UOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.; Centro di Ricerca e Formazione in Nutrizione Umana, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Dr. Cintoni studies how different diets affect various health conditions, particularly in patients dealing with cancer and chronic diseases. His research includes examining the ketogenic diet's impact on patients with gynecological cancers undergoing radiation therapy and investigating the negative effects of ultra-processed foods on gut health. He also explores the nutritional benefits of ancient grains, such as sorghum, for individuals with celiac disease, aiming to improve dietary options for those needing gluten-free diets.
Key findings
In a study on gynecological cancer patients, both ketogenic and Mediterranean diets had similar adherence levels, but those on the ketogenic diet reported more appetite loss during treatment.
Ultra-processed foods were found to reduce the diversity of beneficial gut bacteria, potentially leading to chronic inflammation linked to type 2 diabetes and colorectal cancer.
Sorghum, an ancient grain, may help individuals with celiac disease manage inflammation, blood sugar, and cholesterol levels, although more long-term studies are needed.
Frequently asked questions
Does Dr. Cintoni study the ketogenic diet?
Yes, he investigates the effects of the ketogenic diet on patients with gynecological cancers undergoing radiation therapy.
What are the negative effects of ultra-processed foods according to Dr. Cintoni?
His research shows that ultra-processed foods can harm gut health, decreasing beneficial bacteria and increasing harmful ones.
Is Dr. Cintoni's work relevant to people with celiac disease?
Absolutely, he studies the potential benefits of sorghum as a healthy gluten-free option for individuals with celiac disease.
What impact do diets have on cancer treatment in Dr. Cintoni's research?
His work suggests that dietary choices, such as the ketogenic diet, can influence side effects and overall treatment experience for cancer patients.
How might Dr. Cintoni's research help patients at risk for chronic diseases?
His studies highlight the importance of dietary choices in managing gut health and preventing conditions like type 2 diabetes and colorectal cancer.
Publications in plain English
Mediterranean diet for the management of pre-existing metabolic diseases: Evidence from a systematic review and meta-analysis featured in the Italian national guidelines "La Dieta Mediterranea".
2026
Nutrition (Burbank, Los Angeles County, Calif.)
Muscogiuri G, Maiorino MI, Paolini B, Aversano F, Buscemi C +27 more
Plain English This research looked at how the Mediterranean diet (MD) can help people with metabolic diseases like obesity and type 2 diabetes. The study found that sticking to the MD reduces the risk of death by 7% for those with these conditions. It also showed improvements in weight and cholesterol levels, but the evidence on gut health was limited.
Who this helps: This helps patients with metabolic diseases like obesity and diabetes.
Editorial for "Gut Microbiota, Diet, and Gastrointestinal Cancer".
2026
Microorganisms
Cintoni M, De Maio F
Plain English This paper examines the links between gut bacteria, diet, and gastrointestinal (GI) cancers, which are significant causes of illness and death worldwide. It highlights that these cancers arise from a combination of genetic factors, environmental exposures, and lifestyle choices. Understanding these connections is crucial for developing better prevention and treatment strategies for GI cancers.
Who this helps: This benefits patients at risk for GI cancers, doctors, and researchers working in cancer prevention.
Clinical Tolerability and Safety of Ketogenic Diet in Patients with Gynecological Malignancies Undergoing Radiotherapy: Preliminary Results of a Prospective, Randomized, Open-Label Trial (KOMPARC).
2026
Nutrients
Cintoni M, Autorino R, Rinaldi RM, Leonardi E, Palombaro M +8 more
Plain English Researchers studied the effects of a ketogenic diet compared to a standard Mediterranean diet in 33 patients with cervical and endometrial cancer who were undergoing radiation therapy. They found that both diets had similar levels of adherence and no significant differences in side effects like nausea, diarrhea, or weight loss. However, both groups did lose weight during treatment, and those on the ketogenic diet reported more appetite loss and concerns about their weight.
Who this helps: This research helps cancer patients receiving radiation therapy by exploring nutritional options that may support their treatment.
Low fT3/fT4 ratio as a proxy for muscle wasting in patients with advanced non-small cell lung cancer treated with pembrolizumab.
2025
Frontiers in oncology
Eccher S, Sposito M, Trestini I, Scaglione IM, Pasqualin L +15 more
Plain English This study looked at patients with advanced lung cancer receiving a specific immunotherapy called pembrolizumab to see if certain hormone levels could indicate muscle loss. The researchers found that 58.1% of the 31 patients experienced muscle wasting, with those having a low ratio of two thyroid hormones (fT3 and fT4) being more likely to have this issue—77.3% of muscle-wasting patients fell below a key threshold. This matters because identifying muscle loss can help doctors better understand how well the treatment is working and what the patient's survival might be.
Who this helps: This helps patients with lung cancer and their doctors.
Skeletal Muscle Quality Evaluation for Prognostic Stratification in the Emergency Department of Patients ≥65 Years with Major Trauma.
2025
Journal of clinical medicine
Covino M, Carbone L, Petrucci M, Pulcini G, Cintoni M +9 more
Plain English This study looked at how the quality of skeletal muscle, measured through CT scans, affects the chances of survival for patients aged 65 and older who have suffered major trauma. Out of 263 patients, 33.5% died in the hospital, and those who died had lower skeletal muscle density. Specifically, a muscle density below 38 units was linked to a higher risk of death during their hospital stay and even increased risk after the first week.
Who this helps: This research helps elderly trauma patients by identifying those at higher risk of mortality, allowing for better care and planning.
Understanding Orthorexia Nervosa: A Systematic Review of Meta-analytical Findings.
2025
Current nutrition reports
Moccia L, Anesini MB, Callovini T, Janiri D, Policola C +7 more
Plain English This study looked at a condition called Orthorexia Nervosa (ON), where people become obsessively focused on healthy eating, which can harm their well-being and everyday life. The researchers reviewed existing studies and found that ON varies in prevalence, with some studies showing rates as high as 38% in certain populations. The condition is linked to traits like compulsive exercise and perfectionism, but it isn't officially recognized, making it challenging to diagnose and treat effectively.
Who this helps: This research benefits patients dealing with ON, as well as doctors needing better tools to identify and treat the condition.
The Interplay Between the Gut Microbiota and Colorectal Cancer: A Review of the Literature.
2025
Microorganisms
Cintoni M, Palombaro M, Zoli E, D'Agostino G, Pulcini G +7 more
Plain English This study looked at how the bacteria in our gut, known as the gut microbiota, affect the risk and treatment of colorectal cancer (CRC). Researchers found that an imbalance in gut bacteria, known as dysbiosis, is common among CRC patients and linked to worse outcomes, like more severe tumors and issues with treatment. Eating a diet low in fiber and high in processed foods can raise CRC risk, while a high-fiber diet can help protect against it; restoring a healthy gut microbiota might also improve treatment results and reduce side effects.
Who this helps: This information benefits patients with colorectal cancer and healthcare providers involved in their care.
Impact of Artificial Sweeteners on Inflammation Markers: A Systematic Review of Animal Studies.
2025
Nutrients
Raoul PC, Romano M, Galli FS, Cintoni M, Capristo E +4 more
Plain English This study looked at how artificial sweeteners, such as aspartame and sucralose, affect inflammation in the body by reviewing 37 animal studies. It found that both aspartame and sucralose may increase inflammation markers, with sucralose also harming gut health. Understanding these impacts is important because it could help people make better choices about their diet and health, especially when considering the rising use of these sweeteners in processed foods.
Who this helps: Patients and consumers concerned about their dietary choices and inflammation-related health issues.
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier.
2025
Nutrients
Rondinella D, Raoul PC, Valeriani E, Venturini I, Cintoni M +8 more
Plain English This research paper looks at how ultra-processed foods, which often contain artificial ingredients and low fiber, negatively affect gut health. It found that these foods decrease the diversity of good bacteria in our gut while increasing harmful ones, leading to chronic inflammation linked to conditions like type 2 diabetes and colorectal cancer. This is important because it highlights the need for better dietary choices and regulations on ultra-processed foods to improve health outcomes.
Who this helps: This benefits patients at risk for chronic diseases and healthcare providers looking to improve dietary recommendations.
Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn's disease treated with ustekinumab.
2024
Therapeutic advances in gastroenterology
Ainora ME, Liguori A, Mignini I, Cintoni M, Galasso L +7 more
Plain English This study looked at how a special type of ultrasound can help predict how well a new Crohn's disease treatment called ustekinumab works in patients. Researchers followed 52 patients and found that 56% (29 patients) showed improvement over a year. The ultrasound measures, like changes in bowel thickness and blood flow, were effective in predicting which patients would respond well to the treatment.
Who this helps: Patients with Crohn's disease and their doctors.
Body composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.
2024
Journal of cachexia, sarcopenia and muscle
Trestini I, Belluomini L, Dodi A, Sposito M, Caldart A +23 more
Plain English This study examined how the body composition of lung cancer patients affects their response to the treatment pembrolizumab, an immune therapy. Out of 134 patients analyzed, those with sarcopenia (muscle loss) had a lower response rate to the medication, with only 30.4% responding compared to 70.5% in patients without muscle loss. These findings are important because they suggest that monitoring body composition could help predict which patients will benefit most from this treatment.
Who this helps: This helps patients with lung cancer and their doctors in making more informed treatment decisions.
Enhanced Recovery After Surgery (ERAS) in Pancreatic Surgery: The Surgeon's Point of View.
2024
Journal of clinical medicine
Longo F, Panza E, Rocca L, Biffoni B, Lucinato C +9 more
Plain English This study looked at how a program called Enhanced Recovery After Surgery (ERAS) has improved recovery for patients undergoing pancreatic surgery, which is known to be risky and complicated. Researchers found that using ERAS practices led to shorter hospital stays and quicker recoveries, positively impacting post-surgery outcomes. This is important because it helps make a tough surgery safer and more manageable for patients, allowing them to get back to their lives sooner.
Who this helps: This benefits patients recovering from pancreatic surgery.
Clinical Impact of Sarcopenia in the Decision-Making Process for Patients with Acute Diverticulitis.
2024
Journal of clinical medicine
Puccioni C, Fransvea P, Rodolfino E, Cintoni M, Vacca A +3 more
Plain English This study looked at how the loss of muscle mass, known as sarcopenia, affects the treatment decisions and outcomes for patients with acute diverticulitis, which is a painful inflammation in the digestive tract. Out of 237 patients studied, 46% had sarcopenia, and these patients were older and more frail. While sarcopenic patients were more likely to undergo a specific type of surgery called Hartmann's procedure, their overall risk of complications or death was similar to those without sarcopenia, highlighting the importance of evaluating muscle health before surgery.
Who this helps: This research benefits doctors and patients by improving treatment plans based on muscle mass assessment.
Microbiota-Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies.
2024
International journal of molecular sciences
Raoul P, Maccauro V, Cintoni M, Scarpellini E, Ianiro G +3 more
Plain English This study looked at how the bacteria in our stomach, mouth, and gut interact and how they might affect gastric cancer (GC) and its treatment. The researchers found that changes in these bacteria can influence the development of GC and how well treatments work, and they believe that nutritional therapies like diet changes and probiotics could play a crucial role in managing the disease. Understanding these relationships could lead to new ways to detect and treat gastric cancer more effectively.
Who this helps: This helps patients with gastric cancer and their doctors.
Impact of body composition parameters on radiation therapy compliance in locally advanced rectal cancer: A retrospective observational analysis.
2024
Clinical and translational radiation oncology
Chiloiro G, Cintoni M, Palombaro M, Romano A, Reina S +11 more
Plain English Researchers looked at how body composition, particularly muscle mass and fat, affects the treatment success of patients with locally advanced rectal cancer. They studied 628 patients and found that those with low muscle mass were more likely to have their radiation therapy interrupted, while higher muscle mass and lower fat levels were linked to better survival rates. This matters because understanding these body composition factors can help doctors better manage treatment and improve outcomes for these patients.
Who this helps: This helps patients undergoing treatment for locally advanced rectal cancer and the healthcare providers who support them.
Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota.
2024
Pathogens (Basel, Switzerland)
Raoul P, De Gaetano V, Sciaraffia G, Ormea G, Cintoni M +5 more
Plain English This research examined the links between gut bacteria, diet, and the effectiveness of immunotherapy for stomach cancer, which is a leading cause of cancer deaths. It found that the makeup of gut bacteria and nutritional health can significantly impact how well patients respond to treatment and their chances of survival. For instance, a better diet might improve immune responses and overall health during treatment.
Who this helps: This helps stomach cancer patients by highlighting the importance of diet and gut health in their treatment.
Preoperative low skeletal muscle mass index assessed using L3-CT as a prognostic marker of clinical outcomes in pancreatic cancer patients undergoing surgery: a systematic review and meta-analysis.
2024
International journal of surgery (London, England)
Raoul P, Cintoni M, Coppola A, Alfieri S, Tortora G +3 more
Plain English This research looked at how low muscle mass in pancreatic cancer patients, measured using a specific type of scan, affects their recovery after surgery. They found that more than half (50.9%) of patients had low muscle mass before surgery, and those patients had a 52% higher risk of not surviving as long after the operation. Understanding muscle mass can help doctors predict patient outcomes and emphasizes the need for nutritional support to improve recovery.
Who this helps: This helps patients with pancreatic cancer and their doctors.
Assessing Quality of Life with the Novel QLQ-CAX24 Questionnaire and Body Composition Parameters in Rectal Cancer Patients: A Single-Center Prospective Study.
2024
Nutrients
Cintoni M, Palombaro M, Raoul P, Chiloiro G, Romano A +11 more
Plain English This study looked at how body composition and physical strength affect the quality of life in patients with locally advanced rectal cancer. Researchers analyzed data from 56 patients and found that important factors like muscle mass and nutritional status were strongly linked to quality of life scores; for example, patients with lower muscle mass reported poorer quality of life. This is important because it highlights the need for monitoring and addressing body composition issues during treatment to help improve patients' well-being.
Who this helps: This helps rectal cancer patients and their healthcare providers.
Sorghum (Sorghum vulgare): an ancient grain, a novel choice for a healthy gluten-free diet.
2024
Minerva gastroenterology
Dionisi T, Rinninella E, Raoul P, Cintoni M, Mele MC +6 more
Plain English This research focused on sorghum, an ancient grain that could be a healthy addition to gluten-free diets for people with celiac disease (CD). It found that sorghum contains beneficial compounds that can help reduce inflammation, manage blood sugar, and lower cholesterol, making it potentially good for those struggling with CD. While there is some initial evidence that it can be safe for celiac patients, more long-term studies are needed to confirm its benefits.
Who this helps: This research benefits patients with celiac disease who need gluten-free food options.
Insulin-sensitizing effect and antioxidant action of alpha lipoic acid in oligomenorrheic women with polycystic ovary syndrome.
2023
Minerva obstetrics and gynecology
Scarinci E, Notaristefano G, Tropea A, Fabozzi SM, Alesiani O +6 more
Plain English This study looked at how alpha-lipoic acid, a supplement, affects women aged 15-34 with polycystic ovary syndrome (PCOS), which often causes irregular menstrual cycles and insulin resistance. After six months of taking 800 mg daily, women experienced an increase in menstrual cycles and a decrease in body mass index (BMI), especially those with normal insulin levels. Additionally, those with high insulin levels saw improvements in blood sugar control and increased antioxidant levels. This is important because it offers a potentially effective treatment option without the side effects commonly associated with traditional medications.
Who this helps: This helps women with polycystic ovary syndrome and healthcare providers looking for alternative treatment options.
Predictive and prognostic effect of computed tomography-derived body composition analysis during neoadjuvant chemotherapy for operable and locally advanced breast cancer.
2023
Nutrition (Burbank, Los Angeles County, Calif.)
Trestini I, Caldart A, Cintoni M, Sperduti I, Drudi A +18 more
Plain English This study looked at how body fat changes during chemotherapy in women with operable or locally advanced breast cancer and how these changes are related to treatment outcomes. Researchers found that patients who gained more than 10% of visceral fat during chemotherapy had a worse survival rate; only 71.4% of those patients remained free of disease after five years, compared to 96.3% of those who gained less than 10%. This highlights the importance of monitoring body composition during treatment, as it can help predict how well patients respond to therapy.
Who this helps: This helps patients undergoing chemotherapy for breast cancer, as well as their doctors.
Noninvasive Evaluation of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis: The Role of Contrast-Enhanced Ultrasound Perfusion Imaging and Elastography.
2023
Ultraschall in der Medizin (Stuttgart, Germany : 1980)
Zocco MA, Cintoni M, Ainora ME, Garcovich M, Lupascu A +8 more
Plain English This study looked at new ultrasound techniques to evaluate portal hypertension in patients with liver cirrhosis, which is the increased pressure in the blood vessels of the liver. The researchers found that measuring liver stiffness had a strong correlation with the traditional method of assessing pressure, and specifically, a stiffness value above 24.2 kPa predicted significant hypertension with an 85% accuracy. Additionally, using contrast-enhanced ultrasound, a measurement below 23.3 units indicated significant hypertension with 100% accuracy in identifying patients affected.
Who this helps: This research benefits patients with liver cirrhosis and their doctors by providing noninvasive methods for accurate diagnosis.
Plain English This study examined how special nutrients, known as immunonutrients, can support the immune system in patients. The researchers found that using these nutrients improved immune function in 70% of patients studied, leading to better recovery rates and fewer infections. This is important because it shows that proper nutrition can play a critical role in healing, especially for patients with weakened immune systems.
Who this helps: This benefits patients, particularly those with compromised immune systems or chronic illnesses.
Dynamics of liver stiffness predicts complications in patients with HCV related cirrhosis treated with direct-acting antivirals.
2023
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Nicoletti A, Ainora ME, Cintoni M, Garcovich M, Funaro B +9 more
Plain English This study looked at how liver stiffness (a measure of liver health) changes in patients with cirrhosis caused by hepatitis C when they are treated with new antiviral medications. Researchers found that a liver stiffness decrease of less than 20% one year after treatment, as well as a higher Model for End-stage Liver Disease (MELD) score, indicated a greater risk of developing serious problems like liver cancer or fluid buildup in the abdomen. This is important because it can help doctors monitor and identify patients who may need more intensive care after treatment.
Who this helps: This helps patients with hepatitis C and their doctors.
Polypharmacy and malnutrition in older people: A narrative review.
2023
Nutrition (Burbank, Los Angeles County, Calif.)
Zanetti M, Veronese N, Riso S, Boccardi V, Bolli C +6 more
Plain English This research paper looks at how older people taking multiple medications—often five or more—are at a higher risk of becoming malnourished. The study finds that polypharmacy, or the use of many drugs, can complicate nutrition and may contribute to poor health outcomes like frailty. It emphasizes that reviewing and reducing unnecessary medications could help improve the nutritional status of these patients.
Who this helps: This helps older patients who are taking multiple medications and may be struggling with nutrition.
Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC).
2023
Cancer immunology, immunotherapy : CII
Vita E, Stefani A, Piro G, Mastrantoni L, Cintoni M +18 more
Plain English This study looked at patients with extensive-stage small cell lung cancer (ES-SCLC) who were receiving maintenance immunotherapy. It found that higher levels of the hormone leptin and a better leptin-to-body fat ratio were linked to longer periods of time without cancer progression—about 13.2 months for those with higher leptin compared to 8.05 months for those with lower levels. This matters because it suggests that leptin could help doctors predict which patients might respond better to treatment.
Who this helps: This helps patients and their doctors make more informed treatment decisions.
Hospital Services to Improve Nutritional Intake and Reduce Food Waste: A Systematic Review.
2023
Nutrients
Rinninella E, Raoul P, Maccauro V, Cintoni M, Cambieri A +4 more
Plain English This study looked at how different hospital services can improve what patients eat while also reducing the amount of food that gets wasted. Researchers reviewed 19 studies and found that personalized meal options and efficient room service can help patients eat better and waste less food. This is important because improving nutrition can lead to better health outcomes for patients and lessen the environmental impact of food waste.
Who this helps: Patients in hospitals and healthcare providers focused on nutrition.
Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies.
2023
Nutrients
Cintoni M, Grassi F, Palombaro M, Rinninella E, Pulcini G +7 more
Plain English This research looked at how different nutritional support strategies can affect patients with pancreatic cancer undergoing chemotherapy. The review of nine studies found that patients who received nutritional interventions tended to have better quality of life, improved nutrition, better body composition, and enhanced oral intake, although the findings weren't strong enough to make definitive conclusions. This is important because it highlights that improving nutrition can help pancreatic cancer patients cope better with their treatment and overall health.
Who this helps: This helps patients with pancreatic cancer.
COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy.
2023
Nutrients
Rinninella E, Borriello R, D'Angelo M, Galasso T, Cintoni M +5 more
Plain English Researchers studied how well the COntrolling NUTritional status (CONUT) score could predict how long patients would stay in the hospital and their chances of dying while hospitalized. They found that out of 203 patients, those with moderate to severe malnutrition (CONUT score of 5 or higher) had longer hospital stays, with an average of over 8 days, and a higher risk of death, particularly if their score was over 8. This is important because using the CONUT score can help doctors identify at-risk patients early and manage their nutrition better, potentially improving outcomes.
Who this helps: This helps patients in the hospital, particularly those at risk of malnutrition.
Best practice & research. Clinical gastroenterology
Rinninella E, Tohumcu E, Raoul P, Fiorani M, Cintoni M +4 more
Plain English This paper studied how different diets affect the bacteria that live in our guts, which are important for our health. It found that what we eat can significantly change the types of bacteria present, influencing our immune system and gut barrier. For example, certain nutrients can either help or harm our gut bacteria, which can impact various diseases. Understanding this connection is important for developing new nutrition-based treatments for health issues.
Who this helps: This helps patients and healthcare providers looking for new ways to improve gut health and manage diseases.
Special Issue "Gastrointestinal Microbiota and Gut Barrier Impact Human Health and Disease": Editorial.
2023
Microorganisms
Raoul P, Cintoni M, Rinninella E, Mele MC
Plain English This study focuses on the link between gut bacteria and overall health. It highlights that an imbalance in gut microbiota can worsen conditions like obesity, diabetes, and heart disease, which are becoming more common worldwide. Understanding this connection is crucial because improving gut health can help prevent or treat these serious diseases.
Who this helps: This helps patients at risk of or suffering from diseases related to gut health.
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota.
2023
Nutrients
Fusco W, Lorenzo MB, Cintoni M, Porcari S, Rinninella E +7 more
Plain English This study looked at short-chain fatty acids (SCFAs), which are important substances produced by certain bacteria in our intestines. These SCFAs help keep our gut healthy, and a lack of them can lead to problems like inflammatory bowel disease and colorectal cancer. Research shows that eating specific foods, especially prebiotics, can increase the amount of SCFAs made by gut bacteria, and boosting SCFA levels could help treat related health issues.
Who this helps: Patients with gut-related disorders and those looking to improve their digestive health.
Metabolic Disorders and Psoriasis: Exploring the Role of Nutritional Interventions.
2023
Nutrients
Cintoni M, Palombaro M, Maramao FS, Raoul P, Egidi G +6 more
Plain English This study looked at how diet and lifestyle changes can affect psoriasis, a long-term skin condition often linked to health issues like obesity and diabetes. The findings indicate that maintaining a healthy weight and following a Mediterranean diet, which is high in fiber and vitamins, can lead to less severe psoriasis symptoms. This information is important because it shows that simple dietary changes can improve health for those with psoriasis.
Who this helps: Patients with psoriasis can benefit from these dietary recommendations.
The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy.
2023
Nutrients
Poto R, Fusco W, Rinninella E, Cintoni M, Kaitsas F +7 more
Plain English This study looked at how the bacteria in our gut and the health of our intestinal lining might influence the rise of food allergies, especially in Western countries. Researchers found that poor gut health and a "leaky" gut can allow harmful substances to enter the body, leading to allergic reactions. They also noted that treatments like probiotics and fecal transplants show promise in preventing and treating food allergies by improving gut health.
Who this helps: This helps patients with food allergies and those at risk of developing them.
Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system.
2022
BioFactors (Oxford, England)
Rinninella E, Mele MC, Raoul P, Cintoni M, Gasbarrini A
Plain English This study focused on the relationship between vitamin D and colorectal cancer (CRC), examining how vitamin D influences the immune system and gut bacteria. It found that vitamin D may help prevent CRC by affecting immune responses and maintaining a healthy gut microbiome. Understanding these connections is important because it could lead to better prevention strategies for colorectal cancer.
Who this helps: This helps patients at risk for colorectal cancer and healthcare providers looking for preventive measures.
Prognostic impact of sarcopenia in children with cancer: a focus on the psoas muscle area (PMA) imaging in the clinical practice.
2022
European journal of clinical nutrition
Triarico S, Rinninella E, Mele MC, Cintoni M, Attinà G +1 more
Plain English This study looked at sarcopenia, which is the loss of muscle mass and strength, in children with cancer and how it affects their health outcomes. Researchers found that the psoas muscle area (PMA), measured through CT or MRI scans, can be an effective way to identify sarcopenia and is often overlooked in clinical settings. Understanding and measuring sarcopenia in these patients is important because it can help improve their overall treatment and recovery.
Who this helps: This benefits children with cancer and their healthcare providers by enabling better assessment and management of muscle health.
The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorectal cancer: A systematic review and meta-analysis.
2022
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Di Giorgio A, Rotolo S, Cintoni M, Rinninella E, Pulcini G +8 more
Plain English This study looked at how the amount of muscle mass in the body affects recovery and survival in patients with colorectal cancer that has spread to the abdominal area, specifically those undergoing surgery and chemotherapy treatment. Researchers found that patients with low muscle mass had a 45% higher risk of developing complications after surgery. This is important because it highlights the need to consider muscle health in treatment planning, as improving muscle mass could lead to better patient outcomes.
Who this helps: Patients with colorectal cancer and their doctors.
Food Additives, a Key Environmental Factor in the Development of IBD through Gut Dysbiosis.
2022
Microorganisms
Raoul P, Cintoni M, Palombaro M, Basso L, Rinninella E +2 more
Plain English This study looked at how food additives in processed foods affect gut health and could trigger inflammatory bowel disease (IBD). Researchers found that certain artificial ingredients, like emulsifiers and sweeteners, can harm the gut’s bacteria and lead to chronic inflammation. This is important because it highlights the need for IBD patients to avoid processed foods and work with nutritionists for healthier diets.
Who this helps: This helps patients with inflammatory bowel disease and their healthcare providers.
Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed).
2022
Nutrients
Romano A, Triarico S, Rinninella E, Natale L, Brizi MG +8 more
Plain English This study looked at the nutritional and muscle health of children with bone and soft tissue cancers. It found that 57.1% of the 21 patients had low muscle mass (sarcopenia) when they were diagnosed, and most showed decreases in body weight and muscle area after 12 months of treatment. The research highlights that a drop in nutritional health is linked to worse survival chances, especially if patients have metastasis or do not undergo surgery.
Who this helps: This helps doctors and healthcare providers understand the importance of monitoring nutrition and muscle mass in young cancer patients.
Feasibility of discharge within 72 hours of major colorectal surgery: lessons learned after 5 years of institutional experience with the ERAS protocol.
2022
BJS open
Biondi A, Mele MC, Agnes A, Lorenzon L, Cintoni M +5 more
Plain English This study looked at how safe and practical it is for patients to leave the hospital within 72 hours after major colorectal surgery when following a specific recovery program called ERAS. After analyzing data from 788 patients, researchers found no significant differences in complications or readmission rates when comparing those who were discharged early to those who stayed longer, indicating that early discharge is safe. This research is important because it highlights that many patients can recover at home sooner without increasing health risks.
Who this helps: This benefits patients undergoing colorectal surgery by allowing them to return home more quickly while maintaining safety.
Preoperative Assessment of Skeletal Muscle Mass and Muscle Quality Using Computed Tomography: Incidence of Sarcopenia in Patients with Intrahepatic Cholangiocarcinoma Selected for Liver Resection.
2022
Journal of clinical medicine
Ardito F, Coppola A, Rinninella E, Razionale F, Pulcini G +5 more
Plain English This study looked at the muscle health of patients with a specific type of liver cancer (intrahepatic cholangiocarcinoma) before they underwent surgery. They found that half of the 30 patients had low skeletal muscle mass, which is a condition called sarcopenia, and one-third had low muscle quality. This is important because having less muscle can lead to worse recovery after surgery, highlighting the need for doctors to assess a patient’s nutrition and muscle health before surgery.
Who this helps: Patients undergoing liver surgery for cholangiocarcinoma.
Incidence and Impact of Refeeding Syndrome in an Internal Medicine and Gastroenterology Ward of an Italian Tertiary Referral Center: A Prospective Cohort Study.
2022
Nutrients
Rinninella E, D'Angelo M, Borriello R, Galasso T, Cintoni M +5 more
Plain English This study looked at refeeding syndrome (RS) in patients at an Italian medical center, especially those who were malnourished and received rapid nutrition after fasting. Researchers found that nearly half (48.3%) of the 203 patients were at risk for RS, and it actually occurred in 38 patients (18.7%), leading to longer hospital stays (12.5 days compared to 7.1 days for those without RS). RS is linked to a higher chance of death, with factors like a low body mass index and delayed nutritional support increasing that risk.
Who this helps: This information benefits doctors and healthcare providers, helping them recognize and manage at-risk patients.
Body composition and immunonutritional status in patients treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC) for gastrointestinal peritoneal metastases: a prospective single-center analysis.
2022
Pleura and peritoneum
Rotolo S, Di Giorgio A, Cintoni M, Rinninella E, Palombaro M +7 more
Plain English This study looked at how body composition and nutritional status affect the effectiveness of a new chemotherapy method called pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with advanced abdominal cancer. Out of 51 patients, 58% were able to have more than one treatment, and 55% showed positive changes in their cancer after treatment. The findings showed that patients with poor nutritional scores were more likely to have worse survival rates, highlighting the importance of evaluating nutrition when planning treatment for these patients.
Who this helps: This helps cancer patients and doctors by identifying factors that can improve treatment outcomes.
Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota.
2022
Foods (Basel, Switzerland)
De Siena M, Raoul P, Costantini L, Scarpellini E, Cintoni M +3 more
Plain English This study looked at how food emulsifiers, which are ingredients used in many processed foods, might affect our gut bacteria and lead to metabolic syndrome, a condition that increases the risk of diabetes and heart disease. Researchers found that some emulsifiers can change gut bacteria in ways that could lead to metabolic disorders, while others might actually have beneficial effects on gut health. However, there are still many unknowns about how much emulsifier is safe to eat and how they interact with different people's gut bacteria.
Who this helps: This helps patients concerned about metabolic health and healthcare providers advising on nutrition.
Impact of Diet on Gut Microbiota Composition and Microbiota-Associated Functions in Heart Failure: A Systematic Review of In Vivo Animal Studies.
2022
Metabolites
Palombaro M, Raoul P, Cintoni M, Rinninella E, Pulcini G +4 more
Plain English This study looked at how different diets affect gut bacteria and heart failure in animals. It found that high-fiber and prebiotic diets can improve heart failure symptoms, like lowering blood pressure and reducing heart enlargement. In contrast, high-fat and choline-rich diets worsened heart function and increased inflammation. This matters because it highlights the importance of diet in managing heart failure, offering a potential way to improve treatment.
Who this helps: This helps patients with heart failure by showing how diet can impact their health.
Evidence-based tailored nutrition educational intervention improves adherence to dietary guidelines, anthropometric measures and serum metabolic biomarkers in early-stage breast cancer patients: A prospective interventional study.
2021
Breast (Edinburgh, Scotland)
Trestini I, Sperduti I, Caldart A, Bonaiuto C, Fiorio E +14 more
Plain English This study looked at how a specialized nutrition education program could help women with early-stage breast cancer stick to healthy eating guidelines during treatment. Researchers found that after 12 months, the average adherence to dietary guidelines improved significantly, leading to benefits such as a 21.8% weight loss for those who followed the guidelines closely compared to just 2.5% for others. Additionally, those who adhered well had better blood sugar levels and reduced central obesity.
Who this helps: This helps early-stage breast cancer patients by providing them with effective dietary support during treatment.
NutriCatt Protocol Improves Body Composition and Clinical Outcomes in Elderly Patients Undergoing Colorectal Surgery in ERAS Program: A Retrospective Cohort Study.
2021
Nutrients
Rinninella E, Biondi A, Cintoni M, Raoul P, Scialanga F +7 more
Plain English This study looked at how a special nutrition program called NutriCatt affects older patients undergoing colorectal surgery. Researchers found that patients on the NutriCatt program had better body health markers and experienced fewer serious complications and shorter hospital stays compared to those who followed standard care. Specifically, those using NutriCatt had significant improvements in body composition and a 90% lower risk of severe complications.
Who this helps: This benefits elderly patients undergoing colorectal surgery and their healthcare providers.
Nutritional Interventions Targeting Gut Microbiota during Cancer Therapies.
2021
Microorganisms
Rinninella E, Raoul P, Cintoni M, Palombaro M, Pulcini G +2 more
Plain English This study looked at how changes in diet, specifically nutritional interventions like prebiotics and dietary strategies, can affect the gut bacteria of cancer patients during their treatments. The research found that these dietary changes can improve the diversity of gut bacteria, which may help reduce side effects and enhance treatment responses. Understanding this connection matters because it opens new ways to support cancer patients through their therapies, potentially improving their overall experience and outcomes.
Who this helps: This helps cancer patients undergoing treatment.
Neoadjuvant treatment: A window of opportunity for nutritional prehabilitation in patients with pancreatic ductal adenocarcinoma.
2021
World journal of gastrointestinal surgery
Trestini I, Cintoni M, Rinninella E, Grassi F, Paiella S +8 more
Plain English This study looked at the effects of preparing patients with pancreatic cancer for surgery by improving their nutrition before starting treatment. Researchers found that good nutritional support can help these patients better tolerate treatment, recover faster, and possibly improve their chances of surviving the disease. Specifically, prehabilitation programs have been shown to reduce complications after surgery and shorten hospital stays for patients who have already had surgery.
Who this helps: This helps patients with pancreatic cancer and their doctors.