DR. KIRK DENNIS GREEN, D.O.

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This study examined how common drug resistance is among key groups of people living with HIV in Nigeria, including sex workers and people who inject drugs. Out of 2,309 participants, 31.1% were actively infected with HIV, and 16.7% of those tested had mutations that make their virus resistant to treatment. This is concerning because high resistance rates were found especially among people who inject drugs, suggesting that many may need new treatment options to manage their infections effectively. Who this helps: This research helps patients with HIV, particularly those in vulnerable populations, by highlighting the need for tailored treatment strategies.

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This study looked at how well a new treatment called ciltacabtagene autoleucel (cilta-cel) works for patients with multiple myeloma who have not responded to other treatments. Researchers compared 73 patients treated with cilta-cel in real-world settings to 97 patients from a clinical trial. They found that overall response rates were slightly lower in the real-world group (88% compared to 97%), but survival rates after two years were similar (72% vs. 74%), and real-world patients experienced fewer side effects. Who this helps: This benefits patients with relapsed refractory multiple myeloma.

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This study looked at how effective an online approach for promoting and distributing HIV self-testing kits in India could be. Over a year, they reached more than 1.4 million people, leading to 1,190 registrations and 712 people successfully ordering a test kit. Results showed that 98.9% received follow-up support, and 1.8% tested positive, with 80% of those starting treatment; overall, most users (95.9%) found the kits easy to use. Who this helps: This helps individuals at risk of HIV, especially men who have sex with men and younger people, by making testing more accessible.

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This study looked at how pelvic radiotherapy affects the gut bacteria and metabolites in patients, as many of them experience gastrointestinal (GI) symptoms during treatment. Out of 227 patients screened, 17 participated, and the researchers found that those with more severe GI symptoms had lower levels of certain substances like heptanal and octanal at the start, and changes in gut bacteria diversity at four weeks into treatment. This research is important because identifying specific markers and patterns in gut health could help doctors manage and predict GI toxicity in patients undergoing pelvic radiotherapy. Who this helps: This helps patients receiving pelvic radiotherapy and their healthcare providers.

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This study focused on creating a helpful resource for critical care nurses who often perform complex procedures that are less common but carry higher risks for patients. Researchers developed a printed packet filled with key information, diagrams, and quick access to hospital policies. Feedback from 43 nurses showed that 100% found the resource relevant, with an average rating of 9.09 out of 10 for its helpfulness in improving knowledge and practice. Who this helps: This benefits critical care nurses and ultimately their patients by ensuring safer and more effective care.

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This study looked at the differences in Emergency Medical Services (EMS) between urban and rural areas in Rivers State, Nigeria. Researchers found that people in rural areas face more obstacles to accessing EMS, such as longer response times, cultural beliefs that prioritize faith-based healing, and high costs, making it harder for them to get help. Improving EMS is crucial because these services can significantly reduce health risks in poorer communities. Who this helps: This helps patients in rural areas who need emergency medical care.

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This research looked at the use of antibiotics before surgery for patients undergoing laparoscopic cholecystectomy, a common procedure for gallbladder removal. The review found that routine use of antibiotics before low-risk surgeries does not significantly lower infection rates, and for high-risk patients, the benefits are unclear due to limited data. This matters because unnecessary antibiotic use can contribute to drug resistance and increased healthcare costs, highlighting the need for more focused studies on high-risk patient groups. Who this helps: This helps doctors and healthcare professionals improve their prescribing practices for patients undergoing gallbladder surgery.

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Researchers studied a new treatment, Fab20, designed to stop a specific interaction in the immune system that can lead to autoimmune diseases. They found that Fab20 effectively blocks B-cell activation, keeping these immune cells inactive and reducing the production of antibodies. Specifically, it binds to its target with a strength of 70 nM and helps maintain the inactive state of B cells for up to 14 days, suggesting it could be a safer and more effective therapy than previous treatments. Who this helps: This benefits patients with autoimmune diseases.

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The study focused on improving airway clearance treatments for children with neurological impairments who were hospitalized with pneumonia. Researchers aimed to raise the percentage of these children receiving the recommended treatments from 54% to 80%, and they successfully achieved this within six months. This is important because better airway clearance can lead to improved recovery for these vulnerable patients. Who this helps: This helps children with neurological impairments and their healthcare providers.

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This study looked at how to create mental health apps that are more effective for young people from diverse backgrounds, especially those facing economic challenges. Researchers worked with 17 youth aged 11-22 in the Netherlands and found that while these young people found apps helpful for immediate stress relief—like through motivational quotes or homework support—they felt such apps wouldn't help with more serious mental health issues. The study highlights the importance of designing apps that communicate genuinely and safely, consider individual identity and backgrounds, and foster community connections. Who this helps: This helps young people from minoritized backgrounds and the professionals who support their mental health.

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This research investigated the levels and causes of antibiotic resistance in pneumococcal infections in southern Ontario from 2014 to 2024. They found that overall resistance to antibiotics has remained stable, with the highest resistance seen for macrolides (31.4%) and tetracyclines (17.4%). This is important because it helps understand how antibiotic resistance develops and informs future vaccination strategies to prevent these infections. Who this helps: Patients and healthcare providers managing pneumococcal diseases.

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This study looked at specific bacteria called lactobacilli found in healthy chickens to see if they could help control Salmonella infections, a common problem in poultry. Researchers found that these bacteria were effective in killing Salmonella, with one strain (Lactobacillus crispatus) showing the strongest results, inhibiting Salmonella's growth within 3 to 6 hours. This matters because using these probiotics can reduce the need for antibiotics in farming, improving animal health and food safety. Who this helps: This benefits poultry farmers and consumers seeking safer chicken products.

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A real-world multicenter study of 195 patients with relapsed/refractory multiple myeloma treated with teclistamab — a bispecific antibody — found that patients with pre-existing kidney impairment had similar response rates and adverse event profiles as those with normal kidney function. Patients with kidney disease required more blood transfusions but were not at higher risk for cytokine release syndrome or infections. The findings support using teclistamab in renally impaired patients and call for dedicated prospective studies in this population.

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This study looked at how people living with HIV and those at risk used telehealth services for HIV prevention and treatment during the COVID-19 pandemic in Asia. It found that 56.8% of people living with HIV and 66.5% of those at risk used these telehealth services, with many increasing their usage in 2021. This is important because while telehealth can improve access to care, challenges like privacy concerns and limited technology need to be addressed to make these services more effective. Who this helps: Patients and healthcare providers working in HIV care.

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This study looked at the differences in stool samples from ulcerative colitis (UC) patients who had an ileoanal pouch versus those with an intact colon. Researchers found that the bacteria in the stools of patients with an ileoanal pouch produced less variety of compounds than those with an intact colon. Specifically, the pouch group had much lower levels of certain compounds like sulfide (9% compared to 57%) and branched-chain fatty acids (45%-64% compared to 93%-96%), while a beneficial compound, butyric acid, was higher in the pouch group (91% compared to 29%). Understanding these differences can help develop better treatments for UC patients. Who this helps: This helps ulcerative colitis patients and their healthcare providers.

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This study looked at how travel time to HIV care affects access and health outcomes for people living with HIV in South Carolina. It found that those who had to travel more than 30 minutes to their HIV clinic were significantly more likely to miss appointments and face transportation issues, with 64.7% missing appointments compared to 41.9% of those traveling less than 15 minutes. This is important because consistent access to care is crucial for managing HIV effectively and improving health outcomes. Who this helps: This research benefits patients living with HIV, especially those in rural areas who struggle with transportation to care.

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This study examined how well HIV prevention services can be combined with family planning for adolescent girls and young women in Uganda. Researchers interviewed 128 people, including young women and healthcare providers, and held workshops to co-create better service models. They found specific obstacles and opportunities related to policy, resources, and community involvement that must be addressed to successfully integrate these services. Who this helps: This benefits adolescent girls and young women seeking both HIV prevention and contraceptive services.

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This study focused on understanding choroid plexus (CP) tumors, which are rare brain cancers mainly affecting children. Researchers discovered that the protein SOX2 plays a key role in the development and growth of these tumors. By studying mouse models, they found that when SOX2 was turned off, tumor growth slowed down significantly, indicating that SOX2 is essential for maintaining the characteristics of tumor cells. Who this helps: This research helps doctors improve treatment strategies for children with choroid plexus tumors.

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This study looked at invasive group A streptococcal (iGAS) infections in children in Canada over 32 years. Researchers found that the number of cases rose sharply to 6.0 cases per 100,000 children in 2023, compared to only 1.8 cases per 100,000 in the early 1990s. They also noted that many of these infections were severe, with 10 children dying, and a significant portion of cases involved viral infections along with the bacteria. Who this helps: This research benefits pediatricians and public health officials working to understand and combat infections in children.

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This research paper reviews different methods that don't use heat to keep food safe and fresh. It highlights techniques like pulsed electric fields and ultraviolet light that can kill germs and prevent spoilage without damaging nutrition or taste. This is important because consumers want food that is both safe to eat and healthy, helping food producers meet their needs without compromising quality. Who this helps: This benefits food producers and consumers looking for safe, nutritious, and high-quality products.

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This research studied how B cells, which produce antibodies, can change and improve their ability to recognize different antigens beyond their initial capabilities. The findings show that when B cells have enough resources and face less competition, they can develop new ways to recognize multiple targets, leading to a wider range of antibody specificities. Specifically, the study highlighted that these changes are influenced by their environment in germinal centers, where they can refine their antibody responses. Who this helps: This benefits patients by potentially improving vaccine responses and therapies that rely on antibody production.

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This study examined how senior doctors at a specific NHS Trust in England feel about clinical excellence awards (CEAs), which are bonuses based on performance. Approximately 57% of the surveyed doctors supported CEAs, but 32% did not apply for them, mainly because they believed they would not be successful. The results show that while CEAs can provide recognition for hard work—especially for part-time and female doctors—there are concerns about fairness and other barriers that prevent full participation. Who this helps: This benefits senior doctors in the NHS who seek recognition for their contributions to patient care.

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This study looked at how different diets—specifically the Mediterranean diet and the Western diet—affect fatigue in patients with autoimmune hepatitis, a condition that causes extreme tiredness. Involving 48 participants, the researchers switched diets between the two groups and tracked changes in fatigue levels using a specific survey. They hope to find that the Mediterranean diet reduces fatigue more than the Western diet, which could provide a new way to help these patients feel better and improve their quality of life. Who this helps: This helps patients with autoimmune hepatitis who struggle with fatigue.

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This study looked at factors that increased COVID-19 infections and deaths in care homes in the West of England. It found that larger care homes had significantly higher rates of infection (12.6 times higher) and mortality (16.5 times higher) compared to smaller ones between August 2020 and February 2021. The research highlights the importance of understanding these risks so care homes can be better prepared for future pandemics, particularly addressing issues like staff shortages and the need for better infection control. Who this helps: This benefits care home residents and staff by improving safety during health crises.

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This study looked at how small labs can use a new, smaller sequencing machine to analyze entire human genomes more efficiently and at a lower cost. They successfully sequenced 807 samples with a high quality rate, showing 96.6% of the data met a quality benchmark, and they could even complete a large sequencing project in under 12 hours. This matters because it makes comprehensive genetic testing more accessible for research and clinical care, helping in disease prevention and treatment strategies. Who this helps: This benefits researchers and healthcare providers working with genetic information.

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This study looked at how Bogong moths, which migrate up to 1,000 kilometers from southeast Australia to the cool caves of the Australian Alps, find their way at night. Researchers found that these moths can use the stars to navigate, even when their magnetic sense is turned off; they flew in the right direction during tests that mimicked natural night skies. Understanding how these moths navigate is important because it reveals the complex systems animals use to move long distances, which can help inform conservation efforts. Who this helps: This information benefits researchers and conservationists focused on wildlife migration patterns.

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This study looked at how well a program that screens for social risks in emergency department (ED) patients works. Researchers found that out of nearly 1,700 patients screened, about 73% had at least one social risk, with the most common issues being social isolation (39%) and depression (23%). The program was effective, helping over 88% of patients at medium risk and up to 100% of high-risk patients connect with needed resources or social workers. Who this helps: This benefits patients in the emergency department who are facing social challenges, allowing them to receive appropriate support.

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This study explored how attending a weekly music class called Kindermusik affected stress levels and emotions in older adults with dementia and their caregivers. Over 12 weeks, 14 participants attended the class, and results showed that caregivers experienced less stress and improved moods on days when their loved ones enjoyed the music class, with those days linked to a positive emotional state in the person with dementia. Improving the timing and support for caregivers could lead to better outcomes as more involvement in these classes may further help both the caregivers and the individuals with dementia. Who this helps: This helps caregivers and older adults with dementia by offering support and emotional relief through music therapy.

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This study looks at a 54-year-old man who suffered a stroke affecting certain parts of his brain, specifically the thalamus and midbrain. After his condition improved, he experienced unusual eye movement problems including difficulty moving the eyes vertically and drooping eyelids. Understanding these eye movement issues is important as it can help in diagnosing and treating similar cases in the future. Who this helps: This benefits doctors and patients recovering from strokes affecting the brain's eye movement control.

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This study focused on improving the growth and function of human B cells, which are vital for our immune system and help fight infections. Researchers created a special system to grow these cells and discovered that two factors, CD40L and IL-4, are crucial for keeping the cells alive and helping them produce specific antibodies, while another factor, BAFF, has little effect. This work is important because it lays the groundwork for better understanding human immune responses and could help in developing new therapies that require human antibodies. Who this helps: Patients needing targeted therapies and doctors involved in immunotherapy.

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This study looked at left ventricular assist devices (LVADs), which are used to help patients with severe heart failure, either temporarily or until they can get a heart transplant. Researchers found that while echocardiography (a heart imaging technique) is good for checking certain aspects of the devices, it struggles to show some details, especially inside the tubes of the device. Instead, CT scans are now the preferred method for spotting complications linked to these devices, especially for the HeartMate II and HeartMate 3 models. Who this helps: This research benefits patients with end-stage heart failure who are using LVADs.

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This study examined a new method for analyzing genetic material that simplifies a complicated process known as hybrid capture. Researchers created a faster way to prepare samples for sequencing, reducing the time needed by more than 50% and improving the accuracy of identifying genetic variations by significantly decreasing false positive and negative rates for certain mutations. This matters because it makes genetic testing quicker, more efficient, and more reliable, particularly for diagnosing conditions like Huntington's disease. Who this helps: This benefits patients needing faster genetic diagnoses, as well as doctors looking for accurate test results.

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This study created and validated a unique dataset that focuses on images of the eyes and surrounding areas to help develop better computer programs for eye-related surgeries. Researchers annotated 2,842 images, finding strong agreement among different reviewers, with an average accuracy score called the Dice score of 0.82 to 0.90 across various tests. This dataset and the tools provided will help speed up the creation of useful technologies for doctors performing eye surgeries, ultimately improving patient care and outcomes. Who this helps: Patients undergoing eye surgeries.

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This study focused on how certain immune cells called age-associated B cells (ABCs) affect the development of liver cancer known as hepatocellular carcinoma (HCC). The researchers found that HCC patients had more of these immune structures called tertiary lymphoid structures (TLS) in their livers, which are linked to cancer progression. When they reduced the number of ABCs, they noticed a decrease in the size of both TLS and tumors in mice with HCC. This research is important because it reveals a potential new way to slow down liver cancer by targeting ABCs to limit TLS formation. Who this helps: Patients with liver cancer.

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This study looked at how different types of viruses in coral reefs affect the growth of harmful bacteria. Researchers found that healthy reefs had viruses that kill bacteria and slow their growth, while degraded reefs had viruses that allow bacteria to grow faster. Specifically, the healthy reefs were linked to certain viral genes that support this "bacterial killing," while the degraded reefs had genes associated with boosting bacterial populations. Understanding how these viruses work is important because it can help us develop new ways to save declining coral reefs. Who this helps: This helps coral reef conservationists and marine biologists working to protect ocean ecosystems.

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This study looked at how well different methods of providing hepatitis C self-testing (HCVST) worked and how much they cost in Vietnam. Researchers found that among nearly 2,900 people tested, those using self-testing were more likely to be first-time testers (67.6%) compared to those using standard tests (59.1%). However, self-testing was more expensive; for example, it cost $636 at community organizations compared to $408 for standard testing. Who this helps: This benefits patients, especially those in key populations and living with HIV, by increasing access to testing.

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This study looked at a new group of brain tumors found in children, called pediatric-type diffuse low grade gliomas. Researchers identified four types of these tumors and noted that successfully diagnosing them requires looking at both their physical and genetic characteristics. Understanding these tumors is important because it can improve treatment methods and patient outcomes, particularly since they have unique features that may respond differently to therapies. Who this helps: This helps doctors and pediatric patients with brain tumors.

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This study looked at arthritis in raccoons from the southeastern United States, focusing on four cases reported between March 2023 and March 2024 in Louisiana and Georgia. The raccoons had joint lesions of varying severity, and three of them also had other health issues like canine distemper and dental disease, which might have made their arthritis worse. Researchers identified two unique genetic sequences related to the bacteria thought to cause this arthritis, which is similar to strains linked to arthritis in humans and pets. Who this helps: This research benefits veterinarians and wildlife health professionals who treat raccoons and monitor zoonotic diseases.

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This study examined the combination of two drugs, enzalutamide and venetoclax, to treat prostate cancer that no longer responds to hormonal therapy. Out of 10 patients, 40% had stable disease and the average overall survival was 19 months. While the treatment had manageable side effects, it also showed that venetoclax levels were not as high as hoped. Who this helps: This benefits patients with advanced prostate cancer who may have limited treatment options.

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This study focused on developing a reliable way to measure different types of xylene, a chemical found in many household and industrial products, in the blood of rodents. Researchers successfully created a method that can measure these xylene types accurately, even at very low levels, with an impressive accuracy rate of 15.3% and a precision of 10.8%. This is important because better detection methods can improve our understanding of xylene's effects on health, especially since the chemical is commonly encountered in everyday life. Who this helps: This benefits researchers and health professionals studying the effects of chemical exposure on health.

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This study reviewed several research papers to see how blood flow restricted exercise (BFRE) affects health and fitness. They found that BFRE can help improve muscle growth by a small amount (39%), strength significantly (61%), aerobic fitness, blood pressure, and vascular health (all around 50% improvement), but it doesn't significantly improve physical function or pain. This matters because BFRE is a useful exercise method for enhancing fitness and health, especially for those who might struggle with traditional heavy weight training. Who this helps: Patients who need a safer way to exercise, especially those recovering from injuries or dealing with certain health conditions.

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This study looked at how much radiation surgeons are exposed to during minimally invasive spine surgery (MIS) when not using special navigation technology. They found that surgeons performing MIS procedures took an average of 192 X-rays per case, which resulted in a radiation dose of 0.96 mGy*m², significantly higher than the 89 X-rays and 0.37 mGy*m² found in traditional open surgery. This is important because excessive radiation can pose health risks to surgeons, highlighting the need for better navigation tools in surgeries. Who this helps: This helps surgeons and healthcare facilities by raising awareness about radiation risks and the importance of using navigation technology.

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This study focuses on improving how care information for patients with frailty is collected and shared among health care teams. Researchers plan to create AI tools that can generate clear and personalized summaries of patient encounters, aiming for accuracy and relevance to patient needs. The project engages local health care teams and will test two methods for developing these AI models to find the best way to integrate them into existing care systems. Who this helps: This benefits patients with frailty and the doctors who care for them.

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This study looked at how a specific enzyme in plants called Diaminopelargonic acid aminotransferase (BioA) helps produce biotin, an essential vitamin. Researchers found that, unlike bacteria, which use different amino donors, plant BioA uses spermidine for this process. They also discovered that carbon dioxide can enhance this enzyme's activity, and cadaverine can inhibit it, which shows how biotin production can be controlled in plants. Who this helps: This benefits researchers developing new antibacterial and herbicide treatments.

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This research focused on a free prenatal clinic set up by students in Alachua County, Florida, to help uninsured families. Over its first year, the clinic served 16 patients, successfully addressing various health issues that could affect mothers and babies and ensuring that most patients smoothly transitioned to regular obstetric care when needed. This work is important because it highlights how community-driven healthcare can improve maternal and child health outcomes for those lacking insurance. Who this helps: This benefits uninsured pregnant women and their families.

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This study looked at the diagnostic needs for detecting infections and exacerbations in people with Cystic Fibrosis (CF). Participants in three focus groups, including patients and healthcare professionals, identified important gaps, such as the need for quicker and less invasive testing options, with many emphasizing accurate results and faster turnaround times. Improving these diagnostic tools is crucial because it could enhance patient care by allowing for earlier detection and more effective management of infections. Who this helps: This helps patients with Cystic Fibrosis and their healthcare providers.