliances, which means they can recognize and organize their relationships in tiers. For example, they can cooperate in pairs or small groups, then come together in larger teams, showing that a dolphin can understand its place in these social structures despite their varying histories or strength of individual bonds. This matters because it shows that complex social thinking isn't just a human trait; it exists in other species as well, which can deepen our understanding of animal behavior and evolution. Who this helps: This benefits researchers studying animal behavior and social structures in wildlife.

PubMed

Evidence that bottlenose dolphins can communicate with vocal signals to solve a cooperative task.

2021

Royal Society open science

King SL, Guarino E, Donegan K, McMullen C, Jaakkola K

Plain English
This study explored whether bottlenose dolphins can communicate using sounds to work together on a task where they had to press buttons at the same time. The results showed that dolphins were much better at cooperating when they used whistles before pressing the buttons. Specifically, they were more successful when they pressed the buttons right after they whistled, leading to quicker responses and more successful attempts. Who this helps: This benefits researchers studying animal communication and cooperation.

PubMed

Assessment of the ANDE 6C Rapid DNA system and investigative biochip for the processing of calcified and muscle tissue.

2021

Forensic science international. Genetics

Manzella AM, Carte KM, King SL, Moreno LI

Plain English
Researchers tested a rapid DNA machine (ANDE 6C) designed to quickly identify people from bone, teeth, and muscle tissue—especially useful after disasters when bodies are hard to identify. The machine worked best on teeth samples (50% success) but performed poorly on muscle tissue (0% success), yet it still processed samples much faster and more simply than traditional lab methods. The machine could become a practical tool for identifying disaster victims and unknown remains in laboratories, but it requires special equipment and trained technicians to prepare the tissue samples beforehand—meaning it won't work as a field-portable solution, and labs would need backup samples available in case the first attempt fails.

PubMed

Climate and human water use diminish wetland networks supporting continental waterbird migration.

2020

Global change biology

Donnelly JP, King SL, Silverman NL, Collins DP, Carrera-Gonzalez EM +2 more

Plain English
This study looked at how climate change and human water use are affecting wetlands in western North America, which are critical for waterbirds during migration. From 1984 to 2018, researchers found that wetland areas in snowmelt regions decreased by 47%, while wetlands in areas influenced by monsoons actually increased by 8%. This matters because the loss of wetlands in northern areas makes it harder for migrating birds to find resting places, potentially disrupting their migration patterns. Who this helps: This helps migratory waterbirds that rely on wetlands for stopovers during their travels.

PubMed

Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.

2020

Scientific reports

Evans SL, Dowell NG, Prowse F, Tabet N, King SL +1 more

Plain English
This study looked at how the brains of people with a specific genetic marker, known as the APOE e4 allele, function at mid-age (ages 45-55), particularly focusing on memory. Researchers tested 32 individuals—16 with the e4 allele and 16 without—using MRI scans to assess brain structure and performance on a memory task. They found that carriers of the e4 allele did not show different memory abilities compared to non-carriers, but their brain activity patterns indicated issues in processing memory, which could explain their higher risk for cognitive decline and Alzheimer's disease as they age. Who this helps: This research benefits patients at risk for Alzheimer's disease, particularly those with the APOE e4 allele.

PubMed

IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors.

2020

Cancer immunology research

Tian T, Lofftus S, Pan Y, Stingley CA, King SL +9 more

Plain English
This study looked at two signaling molecules, IL1α and IL1β, to see how they affect the growth of cancer tumors. Researchers found that tumors grew well in mice lacking IL1 receptor (IL1R1) and those with IL1α, but tumors were mostly absent in mice with IL1β. The study showed that blocking IL1β can slow down tumor growth, especially when combined with other treatments, pointing to IL1α as a key player in boosting the body’s immune response against cancer. Who this helps: This benefits cancer patients seeking more effective treatments.

PubMed

Affiliation history and age similarity predict alliance formation in adult male bottlenose dolphins.

2020

Behavioral ecology : official journal of the International Society for Behavioral Ecology

Gerber L, Connor RC, King SL, Allen SJ, Wittwer S +7 more

Plain English
This study looked at how male bottlenose dolphins in Shark Bay, Australia, form long-lasting social groups, or alliances, that help them compete for mating opportunities. Researchers tracked 59 dolphins over 14 years and found that most friendships formed in their teenage years continued into adulthood. The study revealed that adult dolphins are more likely to form alliances with those who are of similar age, rather than just with family members. Who this helps: This information helps scientists understand dolphin social behavior and can inform conservation efforts.

PubMed

Acoustic coordination by allied male dolphins in a cooperative context.

2020

Proceedings. Biological sciences

Moore BL, Connor RC, Allen SJ, Krützen M, King SL

Plain English
This study looked at how male bottlenose dolphins work together to attract females by coordinating their sounds and movements. The researchers found that these dolphins synchronize their vocalizations and match their vocal tempo when trying to impress a female, showing that they engage in cooperative behavior similar to humans. This matters because it highlights that teamwork and communication strategies seen in humans also exist in other species, revealing deeper insights into animal behavior. Who this helps: This helps researchers and scientists understand social behaviors in animals and their implications for cooperation.

PubMed

Bias and Misrepresentation of Science Undermines Productive Discourse on Animal Welfare Policy: A Case Study.

2020

Animals : an open access journal from MDPI

Jaakkola K, Bruck JN, Connor RC, Montgomery SH, King SL

Plain English
This study looked at how biases and inaccuracies in scientific reviews can affect discussions about animal welfare policy, specifically focusing on a review about the welfare of killer whales in captivity. The researchers found that the reviewed paper had serious flaws, including misleading references and overstatements, which distort true scientific knowledge about the issue. This is important because such misrepresentations can lead to poor policy-making that doesn't actually benefit animal welfare or inform the public correctly. Who this helps: This helps policymakers, animal welfare advocates, and the general public.

PubMed

The effects of exercise to promote quality of life in individuals with traumatic brain injuries: a systematic review.

2020

Brain injury

O'Carroll GC, King SL, Carroll S, Perry JL, Vanicek N

Plain English
This research looked at how exercise affects quality of life for people who have suffered traumatic brain injuries. Out of 13 studies reviewed, eight showed that regular exercise led to improvements in quality of life, with most programs lasting between 8 to 12 weeks, and participants exercising 3 to 5 times a week for 30 to 60 minutes. While the results varied, the overall trend indicates that exercise can be beneficial for these individuals. Who this helps: This helps patients with traumatic brain injuries looking to improve their quality of life.

PubMed

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression.

2019

Behavioural pharmacology

Dixon CI, Walker SE, Swinny J, Belelli D, Lambert JJ +2 more

Plain English
This study looked at how early-life stress (ELS) affects adult mice's reactions to cocaine, specifically focusing on a brain receptor involved in addiction. Researchers found that exposure to ELS made all mice more responsive to cocaine, with the strongest effects seen in mice lacking the GABAA α2 receptor, where ELS led to a reduction in their usual sensitivity to cocaine over time. Understanding this relationship is important because it highlights how stress early in life can alter drug responses and addiction risks. Who this helps: This research benefits patients at risk for addiction, especially those with a background of early-life stress.

PubMed

Exaggerated interpretation bias for uncertain information as a predictor of anxiety-related symptoms: A new method of assessment for IU.

2019

Journal of behavior therapy and experimental psychiatry

Oglesby ME, Stentz LA, Portero AK, King SL, Schmidt NB

Plain English
This research studied how people’s fear of uncertainty influences their anxiety symptoms, particularly for conditions like generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder. The study involved nearly 224 participants who completed tasks measuring their interpretation of uncertain situations, revealing that those with a heightened sensitivity to uncertain information showed stronger anxiety symptoms. This matters because understanding how interpretation bias contributes to anxiety can lead to better assessments and treatments for those struggling with these conditions. Who this helps: Patients dealing with anxiety disorders.

PubMed

Telehealth in Academic Medicine: Roles, Opportunities, and Risks.

2019

Academic medicine : journal of the Association of American Medical Colleges

King SL, Shipman SA

PubMed

Social Functioning in Youth with Attention-Deficit/Hyperactivity Disorder and Sluggish Cognitive Tempo.

2019

The Yale journal of biology and medicine

Ferretti NM, King SL, Hilton DC, Rondon AT, Jarrett MA

Plain English
This study looked at how young people with attention-deficit/hyperactivity disorder (ADHD) struggle in social situations, focusing on how they deal with peer rejection, make friends, and understand social cues. It found that these youth often face significant social challenges, including more withdrawal and isolation, especially if they also show symptoms of sluggish cognitive tempo (SCT). These findings matter because they highlight the need for better strategies and treatments to help these young people improve their social skills. Who this helps: This research benefits patients with ADHD and SCT, their families, and healthcare providers.

PubMed

A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation.

2019

Glycobiology

Steentoft C, Yang Z, Wang S, Ju T, Vester-Christensen MB +10 more

Plain English
This research focused on creating a collection of mouse antibodies that target human enzymes involved in a process called O-glycosylation, which is important for various cellular functions. The study found several new antibodies that can help scientists track these enzymes in cells and tissues, with improved methods to confirm their effectiveness. This is significant because having reliable tools to study these enzymes will enhance our understanding of their roles in health and disease. Who this helps: Patients and researchers studying diseases related to carbohydrate structures.

PubMed

Tool use and social homophily among male bottlenose dolphins.

2019

Proceedings. Biological sciences

Bizzozzero MR, Allen SJ, Gerber L, Wild S, King SL +4 more

Plain English
This study examined how male bottlenose dolphins in Shark Bay, Australia, form social ties based on shared behaviors, specifically the use of marine sponges for foraging. Researchers found that male dolphins who use sponges tended to associate more with other male sponge users, spending less time resting and traveling, and more time foraging, but socializing habits were similar across both groups. These findings show that even for dolphins, social connections can be influenced by specific skills, which helps us understand their social structures and behavior. Who this helps: This research benefits marine biologists and conservationists studying dolphin behavior and social structures.

PubMed

Multi-network-based diffusion analysis reveals vertical cultural transmission of sponge tool use within dolphin matrilines.

2019

Biology letters

Wild S, Allen SJ, Krützen M, King SL, Gerber L +1 more

Plain English
This study examined how bottlenose dolphins pass down a specific tool-using behavior called "sponging" from mothers to their offspring in Shark Bay, Australia. Researchers found that this behavior is mainly learned from mother dolphins to their female calves, showing a strong pattern of vertical transmission. Understanding this process is important because it reveals how behaviors can be shared socially among animals, which can impact their survival and adaptation strategies. Who this helps: This research benefits conservationists and marine biologists studying dolphin behavior and social structures.

PubMed

Vocal behaviour of allied male dolphins during cooperative mate guarding.

2019

Animal cognition

King SL, Allen SJ, Krützen M, Connor RC

Plain English
This study looked at how male dolphins communicate while working together to protect a female who is ready to mate. Researchers found that when interacting with a female, these dolphins made sounds called whistles and pops more often, with whistles being used to greet new dolphins and pops to keep the female close during guard changes. Specifically, they discovered that vocalizations increased significantly when the males needed to coordinate their positions around the female, which helps ensure her safety. Who this helps: This research helps dolphin scientists and wildlife conservationists understand dolphin behavior better.

PubMed

Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans.

2018

Frontiers in immunology

Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka MR +8 more

Plain English
This study examined how B cells, which are crucial for the immune response, change as they mature in special areas called germinal centers. Researchers found that as B cells develop, they lose some complex sugars (O-glycans) on their surface, specifically a type linked to a protein called CD45. These changes are coordinated by two enzymes, ST3Gal1 and GCNT1, and understanding this process is important because it could influence how effectively B cells function in producing antibodies. Who this helps: This helps patients by improving our knowledge of immune responses, which could lead to better treatments for infections and autoimmune diseases.

PubMed

Frequent Co-Authors

Stephanie L King Richard C Connor Simon J Allen Michael Krützen Sarah L King Livia Gerber Erik P Willems Samuel Wittwer Amanda R Ridley Scott A Shipman

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.