Yusuf S Nasrullah

Verve Therapeutics, Cambridge, MA, USA.

1 publication 2021 – 2021
Gene EditingCRISPR-Cas SystemsCells, CulturedAdenineCholesterol, LDL

What does Yusuf S Nasrullah research?

Yusuf S Nasrullah studies how to use a method called CRISPR to change genes in living organisms, specifically to help lower cholesterol levels. High cholesterol is a major risk factor for heart disease, and many people rely on medication to manage it. In his research, Yusuf has explored how a single injection that targets a specific gene can drastically reduce cholesterol levels, offering a potentially permanent alternative to daily medications. His work shows the promise of gene-editing techniques in creating transformative health treatments.

Key findings

  • A single CRISPR base editing injection reduced cholesterol levels in primates by about 60%.
  • The low cholesterol levels persisted for at least 8 months without further treatment.
  • This approach indicates the potential for a one-time treatment solution for patients with high cholesterol.

Frequently asked questions

Does Dr. Nasrullah study cholesterol levels?
Yes, Dr. Nasrullah's research focuses on lowering cholesterol levels using gene-editing techniques.
What treatments has Dr. Nasrullah researched?
He has researched a one-time gene-editing treatment that uses CRISPR to achieve long-lasting reductions in cholesterol.
Is Dr. Nasrullah's work relevant to heart disease patients?
Yes, his work on gene editing offers potential new treatments for heart disease patients, particularly for those struggling with high cholesterol.

Publications in plain English

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.

2021

Nature

Musunuru K, Chadwick AC, Mizoguchi T, Garcia SP, DeNizio JE +37 more

Plain English
Researchers used a gene-editing tool called CRISPR to permanently disable a gene in monkeys' livers that controls cholesterol production, delivering it through tiny fat particles injected into the bloodstream. After a single injection, the monkeys' cholesterol dropped by about 60% and stayed low for at least 8 months without any additional treatment. This proves that gene editing could offer heart disease patients a one-time treatment instead of taking cholesterol drugs for life.

PubMed

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.