Soumi Sadhu

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This research focuses on how a foot strengthening program can improve foot function and reduce injury risk in male Bhangra dancers. The study will involve 140 dancers, with half participating in a 12-week foot exercise program, and will measure changes in foot biomechanics and pressure. This is important because better foot mechanics can help prevent injuries in dancers, allowing them to perform safely and effectively. Who this helps: This helps Bhangra dancers and their instructors.

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This research focused on the RISE ABOVE program, which aims to help people with epilepsy deal with the negative feelings and beliefs that come from societal stigma. The study found that after completing the program, participants reported a 30% reduction in perceived stigma and improvements in their psychological well-being. This is important because it shows that structured support can help reduce the internal struggles caused by stigma, making life better for those affected. Who this helps: This benefits people with epilepsy and the healthcare professionals supporting them.

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This study looked at how other health issues relate to symptoms and signs of dry eye disease (DED) in a group of 371 people in India. Researchers found that older age and longer duration of DED were linked to more signs of the disease than symptoms, while conditions like allergies, gut issues, and psychological disorders led to more severe symptoms without corresponding signs. This is important because it shows that various systemic health conditions can change how DED appears, making it essential for doctors to consider a patient's overall health when diagnosing and treating dry eyes. Who this helps: This helps patients suffering from dry eye disease by improving diagnosis and treatment approaches.

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This study looked at how mesenchymal stem cells (MSCs) can help reduce the severity of cerebral malaria, a dangerous condition caused by malaria parasites affecting the brain. The researchers found that MSCs decreased the number of parasites, improved survival rates by 60%, and protected the brain's blood barrier in infected mice. This matters because conventional treatments do not address the severe immune reactions associated with cerebral malaria, and MSCs could offer a new way to help manage these dangerous complications. Who this helps: Patients with cerebral malaria.

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This study looked at how to make a special type of paper using rice starch and silver nanoparticles to create food packaging that can help keep food fresh. The researchers found that the new coated paper was thicker, denser, and much better at stopping water vapor compared to the regular paper, which means it helps prevent mold on food. There were also significant antibacterial effects against harmful germs, and the shelf life of bread packaged in this paper was notably longer. Who this helps: This benefits food manufacturers and consumers by improving food safety and extending the freshness of packaged goods.

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This study looked at how a specific type of immune cell, called Natural Killer T (NKT) cells, affects the body's defense against leprosy, which is caused by a bacterial infection. Researchers found that patients with the milder form of leprosy (TT/BT) had more NKT cells that help fight infections, while those with the more severe form (LL/BL) had NKT cells that promote disease. Understanding how these cells work could lead to new treatments for leprosy. Who this helps: This helps patients with leprosy and healthcare professionals treating them.

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This study examined how adults with epilepsy experience a self-management online program called RISE ABOVE, which is designed to help them deal with stigma related to their condition. Out of 20 participants, most reported positive outcomes like better emotional awareness and feeling empowered to express themselves, while some struggled with certain aspects of the program, such as its length and difficulty relating to the content. These findings are important because they highlight how the program can be improved to better support people with epilepsy in managing internalized stigma. Who this helps: This helps adults living with epilepsy who face stigma and seek ways to cope.

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This study looked at how a specific immune cell type, called Th9 cells, and a protein they produce known as IL-9 affect respiratory illnesses caused by viruses. The research found that IL-9 can worsen inflammation and mucus production in conditions like COVID-19 and respiratory syncytial virus (RSV), making it harder to breathe. Understanding how IL-9 works could lead to new treatments for these viral infections. Who this helps: This helps patients with respiratory viral illnesses, especially those with conditions like asthma or COVID-19.

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This research explored a new sensing technology made from a special material that changes its ability to absorb light based on temperature and light exposure. The findings showed that the sensors created from this material, when treated with UV light, can specifically detect acetone vapor more effectively, with significant improvements in absorption noted; this means they can respond better to changes in temperature and gas presence. This development is important because it can lead to more sensitive and flexible sensors that could be used for detecting harmful gases. Who this helps: This benefits patients and industries needing quick and accurate gas detection, such as in medical diagnostics and environmental monitoring.

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This research looked at how flexible chains that are "active" (meaning they can move on their own) create different movement patterns based on their length and the activity of connected segments. The study found that short chains with three segments always move in a circle, while longer chains also form various round and wave-like patterns. Understanding these movement types helps scientists and engineers design better materials and systems that could mimic natural movements or improve robotic functions. Who this helps: Researchers and engineers working on active materials and robotics.

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This study focused on improving the production of a key component needed for CAR-T cell therapy, which is a promising cancer treatment with an 80% success rate for acute lymphoblastic leukemia. The researchers made significant enhancements to the manufacturing process by optimizing various techniques, allowing for the easier and more efficient production of these therapeutic cells. This matters because it could lead to wider availability of CAR-T therapies for patients, potentially including those with autoimmune diseases like lupus. Who this helps: Patients with cancers and autoimmune diseases.

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This study looked at using acetaminophen, a common pain reliever, as a potential treatment against the flu. Researchers tested 1,120 existing drugs and found that acetaminophen interacted well with a key part of the influenza virus, showing promise in stopping the virus from reproducing in laboratory tests. This is important because flu viruses can often resist current treatments, so finding a safe and readily available option like acetaminophen could help improve flu care. Who this helps: This helps patients who are at risk of severe flu infections.

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Physicists measured a new property of the hot, dense matter created when lead nuclei collide at near-light speed at the Large Hadron Collider, specifically how momentum fluctuations of particles correlate over long distances. The measurements, broken down by particle type, showed patterns consistent with the collective outward expansion (radial flow) of the matter, and revealed sensitivity to the matter's bulk viscosity. This new observable helps constrain fundamental properties of the quark-gluon plasma — the extreme state of matter that existed just after the Big Bang.

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This study examined the plant Argyreia capitiformis, traditionally used by the Chakma community in Bangladesh to relieve pain and other minor ailments. The researchers found that the plant's extract significantly reduced pain by up to 76.99% at certain doses, showed an anti-inflammatory effect with a maximum inflammation reduction of 45.45%, and lowered blood sugar levels from 8.58 mM to 4.62 mM in tested animals. These findings support the potential of A. capitiformis as a natural remedy for pain, inflammation, and high blood sugar, which could help inform better treatment options. Who this helps: Patients dealing with pain, inflammation, and diabetes.

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Researchers explored a method called osmotic dehydration to make lemon peel a valuable ingredient by preserving its beneficial compounds. They found that at a temperature of about 59°C, with a sugar concentration of 70°Brix, and after soaking for about 2 hours and 39 minutes, the lemon peel lost 3.4 grams of water per gram of peel while still keeping a lot of its important nutrients, like vitamin C and phenols. This matters because it means lemon peel can be used effectively in health products instead of being wasted. Who this helps: This helps food manufacturers looking for sustainable ingredients and health-conscious consumers.

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This study focused on a rare infection caused by a type of worm called Dirofilaria repens, which can show up as bumps under the skin, particularly around the eyes. The researchers detailed a case of an 11-year-old boy who had swelling under his eye, which imaging tests and a follow-up tissue examination confirmed was caused by this infection. Understanding and diagnosing this condition correctly is important because it helps ensure patients get the right treatment for their symptoms. Who this helps: This helps patients with unusual skin bumps after mosquito bites.

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This paper examines how automated systems can make the production of advanced cell therapies, which are expensive and complex, more efficient and affordable. It highlights various design features and strategies that can help scale up manufacturing, such as using modular systems and ensuring quality control. The findings indicate that improved automation can reduce costs and enhance access to these important treatments. Who this helps: This helps patients who need cell therapies and the healthcare providers who deliver these treatments.

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This study looked at an online program called RISE ABOVE designed to help adults with epilepsy manage the stigma they face. Out of 20 participants, over 80% found the program helpful, and there were significant improvements in areas such as stigma, stress, and satisfaction with social activities—showing large reductions in stigma and stress levels. This matters because it shows that online programs can effectively support people with epilepsy in dealing with stigma, which can improve their overall wellbeing. Who this helps: This helps adults with epilepsy by providing them with tools to manage stigma and improve their mental health.

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This research focused on finding natural compounds that can effectively target a protein called ChREBP, which plays a key role in worsening non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM). The study screened over 500 different substances, including 20 existing diabetes medications and 494 natural compounds, and identified five promising candidates: dieckol, isocorilagin, stachyurin, stachysetin, and thonningianin A. These compounds showed strong potential for safely inhibiting ChREBP, which could lead to better treatments for NAFLD and T2DM. Who this helps: This research benefits patients suffering from non-alcoholic fatty liver disease and type 2 diabetes.

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This study looked at how a substance called succinate, produced by gut bacteria, affects inflammation in people with ulcerative colitis (UC). Researchers found that patients with UC had more succinate-producing bacteria and higher levels of succinate in their intestines, which led to increased inflammation by activating certain immune cells. By either increasing good bacteria that process succinate or blocking the effects of succinate, inflammation could be reduced, suggesting this approach could be a new way to treat UC. Who this helps: This helps patients with ulcerative colitis.

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This study looked at how well AI models, like ChatGPT and Gemini, can give personalized dietary advice to breast cancer patients, especially those who may not have access to nutrition counseling. It found that while both AI and human dietitians provided useful meal plans, the AI models were particularly good at creating grocery lists that fit patients' cultural and budgetary needs. Although the dietitians' plans were closer to recommended calorie levels, the AI's macronutrient recommendations were also solid, indicating that these tools can help improve dietary support for cancer patients. Who this helps: This benefits breast cancer patients who lack easy access to nutritional counseling.

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This study looked at how general doctors across nine countries feel about prescribing antibiotics and the growing problem of antibiotic resistance. Out of nearly 10,000 doctors surveyed, 62% acknowledged that antibiotic resistance is a concern in their country, and 94% agreed on the need for more training on antibiotic use. This matters because proper antibiotic prescribing can help fight antibiotic resistance, especially for vulnerable groups like pregnant women and children who may need careful treatment. Who this helps: This benefits doctors and ultimately improves care for patients, especially those with complex health needs.

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The study explored the effects of two plant extracts on models related to COVID-19 and immune system functions. It found that these extracts improved T cell development and enhanced the activity of neutrophils, which are important for fighting infections. These results are significant because they could lead to new treatment options for COVID-19. Who this helps: This helps patients suffering from COVID-19 by potentially providing new therapies.

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This study examined the potential health benefits of Bauhinia acuminata L. fruit, particularly its effects on diabetes, inflammation, and bacteria. Researchers found that the fruit extract showed significant abilities to lower blood sugar levels, reduce swelling, and fight bacterial growth, especially through specific compounds they isolated — β-sitosterol and β-sitosterol-3-O-β-D-glucoside. Importantly, no toxic effects were observed, indicating that the extract could be safe for use. Who this helps: This research benefits patients with diabetes and inflammatory conditions, as well as healthcare providers exploring natural treatment options.

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This study looked at immune cells and nerve fibers in the eyes of people with dry eye disease (DED) and compared them to healthy individuals. The researchers found that people with DED had 58 more immune cells in the cornea per square millimeter and that those with an autoimmune type of DED (Sjogren Syndrome) had 51 more immune cells than those with a non-autoimmune type, while both groups had fewer nerve fibers and shorter nerve length compared to healthy people. Understanding these differences is important for improving diagnosis and treatment for dry eye conditions. Who this helps: Patients with dry eye disease, especially those with Sjogren Syndrome.

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This study explored how mixing a special type of tiny particles called MoS quantum dots with a material known as MAPI can enhance solar cell performance. Researchers found that adding these quantum dots improved the cells' ability to absorb sunlight and transfer energy, leading to efficiency gains of 14% to 28% depending on the testing labs. This is important because more efficient solar cells can generate more electricity from sunlight, making renewable energy sources more viable. Who this helps: This benefits researchers and companies working to improve solar technology for consumers.

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This study explored a new, non-toxic material called methylammonium iodobismuthate (MABI) as a catalyst to convert nitrate into ammonia, an important compound for agriculture. Researchers found that MABI achieved an ammonia production rate of 27.53 micrograms per hour with a high efficiency of 40%. This advancement could lead to more sustainable and environmentally friendly methods for ammonia production, reducing energy use and potential harm from conventional processes. Who this helps: This benefits farmers, industries that rely on ammonia, and environmental advocates.

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This study focused on creating and testing special materials called metallogels made from metals like cobalt and zinc. Researchers found that these metallogels, especially one made with zinc and a certain solvent, effectively killed cancer cells in the HepG2 cancer cell line, reducing cell growth significantly. This matters because it could lead to new treatments for cancer that use these self-repairing materials. Who this helps: Patients with cancer.

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This research focused on how a compound called Resolvin D2 (RvD2) can help manage atherosclerosis by reducing the number of aging, malfunctioning cells (known as senescent cells) in artery plaques. The study found that in mice, RvD2 treatment led to fewer senescent cells and less plaque damage, and when specific signals that prevent cell removal were blocked, the clearance of these unhealthy cells improved. This research is important because reducing senescent cells in plaques could help lessen heart disease and improve overall cardiovascular health. Who this helps: This helps patients at risk for heart disease.

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This study focused on a rare type of cancer in the chest called ALK-rearranged malignant mesenchymal neoplasms. Researchers found three young patients, aged 25 to 33, who had these tumors, two of whom had already spread by the time they were diagnosed. One patient responded to a treatment called crizotinib, highlighting the potential for targeted therapy, but another patient unfortunately passed away just a week after being diagnosed. Who this helps: This research benefits young patients with unexplained tumors in the chest and doctors treating them.

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This study looked at how testosterone affects a specific part of the immune system that is involved in autoimmune diseases, like psoriasis. Researchers found that testosterone reduces the levels of a protein called IL-17, which drives inflammation. In their experiments, treating female mice with testosterone made their psoriasis less severe, while removing testosterone from male mice made it worse, highlighting testosterone’s important role in controlling inflammation. Who this helps: This research helps patients with autoimmune diseases, particularly women who are more affected by these conditions.

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This research paper explores how scientists are modifying gut bacteria, particularly focusing on a strain called E. coli Nissle 1917, to help treat various health issues. They found that by engineering this bacteria to break down excess phenylalanine, it can play a critical role in managing the genetic disorder phenylketonuria (PKU). The findings highlight the future potential of using these engineered bacteria as targeted treatments for gut health issues, which could lead to more effective therapies compared to traditional methods. Who this helps: Patients with phenylketonuria and other gut-related health conditions.

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This study looked at how vision problems, specifically hyperopia (far-sightedness), are treated in school-aged children around the world. Researchers will review existing studies to see how different treatments affect children’s eyesight and overall quality of life. The goal is to gather useful information that can help improve care for these children as there is a lot of variation in how eye care providers handle this condition. Who this helps: This helps children with hyperopia, their parents, and eye care providers.

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This study looked at how different types of stigma affect people's experiences with an online program called RISE ABOVE, designed to help those with epilepsy manage stigma-related issues. It involved 20 participants, half of whom had uncontrolled seizures, and found that while the program led to moderate to large improvements in stress and social satisfaction, people with fewer overlapping stigmas benefited the most. This research highlights the need for tailored support in programs for those facing multiple stigmas, as the effectiveness varied based on the number of stigmas participants experienced. Who this helps: Patients with epilepsy, especially those facing additional stigma from other marginalized identities.

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This study compared two asthma treatments, fluticasone furoate/vilanterol (FF/VI) and budesonide/formoterol (BUD/FOR), to see which one is more effective for patients starting treatment. It found that patients using FF/VI had significantly fewer severe asthma flare-ups after a year—0.072 flare-ups per person compared to 0.226 per person for BUD/FOR. Additionally, those taking FF/VI needed fewer oral corticosteroids and stayed on their medication longer, making it the better choice for managing asthma. Who this helps: This benefits asthma patients and their doctors by providing evidence for more effective treatment options.

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This study looked at two asthma inhaler treatments, fluticasone furoate/vilanterol (FF/VI) and beclometasone dipropionate/formoterol fumarate (BDP/FOR), to see which one works better in real life for patients starting treatment in England. It found that patients using FF/VI had a lower rate of asthma flare-ups (0.0681 per year) after 12 months compared to those on BDP/FOR (0.1104 per year), and FF/VI users were also less likely to stop their treatment. This research is important because it provides evidence that FF/VI may be a more effective and consistent treatment choice for asthma patients. Who this helps: Patients with asthma.

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This study looked at a new type of technology called in-sensor computing (ISC), which combines sensors and processing on one chip to make data processing faster. The researchers discovered that because of this close integration, ISC systems could be vulnerable to a security threat known as a covert channel attack. They highlighted that this could have serious consequences for real-world applications and hope their findings will encourage others to develop better security measures for ISC. Who this helps: This benefits engineers and researchers developing sensor technologies and cybersecurity solutions.

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This research focused on how DNA moves through glass nanopores, which are tiny tubes used for studying biomolecules. The scientists found that the shape of these nanopores affects how quickly DNA travels through them and how much it folds as it goes. Specifically, they measured changes in conductance, time taken for DNA to pass through, and other factors, which can help improve how these nanopores are used in technology. Who this helps: This helps researchers and engineers designing better tools for DNA analysis and medical diagnostics.

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In this study, researchers looked at how the dengue virus affects the thymus, an important organ for producing immune cells. They found that infection with the dengue virus led to a significant shrinking of the thymus, with a loss of crucial immune cells, but by removing certain immune cells called myeloid cells or using a treatment to reduce oxidative stress, they could partially protect the thymus. This is important because it shows that the damage to the thymus during dengue infection is linked to immune cell interactions and not just the level of the virus in the body. Who this helps: This benefits patients with dengue virus infections, particularly those experiencing severe symptoms.

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This research focuses on pure neuritic leprosy (PNL), a form of leprosy that causes nerve damage without skin symptoms, making it hard to diagnose. The study found that current diagnostic methods like nerve biopsies are invasive and limited, highlighting the need for better, non-invasive tests. New techniques like multiplex PCR and improved imaging could help detect the bacteria causing PNL more effectively, aiming to provide timely treatment and prevent disabilities. Who this helps: This benefits patients with pure neuritic leprosy and healthcare providers involved in their diagnosis and treatment.

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This study looked at how different shapes of titania nanoparticles affect the production of hydrogen. Researchers created two types of titania: one in the shape of long rods and the other as small spheres. They found that the rod-shaped particles, known as rutile, produced more hydrogen than the spherical ones, even though typically the spherical ones (anatase) are better at this process. This finding is important because it suggests that the shape of these particles can significantly influence their effectiveness in producing clean energy from hydrogen. Who this helps: This helps scientists working on better materials for clean energy production.

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This study looked at a new method for closing large surgical wounds in patients with advanced oral cancer after a specific type of surgery. Researchers found that using a thoracoabdominal flap to close these wounds resulted in very few problems, with only two patients having minor fluid build-up and one showing some tissue death. This method is important because it improves the appearance of the surgical site and leads to better recovery than traditional skin grafts. Who this helps: This benefits patients with advanced oral cancer undergoing reconstructive surgery.

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This study examined the effectiveness of a compound called berbamine (Berb) against the virus that causes COVID-19 (SARS-CoV-2) and its variants. The researchers found that berbamine significantly reduced the amount of virus in infected mice, nearly eliminating it when combined with other medications. This is important because it suggests that berbamine could help prevent the spread of COVID-19 and aid in recovery from the infection. Who this helps: This benefits patients with COVID-19 and healthcare providers treating them.